3 vs 4.5 mg - Some Science

[Guest guest]

For the scientists, the official UK data for

Naltrexone says-

Pharmacodynamic properties-

Naltrexone is a specific, high affinity, long acting

competitive antagonist at opioid receptors. It

has negligible opioid agonist activity. Tolerance

does not develop with prolonged use.

Pharmacokinetic properties-

Naltrexone is rapidly absorbed after oral

administration. It is metabolised by the liver and

excreted primarily in the urine, less than 5% is

excreted in the faeces. Naltrexone has an

elimination half-life of four hours. The major

metabolite 6-beta-naltrexol has an elimination

half-life of 12.9 hours.

This means that both 3 and 4.5 mg dose will be in

the body for the same length of time. I have not

found any scientific studies on LDN doses. Using

different doses for different people is usual cos the

human body is not a standard machine.

We need a dose-response study for LDN. These

are done by the pharma co before a drug is

registered. I don't think this data exists for LDN.

Without such data it is a matter of trial and error.

I have not seen any research data if anyone has

some please share it.

Kind regards,

Mark

(Pharmacist from Oxford England0