Guest guest Posted February 17, 2001 Report Share Posted February 17, 2001 I'll save everyone the trouble of a medline search as the following does look interesting: 1: Res Commun Chem Pathol Pharmacol 1981 May;32(2):355-63 Related Articles, Books Structural requirements for chelate antidotal efficacy in acute antimony(III) intoxication. Basinger MA, MM The LD50 for i.p. potassium antimonyl tartrate was determined to be 54.6 mg/kg in mice, with a 95% confidence range of 48.4 to 61.7 mg/kg. An examination of the antidotal efficacy of a number of different structural types of chelating agents showed that very few types were able to act as antidotes when potassium antimonyl tartrate was administered i.p. to mice at a level of 120 mg/kg. The most effective antidotes, by a substantial margin, were the water soluble vicinal dithiols: 2,3-dimercaptosuccinic acid and sodium 2.3-dimercaptopropane-1-sulfonate, with the first of these being significantly better than the second. Appreciably less effective, but still useful, was D-penicillamine. At this level of administration of antimony(III), BAL is not an effective antidote. Among other chelating agents which were also not effective at this level of antimony(III) are tartaric acid, EDTA, cysteine, sodium diethyldithiocarbamate and potassium dithiooxalate. Again we have the problem of acute vs chronic intoxication, where the paper is in a case where most of the antimony resides in the extracellular space (to which DMSA is restricted) and the role of the DMSA may simply be to keep it from getting into the cells. Any information on whether antimony inside cells in chronic intoxication is in equilibrium with that outside cells (as e. g. mercury and arsenic are not) or any clinical reports of definitive treatment successes would be very helpful. Also if anyone has the paper, if it happens to report urine antimony concentrations in control and DMSA treated animals it may be possible to make some estimate of efficacy by mass balance calc Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 19, 2001 Report Share Posted March 19, 2001 All, Andy Cutler posted this search result below, it makes an association between Antimony, Tartaric Acid and Potassium. I have a recent Great Plains urinary organic acid profile for my son and wondered if anyone knew what elevated Tartaric acid may be doing, I presume that it may be part of an incomplete detox path, as reference is made to Tartaric acid as a chelator, presumably it aught to be doing some good. The fact that it is elevated in the urine (79 ref: 0-16) is maybe no bad thing if only it was able to drag out the nasties! What could be going wrong? Has anyone had similar results? As he also has high Succinic acid (95 ref: 0-20) then, does administration of DimercaptoSUCCINIC acid make any sense? Also Oxalic acid is 445 ref: 0-100, suppose it had some thiols and potassium attatched, would it then qualify as Dithiooxalate also (below)? Could it be that he is doing everything except 'thiolate' (not sure if I just made this word up)? Citric acid knocks me dead! it is 2043 ref:20-200, but he does drink a lot of orange juice. Any ideas? Jon . [ ] Antimony and DMSA > I'll save everyone the trouble of a medline search as the following > does look interesting: > > 1: Res Commun Chem Pathol Pharmacol 1981 May;32(2):355-63 Related > Articles, Books > > Structural requirements for chelate antidotal efficacy in acute > antimony(III) intoxication. > > Basinger MA, MM > > The LD50 for i.p. potassium antimonyl tartrate was determined to be > 54.6 mg/kg in mice, with a 95% confidence range of 48.4 to 61.7 mg/kg. > An examination of the antidotal efficacy of a number of different > structural types of chelating agents showed that very few types were > able to act as antidotes when potassium antimonyl tartrate was > administered i.p. to mice at a level of 120 mg/kg. The most effective > antidotes, by a substantial margin, were the water soluble vicinal > dithiols: 2,3-dimercaptosuccinic acid and sodium > 2.3-dimercaptopropane-1-sulfonate, with the first of these being > significantly better than the second. Appreciably less effective, but > still useful, was D-penicillamine. At this level of administration of > antimony(III), BAL is not an effective antidote. Among other chelating > agents which were also not effective at this level of antimony(III) > are tartaric acid, EDTA, cysteine, sodium diethyldithiocarbamate and > potassium dithiooxalate. > > > Again we have the problem of acute vs chronic intoxication, where the > paper is in a case where most of the antimony resides in the > extracellular space (to which DMSA is restricted) and the role of the > DMSA may simply be to keep it from getting into the cells. Any > information on whether antimony inside cells in chronic intoxication > is in equilibrium with that outside cells (as e. g. mercury and > arsenic are not) or any clinical reports of definitive treatment > successes would be very helpful. > > Also if anyone has the paper, if it happens to report urine antimony > concentrations in control and DMSA treated animals it may be possible > to make some estimate of efficacy by mass balance calc > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 20, 2001 Report Share Posted March 20, 2001 h Re: [ ] Antimony and DMSA >All, > >Andy Cutler posted this search result below, it makes an association between >Antimony, Tartaric Acid and Potassium. I have a recent Great Plains urinary >organic acid profile for my son and wondered if anyone knew what elevated >Tartaric acid may be doing, I presume that it may be part of an incomplete >detox path, as reference is made to Tartaric acid as a chelator, presumably >it aught to be doing some good. The fact that it is elevated in the urine >(79 ref: 0-16) is maybe no bad thing if only it was able to drag out the >nasties! What could be going wrong? Has anyone had similar results? As he >also has high Succinic acid (95 ref: 0-20) then, does administration of >DimercaptoSUCCINIC acid make any sense? Also Oxalic acid is 445 ref: 0-100, >suppose it had some thiols and potassium attatched, would it then qualify as >Dithiooxalate also (below)? Could it be that he is doing everything except >'thiolate' (not sure if I just made this word up)? Citric acid knocks me >dead! it is 2043 ref:20-200, but he does drink a lot of orange juice. > >Any ideas? > >Jon . > > > [ ] Antimony and DMSA > > >> I'll save everyone the trouble of a medline search as the following >> does look interesting: >> >> 1: Res Commun Chem Pathol Pharmacol 1981 May;32(2):355-63 Related >> Articles, Books >> >> Structural requirements for chelate antidotal efficacy in acute >> antimony(III) intoxication. >> >> Basinger MA, MM >> >> The LD50 for i.p. potassium antimonyl tartrate was determined to be >> 54.6 mg/kg in mice, with a 95% confidence range of 48.4 to 61.7 mg/kg. >> An examination of the antidotal efficacy of a number of different >> structural types of chelating agents showed that very few types were >> able to act as antidotes when potassium antimonyl tartrate was >> administered i.p. to mice at a level of 120 mg/kg. The most effective >> antidotes, by a substantial margin, were the water soluble vicinal >> dithiols: 2,3-dimercaptosuccinic acid and sodium >> 2.3-dimercaptopropane-1-sulfonate, with the first of these being >> significantly better than the second. Appreciably less effective, but >> still useful, was D-penicillamine. At this level of administration of >> antimony(III), BAL is not an effective antidote. Among other chelating >> agents which were also not effective at this level of antimony(III) >> are tartaric acid, EDTA, cysteine, sodium diethyldithiocarbamate and >> potassium dithiooxalate. >> >> >> Again we have the problem of acute vs chronic intoxication, where the >> paper is in a case where most of the antimony resides in the >> extracellular space (to which DMSA is restricted) and the role of the >> DMSA may simply be to keep it from getting into the cells. Any >> information on whether antimony inside cells in chronic intoxication >> is in equilibrium with that outside cells (as e. g. mercury and >> arsenic are not) or any clinical reports of definitive treatment >> successes would be very helpful. >> >> Also if anyone has the paper, if it happens to report urine antimony >> concentrations in control and DMSA treated animals it may be possible >> to make some estimate of efficacy by mass balance calc >> >> >> >> Quote Link to comment Share on other sites More sharing options...
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