Re: EXPERIMENTING WITH DOSAGE?

[Guest guest]

Hallo dynaman,

I have been experimenting with dosages.

First I started with 4.5 mg (in august), which

was great. But after some months I got stiffness,

so I tried 3.0 mg but the stiffness remained the same

and the m.s. got worse. In may I took 4.5 mg again

and yes: that is a much better dosage for me.

Every (m.s.-)person is different, so I think you have

to see for yourself.

Greetings,

Simon

>From: " dynaman1 " <yurstruly@...>

>Reply-low dose naltrexone

>low dose naltrexone

>Subject: [low dose naltrexone] EXPERIMENTING WITH DOSAGE?

>Date: Tue, 05 Jul 2005 15:18:27 -0000

>

>I've heard that the 3mg dose actually might be stronger than 4.5mg, the

>theory being that 3mg blocks endorphins for a shorter time, resulting

>in a different and perhaps stronger endorphin rush. Does anyone have

>knowledge or experience with that idea?

>

>After three months on 4.5mg LDN, my early PD tremors seem a bit worse.

>I just got a refill of 4.5mg LDN. Should I try 3.0mg instead? My only

>side effects seem to be a stiff trapezius muscle (3 different times)

>and some vivid dreams, which don't bother me. I enjoy good drama.

>

>Thanks!

>

>

>

_________________________________________________________________

Altijd in contact met de kleinkinderen: MSN Messenger

http://messenger.msn.nl/

[Guest guest]

Thank you Simon. I suppose, whether it's for Parkinsons or MS, that

experimenting with dosage is wise. Problem is, early PD is subtle and

it's hard to tell what's happening. Any thoughts from other PD

patients on experimenting with dosage on the theory that 3.0 might

promote a stronger endorphin rush since it blocks endorphins for a

shorter time than does 4.5mg? Thanks!

> Hallo dynaman,

>

> I have been experimenting with dosages.

> First I started with 4.5 mg (in august), which

> was great. But after some months I got stiffness,

> so I tried 3.0 mg but the stiffness remained the same

> and the m.s. got worse. In may I took 4.5 mg again

> and yes: that is a much better dosage for me.

>

> Every (m.s.-)person is different, so I think you have

> to see for yourself.

>

> Greetings,

>

> Simon

>

> >From: " dynaman1 " <yurstruly@y...>

> >Reply-low dose naltrexone

> >low dose naltrexone

> >Subject: [low dose naltrexone] EXPERIMENTING WITH DOSAGE?

> >Date: Tue, 05 Jul 2005 15:18:27 -0000

> >

> >I've heard that the 3mg dose actually might be stronger than

4.5mg, the

> >theory being that 3mg blocks endorphins for a shorter time,

resulting

> >in a different and perhaps stronger endorphin rush. Does anyone

have

> >knowledge or experience with that idea?

> >

> >After three months on 4.5mg LDN, my early PD tremors seem a bit

worse.

> >I just got a refill of 4.5mg LDN. Should I try 3.0mg instead? My

only

> >side effects seem to be a stiff trapezius muscle (3 different

times)

> >and some vivid dreams, which don't bother me. I enjoy good drama.

> >

> >Thanks!

> >

> >

> >

>

> _________________________________________________________________

> Altijd in contact met de kleinkinderen: MSN Messenger

> http://messenger.msn.nl/

[Guest guest]

Simon, All, I just started on my 1.5mg doseage so I just can not say right now but in around 3 weeks I will be on to my 3.0mg tests. I'm keeping track of just what is happening to my MSA week by week. Nothing to report yet execpt that I am having NO PROBLEM GETING TO SLEEP AT NIGHT, but as of right now that is all there is to report

RK

[low dose naltrexone] EXPERIMENTING WITH DOSAGE?> >Date: Tue, 05 Jul 2005 15:18:27 -0000> >> >I've heard that the 3mg dose actually might be stronger than 4.5mg, the> >theory being that 3mg blocks endorphins for a shorter time, resulting> >in a different and perhaps stronger endorphin rush. Does anyone have> >knowledge or experience with that idea?> >> >After three months on 4.5mg LDN, my early PD tremors seem a bit worse.> >I just got a refill of 4.5mg LDN. Should I try 3.0mg instead? My only> >side effects seem to be a stiff trapezius muscle (3 different times)> >and some vivid dreams, which don't bother me. I enjoy good drama.> >> >Thanks!> >> >> >> > _________________________________________________________________> Altijd in contact met de kleinkinderen: MSN Messenger > http://messenger.msn.nl/

[Guest guest]

Hi Dynaman, when it comes to Parkinson's, some researchers believe the

disease is a brain inflammation. They have found that the

administration of naloxone (=naltrexone) in very small amounts can be

neuroprotective in rats and should represent an effective treatment

for people. They are not so sure endorphins are the reason for the

good results. Unfortunately, they haven't come up with the correct

dosage for us yet so we only have Dr. Bihari's experience to go by. I

myself don't think 3.0 or 4.5 mg is a big difference but I would go

with 4.5 mg. And, I agree that PD is such a slow mover, it's very hard

to determine what LDN is doing but it's worth the try for as long as

it takes.

See attachment for PD

http://www.fasebj.org/cgi/content/full/19/6/550

for MS

http://jnnp.bmjjournals.com/cgi/content/full/74/4/495

> > Hallo dynaman,

> >

> > I have been experimenting with dosages.

> > First I started with 4.5 mg (in august), which

> > was great. But after some months I got stiffness,

> > so I tried 3.0 mg but the stiffness remained the same

> > and the m.s. got worse. In may I took 4.5 mg again

> > and yes: that is a much better dosage for me.

> >

> > Every (m.s.-)person is different, so I think you have

> > to see for yourself.

> >

> > Greetings,

> >

> > Simon

> >

> > >From: " dynaman1 " <yurstruly@y...>

> > >Reply-low dose naltrexone

> > >low dose naltrexone

> > >Subject: [low dose naltrexone] EXPERIMENTING WITH DOSAGE?

> > >Date: Tue, 05 Jul 2005 15:18:27 -0000

> > >

> > >I've heard that the 3mg dose actually might be stronger than

> 4.5mg, the

> > >theory being that 3mg blocks endorphins for a shorter time,

> resulting

> > >in a different and perhaps stronger endorphin rush. Does anyone

> have

> > >knowledge or experience with that idea?

> > >

> > >After three months on 4.5mg LDN, my early PD tremors seem a bit

> worse.

> > >I just got a refill of 4.5mg LDN. Should I try 3.0mg instead? My

> only

> > >side effects seem to be a stiff trapezius muscle (3 different

> times)

> > >and some vivid dreams, which don't bother me. I enjoy good drama.

> > >

> > >Thanks!

> > >

> > >

> > >

> >

> > _________________________________________________________________

> > Altijd in contact met de kleinkinderen: MSN Messenger

> > http://messenger.msn.nl/

[Guest guest]

> I've heard that the 3mg dose actually might be stronger than 4.5mg, the

> theory being that 3mg blocks endorphins for a shorter time, resulting

> in a different and perhaps stronger endorphin rush. Does anyone have

> knowledge or experience with that idea?

>

> After three months on 4.5mg LDN, my early PD tremors seem a bit worse.

> I just got a refill of 4.5mg LDN. Should I try 3.0mg instead? My only

> side effects seem to be a stiff trapezius muscle (3 different times)

> and some vivid dreams, which don't bother me. I enjoy good drama.

>

> Thanks!

========

I asked Dr. Gluck, Dr. Bihari's assistant about this. He said the 3.0mg

is the weaker dose and 4.5mg is the stronger dose.

[Guest guest]

In a majority of cases men do best with 3.0 and women do best with 4.5. It

does not appear to be a body weight or mass thing. I have heard that

someone was thinking along the lines of different hormones. But maybe the

idea of 3mg blocking endorphins for a shorter time and resulting in a

stronger endorphin rush might be plausible.

Who knows!

Aletha

[low dose naltrexone] Re: EXPERIMENTING WITH DOSAGE?

>

>> I've heard that the 3mg dose actually might be stronger than 4.5mg, the

>> theory being that 3mg blocks endorphins for a shorter time, resulting

>> in a different and perhaps stronger endorphin rush. Does anyone have

>> knowledge or experience with that idea?

>>

>> After three months on 4.5mg LDN, my early PD tremors seem a bit worse.

>> I just got a refill of 4.5mg LDN. Should I try 3.0mg instead? My only

>> side effects seem to be a stiff trapezius muscle (3 different times)

>> and some vivid dreams, which don't bother me. I enjoy good drama.

>>

>> Thanks!

> ========

>

> I asked Dr. Gluck, Dr. Bihari's assistant about this. He said the

> 3.0mg is the weaker dose and 4.5mg is the stronger dose.

>

>

>

>

>

>

>

>

[Guest guest]

Hi ,

Could you clarify with Dr. Gluck:

1. Does he mean that 4.5 give a stronger response than 3.0 in

stopping PD progression, and therefore the idea that 3.0 give a

stronger endorphin rush is incorrect?

2. Does Dr. Bihari or anyone else believe, to any reasonable

degree of assurance, that PD is caused by brain inflammation (perhaps

causing the loss of dopamine receptor cells?), and that 4.5 give a

better anti-inflammatory response than 3.0? (By the way, Dr. Bihari

was hospitalized during the LDN conference in June. Anyone know how

he's doing?)

3. Another person responded to my dosage question with

(paraphrasing): " a majority of men do best with 3.0 and women do

best

with 4.5, based more on different hormones than weight or mass. "

But

my doc prescribed 4.5 based on my body weight of 165#.

The BASIC QUESTION: In males with early PD (and later stages as

well), does experience show that 3.0mg or 4.5mg LDN produces a better

result in slowing and stopping disease progression?

Should female PD patients take 4.5? Or doesn the difference between

3.0 and 4.5 not matter much in terms of sex, and it's more about

individual experimentation?

Thanks for your help!

> > I've heard that the 3mg dose actually might be stronger than

4.5mg, the

> > theory being that 3mg blocks endorphins for a shorter time,

resulting

> > in a different and perhaps stronger endorphin rush. Does anyone

have

> > knowledge or experience with that idea?

> >

> > After three months on 4.5mg LDN, my early PD tremors seem a bit

worse.

> > I just got a refill of 4.5mg LDN. Should I try 3.0mg instead? My

only

> > side effects seem to be a stiff trapezius muscle (3 different

times)

> > and some vivid dreams, which don't bother me. I enjoy good drama.

> >

> > Thanks!

> ========

>

> I asked Dr. Gluck, Dr. Bihari's assistant about this. He

said the 3.0mg is the weaker dose and 4.5mg is the stronger dose.

>

>

[Guest guest]

Hi again Dynaman,

You might try emailing Dr. Gluck yourself. His email add. is on the

LDN website. As a PD'er on LDN for 1 year, I would like to ask him how

Dr. Bihari' origional, year 2000, PD patients mentioned in their LDN

website (autoimmune Parkinson's) are doing now. PD can progress at

such a slow rate I would think that a PD'er would have to be on LDN

for years before one can say LDN " works " .

As far as PD being caused by " brain inflammation " , that's the belief

of certain researchers such as Dr. Liu and Dr. Hong whose papers I've

attached previously on this site. And will do so again. They are very

technical but if you print them out and take the time to read them,

you can get the gist of them and believe/hope that there is something

to LDN. I actually emailed Dr. Hong (see his article for his email

add.) at the NIH and he said he would recommend LDN (although he

doesn't know the doseage) for someone with PD. Dr. Bihari recommends

4.5mg for almost everyone. Drs. Hong and Liu have found that a small

dose of naloxone (naltrexone) within a certain optimum range reduces

brain inflamation in rats and they believe it can be an effective

therapy for PD.

I would guess that there are very few people with PD on LDN and that

it's important as " pioneers " that we can somehow keep tabs on how we

are doing. The various Parkison's websites do not seem much interested

in LDN.

http://www.fasebj.org/cgi/content/full/19/6/550

http://jpet.aspetjournals.org/cgi/content/full/304/1/1

> > > I've heard that the 3mg dose actually might be stronger than

> 4.5mg, the

> > > theory being that 3mg blocks endorphins for a shorter time,

> resulting

> > > in a different and perhaps stronger endorphin rush. Does anyone

> have

> > > knowledge or experience with that idea?

> > >

> > > After three months on 4.5mg LDN, my early PD tremors seem a bit

> worse.

> > > I just got a refill of 4.5mg LDN. Should I try 3.0mg instead? My

> only

> > > side effects seem to be a stiff trapezius muscle (3 different

> times)

> > > and some vivid dreams, which don't bother me. I enjoy good drama.

> > >

> > > Thanks!

> > ========

> >

> > I asked Dr. Gluck, Dr. Bihari's assistant about this. He

> said the 3.0mg is the weaker dose and 4.5mg is the stronger dose.

> >

> >

[Guest guest]

> > > I've heard that the 3mg dose actually might be stronger than

> 4.5mg, the

> > > theory being that 3mg blocks endorphins for a shorter time,

> resulting

> > > in a different and perhaps stronger endorphin rush. Does anyone

> have

> > > knowledge or experience with that idea?

> > >

> > > After three months on 4.5mg LDN, my early PD tremors seem a bit

> worse.

> > > I just got a refill of 4.5mg LDN. Should I try 3.0mg instead? My

> only

> > > side effects seem to be a stiff trapezius muscle (3 different

> times)

> > > and some vivid dreams, which don't bother me. I enjoy good drama.

> > >

> > > Thanks!

> > ========

Cantact Dr. Gluck with your question at low dose naltrexone-owner

If the address above doesn't print out fully on this page then I'll type it in

another way.

low dose naltrexone-ownerput the at sign here

You have questions he would be best to answer and I think it would be best if

you contact him direct instead of through another individual. He's real good at

answering people.