Spironolactone vs Antidepressant Treatment

[Guest guest]

I came accross this last night:

From Wikipedia, the free encyclopedia

Research has also shown spironolactone can interfere with the effectiveness of

antidepressant treatment. The drug is actually (among its other receptor

interactions) a mineralocorticoid (MR) antagonist, and has been found to reduce

the effectiveness of antidepressant drugs in the treatment of major depression,

it is presumed, by interfering with normalization of the

hypothalamic-pituitary-adrenal axis in patients receiving antidepressant

therapy.[6]

6)^ Holsboer, F. The Rationale for Corticotropin-Releasing Hormone Receptor

(CRH-R) Antagonists to Treat Depression and Anxiety. J. Psychiatr. Res. 33,

181–214 (1999)

Has anyone had any experience or shed any light on this? Thanks.

- 64 yo morb. ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank &

testicle pain. I have decided against an adrenalectomy at this time since

Meds. are working so well. Current BP being watched after Oral Surgery and

associated dietary changes.

Other Issues/Opportunities: COPD w/ft Oxygen, OSA w Bi-Pap settings 13/19, Type

II Diab. and PTSD

Meds: Duloxetine hcl 80 MG, Mirtazapine 15 MG, Methadone 10 MG(titrating off

S-L-O-W-L-Y) , Metoprolol Tartrate 200 MG, Metformin 2000MG, Lisinopril 2.5MG

and Spironolactone 75 MG.