Actos

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Reported April 25, 2005

Diabetes Drug Helps Multiple Sclerosis

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CHICAGO (Ivanhoe Broadcast News) -- Nearly 350,000 Americans suffer from multiple sclerosis, a disease that strikes women twice as often as men. Some treatments are available for this crippling disease, but all require injections. Now a common diabetes drug could be the latest breakthrough for MS.

Eight-month-old na has just arrived from Guatemala. Her adoptive mother, Marjorie Fujara, is ready for the challenges of motherhood, but at age 41, Marjorie faces a more serious challenge.

Eight years ago, doctors diagnosed Marjorie with multiple sclerosis. "It was devastating," she says. "My mother was diagnosed with MS and had a very aggressive course with hers."

Marjorie's mother died from MS after 12 years. Today, she is in a trial to test a new treatment -- a drug that is used for diabetes.

Neuroscientist Feinstein, Ph.D., of University of Illinois at Chicago, says, "The relationship between type 2 diabetes and multiple sclerosis -- there probably isn't any really strong correlation, and it's just a serendipitous discovery that we came across."

The drug pioglitazone is known to type 2 diabetes patients as Actos. Lab studies with the drug for MS look encouraging. If the study results continue to show promise, pioglitazone could become the first treatment for MS taken in pill form, eliminating the need for injections.

So far, things are looking good for Marjorie. Her symptoms are not flaring up as often, and she has no side effects. "Just knowing there are people -- bright, dedicated researchers out there -- really gives me a lot of hope," she says.

This new drug trial for ms is nearly half over. Researchers at the University of Illinois expect to release the results in the spring of 2006. Researchers around the world are also testing this same drug for the treatment of Alzheimer's and Parkinson's disease.

This article was reported by Ivanhoe.com, who offers Medical Alerts by e-mail every day of the week. To subscribe, go to: http://www.ivanhoe.com/newsalert/.

If you would like more information, please contact:

Sharon Office of Public AffairsUniversity of Illinois at Chicago601 South MC 288Chicago, IL 60607-7113(312) 355-2522

[Guest guest]

Boy we really went off the original topic discussion on this one -so

I changed the topic name.

If children are on this do they have routine blood checkups for

their liver function?

http://www.healthsquare.com/newrx/ACT1535.HTM

Or for that matter all the other (many) possible side effects. May

want to read all -not just the cut and paste I have below -on the

following link...and not just about the possible risks to the liver

either -but the enlarged hearts observed in mice, rats, and

dogs...and monkeys too. Not all died from it and the dosages were

13x higher than that used in humans (adults) - no pediatric

dosage is set so what's too high a dosage for children?

Too much to read -but here's just one clip:

" Delayed postnatal development, attributed to decreased body weight,

was observed in offspring of rats at oral doses of 10 mg/kg and

above during late gestation and lactation periods (approximately 2

times the maximum recommended human oral dose based on mg/m 2 ).

There are no adequate and well-controlled studies in pregnant women.

ACTOS should be used during pregnancy only if the potential benefit

justifies the potential risk to the fetus.

Pediatric Use

Safety and effectiveness of ACTOS in pediatric patients have not

been established. "

Read more here:

http://www.drugs.com/pdr/Actos_Tablets.html

=====

[Guest guest]

I don't know if demyelination is a problem in apraxia. I really don't

know much about actos - I assume MDs who are prescribing it taken the

necessary precautions (and parents have to use their judgment

regarding the MD's qualifications). It's always interesting to me that

mainstream medicine is so vocal about the risks of autism treatments

(that is, meds, supplements, etc that might actually reverse some of

the medical problems found in autism, rather than just control

symptoms), but at the same time most docs have no problem with rampant

use of stimulants like ritalin, antipsychotics and other dangerous

drugs to control symptoms of adhd and autism. Yes, actos needs to be

used safely under a doctor's care - but the problem it's being used to

address is serious.

>

> Boy we really went off the original topic discussion on this one -so

> I changed the topic name.

>

> If children are on this do they have routine blood checkups for

> their liver function?

> http://www.healthsquare.com/newrx/ACT1535.HTM

>

> Or for that matter all the other (many) possible side effects. May

> want to read all -not just the cut and paste I have below -on the

> following link...and not just about the possible risks to the liver

> either -but the enlarged hearts observed in mice, rats, and

> dogs...and monkeys too. Not all died from it and the dosages were

> 13x higher than that used in humans (adults) - no pediatric

> dosage is set so what's too high a dosage for children?

>

> Too much to read -but here's just one clip:

>

> " Delayed postnatal development, attributed to decreased body weight,

> was observed in offspring of rats at oral doses of 10 mg/kg and

> above during late gestation and lactation periods (approximately 2

> times the maximum recommended human oral dose based on mg/m 2 ).

> There are no adequate and well-controlled studies in pregnant women.

> ACTOS should be used during pregnancy only if the potential benefit

> justifies the potential risk to the fetus.

>

> Pediatric Use

> Safety and effectiveness of ACTOS in pediatric patients have not

> been established. "

>

> Read more here:

> http://www.drugs.com/pdr/Actos_Tablets.html

>

> =====

>

[Guest guest]

Hi !

I agree that too many in the past at least were quick to

prescribe Ritalin, but since my oldest now 11 year old son Dakota

had been diagnosed with ADHD many times prior to EFAs, I know that

each doctor did make me aware of any side effect possible of the

ADHD drug Adderall (the one that a few wanted to put Dakota on) We

fortunately were able to help Dakota with his ADHD with the fish

oils -with a higher EPA ratio then what we use with Tanner (who had

apraxia) The side effects of the ADHD meds are not gruesome ones like

actos, there are mild side effects, unless the child is allergic to

it that is. The following has them listed:

http://www.drugs.com/adderall.html

http://www.drugs.com/ritalin.html

Unlike Ritalin and even Adderall that most know about for it's use

in children, Actos on the other hand most never even heard of. And

for those that do for most of the world, it's not an autism

treatment, it's a diabetes medication. Autism isn't mentioned. In

fact they don't even have a pediatric dosage. And again the risks

are not mild as I wrote below, they are very severe and even at a

double dosage (for adults) and one would hope that the children are

being tested for things like heart enlargement. Actually how do you

test for heart enlargement unless you know the size of the child's

heart before? Is anyone even looking at that one (of many) risk

considering this appeared to happen in all of the various animals

when a too high dosage was given and there again is no pediatric

dosage set? So what is too high for a child?

=====

[Guest guest]

I was asked to dispel some myths on ACTOS and autism treatment.

Please do the research on why and what this medication is achieving

in neurologically based disorders that are being studied. ACTOS a

PPAR agonist works on NFKB pathway, lowers inflamatory cytokines. It

does not alter glucose levels. I would assume if a child exhibited

elevated inflammatory cytokines from viral activation/toxicity, it

would be the at the doctors discretion to use this drug for the

overwhelmiong benefits it has achieved in numerous studies. Yes there

are side effects, and like all medications there are side effects.

Risk/benefit must be taken into consideration, to see a child beocome

engaged and social is a benefit.Adderall/ritalin are known for

increasing suicidial thoughts/aggression/addiction. So again,

risk/benefit analysis with any choice of medications.

>

> Hi !

>

> I agree that too many in the past at least were quick to

> prescribe Ritalin, but since my oldest now 11 year old son Dakota

> had been diagnosed with ADHD many times prior to EFAs, I know that

> each doctor did make me aware of any side effect possible of the

> ADHD drug Adderall (the one that a few wanted to put Dakota on) We

> fortunately were able to help Dakota with his ADHD with the fish

> oils -with a higher EPA ratio then what we use with Tanner (who had

> apraxia) The side effects of the ADHD meds are not gruesome ones

like

> actos, there are mild side effects, unless the child is allergic to

> it that is. The following has them listed:

> http://www.drugs.com/adderall.html

> http://www.drugs.com/ritalin.html

>

> Unlike Ritalin and even Adderall that most know about for it's use

> in children, Actos on the other hand most never even heard of. And

> for those that do for most of the world, it's not an autism

> treatment, it's a diabetes medication. Autism isn't mentioned. In

> fact they don't even have a pediatric dosage. And again the risks

> are not mild as I wrote below, they are very severe and even at a

> double dosage (for adults) and one would hope that the children are

> being tested for things like heart enlargement. Actually how do you

> test for heart enlargement unless you know the size of the child's

> heart before? Is anyone even looking at that one (of many) risk

> considering this appeared to happen in all of the various animals

> when a too high dosage was given and there again is no pediatric

> dosage set? So what is too high for a child?

>

> =====

>

[Guest guest]

Late talker/speech delay vs. apraxia? Learn about children's

communicationGrace...how old is your son or do you know how young a child can be

to have it prescribed. I researched it when I read about it yesterday but

didn't find that information. Aggie

[ ] Digest Number 5677

Late talker/speech delay vs. apraxia? Learn about children's communication

Messages In This Digest (25 Messages)

1a. Re: In your experience, how much speech therapy is enough (or too mu

From: trmckenna1

1b. Re: In your experience, how much speech therapy is enough (or too mu

From: luckymom987

2a. Speach device From: Doodlebug312

2b. Re: Speach device From:

2c. Re: Speach device From: MOMFULLX@...

2d. Re: Speach device From: klbushey@...

3.1. Re: Hijacked list - (was Tanner) From: srmccann2003

3.2. Re: Hijacked list - (was Tanner) From:

3.3. Re: Hijacked list - (was Tanner) From: elmccann

3.4. Re: Hijacked list From: sharon lang

3.5. Re: Hijacked list - (was Tanner) From: ilizzy03

3.6. Re: Hijacked list - (was Tanner) From: tbniesh@...

3.7. Re: Hijacked list - (was Tanner) From: ilizzy03

3.8. Re: Hijacked list - (was Tanner) From: bdkirk03

4.1. How soon after eval for NACD do we get our programming? - From:

dana pope

5a. Re: Coromega vs. EyeQ From: kiddietalk

5b. Re: Coromega vs. EyeQ From: ilizzy03

6a. Re: 26 month old boy, very articulate but can't smile on command.

From: ilizzy03

6b. Re: 26 month old boy, very articulate but can't smile on command.

From: kiddietalk

7a. Actos From: Grace Jaye

8a. Re: Earobics From: Aubrey

9. DQ1 Sensitivity --- Celiac Expert interested--- From: ilizzy03

10a. Re: swinging question/vestibular system From: ilizzy03

11. lda news From: Jeanne Buesser

12. westwood parents with educational concerns From: Jeanne Buesser

View All Topics | Create New Topic Messages

1a. Re: In your experience, how much speech therapy is enough (or too mu

Posted by: " trmckenna1 " trmckenna1@... trmckenna1

Mon Feb 11, 2008 8:30 am (PST)

I am curious to know what you mean by " more formal " speech therapy?

Is the school providing one-on-one therapy or group therapy? Is your

child a late talker or does she have a speech disorder like apraxia?

When my child transitioned out of EI we had two one-on-one with a

school therapist and 1 one-on-one private therapy. They both worked

with the Kaufman cards and worksheets out of the Easy Does it for

Apraxia workbook. They both worked on getting him to learn the basic

sounds connected with a long vowel. My son had a lot of trouble with

lip placement for b,m,and p. So they both worked on getting him to

put his lips together and oral motor exercises to help with this.

Once he was able to follow the prompting of lips together they moved

on to adding long vowels-like bee, bye, bow, bay, boo. Therapy for

the child is/should always be individualized for what the child is

having trouble with. Through the school they should be working on

the IEP goals. In the link section there is a folder that you may be

interested in. It has many links and ideas that might help you for

at home. 5 speech sessions, OT, and PT is a great amount of

therapy. You are lucky you were able to get that for your daughter.

Pat yourself on the back because that is wonderful you were able to

get that for your child!!

/links

folder=therapy idea - for at home

HTH,

Tina

>

> I am curious to know what you mean by " more formal " speech therapy?

> Is the school providing one-on-one therapy or group therapy? Is your

> child a late talker or does she have a speech disorder like apraxia?

> When my child transitioned out of EI we had two one-on-one with a

> school therapist and 1 one-on-one private therapy. They both worked

> with the Kaufman cards and worksheets out of the Easy Does it for

> Apraxia workbook. They both worked on getting him to learn the basic

> sounds connected with a long vowel. My son had a lot of trouble with

> lip placement for b,m,and p. So they both worked on getting him to

> put his lips together and oral motor exercises to help with this.

> Once he was able to follow the prompting of lips together they moved

> on to adding long vowels-like bee, bye, bow, bay, boo. Therapy for

> the child is/should always be individualized for what the child is

> having trouble with. Through the school they should be working on

> the IEP goals. In the link section there is a folder that you may be

> interested in. It has many links and ideas that might help you for

> at home. 5 speech sessions, OT, and PT is a great amount of

> therapy. You are lucky you were able to get that for your daughter.

> Pat yourself on the back because that is wonderful you were able to

> get that for your child!!

>

> /links

> folder=therapy idea - for at home

>

> HTH,

> Tina

>

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Messages in this topic (7)

2a. Speach device

Posted by: " Doodlebug312 " doodlebug312@... sabrinauchetel

Mon Feb 11, 2008 8:47 am (PST)

Hi, My name is I'm new here. My son Charlie is 4 years and 9 mths

old and has just been officially diagnosed with apraxia. It has been highly

recommend that he get an ACC Device. While waiting to hear back from my CPSE

Chairperson I did a little research into. As I'm sure you have found out they

can be quite pricey. I contacted my broker insurance and they told me that I

would need to send in allot of documentation form the Doctors and Specialists.

Basically an novel for there review. I have been very fortunate with my school

district and they will have him evaluated for it and he should get it. They said

it is his for home and school for as long as it is necessary.

Good luck.