Re: Naltrexone & decreased libido

[Guest guest]

YES BUT THIS BEARS NO RELEVANCE TO US BECAUSE THAT WAS HIGH DOSE NALTREXONE AND WE ARE TAKING LOW DOSE.

IF ANYTHING, I THINK LDN MAY HELP THE LIBIDO DEPENDING ON WHERE YOUR LESIONS ARE BECAUSE OF THE ORCHESTRARION OF THE IMMUNE SYSTEM. KATHY [low dose naltrexone] Naltrexone & decreased libido

Naltrexone (Revia®) Naltrexone is a long-acting pure opioid antagonist which is effective orally.Indications: An adjunct to the maintenance of the opioid-free state in detoxified, formerly opioid-dependent individuals. For the treatment of alcohol dependence, as a component of a comprehensive psychotherapeutic counseling program to support abstinence and reduce the risk of relapse.Mechanism of action: Competitively inhibits all opioid receptors. Opioid receptors are thought to be responsible for some of the reinforcing effects of alcohol.Pharmacokinetics: Oral bioavailability is 5 to 40% due to high first pass metabolism. Inactivated primarily by liver metabolism. One major active metabolite with mean half-life of 13 hours.Evidence of effectiveness: Two small RCTs (7),(8) compared 12 weeks of naltrexone with placebo in the treatment of alcohol dependence. In these studies naltrexone modestly increased measures of alcohol abstinence (e.g. abstinence rate for naltrexone 42%, for placebo 20%). At the present time there are no long-term follow-up data or evidence that naltrexone leads to any clinically significant outcomes (e.g. abstinence rates at one year).Major adverse effects: The main adverse effects in these RCTs were somnolence, nervousness, vomiting, weight loss, dry mouth, decreased libido, insomnia, nausea, vomiting, and dyspepsia.Dose and cost: Naltrexone 50 mg daily ($5.70/day).Conclusions: Naltrexone is a pure long acting orally active opioid antagonist which may prove effective as an adjunct in opioid and alcohol dependence treatment programs.http://www.ti.ubc.ca/pages/letter17.htm

[Guest guest]

They would be referring to Full dose naltrexone (e.g. 50 mg ReVia)

that blocks the opiate receptors from endogenous endorphins ( &

exogenous opioids) thus antagonizing the associated pleasurable

feelings that may be facilitating that behavior.

LDN (e.g. 1.75 mg – 4.5 mg) taken between 9PM-3AM is expected to

temporarily block these receptors and cause the body to produce

200-300% more endorphins during their typical release time and last

the rest of the day beyond this block.

LDN's effects thus appear rather dose and time dependent.

Endorphin comes from endo(genous) + (mo)rphin(e) as it was discovered

after morphine. In 1975 U.S. physiologist discovers

endorphins (morphine-like chemicals) in the brain. Around 1803 German

chemist Friedrich Wilhelm Saturner isolates morphine from long used opium.

http://en.wikipedia.org/wiki/Endorphin

http://opioids.com/timeline (more here)

http://www.low dose naltrexone.org

> This is from an article on compulsive sexual behavior. Some in this

> group have said their libido has gotten a boost from LDN. How can that

> be if it's used to reduce it?

>

> Naltrexone. This medication is used to help people addicted to drugs or

> alcohol. It blocks the pleasurable feeling or " high " associated with

> using these substances. There's some evidence that naltrexone (ReVia)

> may also be helpful for treating people obsessed with sex.

>

> http://www.cnn.com/HEALTH/library/DS/00144.html