Re: chelators and arsenic... help!

[Guest guest]

Does this mean that if one has arsenic along with other heavy metals,

arsenic needs to be chelated before starting on DMSA? My son has arsenic

along with lead, mercury and a host of other elements, and I have him on

DMSA only, is that a problem? What should I use to chelate arsenic if DMSA

and ALA are both problems?

Please help!

[ ] chelators and arsenic

>

>When we were first searching for options to clear our bodies of the

>arsenic

>poisoning we got from the golf course, I came across several articles

>listing

>DMSA as a good arsenic chelator. We've since seen from many many rounds

>of

>chelation followed by urine and stool tests that both DMSA and DMPS lead

>to

>increases in arsenic excretion for all three of us (to be accurate,

>while my

>son and husband have used DMSA, I've never done DMSA but three of my

>rounds

>of DMPS did show high arsenic). All three of us have also had

>reductions in

>hair arsenic in testing. The only metals still showing up in DMSA

>provocative urine testing for my son are arsenic and nickel, with a very

>

>small amount of mercury. Gaylen

> ***********************

>

> NAC and DMSA are both known to chelate arsenic, but

>some studies and some clinical experience has found that lipophilic

>chelators like DMSA(and perhaps thus

>ALA) can cause more arsenic in the brain and more side effects. See

>following animal study using DMSA, and a clinical case where NAC worked

>well for arsenic chelation.

>

>N-Acetylcysteine In The Treatment Of Human Arsenic Poisoning.

>(NAC)

>

>Abstract: A 32-year-old man was brought to the emergency department 5

>1/2 hours after ingesting a potentially lethal dose (900 mg) of sodium

>arsenate ant poison in a suicide attempt. The patient deteriorated

>progressively for 27 hours. After intramuscular dimercaprol and

>supportive measures failed to improve his condition, he was given

>N-acetylcysteine intravenously. The patient showed remarkable clinical

>improvement during the following 24 hours and was discharged from the

>hospital several days later.

> D, Willis S, Cline D. N-Acetylcysteine In The Treatment Of Human

>Arsenic Poisoning. J Am Board Fam Pract 3:293-296;1990

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> Arsenic-induced changes in certain

>neurotransmitter levels and their

> recoveries following chelation in rat whole

>brain.

> AUTHORS: Tripathi N; Kannan GM; Pant BP; Jaiswal DK; Malhotra

>PR; Flora SJ

> AUTHOR AFFILIATION: Divison of Pharmacology and Toxicology, Defence

>Research and

> Development Establishment, Gwalior, India.

> SOURCE: Toxicol Lett 1997 Aug

>22;92(3):201-8

> CITATION IDS: PMID: 9334831 UI: 97475307

> ABSTRACT:

> Arsenic as sodium arsenite (100 ppm in

>drinking water) was administered to male rats for 16 weeks. Animals

>were then treated either with meso-2,3-dimercaptosuccinic acid

>(DMSA), sodium 2,3-dimercaptopropane 1-sulfonate (DMPS), dimethyl DMSA

>(DmDMSA), or diisopropyl DMSA (DiPDMSA) twice daily (50 mg/kg)

>intraperitoneally for 5 days. After 5 days of rest period, the animals

>were again given a second course of chelation therapy.

>The animals were sacrificed subsequently for the determination of whole

>brain biogenic amines levels, acetylcholinesterase (AChE),

>monoamine oxidase (MAO) and delta-aminolevulinic acid dehydratase

>(ALAD) activities. A number of biochemical parameters and arsenic

>concentrations in some tissues were also determined.

> ****** The results suggest a significant increase in brain arsenic

>concentration accompanied by alterations in neurotransmitters levels

>following As(III) exposure. Although chelation treatment was effective

>in reducing As burden, the altered biochemical variables responded

>less favorably to chelation therapy.***********

> The DMSA-diesters, particularly DiPDMSA, produced a more pronounced

>increase in brain arsenic burden, as well as alterations in a few

>neurotransmitters. It can be concluded that the lipophilic character of

>As antidotes may lead to unfavorable results following intraperitoneal

>administration.

>

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