Re: I just took 4.5mgs in day

[Guest guest]

> I was feeling crapy today due to sinus and female stuff so I decided to

> experiment taking in daytime. I didn't take til 2pm and trying to

> figure out what I'm feeling and will let you know. Seems I'm feeling

> something in my hands and legs/feet and I may be feeling more alert.

>

> If the LDN works when taking between 9pm and 3am, what exactly will LDN

> do to the brain during day when it's not blocking what happens to brain

> during 9pm to 3am? Does anyone really know? Can more endorphins be

> made by taking LDN in day or can that only happen taking at night?

>

> Rhonda

=============

Check with Bihari's office or Dr. Gluck on this. I fear we could have some

people getting too much endorphin block and cause more harm with their disease

than good with these experiments. Yes, you are causing a block in your

endorphins during the daytime LDN dose.

You're not going to have a perfect day every single day on LDN. Monthly female

cycles and infections, fevers, weather and allergies will cause disturbance in

how you feel.

[Guest guest]

Unique to the individual, as was explained

to me. Most, by large majority (95+%) produce endorphins in the early

morning hours (light/dark issue NOT SLEEP

ISSUE but some people’s body clocks are different. I was

frankly surprised that this one aspect was normal for me as nothing I have ever

done has been qualified as normal.

Lets say, for sake of argument, that you

are “normal” and between 2 and 4 in the morning is when your

endorphins do their thing. Roughly 70-75% are pumped out at that point

and residuals follow during the rest of the day. Taking an off peak

stimulant would most probably only add 5 – 10% kick where otherwise you

could be getting up to 200% (arbitrary numbers, but not too far out of range

from what I have read on pubmed and other Dr. Zagon papers. So, if you

happen to take your LDN at the low point of the day, you could get a cyclical

10% boost that feels good then, but does little else during the balance of the

24 hours.

However, if you are not “normal”

and you body clock thinks that noon or 2 in the afternoon is when it wants to

make endorphins, taking them at night for you would be like taking them in the

daytime for anyone else.

I hope this makes some sense to you.

Without some serious testing to determine your endorphin cycle, it really is a

guessing game. And no, I have not had that done and can only go on what I

have read. You would need to be in contact with someone doing university

level experimenting to get answers to these questions. That is why

you have nothing to loose with a trial if

you are not experiencing good things at night, but you do want the on/off

triggering of the endorphins and opiate receptors which is where the original

concept came of doing this only once per day.

Bruce Guilmette, Ph.D.

Survive Cancer Foundation, Inc.

http://www.survivecancer.net

From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of Rhonda

Sent: Thursday, July 14, 2005 2:35

PM

low dose naltrexone

Subject: [low dose naltrexone] I

just took 4.5mgs in day

I was feeling crapy today due to sinus and female stuff so I decided to

experiment taking in daytime. I didn't take

til 2pm and trying to

figure out what I'm feeling and will let you

know. Seems I'm feeling

something in my hands and legs/feet and I may be

feeling more alert.

If the LDN works when taking between 9pm and 3am,

what exactly will LDN

do to the brain during day when it's not blocking

what happens to brain

during 9pm to 3am? Does anyone really

know? Can more endorphins be

made by taking LDN in day or can that only happen

taking at night?

Rhonda

[Guest guest]

Around 6pm I had energy kick in so I guess endorphins kicked up a

notch. I don't plan to do day doses again but was just curious since

a couple people on the group tried this. Seems one man did doses 3

times a day but not sure he still is. I'm still debating whether to

take my night dose tonight. I've had one person tell me not to.

Well, here comes that thunderstorm I've been feeling all day long! At

least I didn't get a Migraine. We've had a Humid bad week here this

week and I always feel storms/fronts/barometer changes and didn't go

thru this when younger. It's crazy! and others don't feel nothing

which I don't understand! Think I'll go workout.

Rhonda

> I was feeling crapy today due to sinus and female stuff so I decided

to

> experiment taking in daytime. I didn't take til 2pm and trying to

> figure out what I'm feeling and will let you know. Seems I'm

feeling

> something in my hands and legs/feet and I may be feeling more alert.

>

> If the LDN works when taking between 9pm and 3am, what exactly will

LDN

> do to the brain during day when it's not blocking what happens to

brain

> during 9pm to 3am? Does anyone really know? Can more endorphins

be

> made by taking LDN in day or can that only happen taking at night?

>

> Rhonda