Inherited neuropathies: new genes don't fit old models

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Neuron. 2006 Sep 21;51(6):672-4.

Inherited neuropathies: new genes don't fit old models.

Scherer SS.

Department of Neurology, 464 Stemmler Hall, University of Pennsylvania

School of Medicine, Philadelphia, 19104, USA.

Mutations in GARS cause dominantly inherited neuropathies in humans.

GARS encodes glycyl-tRNA synthetase, the enzyme that couples glycine to

its tRNA. In this issue of Neuron, Seburn et al. have identified and

characterized a mutant mouse with a dominantly inherited axonal

neuropathy caused by a Gars mutation that is inferred to have a gain of

function.