Re: [Norton AntiSpam] Tovaxin Trial Stops MS!!!!

[Guest guest]



WOW! THIS IS VERY EXCITING!

[Norton AntiSpam] [low dose naltrexone] xin Trial Stops MS!!!!

Tom just sent us an email about the Promising Phase I & II trials of xin, an MS Vaccine and I for one am EXCITED about it!

It attacks each person's personal BAD T-Cells.

(An individualized vaccine therapy!)

This beats Tysabri hands down because it works differently.

xin Phase III trials begin late 2005.

1. a page from the xin Vaccine company

2. an email from a patient in the CLINICAL TRIALS and his experiences and recovery progress.

If I see some emails about this I will think someone heard the GOOD NEWS

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http://www.pharmafrontierscorp.com/toxavin.php

xinâ„¢

xin MS Vaccine

xinâ„¢ is a novel T-cell therapeutic vaccine that parallels the concept of autologous cancer vaccines. Instead of modifying cancerous cells, xinTM consists of attenuated autoreactive T cells. Attenuation of these cells during the vaccine production process renders the cells non-replicating but viable and causes them to elicit an immune response when injected subcutaneously into the patient. This immune response is directed against T cells within the patient that are self-reactive with myelin. This immune response, directed against a specific subset of autoreactive T cells, greatly reduces the number of these autoreactive cells in MS patients. xinTM has considerable potential because it attacks the underlying cause of MS rather than just addressing its symptoms.

xinâ„¢ Clinical Trialsxinâ„¢ is currently being evaluated in two Phase I/II clinical trials under an Investigational New Drug (IND) application. One trial is a 9 patient dose escalation study designed to further evaluate toxicity, tolerability and clinical efficacy of the vaccine. Patient enrollment for this study began in June 2002 and is scheduled to be completed in 2005.The second trial is a Phase II open-label, retreatment study of up to 50 patients who received clinical benefit from xinâ„¢ in previous Phase I/II studies of this product, and who have been treated or could not tolerate standard treatments for MS. Each patient will receive two treatments with xinâ„¢. This study is designed to further study the safety and tolerability of xinâ„¢ in MS patients, to perform preliminary evaluation of the timing of booster doses for subsequent studies, and to evaluate efficacy.

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This next part is from a patient in the CLINICAL TRIALS

Hi To All,

I am in an FDA trial for an MS vaccine. The vaccine appears to have arrested my disease and has done the same for the other people in the study. I have two small websites that show a timeline of events. The first one is http://www.ihavems.com/ It starts with the first injection and goes for 18 months. My websites are little 10-page boilerplate sites, so my timeline continues on a second website http://www.timswellness.com/ from June 2004 to the present. My Dad and I work on the sites together.

The study that I am in is small, only 9 to 15 patients. There is a concurrent one that is retreating any of the 114 patients that were in the MS vaccine study done at Baylor in the late 1990s. The vaccine is called xin and you can see an animation of how it works at http://www.pharmafrontierscorp.com/toxavin.php

All of the patients in my study have responded positively. There is one person in the study who has primary progressive. She did not respond at first, but they have discover the peptide sequence for the CD-8 T-cells that cause PP. Since then she has seen her EDSS go down by 0.5. My EDSS has gone from 5.5 to 3.0.

I am actually out doing things again. I just returned from a solo trip to see some friends in San Francisco. This is amazing, since two years ago, my parents were taking me from our home in Michigan to Houston in a wheelchair.

xin is an autologous vaccine. That means they take some of my blood, cull out the T-cells and introduce them to human myelin. Those that react to the myelin are culled out and replicated. Once there are enough for the vaccine, about 45 million cells, the T-cells are irradiated so that they are still alive, but cannot reproduce. That is the vaccine.

The vaccine is injected just under my skin, you can see some pictures at http://www.timswellness.com/ , and the body treats these T-cells as a foreign invader and makes antibodies to eliminate only these specific T-cells. These antibodies not only take out the T-cells from the vaccine, but also eliminate all of that same type of T-cell throughout my body.

The body produces 2 to 3 trillion red blood cells per day. I am not sure how many T-cells are produced per day, but if 1 or 2 per million are troublemakers, that means there are hundreds of millions of myelin reactive T-cells floating around in the blood stream of someone with MS. A flare is when the body produces too many of these bad T-cells. No one is sure why this happens, but it may be caused by an upper respiratory infection, or a cold sore, or some other immune response that triggers the body to produce T-cells that mistake myelin as something bad.

By eliminating these 1 or 2 per 1 million T-cells does not compromise the immune system, but it does eliminate all of the T-cells that destroy the myelin. No bad T-cells means no more attacks. Anyone on xin will need to get a booster twice a year to keep the antibodies at a level sufficient to continue to eliminate all of the myelin reactive T-cells as they are produced. This is just like a flu shot.

I think about 30 to 40% of the damage that was done by the attacks has been reversed. The body will repair itself, as long as the attacks stop. I am helping myself by doing a lot of exercising and activities that improve my small motor skills.

I am doing many things that I was no longer able to do. When I started the vaccine, my parent's were cutting my food and feeding it to me. I am able to cut my own food, and today, I peeled some shrimp. Realizing that I can again do something as insignificant as peel a shrimp really makes me feel good. I used to wonder why people got so excited to see a disabled family member regain some little ability, now I understand, and I understand why my family is trilled at even my smallest improvement.

Phase III should begin at the end of this year or the beginning of 2006. http://biz./bw/050608/85342.html?.v=1 There will be many sites throughout the US and in some foreign countries. You can watch the companies webpage for updates http://www.pharmafrontierscorp.com/

Best regards, Tim