Re: Melatonin not a good sleep aid because it works via opiatergic mechanism...

[Guest guest]

Let chat a little about melatonin. The two most important

regulatory systems in the body are the neuro-endocrine system, which controls

such essential functions as body temperature, sex drive, reproduction,

appetite, sleep, balance, and muscular coordination and the immune system,

which keeps the body from succumbing to diseases triggered by bacteria,

viruses, chemical pollutants, and excessive free radical activity. The

pineal gland, and its primary hormone melatonin, appears to play a vital role

in modulating the activity of both these critical systems. The pineal

gland translates changes in environmental lighting into neuro-endocrine signals

that impose a circadian rhythm upon the body which, in turn, keeps the body

operating in the kind of harmonious balance characteristic of good

health.

The amount of melatonin circulating in the blood has been

shown to oscillate according to light signals coming in from the

environment. Melatonin levels are thus relatively low during daylight

hours and rise substantially during darkness, normally reaching their peak

sometime after midnight. One of the keys to maintaining good health is to

maintain normal, youthful patterns of melatonin secretion and activity within

the body. Unfortunately, the body’s supply of melatonin declines

progressively with advancing age, which renders us increasingly vulnerable to

physiologic malfunctions such as sleep disorders, and catastrophic diseases

such as cancer.

Studies of melatonin patterns in both healthy and diseased

subjects suggest that melatonin is one of the body’s first lines of

defense in response to the growth of malignant cells. Its’ been

theorized by R. Renlkin in the book “The pineal and human disease”,

published by Lundsdale House in 1986 that increased melatonin production, which

activates the immune system, keeps abnormal cells under control, but when there

is inadequate or insufficiently active melatonin available (such as in people

over 40) to curb the growth of these cells, very small tumors start to form.

The decrease in blood levels of melatonin in patients with

cancer is caused by a decline in the activity of serotonin-N-acetyltransferase

(SNAT) the enzyme that stimulates melatonin biosynthesis which is inhibited by

alpha – and beta – adrenergic nerve fibers touching melatonin –

producing cells (pinealocytes) which are, in turn, stimulated by neurons in the

hypothalamic region of the brain.

There is strong evidence suggesting that healthy people

should take daily doses of melatonin, in the range of 3 – 9 mg (at night)

as a means of protection against cancer and other immuno – depressed diseases.

Melatonin has been taken in this dosage range by literally tens of thousands of

people over the last 40 years without any evidence of harmful side effects.

Now, when I started taking LDN as an immune boosting

substance, I talked at length with Dr. Zagon about the different interactions

of the supplements I am taking, including melatonin. He found no

contraindications whatsoever. That works for me.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of jlbl2l

Sent: Monday, July 18, 2005 9:59

PM

low dose naltrexone

Subject: [low dose naltrexone]

Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort

of opioidergic channels apparently if no

one knew and I have seen people here advocate its

use. While it isnt

entirely clear how it works, there is enough

evidence of its

interaction with opioid channels in humans (via

pubmed.com) and of its

blockage with opioid antagonists that i dont think

we should advocate

use of it for a sleep aid probably while on

naltrexone.

Just a thought

[Guest guest]

Bruce,

Your knowledge is a blessing to me....I love to learn.

MANY THANKS,

Sue

RE: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Let chat a little about melatonin. The two most important regulatory systems in the body are the neuro-endocrine system, which controls such essential functions as body temperature, sex drive, reproduction, appetite, sleep, balance, and muscular coordination and the immune system, which keeps the body from succumbing to diseases triggered by bacteria, viruses, chemical pollutants, and excessive free radical activity. The pineal gland, and its primary hormone melatonin, appears to play a vital role in modulating the activity of both these critical systems. The pineal gland translates changes in environmental lighting into neuro-endocrine signals that impose a circadian rhythm upon the body which, in turn, keeps the body operating in the kind of harmonious balance characteristic of good health.

The amount of melatonin circulating in the blood has been shown to oscillate according to light signals coming in from the environment. Melatonin levels are thus relatively low during daylight hours and rise substantially during darkness, normally reaching their peak sometime after midnight. One of the keys to maintaining good health is to maintain normal, youthful patterns of melatonin secretion and activity within the body. Unfortunately, the body’s supply of melatonin declines progressively with advancing age, which renders us increasingly vulnerable to physiologic malfunctions such as sleep disorders, and catastrophic diseases such as cancer.

Studies of melatonin patterns in both healthy and diseased subjects suggest that melatonin is one of the body’s first lines of defense in response to the growth of malignant cells. Its’ been theorized by R. Renlkin in the book “The pineal and human disease”, published by Lundsdale House in 1986 that increased melatonin production, which activates the immune system, keeps abnormal cells under control, but when there is inadequate or insufficiently active melatonin available (such as in people over 40) to curb the growth of these cells, very small tumors start to form.

The decrease in blood levels of melatonin in patients with cancer is caused by a decline in the activity of serotonin-N-acetyltransferase (SNAT) the enzyme that stimulates melatonin biosynthesis which is inhibited by alpha – and beta – adrenergic nerve fibers touching melatonin – producing cells (pinealocytes) which are, in turn, stimulated by neurons in the hypothalamic region of the brain.

There is strong evidence suggesting that healthy people should take daily doses of melatonin, in the range of 3 – 9 mg (at night) as a means of protection against cancer and other immuno – depressed diseases. Melatonin has been taken in this dosage range by literally tens of thousands of people over the last 40 years without any evidence of harmful side effects.

Now, when I started taking LDN as an immune boosting substance, I talked at length with Dr. Zagon about the different interactions of the supplements I am taking, including melatonin. He found no contraindications whatsoever. That works for me.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of jlbl2lSent: Monday, July 18, 2005 9:59 PMlow dose naltrexone Subject: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort of opioidergic channels apparently if no one knew and I have seen people here advocate its use. While it isnt entirely clear how it works, there is enough evidence of its interaction with opioid channels in humans (via pubmed.com) and of its blockage with opioid antagonists that i dont think we should advocate use of it for a sleep aid probably while on naltrexone. Just a thought

[Guest guest]

some researchers also feel it should not be taken by people with auto-immune disorders. I remember Weil saying in his book for optimal wellness that it should only be taken short-term. He said we do not know enough about it and since some researchers believe calcification of the pineal gland is either directly or indirectly involved with ms, I choose not to try that supplement because it is produced by the pineal gland. Just another opinion and I'm sure some people feel it is beneficial for them.

[low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort of opioidergic channels apparently if no one knew and I have seen people here advocate its use. While it isnt entirely clear how it works, there is enough evidence of its interaction with opioid channels in humans (via pubmed.com) and of its blockage with opioid antagonists that i dont think we should advocate use of it for a sleep aid probably while on naltrexone. Just a thought

[Guest guest]

Bruce, I am glad to hear in your other posts that you are well and pushing your cancer toward remission!

I have tried to add Melatonin to my morning regimen (150 mcg... repeat micrograms ) but each time I do, I experience peripheral neuropathy in my limbs later in the day and especially toward bedtime when I am readding in bed or at times if I get up during the night.

Sometimes it is very mild but at other times it is so strong that it is really frightening.

Do you happen to know what causes this?

Anyone else?

RE: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Let chat a little about melatonin. The two most important regulatory systems in the body are the neuro-endocrine system, which controls such essential functions as body temperature, sex drive, reproduction, appetite, sleep, balance, and muscular coordination and the immune system, which keeps the body from succumbing to diseases triggered by bacteria, viruses, chemical pollutants, and excessive free radical activity. The pineal gland, and its primary hormone melatonin, appears to play a vital role in modulating the activity of both these critical systems. The pineal gland translates changes in environmental lighting into neuro-endocrine signals that impose a circadian rhythm upon the body which, in turn, keeps the body operating in the kind of harmonious balance characteristic of good health.

The amount of melatonin circulating in the blood has been shown to oscillate according to light signals coming in from the environment. Melatonin levels are thus relatively low during daylight hours and rise substantially during darkness, normally reaching their peak sometime after midnight. One of the keys to maintaining good health is to maintain normal, youthful patterns of melatonin secretion and activity within the body. Unfortunately, the body’s supply of melatonin declines progressively with advancing age, which renders us increasingly vulnerable to physiologic malfunctions such as sleep disorders, and catastrophic diseases such as cancer.

Studies of melatonin patterns in both healthy and diseased subjects suggest that melatonin is one of the body’s first lines of defense in response to the growth of malignant cells. Its’ been theorized by R. Renlkin in the book “The pineal and human disease”, published by Lundsdale House in 1986 that increased melatonin production, which activates the immune system, keeps abnormal cells under control, but when there is inadequate or insufficiently active melatonin available (such as in people over 40) to curb the growth of these cells, very small tumors start to form.

The decrease in blood levels of melatonin in patients with cancer is caused by a decline in the activity of serotonin-N-acetyltransferase (SNAT) the enzyme that stimulates melatonin biosynthesis which is inhibited by alpha – and beta – adrenergic nerve fibers touching melatonin – producing cells (pinealocytes) which are, in turn, stimulated by neurons in the hypothalamic region of the brain.

There is strong evidence suggesting that healthy people should take daily doses of melatonin, in the range of 3 – 9 mg (at night) as a means of protection against cancer and other immuno – depressed diseases. Melatonin has been taken in this dosage range by literally tens of thousands of people over the last 40 years without any evidence of harmful side effects.

Now, when I started taking LDN as an immune boosting substance, I talked at length with Dr. Zagon about the different interactions of the supplements I am taking, including melatonin. He found no contraindications whatsoever. That works for me.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of jlbl2lSent: Monday, July 18, 2005 9:59 PMlow dose naltrexone Subject: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort of opioidergic channels apparently if no one knew and I have seen people here advocate its use. While it isnt entirely clear how it works, there is enough evidence of its interaction with opioid channels in humans (via pubmed.com) and of its blockage with opioid antagonists that i dont think we should advocate use of it for a sleep aid probably while on naltrexone. Just a thought

[Guest guest]

Steve,

Question 1: Why in the

morning? Melatonin is one of those things like LDN that is produced in the

majority by the pineal somewhere between 3 and 4 in the early morning hours.

Question 2: Where in the

world did you find a mcg version? I have never seen anything smaller than a 1

mg tablet?

This is, as far as I know, a

unique thing with the peripheral neuropathy. I will some digging for you. I

have never heard of it, but I do know a couple of people who have worked

extensively with melatonin icw cancer protocols and I will also pose this

question to them. Will post when I get a response or find something on it.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of Steve Nardi

Sent: Tuesday, July 19, 2005 7:44

AM

low dose naltrexone

Subject: Re: [low dose naltrexone]

Melatonin not a good sleep aid because it works via opiatergic mechanism...

Bruce, I am glad to hear in your other posts that you are

well and pushing your cancer toward remission!

I have tried to add Melatonin to my morning regimen

(150 mcg... repeat micrograms ) but each time I do, I experience

peripheral neuropathy in my limbs later in the day and especially toward

bedtime when I am readding in bed or at times if I get up during the night.

Sometimes it is very mild but at other times it is so strong

that it is really frightening.

Do you happen to know what causes this?

Anyone else?

[low dose naltrexone]

Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort

of opioidergic channels apparently if no

one knew and I have seen people here advocate its

use. While it isnt

entirely clear how it works, there is enough

evidence of its

interaction with opioid channels in humans (via

pubmed.com) and of its

blockage with opioid antagonists that i dont think

we should advocate

use of it for a sleep aid probably while on

naltrexone.

Just a thought

[Guest guest]

Thanks...I take in the morning because I have no problem sleeping without it.

RE: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Let chat a little about melatonin. The two most important regulatory systems in the body are the neuro-endocrine system, which controls such essential functions as body temperature, sex drive, reproduction, appetite, sleep, balance, and muscular coordination and the immune system, which keeps the body from succumbing to diseases triggered by bacteria, viruses, chemical pollutants, and excessive free radical activity. The pineal gland, and its primary hormone melatonin, appears to play a vital role in modulating the activity of both these critical systems. The pineal gland translates changes in environmental lighting into neuro-endocrine signals that impose a circadian rhythm upon the body which, in turn, keeps the body operating in the kind of harmonious balance characteristic of good health.

The amount of melatonin circulating in the blood has been shown to oscillate according to light signals coming in from the environment. Melatonin levels are thus relatively low during daylight hours and rise substantially during darkness, normally reaching their peak sometime after midnight. One of the keys to maintaining good health is to maintain normal, youthful patterns of melatonin secretion and activity within the body. Unfortunately, the body’s supply of melatonin declines progressively with advancing age, which renders us increasingly vulnerable to physiologic malfunctions such as sleep disorders, and catastrophic diseases such as cancer.

Studies of melatonin patterns in both healthy and diseased subjects suggest that melatonin is one of the body’s first lines of defense in response to the growth of malignant cells. Its’ been theorized by R. Renlkin in the book “The pineal and human disease”, published by Lundsdale House in 1986 that increased melatonin production, which activates the immune system, keeps abnormal cells under control, but when there is inadequate or insufficiently active melatonin available (such as in people over 40) to curb the growth of these cells, very small tumors start to form.

The decrease in blood levels of melatonin in patients with cancer is caused by a decline in the activity of serotonin-N-acetyltransferase (SNAT) the enzyme that stimulates melatonin biosynthesis which is inhibited by alpha – and beta – adrenergic nerve fibers touching melatonin – producing cells (pinealocytes) which are, in turn, stimulated by neurons in the hypothalamic region of the brain.

There is strong evidence suggesting that healthy people should take daily doses of melatonin, in the range of 3 – 9 mg (at night) as a means of protection against cancer and other immuno – depressed diseases. Melatonin has been taken in this dosage range by literally tens of thousands of people over the last 40 years without any evidence of harmful side effects.

Now, when I started taking LDN as an immune boosting substance, I talked at length with Dr. Zagon about the different interactions of the supplements I am taking, including melatonin. He found no contraindications whatsoever. That works for me.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of jlbl2lSent: Monday, July 18, 2005 9:59 PMlow dose naltrexone Subject: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort of opioidergic channels apparently if no one knew and I have seen people here advocate its use. While it isnt entirely clear how it works, there is enough evidence of its interaction with opioid channels in humans (via pubmed.com) and of its blockage with opioid antagonists that i dont think we should advocate use of it for a sleep aid probably while on naltrexone. Just a thought

[Guest guest]

Bruce,

You are such a wealth of information. I always appreciate your knowledge and explanations. I'm sure I speak for many when I say "thanks!"

Barb

RE: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Let chat a little about melatonin. The two most important regulatory systems in the body are the neuro-endocrine system, which controls such essential functions as body temperature, sex drive, reproduction, appetite, sleep, balance, and muscular coordination and the immune system, which keeps the body from succumbing to diseases triggered by bacteria, viruses, chemical pollutants, and excessive free radical activity. The pineal gland, and its primary hormone melatonin, appears to play a vital role in modulating the activity of both these critical systems. The pineal gland translates changes in environmental lighting into neuro-endocrine signals that impose a circadian rhythm upon the body which, in turn, keeps the body operating in the kind of harmonious balance characteristic of good health.

The amount of melatonin circulating in the blood has been shown to oscillate according to light signals coming in from the environment. Melatonin levels are thus relatively low during daylight hours and rise substantially during darkness, normally reaching their peak sometime after midnight. One of the keys to maintaining good health is to maintain normal, youthful patterns of melatonin secretion and activity within the body. Unfortunately, the body’s supply of melatonin declines progressively with advancing age, which renders us increasingly vulnerable to physiologic malfunctions such as sleep disorders, and catastrophic diseases such as cancer.

Studies of melatonin patterns in both healthy and diseased subjects suggest that melatonin is one of the body’s first lines of defense in response to the growth of malignant cells. Its’ been theorized by R. Renlkin in the book “The pineal and human disease”, published by Lundsdale House in 1986 that increased melatonin production, which activates the immune system, keeps abnormal cells under control, but when there is inadequate or insufficiently active melatonin available (such as in people over 40) to curb the growth of these cells, very small tumors start to form.

The decrease in blood levels of melatonin in patients with cancer is caused by a decline in the activity of serotonin-N-acetyltransferase (SNAT) the enzyme that stimulates melatonin biosynthesis which is inhibited by alpha – and beta – adrenergic nerve fibers touching melatonin – producing cells (pinealocytes) which are, in turn, stimulated by neurons in the hypothalamic region of the brain.

There is strong evidence suggesting that healthy people should take daily doses of melatonin, in the range of 3 – 9 mg (at night) as a means of protection against cancer and other immuno – depressed diseases. Melatonin has been taken in this dosage range by literally tens of thousands of people over the last 40 years without any evidence of harmful side effects.

Now, when I started taking LDN as an immune boosting substance, I talked at length with Dr. Zagon about the different interactions of the supplements I am taking, including melatonin. He found no contraindications whatsoever. That works for me.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of jlbl2lSent: Monday, July 18, 2005 9:59 PMlow dose naltrexone Subject: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort of opioidergic channels apparently if no one knew and I have seen people here advocate its use. While it isnt entirely clear how it works, there is enough evidence of its interaction with opioid channels in humans (via pubmed.com) and of its blockage with opioid antagonists that i dont think we should advocate use of it for a sleep aid probably while on naltrexone. Just a thought

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[Guest guest]

It is not a sleep issue, but rather a

major support issue for the immune system. A number of cancer protocols use it

extensively and it is a boost for the pineal gland and everything that it

controls including the immune system. Generally 3 mgs is enough for sleep. 9

is what I take and not for sleep, but as a immune support booster.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of Steve Nardi

Sent: Tuesday, July 19, 2005 8:46

AM

low dose naltrexone

Subject: Re: [low dose naltrexone]

Melatonin not a good sleep aid because it works via opiatergic mechanism...

Thanks...I take in the morning because I have no problem

sleeping without it.

[low dose naltrexone]

Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort

of opioidergic channels apparently if no

one knew and I have seen people here advocate its

use. While it isnt

entirely clear how it works, there is enough

evidence of its

interaction with opioid channels in humans (via

pubmed.com) and of its

blockage with opioid antagonists that i dont think

we should advocate

use of it for a sleep aid probably while on

naltrexone.

Just a thought

[Guest guest]

I actually swelled up in the face from Melatonin years ago and cut the

pill down to a 4th and still did and felt horrible from taking it.

That's when I turned to wine to sleep. Took Valerian and Kava also.

That was 10 years ago when sleeping problems surfaced and probably due

to the lesion I didn't know I had and stress.

Rhonda

> Melatonin works via some sort of opioidergic channels apparently if

no

> one knew and I have seen people here advocate its use. While it isnt

> entirely clear how it works, there is enough evidence of its

> interaction with opioid channels in humans (via pubmed.com) and of

its

> blockage with opioid antagonists that i dont think we should advocate

> use of it for a sleep aid probably while on naltrexone.

>

> Just a thought

[Guest guest]

I am going to order the book you just mentioned and thank you for your very informative reply. Kathy

RE: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Let chat a little about melatonin. The two most important regulatory systems in the body are the neuro-endocrine system, which controls such essential functions as body temperature, sex drive, reproduction, appetite, sleep, balance, and muscular coordination and the immune system, which keeps the body from succumbing to diseases triggered by bacteria, viruses, chemical pollutants, and excessive free radical activity. The pineal gland, and its primary hormone melatonin, appears to play a vital role in modulating the activity of both these critical systems. The pineal gland translates changes in environmental lighting into neuro-endocrine signals that impose a circadian rhythm upon the body which, in turn, keeps the body operating in the kind of harmonious balance characteristic of good health.

The amount of melatonin circulating in the blood has been shown to oscillate according to light signals coming in from the environment. Melatonin levels are thus relatively low during daylight hours and rise substantially during darkness, normally reaching their peak sometime after midnight. One of the keys to maintaining good health is to maintain normal, youthful patterns of melatonin secretion and activity within the body. Unfortunately, the body’s supply of melatonin declines progressively with advancing age, which renders us increasingly vulnerable to physiologic malfunctions such as sleep disorders, and catastrophic diseases such as cancer.

Studies of melatonin patterns in both healthy and diseased subjects suggest that melatonin is one of the body’s first lines of defense in response to the growth of malignant cells. Its’ been theorized by R. Renlkin in the book “The pineal and human disease”, published by Lundsdale House in 1986 that increased melatonin production, which activates the immune system, keeps abnormal cells under control, but when there is inadequate or insufficiently active melatonin available (such as in people over 40) to curb the growth of these cells, very small tumors start to form.

The decrease in blood levels of melatonin in patients with cancer is caused by a decline in the activity of serotonin-N-acetyltransferase (SNAT) the enzyme that stimulates melatonin biosynthesis which is inhibited by alpha – and beta – adrenergic nerve fibers touching melatonin – producing cells (pinealocytes) which are, in turn, stimulated by neurons in the hypothalamic region of the brain.

There is strong evidence suggesting that healthy people should take daily doses of melatonin, in the range of 3 – 9 mg (at night) as a means of protection against cancer and other immuno – depressed diseases. Melatonin has been taken in this dosage range by literally tens of thousands of people over the last 40 years without any evidence of harmful side effects.

Now, when I started taking LDN as an immune boosting substance, I talked at length with Dr. Zagon about the different interactions of the supplements I am taking, including melatonin. He found no contraindications whatsoever. That works for me.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of jlbl2lSent: Monday, July 18, 2005 9:59 PMlow dose naltrexone Subject: [low dose naltrexone] Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort of opioidergic channels apparently if no one knew and I have seen people here advocate its use. While it isnt entirely clear how it works, there is enough evidence of its interaction with opioid channels in humans (via pubmed.com) and of its blockage with opioid antagonists that i dont think we should advocate use of it for a sleep aid probably while on naltrexone. Just a thought