Lets flip this around a little - why naltrexone might work in high dose also...

[Guest guest]

I have been researching pubmed and the entire internet and have came to

one conclusion : not only does naltrexone work at low doses and boost

the immune system, but it also works in high doses, even better.

For example, this recent study on pubmed. You would think that since

endorphins boost the immune system, that a blocker of them would be

immunosupressive. It is just the opposite based on the conclusions of

many pubmed studies (check for yourself) - naltrexone + immune search .

What is happening is that endorphins boost the immune system only

acutely but if they are chronically applied they actually are

immunosupressive! (check pubmed again). Its because endorphins are

relased during stress to boost the immune system but if they are

constantly released (constant stress for example) either a tolerance to

them is gained (and possibly reversed with naltrexone) and its likely

that receptor binding downregulation occurs! So acutely, endorphins are

good. Chronically they are bad for the immune system.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15210757 & query_hl=78

" Naltrexone, an opioid antagonist, has been used in clinical trials to

treat alcoholism. As the opioid peptides beta-endorphin and enkephalin

increase splenic NK cell function in laboratory animals, it is

anticipated that naltrexone treatment will cause immunosuppression.

However, we report in this study that **chronic** naltrexone

administration in laboratory rats **increases** the cytolytic activity

of NK cells. It also prevents alcohol's suppressive effect on these

cells. We identified that, in the splenocytes, delta opioid receptor

expression is tightly controlled by negative feedback regulation of

micro opioid receptors. Naltrexone disrupts this feedback control by

reducing micro opioid receptor function, thereby **up-regulating delta

opioid receptor binding, which results in an enhanced NK cell cytolytic

response to delta opioid receptor ligands**. We conclude that

naltrexone, which has been shown to be a promising agent for the

clinical management of alcoholism, may have potential use in the

treatment of immune deficiency in alcoholic and nonalcoholic patients.

In addition it is reported MANY times on the net by doctors and is

being explored as a fertility treatment. There is much ancedontal

evidence that heroin addicts treated with normal dose naltrexone become

pregnant much easier and get there menstrual cycles back. You would

think if naltrexone was immunosupressive this would not occur. But in

fact the people who take the high dose seem to be healthier!

(immunoenhancement) There is even a study on pubmed saying that

naltrexone (normal dose) should be studied for AIDS asap.

There is a very simple explnation of this : As with any antagonist,

your body will try to compensate by increasing receptor sites for

binding. So either it is the blocking itself of the endorphins, or it

is the sensitivity that changes. Its not quite clear.

Anyways based on my research, naltrexone is actually immunopotentiating

during chronic administration of high dose, and endorphins are only

immunoenhancing in the short term, but chronically are immunosupressive.

This was all found on pubmed.com

Very cool stuff.

Based on this I am going to test taking 4.5 3 times a day instead which

would actually be blocking and unblocking the receptors constantly,

something that will sort of rev-up Dr Bihari's idea. Yes during the day

it works also - it did in the recent germany study, though i will still

take the nightly dose.

I imagine this will speed up receptor upregulation etc..

I will let everyone know the results but I am very confident this will

be beneficial.

"