D3 regulates genes responsible for detoxification in intestine

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Toxicol Appl Pharmacol. 2007 Jan 1;218(1):37-44. Epub 2006 Oct 13. 1,25-Dihydroxyvitamin D3 regulates genes responsible for detoxification in intestine.Kutuzova GD...Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706-1544, USA.1Alpha,25-Dihydroxyvitamin

D(3) (1,25-(OH)(2)D(3)), the biologically active form of vitamin D(3),

not only plays a major role in mammalian calcium and phosphorous

homeostasis but also exerts pleiotropic effects on cell proliferation,

differentiation and the immune system. Further, vitamin D is believed

to play a significant role in the prevention of colon, prostate, and

breast cancer and in reducing the risk of autoimmune diseases. To gain

insight into the mechanism whereby vitamin D can have such diverse

actions, we have employed microarray technology. We studied the effect

of a single dose of 1,25-(OH)(2)D(3) on gene expression in the

intestine of vitamin D-deficient rats. Within 6 h, 1,25-(OH)(2)D(3)

stimulates the expression of several phase I and phase II

biotransformation genes. There is also an increased expression of

antioxidant genes. These results support the idea that vitamin D is a

significant factor in detoxification and protection against

environmental toxins.PMID: 17123563 [PubMed - indexed for MEDLINE]