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Re: Neu5GC

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Hi Hiedi...

I honor your experience and value your opinion but I have been diagnosed with a

" leaky gut " complicated by a gluten intolerance and meat protein is one of the

few things I don't react too.

I think this leaky gut thing should be taken on a case by case basis.

And yes milk is out of my diet at this pint in any form....

Tim

Neu5GC

This article was posted on the kefir group. I think it is

interesting ... my take is that " leaky gut " is probably

the root problem, because proteins aren't supposed to

get into the blood stream intact, which they don't mention

here! It could account for why some people feel so much

better when they go off meat though ... the effects

of this molecule could be a lot like what gliadin does

when it gets into the blood.

-- Heidi

=======

<http://www.timesonline.co.uk/article/0,,8122-836307,00.html>http://www.timesonl\

ine.co.uk/article/0,,8122-836307,00.html

B " H

By Maggie Fox, Health and Science Correspondent

WASHINGTON (Reuters) - A non-human molecule found in red meat and

milk makes its way into the human system when eaten -- and seems to

build up especially in tumors, U.S. researchers reported on Monday.

The compound, called sialic acid, is found on the surfaces of animal

cells but is not found in people, and may be one reason why animal-

to-human organ and tissue transplants do not work well. Animals have

a version called Neu5Gc, while humans carry Neu5Ac.

But researchers at the University of California San Diego found it

does show up in the human body, and showed it can be absorbed from

eating red meat and milk.

They also showed that the body produces an immune response against

the molecule.

Dr. Ajit Varki and colleagues, reporting in the Proceedings of the

National Academy of Sciences (news - web sites), say it is too soon

to make any recommendations based on their findings.

" Of course, there are already existing recommendations that people

should not consume too much food containing saturated fats, such as

dairy products and red meats, " Varki said in a statement.

" The highest amount (of Neu5Gc) was found in lamb, pork, and beef

(so-

called 'red meat'), " the researchers wrote. Levels were very low or

undetectable in poultry and fish, vegetables and hen's eggs.

Varki, who is not a vegetarian, noted that many studies have linked

a diet rich in meat and milk with cancer, heart disease and other

diseases.

AUTOIMMUNE DISEASE

" The small amounts of Neu5Gc in normal tissues also raise the

possibility that anti-Neu5Gc antibodies are involved in

autoimmunity, " the researchers said.

Autoimmune disease occur when the body mistakenly attacks healthy

tissue and include type-1 or juvenile diabetes and some types of

arthritis. " In this regard, it is interesting that vegetarian diet

has been suggested to improve rheumatoid arthritis, " they wrote.

But much research has focused on the fat content of animal fat or

byproducts of cooking meat as the cause of disease.

Varki's collaborator Dr. Elaine Muchmore developed an antibody -- an

immune system targeting protein -- that would hook onto Neu5Gc. The

team found Neu5Gc in human tumor samples and to a much lower degree

in healthy tissue.

More tests showed that most people had made their own antibodies

that

recognized Neu5Gc, and thus could potentially initiate an

inflammatory immune response.

Varki and two colleagues drank Neu5Gc purified from pork sources,

and

the molecule showed up in their urine, blood, hair and saliva.

" We need to find out if there is any association between the

presence

of Neu5Gc and/or the anti-Neu5Gc antibodies with any disease, " Varki

said. " This will require large-scale population studies. "

In some cases the human immune response was similar to that seen

when people are exposed to another animal molecule, this one a cell

surface molecule called alpha galactose.

Varki noted that the molecule is almost certainly not immediately

toxic to people.

" Meat eating has certainly been a feature of human ancestors for

many

hundreds of thousands of years, " he said.

" Thus, it is indeed possible that humans have developed some kind of

tolerance or indifference to Neu5Gc. However, most humans are

continuing to make antibodies against Neu5Gc. "

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>Hi Hiedi...

>I honor your experience and value your opinion but I have been diagnosed with a

" leaky gut " complicated by a gluten intolerance and meat protein is one of the

few things I don't react too.

>I think this leaky gut thing should be taken on a case by case basis.

>And yes milk is out of my diet at this pint in any form....

>Tim

Oh, I don't react to meat either and eat a lot of it! But

I figure the article is going to get out sooner or later so

best to think about it sooner. Gluten causes leaky gut

in a lot of people ... when you stop eating gluten the

leaky gut stops.

The thing is, meat SHOULD NOT be a problem for humans --

i.e. it's been such a staple for so long, that to find it

in tumors etc. is really WEIRD. So there has to be a

complicating factor. (like leaky gut).

Anyway, a lot of people have reported that when they

" go vegetarian " they get relief from this or that,

though in this group we have evidence they may

have other problems later. Could be they didn't

need to go vegetarian, all they needed was gut healing.

I'm real sure we are all going to hear a LOT about this

Neu5GC thing, and it will be used as an anti-meat thing,

not to promote gut health.

-- Heidi

>

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Interesting article Heidi,

I tried vegetarian severals times and got sick as a dog.

I guess I'm one those who needs meat or I get really weak.

-Vee

>

> >Hi Hiedi...

> >I honor your experience and value your opinion but I have been

diagnosed with a " leaky gut " complicated by a gluten intolerance and

meat protein is one of the few things I don't react too.

> >I think this leaky gut thing should be taken on a case by case

basis.

> >And yes milk is out of my diet at this pint in any form....

> >Tim

>

> Oh, I don't react to meat either and eat a lot of it! But

> I figure the article is going to get out sooner or later so

> best to think about it sooner. Gluten causes leaky gut

> in a lot of people ... when you stop eating gluten the

> leaky gut stops.

>

> The thing is, meat SHOULD NOT be a problem for humans --

> i.e. it's been such a staple for so long, that to find it

> in tumors etc. is really WEIRD. So there has to be a

> complicating factor. (like leaky gut).

>

> Anyway, a lot of people have reported that when they

> " go vegetarian " they get relief from this or that,

> though in this group we have evidence they may

> have other problems later. Could be they didn't

> need to go vegetarian, all they needed was gut healing.

> I'm real sure we are all going to hear a LOT about this

> Neu5GC thing, and it will be used as an anti-meat thing,

> not to promote gut health.

>

> -- Heidi

>

> >

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>Interesting article Heidi,

>I tried vegetarian severals times and got sick as a dog.

>I guess I'm one those who needs meat or I get really weak.

>-Vee

Not to mention most vegetarians eat " fake meat "

which is often made with purified *wheat gluten*.

Good recipe for health problems!

-- Heidi

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