RE: Polycystic Ovary Syndrome , how many have it?

[Guest guest]

Just helped a friend get off glucophage

with LDN and luteiolin/rutin falavinoid mixture from Synorx.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From:

low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of jasonlbreckenridge

Sent: Friday, July 22, 2005 1:50

PM

To:

low dose naltrexone

Subject: [low dose naltrexone]

Polycystic Ovary Syndrome , how many have it?

Curious as there may be a

link and autoimmune diseases? Anyone take

metforim (glucophage)?

THX

[Guest guest]

You are getting way more than you asked for here. Forgive me for

writing a mini-novel, but I do need some insights if you have any.

I have PCOS. I did take Metformin. Then, I stopped after I have my

third daughter because she had colick and I noticed she was much

happier if I did not take it. (I was breastfeeding). It was at this

point that my illness went into high gear, but it started small and

did not raise alarms for a couple of months. On a side note, I was

given a vaccine before I left the hospital with my baby. Shortly

after, I had a dental cleaning as well. Now I wonder if those

contributed to this??

Anyway, I did not worry about it at first. It was just a numb big

toe. But then, it kept getting worse. (vibrating, terrible fatigue,

severe muscle pain and stiffness in upper back, folliculitis,

purpura, red streaks in vein areas sometimes, sore joints (the

shoulder, knee, hips and big toe...in my left side more than right),

muscle twitching all over my body, paresthesias, tingling, etc. It

has been 18 months and I am still dealing with this off and on. After

many tests (normal MRI, abnormal EMG, normal spinal tap, normal Lymes

test, normal evoked potential, mostly normal but some abnormal

bloodwork...sometimes high CRP, high MPV, high hemoglobin and

hematocrit, high neutros, high segs, high monos). After seeing three

neurologists, and three rheumies, no one has diagnosed or helped me.

My bloodwork is always different, but always some abnormal. I have

not been given any treatments or explanations for these. The CRP is

sometimes way high (.23 reference <.07) and sometimes normal. Monos

(12 reference 1-8), Hgb, MPV, monos were high last time. I don't have

a background to interpret any of this. The time before last I had

high amylase, BUN, and WBC as well. (Those were OK recently

however ???)

Oh, I guess I take that back, I was diagnosed with " Peripheral

Neurapathy " and " Wartenberg's Migratory Polyneuritis " . And I already

had a diagnosis of Fibromyalgia, but it is hard for me to believe

that FM is causing all of this. I don't think PN or Wartenberg's

explains all my symptoms either, and I just don't buy it.

It seemed like I was somewhat better for a while, until the heat of

the summer, and now I am majorly flaring again. And I am sure I have

a cyst on my left ovary because I have pain there. I switched OBs and

my new OB didn't want me to go back to Metformin.

I ordered LDN and have not received it yet. I sure hope it helps. I

am in lots of pain at the moment.

Any suggestions or tips anyone has for me are definitely appreciated!

I am at my wits end trying to take care of my three kids and deal

with this. I want to get better!! I had given up on Drs completely,

but now I am considering going back for another round of beating my

head against the wall. I am not sure it is worth the time, emotional

stress, and money judging from my experience so far. Maybe LDN will

do the trick and I can forget about this and move on with my life.

> Curious as there may be a link and autoimmune diseases? Anyone take

> metforim (glucophage)?

>

> THX

[Guest guest]

One suggestion just based on the symptoms you described to me is to

do FULL tests on vitamin b12 defiency because metformin is known to

rapidly cause b12 defiency which your symptoms mirror very much. I

suggest intramuscular b12 injections hydroxycoblamin or

methylcoblamin not cyanocoblamin if possible. Take folic acid along

with it. If it works, youll know :-)

JL

> > Curious as there may be a link and autoimmune diseases? Anyone

take

> > metforim (glucophage)?

> >

> > THX

[Guest guest]

Thank you . Where do I get B12 intramuscular? Would my family

Dr. do that? Also, in May 2004 I was tested for:

Folate 17.5 ng/mL (ref 2.8-20.)

B12 707 ph/mL (ref. 200-1000)

Do you think I need retested?

I think that I might have a mycoplasma issue and/or chronic lyme's. I

did have a blood test for Lyme (negative) and a spinal tap

(negative). On the other hand, it says on my spinal tap report " if

clinical features of illness are highly indicative of Lyme

neuroberreliosis, additional serologic testing on CSF would be

warranted. " Is that standard lawsuit fine print or is there something

in my results that make them say that? Unfortuneately, I was not

educated at all on anything when I had this and we did not do

additional testing. I don't think I could do a spinal tap again.

Horrid and I had to have two blood patches and almost a week of a

awful headache.

I have been on antibiotic therapy since last Oct. Istarted it because

it has helped all sorts of rhematic illnesses. I didn't know what I

have, but do know it is inflammatory/rheumatic. The antibiotic

(eryththromycin) almost immediately made the numbness go away and

stay away. In May and early June I was feeling good, almost normal. I

decided I might not need the antibiotics anymore. Then I relapsed. I

don't know for sure why as it also corresponded with the temperature

going up, and last summer's heat was hard xtoo. I am back on

antibiotics now. One of my problems is that no Dr. here will give me

antibiotics for anything other than acne and I am not on the best

dose or kind for Lyme or for mycoplasma. I plan to go back to the Dr

to ask for the other kind of antibiotic and hope that the

antibiotic/LDN combo will strengthen my immune system so I can kill

the offenders. Or, if I do have MS hopefully it will fight that too.

Do you think I should get tested again for B12 or Lyme or are there

other tests I missed? Do you think I am way off base??

Sincerely,