FW: Melatonin not a good sleep aid because it works via opiatergic mechanism...

[Guest guest]

I have not done a total and exhaustive study on melatonin,

but after looking at roughly 150 articles using the “hypersensitivity

melatonin peripheral neuropathy” search string in both google and pubmed,

I find melatonin is often used icw B-12 and other things to treat the

condition. The only issue anyone takes with melatonin is in very, very

high dosage. 90+ mg per day.

I did find reference in 2 articles pertaining to issues with

itching and some swelling as a hypersensitive reaction, but nothing thus far

with peripheral neuropathy.

Obviously, if there are issues that can be traced to the use

of anything, not just melatonin, logic dictates that its use should be avoided.

I will post more on this when I hear from the other

researchers I have written to specifically about this.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: Bruce Guilmette,

Ph.D. [mailto:bruce@...]

Sent: Tuesday, July 19, 2005 8:09

AM

'low dose naltrexone '

Subject: RE: [low dose naltrexone]

Melatonin not a good sleep aid because it works via opiatergic mechanism...

Steve,

Question 1: Why in the morning? Melatonin is one of those things

like LDN that is produced in the majority by the pineal somewhere between

3 and 4 in the early morning hours.

Question 2: Where in the world did you find a mcg version? I have

never seen anything smaller than a 1 mg tablet?

This is, as far as I know, a unique thing with the peripheral neuropathy.

I will some digging for you. I have never heard of it, but I do know a

couple of people who have worked extensively with melatonin icw cancer

protocols and I will also pose this question to them. Will post when I

get a response or find something on it.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of Steve Nardi

Sent: Tuesday, July 19, 2005 7:44

AM

low dose naltrexone

Subject: Re: [low dose naltrexone]

Melatonin not a good sleep aid because it works via opiatergic mechanism...

Bruce, I am glad to hear in your other posts that you are

well and pushing your cancer toward remission!

I have tried to add Melatonin to my morning regimen

(150 mcg... repeat micrograms ) but each time I do, I experience

peripheral neuropathy in my limbs later in the day and especially toward

bedtime when I am readding in bed or at times if I get up during the night.

Sometimes it is very mild but at other times it is so strong

that it is really frightening.

Do you happen to know what causes this?

Anyone else?

[low dose naltrexone]

Melatonin not a good sleep aid because it works via opiatergic mechanism...

Melatonin works via some sort

of opioidergic channels apparently if no

one knew and I have seen people here advocate its

use. While it isnt

entirely clear how it works, there is enough

evidence of its

interaction with opioid channels in humans (via

pubmed.com) and of its

blockage with opioid antagonists that i dont think

we should advocate

use of it for a sleep aid probably while on

naltrexone.

Just a thought