For Val and others with PA and PHP.

[Guest guest]

Here's

another one, from 1995:

Am J Hypertens. 1995 Sep;8(9):884-93.

Alterations of calcium metabolism and of parathyroid function in primary aldosteronism,

and their reversal by spironolactone or by surgical removal

of aldosterone-producing adenomas.

Rossi E, et. al.

Fourth Department of Internal Medicine, S. Nuova Hospital, Reggio Emilia,

Italy.

In order to investigate the possible existence of abnormal calcium metabolism

and parathyroid function in primary aldosteronism (PA), we have compared the calcium/parathyroid

hormone (PTH) profile of patients with PA with the profile of healthy

normotensive subjects and of patients with essential hypertension (EH).

Furthermore, we have evaluated the effects of spironolactone and the surgical

removal of aldosterone-producing adenomas on the calcium/PTH profile in the PA

patients. Four groups of 10 subjects each participated in the study: 1)

hypertensive patients with PA, 2) patients with low-renin EH (LREH), 3)

patients with normal-renin EH (NREH), 4) normotensive healthy subjects (NS).

The four groups were well-matched for age, sex, body mass index, and renal

function. The three hypertensive groups

were also matched closely for blood pressure values and for duration of hypertension.

In all subjects, after 1 week of a controlled intake of Na and K, the following

parameters were measured: urine excretion of Na, K, Ca, Mg, and P, plasma

levels of K, Mg, inorganic P, total calcium and ionized calcium, and plasma renin

activity, aldosterone concentration, and intact PTH. Blood pressure and

laboratory parameters were determined again in all the PA patients after 1

month of 100 mg daily spironolactone administration, and in four out of the 10

PA patients 2 months after surgical removal of aldosterone-producing adenomas.

All of these subjects had undergone the same controlled intake of Na and K

indicated above. Serum intact PTH was higher in PA patients than in the other

three groups (P < .01), and serum ionized

calcium was significantly higher in normotensive subjects than in the three hypertensive

groups (v PA P < .01, v LREH and v NREH P < .05). An increase in serum

ionized calcium and a decrease in PTH level were associated with both

spironolactone administration (P < .001) and surgical treatment (P <.05).

These results suggest the

presence of calcium metabolism alterations in both PA and EH patients, but that

these alterations are more exaggerated in PA, so that higher PTH levels are

needed for maintaining low-normal levels of serum ionized calcium.

PMID: 8541003 [PubMed - indexed for MEDLINE]

Val

[Guest guest]

Yes as noted in another article one loses Ca in urine with PA ( renal Can leak) this lowers Ca and kicks up PTH. Chronic stimulation parathyroids can lead to hyperplasia and maybe even adenoma of parathyroid some think. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

Here's

another one, from 1995:

Am J Hypertens. 1995 Sep;8(9):884-93.

Alterations of calcium metabolism and of parathyroid function in primary aldosteronism,

and their reversal by spironolactone or by surgical removal

of aldosterone-producing adenomas.

Rossi E, et. al.

Fourth Department of Internal Medicine, S. Nuova Hospital, Reggio Emilia,

Italy.

In order to investigate the possible existence of abnormal calcium metabolism

and parathyroid function in primary aldosteronism (PA), we have compared the calcium/parathyroid

hormone (PTH) profile of patients with PA with the profile of healthy

normotensive subjects and of patients with essential hypertension (EH).

Furthermore, we have evaluated the effects of spironolactone and the surgical

removal of aldosterone-producing adenomas on the calcium/PTH profile in the PA

patients. Four groups of 10 subjects each participated in the study: 1)

hypertensive patients with PA, 2) patients with low-renin EH (LREH), 3)

patients with normal-renin EH (NREH), 4) normotensive healthy subjects (NS).

The four groups were well-matched for age, sex, body mass index, and renal

function. The three hypertensive groups

were also matched closely for blood pressure values and for duration of hypertension.

In all subjects, after 1 week of a controlled intake of Na and K, the following

parameters were measured: urine excretion of Na, K, Ca, Mg, and P, plasma

levels of K, Mg, inorganic P, total calcium and ionized calcium, and plasma renin

activity, aldosterone concentration, and intact PTH. Blood pressure and

laboratory parameters were determined again in all the PA patients after 1

month of 100 mg daily spironolactone administration, and in four out of the 10

PA patients 2 months after surgical removal of aldosterone-producing adenomas.

All of these subjects had undergone the same controlled intake of Na and K

indicated above. Serum intact PTH was higher in PA patients than in the other

three groups (P < .01), and serum ionized

calcium was significantly higher in normotensive subjects than in the three hypertensive

groups (v PA P < .01, v LREH and v NREH P < .05). An increase in serum

ionized calcium and a decrease in PTH level were associated with both

spironolactone administration (P < .001) and surgical treatment (P <.05).

These results suggest the

presence of calcium metabolism alterations in both PA and EH patients, but that

these alterations are more exaggerated in PA, so that higher PTH levels are

needed for maintaining low-normal levels of serum ionized calcium.

PMID: 8541003 [PubMed - indexed for MEDLINE]

Val