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Re: Re: spiro, day 2

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Probably need to up the potassium. I shouldnt, but i experiment with my doses to watch the relationship to symptoms. If it were me, I would take another 20 meq of potassium and check back in a few hours. I would bet your pressure will drop. My father-in-law started drinking some low Sodium V8, as i suggested, and he is amazed that his BP is now lower than it has been in years. Too bad you cant tolerate it. That is a good natural way to suppliment without having to rely on the pills. Although the pills are cheap, so no big deal to just take them. ============================================================================45-Male-Caucasian, 5'9"- 234lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 100mg

Spiro, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammationOther Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011To: hyperaldosteronism Sent: Monday, June 27, 2011 1:06 PMSubject: Re: spiro, day 2

Thanks . I actually think my doc cut back the K too much too soon and will discuss this at my next appointment later this week.

This is my 6th day of spiro and outside of that one 129/90 reading, my BP has remained higher than usual - average 150s/low 100s rather than my unmedicated 140s/low 90s. This has me a bit worried!

wrote:

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> Sounds like you are on the right track and hope it continues! (I don't envy you with everything else you have going on!) Your Dr. treated your K a little differently than mine, they put me on Siro and did frequent tests to watch the K only eliminating it when the K started to reach max! You may be getting a peak and valley effect instesd of a liner progression! Hope they are right and it smooths out - Good Luck!

>

> - 64 yo morb. ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank & testicle pain. I have decided against an adrenalectomy at this time since Meds. are working so well. Current BP being watched after Oral Surgery and associated dietary changes.

> Other Issues/Opportunities: COPD w/ft Oxygen, OSA w Bi-Pap settings 13/19, Type II Diab. and PTSD

> Meds: Duloxetine hcl 80 MG, Mirtazapine 15 MG, Methadone 10 MG(titrating off S-L-O-W-L-Y) , Metoprolol Tartrate 200 MG, Metformin 2000MG, Lisinopril 2.5MG and Spironolactone 75 MG.

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> > > > Happy to report that this morning, my second day of spiro, my BP was 129/90. Not great but considering that it was running high 160s/100s yesterday, I think I can stop worrying that I was getting a paradoxical reaction of *increased* BP (which happened to me on Diovan, Cardizem, etc. etc.)

> > > >

> > > > The bad news is after cutting my K down from 60 MEQ/day to only 20 MEQ/day, my left trapezius muscle spasm is back in full force already.

> > > >

> > > > --msmith1928

> > > > Nulliparous female, 46, 5'3", 120 lbs, polymenorrhea, hyperinsulinemia, hereditary fructose intolerance, lactose intolerance, probable gluten intolerance. Current meds are spiro 12.5mg/dday, potassium 20MEQ/day, singulair 10mg, norethindrone .35mg to regulate polymenorrhea, cyclobenzaprine 5-10mg when needed, fexofenadine 180mg as needed. Low sodium, fructose- and grain-free diet. Known drug allergies include PCN, sulfa, tetracycline. 1cm left adrenal nodule, supine aldosterone 28.5/renin 0.2, potassium <2.9 (when not taking supplements), 25mg spiro caused gynecomastia and polymenorrhea. AVS showed right adrenal overproduces aldo; unable to sample left; proceeding as if my hyperaldosteronism is bilateral.

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Did he check your u Na? you can out salt Spiro. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

Thanks . I actually think my doc cut back the K too much too soon and will discuss this at my next appointment later this week.

This is my 6th day of spiro and outside of that one 129/90 reading, my BP has remained higher than usual - average 150s/low 100s rather than my unmedicated 140s/low 90s. This has me a bit worried!

wrote:

>

> Sounds like you are on the right track and hope it continues! (I don't envy you with everything else you have going on!) Your Dr. treated your K a little differently than mine, they put me on Siro and did frequent tests to watch the K only eliminating it when the K started to reach max! You may be getting a peak and valley effect instesd of a liner progression! Hope they are right and it smooths out - Good Luck!

>

> - 64 yo morb. ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank & testicle pain. I have decided against an adrenalectomy at this time since Meds. are working so well. Current BP being watched after Oral Surgery and associated dietary changes.

> Other Issues/Opportunities: COPD w/ft Oxygen, OSA w Bi-Pap settings 13/19, Type II Diab. and PTSD

> Meds: Duloxetine hcl 80 MG, Mirtazapine 15 MG, Methadone 10 MG(titrating off S-L-O-W-L-Y) , Metoprolol Tartrate 200 MG, Metformin 2000MG, Lisinopril 2.5MG and Spironolactone 75 MG.

>

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> > > >

> > > > Happy to report that this morning, my second day of spiro, my BP was 129/90. Not great but considering that it was running high 160s/100s yesterday, I think I can stop worrying that I was getting a paradoxical reaction of *increased* BP (which happened to me on Diovan, Cardizem, etc. etc.)

> > > >

> > > > The bad news is after cutting my K down from 60 MEQ/day to only 20 MEQ/day, my left trapezius muscle spasm is back in full force already.

> > > >

> > > > --msmith1928

> > > > Nulliparous female, 46, 5'3", 120 lbs, polymenorrhea, hyperinsulinemia, hereditary fructose intolerance, lactose intolerance, probable gluten intolerance. Current meds are spiro 12.5mg/dday, potassium 20MEQ/day, singulair 10mg, norethindrone .35mg to regulate polymenorrhea, cyclobenzaprine 5-10mg when needed, fexofenadine 180mg as needed. Low sodium, fructose- and grain-free diet. Known drug allergies include PCN, sulfa, tetracycline. 1cm left adrenal nodule, supine aldosterone 28.5/renin 0.2, potassium <2.9 (when not taking supplements), 25mg spiro caused gynecomastia and polymenorrhea. AVS showed right adrenal overproduces aldo; unable to sample left; proceeding as if my hyperaldosteronism is bilateral.

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I generally will cut K in half when first starting if it has been a problem in the past. Esp if K has been very low like yours.But then he knows you better. He may not know PA better. CE Grim MDSince spiro is supposed to normalize K pretty rapidly, my doctor told me to lower it. He said that usually when starting spiro, K is discontinued entirely, but since I get little K in my diet due to food intolerances he's keeping me on it but at a low dose.> >> > Happy to report that this morning, my second day of spiro, my BP was 129/90. Not great but considering that it was running high 160s/100s yesterday, I think I can stop worrying that I was getting a paradoxical reaction of *increased* BP (which happened to me on Diovan, Cardizem, etc. etc.)> > > > The bad news is after cutting my K down from 60 MEQ/day to only 20 MEQ/day, my left trapezius muscle spasm is back in full force already. > > > > --msmith1928> > Nulliparous female, 46, 5'3", 120 lbs, polymenorrhea, hyperinsulinemia, hereditary fructose intolerance, lactose intolerance, probable gluten intolerance. Current meds are spiro 12.5mg/dday, potassium 20MEQ/day, singulair 10mg, norethindrone .35mg to regulate polymenorrhea, cyclobenzaprine 5-10mg when needed, fexofenadine 180mg as needed. Low sodium, fructose- and grain-free diet. Known drug allergies include PCN, sulfa, tetracycline. 1cm left adrenal nodule, supine aldosterone 28.5/renin 0.2, potassium <2.9 (when not taking supplements), 25mg spiro caused gynecomastia and polymenorrhea. AVS showed right adrenal overproduces aldo; unable to sample left; proceeding as if my hyperaldosteronism is bilateral.> >>

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Being from MO and doing this for 45 years I like to see what's in the urine. Can sneak in many ways.Easy to check.Also only way to document Na and K intake and to see if K is higher than Na in urine-goal of DASH.CE Grim MDI average about 800mg of salt a day - doubtful this is an issue, as I never add salt to any food and do not eat anything prepared or processed. The only salt in my diet is what occurs naturally.> > > > > >> > > > > > Happy to report that this morning, my second day of spiro, my BP was 129/90. Not great but considering that it was running high 160s/100s yesterday, I think I can stop worrying that I was getting a paradoxical reaction of *increased* BP (which happened to me on Diovan, Cardizem, etc. etc.)> > > > > > > > > > > > The bad news is after cutting my K down from 60 MEQ/day to only 20 MEQ/day, my left trapezius muscle spasm is back in full force already. > > > > > > > > > > > > --msmith1928> > > > > > Nulliparous female, 46, 5'3", 120 lbs, polymenorrhea, hyperinsulinemia, hereditary fructose intolerance, lactose intolerance, probable gluten intolerance. Current meds are spiro 12.5mg/dday, potassium 20MEQ/day, singulair 10mg, norethindrone .35mg to regulate polymenorrhea, cyclobenzaprine 5-10mg when needed, fexofenadine 180mg as needed. Low sodium, fructose- and grain-free diet. Known drug allergies include PCN, sulfa, tetracycline. 1cm left adrenal nodule, supine aldosterone 28.5/renin 0.2, potassium <2.9 (when not taking supplements), 25mg spiro caused gynecomastia and polymenorrhea. AVS showed right adrenal overproduces aldo; unable to sample left; proceeding as if my hyperaldosteronism is bilateral.> > > > > >> > > > >> > > >> > >> > > >>

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Spiro usually reaches max at in 7-10 days as I recall. CE Grim MD Thanks for the input Dr Grim. I'm seeing him Wednesday and will be having the usual bloodwork done - if my K is below 4 I'm definitely going to tell him I think I need a higher dose. Also planning to ask if there's any immediate danger in keeping the dose higher for a few weeks until the spiro kicks in, since he's monitoring me weekly for the next month or so.> > > >> > > > Happy to report that this morning, my second day of spiro, my BP > > was 129/90. Not great but considering that it was running high 160s/ > > 100s yesterday, I think I can stop worrying that I was getting a > > paradoxical reaction of *increased* BP (which happened to me on > > Diovan, Cardizem, etc. etc.)> > > >> > > > The bad news is after cutting my K down from 60 MEQ/day to only > > 20 MEQ/day, my left trapezius muscle spasm is back in full force > > already.> > > >> > > > --msmith1928> > > > Nulliparous female, 46, 5'3", 120 lbs, polymenorrhea, > > hyperinsulinemia, hereditary fructose intolerance, lactose > > intolerance, probable gluten intolerance. Current meds are spiro > > 12.5mg/dday, potassium 20MEQ/day, singulair 10mg, norethindrone . > > 35mg to regulate polymenorrhea, cyclobenzaprine 5-10mg when needed, > > fexofenadine 180mg as needed. Low sodium, fructose- and grain-free > > diet. Known drug allergies include PCN, sulfa, tetracycline. 1cm > > left adrenal nodule, supine aldosterone 28.5/renin 0.2, potassium > > <2.9 (when not taking supplements), 25mg spiro caused gynecomastia > > and polymenorrhea. AVS showed right adrenal overproduces aldo; > > unable to sample left; proceeding as if my hyperaldosteronism is > > bilateral.> > > >> > >> >> >> >>

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What you want is a timed urine specimen. So figure out about when you wi be at dr if possible. If in AM I recommend u pee when When u get up to stay and record the time. Try not to before u go to dr if u can. When you get to dr office tell them u need to pee and want to collect the whole urine volume so it can be measured and then measure Na K and creatine in the urine. This can be converted to 24 hr estimates of your intake. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

I'll ask the doc to do a pee test Wednesday. Wanted to make sure I've got this straight: are you saying that the K in urine should be higher than the NA? If it's not, then does that indicate that K supplements should be increased? (Assuming that salt intake can't be increased since I'm not adding salt to food and I'm not overeating or anything - there's no need for calorie cutting.)

> > > > > > > >

> > > > > > > > Happy to report that this morning, my second day of

> > spiro, my BP was 129/90. Not great but considering that it was

> > running high 160s/100s yesterday, I think I can stop worrying that I

> > was getting a paradoxical reaction of *increased* BP (which happened

> > to me on Diovan, Cardizem, etc. etc.)

> > > > > > > >

> > > > > > > > The bad news is after cutting my K down from 60 MEQ/day

> > to only 20 MEQ/day, my left trapezius muscle spasm is back in full

> > force already.

> > > > > > > >

> > > > > > > > --msmith1928

> > > > > > > > Nulliparous female, 46, 5'3", 120 lbs, polymenorrhea,

> > hyperinsulinemia, hereditary fructose intolerance, lactose

> > intolerance, probable gluten intolerance. Current meds are spiro

> > 12.5mg/dday, potassium 20MEQ/day, singulair 10mg, norethindrone .

> > 35mg to regulate polymenorrhea, cyclobenzaprine 5-10mg when needed,

> > fexofenadine 180mg as needed. Low sodium, fructose- and grain-free

> > diet. Known drug allergies include PCN, sulfa, tetracycline. 1cm

> > left adrenal nodule, supine aldosterone 28.5/renin 0.2, potassium

> > <2.9 (when not taking supplements), 25mg spiro caused gynecomastia

> > and polymenorrhea. AVS showed right adrenal overproduces aldo;

> > unable to sample left; proceeding as if my hyperaldosteronism is

> > bilateral.

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