MTX blues

[Guest guest]

I can't stop thinking about Mandi and her family today--very, very

sad. This is just a reminder post for anyone using methotrexate,

especially if you're just starting it, to be aware of the

" methotrexate blues. " I sink into a terrible depression about 24

hours after I take it (I do 22.5 mgs/9 cc's by injection) that lasts

for a day, sometimes two, even though I do a Leucovorin rescue 9-10

hours after taking it.

My hubby jokes about keeping me away from sharp objects on that day,

but after we talked last night about Mandi, I think we both have a

better understanding of how serious this can be. Dealing with a

chronic illness and pain is enough reason to be suicidal. Now we're

adding medications that might exacerbate those feelings. Keep a

safety net handy, everyone!