Re: Generic Naltrexone

[Guest guest]

Rhonda

Just picked up my script and it is also generic. I called the pharmacist and he said it's exactly the same as Revia pill; that it has to be.

I faxed my letter to the doctor saying I wanted Revia (not a generic). I guess when the girl called it in she probably said Revia not specifying not a generic and that's what they give you.

What are you going to do?

Arlene

[Guest guest]

Just drop the caps into water. The

capsules are made of gelatin and will dissolve in under 5 minutes, just like it

does in your stomach. Most of the time a gelatin cap will dissolve in under 1

minute.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of Rhonda

Sent: Friday, July 08, 2005 9:30

AM

low dose naltrexone

Subject: [low dose naltrexone]

Generic Naltrexone

Is anyone taking this with the same results as Revia or the compounded

way?

I haven't experimented opening both the 3mgs and

1.5mgs and putting in

water to see if it works that way. I don't

want to waste a day and not

feel good. The compounded way is more

expensive also than the $35 for

30 Revias which last 10 months.

Rhonda

[Guest guest]

I called and asked them to call in REVIA at Eckerds and either put take

one nightly or Use as Necessary. Haven't heard back yet and had to call

Walmart and tell them to get the other script out of the computer since

I can only get one script a month.

I was hoping somebody else on the group used the generic to tell us but

I really do not want to experiment to see if I get the same results.

This isn't a cold here we are halting. Generic would be $10 for 30

pills and Revia $35 so b/c it last 10 months, $35 isn't that bad to

know that it works for me for sure.

Maybe you can try the generic and let us know but I know you want

RESULTS like I got from fatigue releif from the Liquid Revia. Maybe

your pharmacy was like Walmart and only had generic. I will talk to

the pharmacist at Eckerds and see what he says. I hope this gets taken

care of today. Been working on this all week. I'm glad I have some

Revia left and gave 4 away! Yikes...I may open the two compounded LDN

capsules and try that just to see if it works for me that way but it

will be more costly that way.

Rhonda

> Rhonda

> Just picked up my script and it is also generic. I called the

pharmacist

> and he said it's exactly the same as Revia pill; that it has to be.

>

> I faxed my letter to the doctor saying I wanted Revia (not a

generic). I

> guess when the girl called it in she probably said Revia not

specifying not a

> generic and that's what they give you.

>

> What are you going to do?

>

> Arlene

[Guest guest]

I called Eckerds and ask for the company that makes the generic

Naltrexone. Barr Laboratories and I called them and they are going

to email me the list of fillers in the generic within the hour.

Thought better than way than her spelling all of them on the phone.

I will copy and paste to group when I get the info. So I found out

Arlene.

Rhonda

> > Rhonda

> > Just picked up my script and it is also generic. I called the

> pharmacist

> > and he said it's exactly the same as Revia pill; that it has to

be.

> >

> > I faxed my letter to the doctor saying I wanted Revia (not a

> generic). I

> > guess when the girl called it in she probably said Revia not

> specifying not a

> > generic and that's what they give you.

> >

> > What are you going to do?

> >

> > Arlene

[Guest guest]

that is fascinating--does anyone know what kind if filler are in these manufactured tablets-because when you get it compounded it comes direct form the pure powder and you know that you are getting what your suppose to getcyndiOn Jun 9, 2006, at 11:00 PM, bentleyfam26 wrote: asked: "would anyone know if the generic forms of naltrexone(antaxone, nalorex, etc) are the same as or are as good as the Revia.I make my own LDN and have been using Revia. I have some Nodicttablets, they say 50mg naltrexone, but am not sure if they are thesame thing, or the generic forms."Hi !Good question. The word "generic" doesn't have much meaning for Naltrexone tabletsanymore. At this point, ALL forms of 50 or 100mg tablets ofnaltrexone are generic. Here's the deal... Other 50mg versions of naltrexone are named Nalorex (manufactured byBristol-Myers Squibb in the UK); Nodict (manufactured by Sun Pharma inIndia); Naltima (manufactured by INTAS in India), Narpan (by Duopharmain Malaysia), Antaxone (by Pharmazam in Spain), Celupan (by Lacer inSpain), Narcoral (by Siton in Italy), Nemexin (Bristol Myers Squibb inGermany), as well as Revez, Naltrexona, and Naltrexonum.Although all of these brand-name tablets contain naltrexone, eachtablet also contains about 84% filler. Each manufacturer uses adifferent combination of filler ingredients. It's the filler, ratherthan the naltrexone itself, which accounts for differences in patientreactions to the various brands. For more information about the history of Naltrexone, go here: http://gazorpa.com/History.htmlFor more information about filler in commercially prepared Naltrexonetablets, go here: http://gazorpa.com/LDNFillers.html Gee… anyone still awake? I wonder if anyone finds this as fascinatingas I do...ZZZZZZZzzzzzzzzz…. Maureen (Gazorpa)

[Guest guest]

To be honest with you, I dont think the filler is as big of an issue

with the pills (homemade) as it is with the compounded LDN.

>

> > asked: " would anyone know if the generic forms of

naltrexone

> > (antaxone, nalorex, etc) are the same as or are as good as the

Revia.

> > I make my own LDN and have been using Revia. I have some Nodict

> > tablets, they say 50mg naltrexone, but am not sure if they are

the

> > same thing, or the generic forms. "

> >

> > Hi !

> >

> > Good question.

> >

> > The word " generic " doesn't have much meaning for Naltrexone

tablets

> > anymore. At this point, ALL forms of 50 or 100mg tablets of

> > naltrexone are generic.

> >

> > Here's the deal...

> >

> >

> >

> > Other 50mg versions of naltrexone are named Nalorex

(manufactured by

> > Bristol-Myers Squibb in the UK); Nodict (manufactured by Sun

Pharma in

> > India); Naltima (manufactured by INTAS in India), Narpan (by

Duopharma

> > in Malaysia), Antaxone (by Pharmazam in Spain), Celupan (by

Lacer in

> > Spain), Narcoral (by Siton in Italy), Nemexin (Bristol Myers

Squibb in

> > Germany), as well as Revez, Naltrexona, and Naltrexonum.

> >

> > Although all of these brand-name tablets contain naltrexone, each

> > tablet also contains about 84% filler. Each manufacturer uses a

> > different combination of filler ingredients. It's the filler,

rather

> > than the naltrexone itself, which accounts for differences in

patient

> > reactions to the various brands.

> >

> > For more information about the history of Naltrexone, go here:

> >

> > http://gazorpa.com/History.html

> >

> > For more information about filler in commercially prepared

Naltrexone

> > tablets, go here:

> >

> > http://gazorpa.com/LDNFillers.html

> >

> > Gee… anyone still awake? I wonder if anyone finds this as

fascinating

> > as I do...

> >

> > ZZZZZZZzzzzzzzzz….

> >

> > Maureen

> > (Gazorpa)

> >

> >

> >

>

[Guest guest]

....from what I understand, there ARE some pharmacists who make LDN

from naltrexone tablets. And, not trying to be a smarta**, but how

do you REALLY know you are getting what you are supposed to get?

>

> > asked: " would anyone know if the generic forms of

naltrexone

> > (antaxone, nalorex, etc) are the same as or are as good as the

Revia.

> > I make my own LDN and have been using Revia. I have some Nodict

> > tablets, they say 50mg naltrexone, but am not sure if they are

the

> > same thing, or the generic forms. "

> >

> > Hi !

> >

> > Good question.

> >

> > The word " generic " doesn't have much meaning for Naltrexone

tablets

> > anymore. At this point, ALL forms of 50 or 100mg tablets of

> > naltrexone are generic.

> >

> > Here's the deal...

> >

> >

> >

> > Other 50mg versions of naltrexone are named Nalorex

(manufactured by

> > Bristol-Myers Squibb in the UK); Nodict (manufactured by Sun

Pharma in

> > India); Naltima (manufactured by INTAS in India), Narpan (by

Duopharma

> > in Malaysia), Antaxone (by Pharmazam in Spain), Celupan (by

Lacer in

> > Spain), Narcoral (by Siton in Italy), Nemexin (Bristol Myers

Squibb in

> > Germany), as well as Revez, Naltrexona, and Naltrexonum.

> >

> > Although all of these brand-name tablets contain naltrexone, each

> > tablet also contains about 84% filler. Each manufacturer uses a

> > different combination of filler ingredients. It's the filler,

rather

> > than the naltrexone itself, which accounts for differences in

patient

> > reactions to the various brands.

> >

> > For more information about the history of Naltrexone, go here:

> >

> > http://gazorpa.com/History.html

> >

> > For more information about filler in commercially prepared

Naltrexone

> > tablets, go here:

> >

> > http://gazorpa.com/LDNFillers.html

> >

> > Gee… anyone still awake? I wonder if anyone finds this as

fascinating

> > as I do...

> >

> > ZZZZZZZzzzzzzzzz….

> >

> > Maureen

> > (Gazorpa)

> >

> >

> >

>

[Guest guest]

I can't imagine an pharmacist making this from  the tablets-what would the point be -how could you even figure the does out?cyndiOn Jun 10, 2006, at 1:26 PM, wrote:...from what I understand, there ARE some pharmacists who make LDN from naltrexone tablets. And, not trying to be a smarta**, but how do you REALLY know you are getting what you are supposed to get?

[Guest guest]

There are many folks who make their own LDN from naltrexone tablets

with less than 'very accurate' measuring devices, I would imagine a

pharmacist would/should have the necessary measuring devices to be

somewhat more accurate, after all, they are measuring only 3-4.5mg's

of naltrexone powder to mix with filler. A naltrexone tablet is

around 300mg's I think(could be more or less), at least those of us

who make it ourselves are dealing with 18-27mg doses(could be more

or less), not 3-4.5 doses. I would need quite an expensive scale to

measure that kind of dose. It even states on the

lowdosenaltrexne.org site that some pharmacists make LDN out of

naltrexone tablets. If your pharmacist cant figure out how to dose

out a 50mg naltrexone tablet into 3-4.5 mg doses, better get a new

pharmacist! :0)

>

[Guest guest]

It's actually very simple with liquid LDN

If you mix your 50mg tablet with 50 ml of distilled water, then

simple math tells you that for every 1 ml of water, you'll have 1 mg

of naltrexone. drink 3-4.5ml's of the liquid, and you'll be taking 3-

4.5mg's of LDN, without the filler. Well, other than whats in the

naltrexone tablet, which is very little.

> >

>

[Guest guest]

Hi Cyndi,

motivation????

low income,

I have MS,

no medical insurance,

no family doctor,

I loved playiong with my chemistry set when I was a kid (oops, did I

say that?) :0)))

> > >

> > > of course Goodshape has a method-i would expect nothing less of

> > him.

> > > I did ask one of our students to look up the solubility for me.

> > I'm

> > > just really curious. it all has to do with molecules and

> > chemistry

> > > and all that -and then explain to me so i can explain it to you

> > guys.

> > > how much does this cost as opposed to just getting a

prescription

> > and

> > > getting it filled? is it a matter of pride? independence? i'm

not

> > > being critical i'm just curious

> > > cyndi

> > >

> > >

> > >

>

[Guest guest]

yes you did and you have every right to be sarcastic.  it just sucks. I'm sorry I'm being so pesty but it just blows me away -On Jun 11, 2006, at 6:01 PM, wrote:Hi Cyndi,motivation????low income,I have MS,no medical insurance,no family doctor,I loved playiong with my chemistry set when I was a kid (oops, did I say that?) :0)))> > > Making my own LDN costs me about 1-2 dollars per tablet, of which I> > can make about 14-15 doses(I use 3mg), so approximately 2-4 dollars> > per month. No filler to be concerned with, nobody filling the script> > to screw it up. Pride, independence??, what are you talking about?> 

[Guest guest]

The naltrexone dissolves completely. The Filler does not entirely

dissolve.

(This was from a pharmacist in the UK as quoted in the MeSsenger in

April)

http://www.ldnresearchtrust.org/Newsletter/April%203rd%202006.pdf

" Not to make this too complicated, the more soluble something is, the

more likely it is to stay dissolved, and form a uniform liquid.

Naltrexone is soluble in excess of 100mg per millilitre of water; i.e.

you can take 100mg of naltrexone (one hundred times the concentration

of LDN liquid) and dissolve it in ONE MILLILITRE of water. Naltrexone

liquid (LDN liquid), once prepared, has the same concentration of

naltrexone in the top 10ml as it does in the bottom of the bottle. "

J S DICKSON MRPharmS BSC (Hons)

[Guest guest]

Thank you, thats good to know :0)

>

> The naltrexone dissolves completely. The Filler does not entirely

> dissolve.

>

> (This was from a pharmacist in the UK as quoted in the MeSsenger in

> April)

> http://www.ldnresearchtrust.org/Newsletter/April%203rd%202006.pdf

> " Not to make this too complicated, the more soluble something is,

the

> more likely it is to stay dissolved, and form a uniform liquid.

> Naltrexone is soluble in excess of 100mg per millilitre of water;

i.e.

> you can take 100mg of naltrexone (one hundred times the

concentration

> of LDN liquid) and dissolve it in ONE MILLILITRE of water.

Naltrexone

> liquid (LDN liquid), once prepared, has the same concentration of

> naltrexone in the top 10ml as it does in the bottom of the

bottle. "

> J S DICKSON MRPharmS BSC (Hons)

>

[Guest guest]

I still wonder how it holds up in water though.

>

> The naltrexone dissolves completely. The Filler does not entirely

> dissolve.

>

> (This was from a pharmacist in the UK as quoted in the MeSsenger in

> April)

> http://www.ldnresearchtrust.org/Newsletter/April%203rd%202006.pdf

> " Not to make this too complicated, the more soluble something is,

the

> more likely it is to stay dissolved, and form a uniform liquid.

> Naltrexone is soluble in excess of 100mg per millilitre of water;

i.e.

> you can take 100mg of naltrexone (one hundred times the

concentration

> of LDN liquid) and dissolve it in ONE MILLILITRE of water.

Naltrexone

> liquid (LDN liquid), once prepared, has the same concentration of

> naltrexone in the top 10ml as it does in the bottom of the

bottle. "

> J S DICKSON MRPharmS BSC (Hons)

>

[Guest guest]

i'm going to find out for you guys and you'll know once and for allcyndiOn Jun 11, 2006, at 8:42 PM, wrote:I still wonder how it holds up in water though.>> The naltrexone dissolves completely. The Filler does not entirely> dissolve.> > (This was from a pharmacist in the UK as quoted in the MeSsenger in> April) > http://www.ldnresearchtrust.org/Newsletter/April%203rd%202006.pdf> "Not to make this too complicated, the more soluble something is, the> more likely it is to stay dissolved, and form a uniform liquid.> Naltrexone is soluble in excess of 100mg per millilitre of water; i.e.> you can take 100mg of naltrexone (one hundred times the concentration> of LDN liquid) and dissolve it in ONE MILLILITRE of water. Naltrexone> liquid (LDN liquid), once prepared, has the same concentration of> naltrexone in the top 10ml as it does in the bottom of the bottle." > J S DICKSON MRPharmS BSC (Hons)>

[Guest guest]

good post, I agree completely

[low dose naltrexone] Re: Generic naltrexone

My suggestion is that unless we have accurate balances, accurate pipets, and darn good laboratory technique, hire the compounding out. I've worked full time for several years in labs that do testing on FDA approved drugs. Have a pharmacist prepare the LDN for us. They have the tools and technique.

If we place the LDN is water, the stability will likely be compromised. Water, H2O, has some exposed electrons on the oxygen atom. These electrons have a habit of inserting themselves into other molecules. If a liquid dose is made, store it in the fridge for better stability. Just taking a Scientific Wild Ass Guess (SWAG), I wouldn't reccomend storing the aqueous dose longer than 2 weeks (that's stored in the 5C fridge)

According to the United States Pharmacopoeia (USP), any drug on the market has to be 90 - 110% of the label claim. So, a 50mg Naltrexone tablet can be 45mg to 55mg of the active pharmaceutical ingredient (API), The tablet itself likely weighs about 300mg. The extra material is filler. What that filler is varies from manufacturer to manufacturer and maybe even lot to lot.

If we want a 3mg dose, a 10% tolerance on the dose is 0.3mg. If we are confident was can prepare dose after dose of LDN, all +/- 0.3 milligrams (0.0003g), then by all means make the stuff using measuring cups and coffee cans. If we are not confident about repeatedly making drug doses to + / - 0.00003g, then hire the work out to a compounding pharmacist.

My $0.02

__________________________________________________

[Guest guest]

I'm so glad you posted this. I also think the amount can be somewhat

variable. I'm quite sure that I dont take the exact same amount each

night, there is most likely a small difference each evening. I'm

probably using anywhere from 2.5- 4.5. I'm doing fine. Does that

make it right, maybe not, but like I said, it's a personal choice.

>

> In my opinion, since LDN is not a " heavy " , side effect ridden

drug, & since the precise optimum dose for any particular individual

can really only be found by trial & error anyway, I believe that it

is inappropiate/unnecessary to get too obsessive about the need for

the ultimate degree of accuracy in dosage: I believe that, provided

that one takes reasonable care to carry out the procedure as

accurately as possible, minute variations are likely to be

insignificant/unnoticeable in the larger scheme of things: This has

been my experience over the last 9 months or so, at any rate. (-

Using Revia from MedsMex.)

>

> eg. -Who is to say that actually exactly 3mg is better than

2.7mg? -or3.3mg? -For any particular individual?.................Or

perhaps 3.2mg would be best?.........Who really knows?.........-

Could be that one`s exact optimum dose on any particular day is

affected by what one is eating/thinking/sleeping & so on?!

>

> Personally, I am one of those who uses half a Revia Tablet at a

time, which is enough to make 8 doses of 3mg, (ie. 8 doses of 3ml

when mixed with water.) -Just 8 days worth, this is believed to be

an OK length of time.

>

>

> It`s now over 2 years 3months since I commenced taking LDN;

prior to using Revia from MedsMex, I was using Skips, & prior to

that, Irmats. I found all three sources to be fine!

>

> (For your info, a while back, there was even talk here that Revia

from MedsMex, dissolved in water, might be a more potent source of

LDN than that made up by the pharmas! -Personally, I don`t have an

opinion on this..........)

>

> HOWEVER! I do think that it is not particularly helpful to alarm

people by raising theoretical doubts about the practicalities of a

source of LDN that many people in the real world have been finding

beneficial for quite some time now!

> I think that this simply adds the additional & unnecessary stress

of doubts & worries to those who may wish to commence taking LDN

but may have been unable to obtain a script or would prefer or need

to find the most economical source.

>

> Let`s hope that MedsMex get re-stocked soon!

>

> Best Wishes to all,

>

> Gerald (-SPMS)

> [low dose naltrexone] Re: Generic naltrexone

>

>

> My suggestion is that unless we have accurate balances, accurate

pipets, and darn good laboratory technique, hire the compounding

out. I've worked full time for several years in labs that do testing

on FDA approved drugs. Have a pharmacist prepare the LDN for us.

They have the tools and technique.

>

> If we place the LDN is water, the stability will likely be

compromised. Water, H2O, has some exposed electrons on the oxygen

atom. These electrons have a habit of inserting themselves into

other molecules. If a liquid dose is made, store it in the fridge

for better stability. Just taking a Scientific Wild Ass Guess

(SWAG), I wouldn't reccomend storing the aqueous dose longer than 2

weeks (that's stored in the 5C fridge)

>

> According to the United States Pharmacopoeia (USP), any drug on

the market has to be 90 - 110% of the label claim. So, a 50mg

Naltrexone tablet can be 45mg to 55mg of the active pharmaceutical

ingredient (API), The tablet itself likely weighs about 300mg. The

extra material is filler. What that filler is varies from

manufacturer to manufacturer and maybe even lot to lot.

>

> If we want a 3mg dose, a 10% tolerance on the dose is 0.3mg. If

we are confident was can prepare dose after dose of LDN, all +/-

0.3 milligrams (0.0003g), then by all means make the stuff using

measuring cups and coffee cans. If we are not confident about

repeatedly making drug doses to + / - 0.00003g, then hire the work

out to a compounding pharmacist.

>

> My $0.02

> __________________________________________________

>

[Guest guest]

Question though, wouldnt 8 doses give you over 6mg each dose??

> >

> > In my opinion, since LDN is not a " heavy " , side effect ridden

> drug, & since the precise optimum dose for any particular

individual

> can really only be found by trial & error anyway, I believe that

it

> is inappropiate/unnecessary to get too obsessive about the need

for

> the ultimate degree of accuracy in dosage: I believe that,

provided

> that one takes reasonable care to carry out the procedure as

> accurately as possible, minute variations are likely to be

> insignificant/unnoticeable in the larger scheme of things: This

has

> been my experience over the last 9 months or so, at any rate. (-

> Using Revia from MedsMex.)

> >

> > eg. -Who is to say that actually exactly 3mg is better than

> 2.7mg? -or3.3mg? -For any particular

individual?.................Or

> perhaps 3.2mg would be best?.........Who really knows?.........-

> Could be that one`s exact optimum dose on any particular day is

> affected by what one is eating/thinking/sleeping & so on?!

> >

> > Personally, I am one of those who uses half a Revia Tablet at a

> time, which is enough to make 8 doses of 3mg, (ie. 8 doses of 3ml

> when mixed with water.) -Just 8 days worth, this is believed to be

> an OK length of time.

> >

> >

> > It`s now over 2 years 3months since I commenced taking LDN;

> prior to using Revia from MedsMex, I was using Skips, & prior to

> that, Irmats. I found all three sources to be fine!

> >

> > (For your info, a while back, there was even talk here that

Revia

> from MedsMex, dissolved in water, might be a more potent source of

> LDN than that made up by the pharmas! -Personally, I don`t have an

> opinion on this..........)

> >

> > HOWEVER! I do think that it is not particularly helpful to

alarm

> people by raising theoretical doubts about the practicalities of a

> source of LDN that many people in the real world have been finding

> beneficial for quite some time now!

> > I think that this simply adds the additional & unnecessary

stress

> of doubts & worries to those who may wish to commence taking LDN

> but may have been unable to obtain a script or would prefer or

need

> to find the most economical source.

> >

> > Let`s hope that MedsMex get re-stocked soon!

> >

> > Best Wishes to all,

> >

> > Gerald (-SPMS)

> > [low dose naltrexone] Re: Generic naltrexone

> >

> >

> > My suggestion is that unless we have accurate balances,

accurate

> pipets, and darn good laboratory technique, hire the compounding

> out. I've worked full time for several years in labs that do

testing

> on FDA approved drugs. Have a pharmacist prepare the LDN for us.

> They have the tools and technique.

> >

> > If we place the LDN is water, the stability will likely be

> compromised. Water, H2O, has some exposed electrons on the oxygen

> atom. These electrons have a habit of inserting themselves into

> other molecules. If a liquid dose is made, store it in the fridge

> for better stability. Just taking a Scientific Wild Ass Guess

> (SWAG), I wouldn't reccomend storing the aqueous dose longer than

2

> weeks (that's stored in the 5C fridge)

> >

> > According to the United States Pharmacopoeia (USP), any drug

on

> the market has to be 90 - 110% of the label claim. So, a 50mg

> Naltrexone tablet can be 45mg to 55mg of the active pharmaceutical

> ingredient (API), The tablet itself likely weighs about 300mg.

The

> extra material is filler. What that filler is varies from

> manufacturer to manufacturer and maybe even lot to lot.

> >

> > If we want a 3mg dose, a 10% tolerance on the dose is 0.3mg.

If

> we are confident was can prepare dose after dose of LDN, all +/-

> 0.3 milligrams (0.0003g), then by all means make the stuff using

> measuring cups and coffee cans. If we are not confident about

> repeatedly making drug doses to + / - 0.00003g, then hire the work

> out to a compounding pharmacist.

> >

> > My $0.02

> > __________________________________________________

> >