Re: Re: Antimony chelation

[Guest guest]

Andy,

Our son is getting out huge amounts of antimony right now and we are not

using SAME. We used TMG a long long time ago, but with every monthly fecal

test (we've done three) the antimony level has risen. The last test it was

around 90 some percent. So something is getting it out! Interesting,

because antimony didn't show up much in the hair (maybe it doesn't?) and I

didn't really think it was a problem. All we've been giving him is the

standard Phase 2 DMSA/ALA every three hours during the day and four at

night, and supplements to support chelation. Nothing unusual.

Barb

P.S. We won't be testing again until March or early April ($$$) so we won't

be able to track what is happening here, unfortunately.

[ ] Re: Antimony chelation

>> While S-adenosylmethionine (sAMe) will probably bind antimony, both

>> DMSA and ALA have much greater affinity for antimony than sAMe.

>Since

>> you're already giving DMSA and ALA, you don't need to add anything

>> extra to remove antimony.

>

>This certainly is the opposite of what I've heard and seen. More

>information, especially in the form of clinical experience or reports

>would be well appreciated.

>

>A

>

>

>

>

[Guest guest]

And yet, and yet . . . as we have been using DMSA and ALA, antimony has been

showing up in every increasing amounts on fecal tests. So . . . is it just

triggering his natural detox system, or is it chelating antimony?????

Barb

[ ] re: antimony chelation

>Antimony: I have also seen no literature reports of DMSA or ALA

>chelating antimony, I have heard no clinical reports, I wouldn't expect

>it from basic chemistry, and indeed I depend on Dr. Amy Holmes'

>statements that DMSA does not work for antimony but SAMe does. Andy

>Cutler

>

>Antimony & DMSA

>

>1: Res Commun Chem Pathol Pharmacol 1981 May;32(2):355-63

>Structural requirements for chelate antidotal efficacy in acute

>antimony(III) intoxication.

>Basinger MA, MM

>

>The LD50 for i.p. potassium antimonyl tartrate was determined to be 54.6

>mg/kg in mice, with a 95% confidence range of 48.4 to 61.7 mg/kg. An

>examination of the antidotal efficacy of a number of different

>structural types of chelating agents showed that very few types were

>able to act as antidotes when potassium antimonyl tartrate was

>administered i.p. to mice at a level of 120 mg/kg. The most effective

>antidotes, by a substantial margin, were the water soluble vicinal

>dithiols: 2,3-dimercaptosuccinic acid and sodium

>2.3-dimercaptopropane-1-sulfonate, with the first of these being

>significantly better than the second. Appreciably less effective, but

>still useful, was D-penicillamine. At this level of administration of

>antimony(III), BAL is not an effective antidote. Among other chelating

>agents which were also not effective at this level of antimony(III) are

>tartaric acid, EDTA, cysteine, sodium diethyldithiocarbamate and

>potassium dithiooxalate.

>

>Bernie

>

>

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