Re: Now switching to Inspra,comment

[Guest guest]

i think Dr. Grim side effects of gynecomastia for me will be okay bec. i am flat chested. from abbie.Its is advantage for me.Subject: Now switching to InspraTo: hyperaldosteronism Date: Saturday, 15 January, 2011, 1:27 PM

Hi all. After 5+ years od drug resist. hypertension and progressively worsening hypokalemia, we brought Dr. Grim's article about the evolution of PA to my 42 year old husband's internist. At our urging, he started him on spiro 50mg bid and now that's the only BP med he is taking! He was on 6 different BP meds and running 160/90. Now were 135/85. Could be better if he was dashing better but he's trying really hard and getting better at it.

Due to the onset of gynocomastia (took almost 3 months to start appearing), we have filled out the drug reimbursement forms and are waiting for approval for Inspra. Should come any day now. He'll be starting at 50mg bid and may have to go up from there. We hope for improvement in the gynocomastia as well as an improved testosterone level.

I'll keep you posted.

[Guest guest]

I was on Spirinolactone for nearly 25 years. The gynecomastia was pretty painful after about a month. This was before Inspra was first marketed. I learned to live with it. For me, it was/is heartrending when I didn't want my grand-kids in my lap because of the pain and tenderness, significantly worse in the past few months.I am transitioning to Inspra now. I have been on the new drug for a couple of weeks. The tenderness is already less, but I am told to expect it to take a year before I can say is is being reversed.BTW, be careful what information you send to the insurance company to justify Inspra. They rejected my coverage repeatedly. My nephrologist (and I) showered them with reprints & studies justifying the change, to no avail. Finally one day I actually got a phone call from the department head of the appeals and grievance department. After a few minutes of converstaion, me explaning hyperaldo and gynecomastia, "what is this drug going to treat?" he asked. "bi-lateral adrenal hyperplasia leading to hyperaldosteronism," I answered. "so, what does that condition cause?" he asked, (he was leading me), "drug resistant hypertension," I answered (politely and quietly, because inside I was shouting), "bingo", he said., "you are approved. Inspra is medically indicated for the treatment of hypertension." All the esoteric medical terms I was so proud of spouting were only confusing the issue, because they were not listed in his book under Inspra. Hypertension was, so, now they cover it.As Dr. Grim says, "may your pressure be low," and maybe I can add "may you enjoy hugging your grand-kids!"dk> > Subject: Now switching to Inspra> To: hyperaldosteronism > Date: Saturday, 15 January, 2011, 1:27 PM> > > > > > > > > > > > > > > > > > Hi all. After 5+ years od drug resist. hypertension and progressively worsening hypokalemia, we brought Dr. Grim's article about the evolution of PA to my 42 year old husband's internist. At our urging, he started him on spiro 50mg bid and now that's the only BP med he is taking! He was on 6 different BP meds and running 160/90. Now were 135/85. Could be better if he was dashing better but he's trying really hard and getting better at it.> > > > Due to the onset of gynocomastia (took almost 3 months to start appearing), we have filled out the drug reimbursement forms and are waiting for approval for Inspra. Should come any day now. He'll be starting at 50mg bid and may have to go up from there. We hope for improvement in the gynocomastia as well as an improved testosterone level.> > > > I'll keep you posted.>

[Guest guest]

You could have Androgen Excess.

> >

> > From: regnnicole <regnnicole@>

> > Subject: Now switching to Inspra

> > To: hyperaldosteronism

> > Date: Saturday, 15 January, 2011, 1:27 PM

> >

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> > Hi all. After 5+ years od drug resist. hypertension and progressively

worsening hypokalemia, we brought Dr. Grim's article about the evolution of PA

to my 42 year old husband's internist. At our urging, he started him on spiro

50mg bid and now that's the only BP med he is taking! He was on 6 different BP

meds and running 160/90. Now were 135/85. Could be better if he was dashing

better but he's trying really hard and getting better at it.

> >

> >

> >

> > Due to the onset of gynocomastia (took almost 3 months to start appearing),

we have filled out the drug reimbursement forms and are waiting for approval for

Inspra. Should come any day now. He'll be starting at 50mg bid and may have to

go up from there. We hope for improvement in the gynocomastia as well as an

improved testosterone level.

> >

> >

> >

> > I'll keep you posted.

> >

>

[Guest guest]

You could have Androgen Excess.

> >

> > From: regnnicole <regnnicole@>

> > Subject: Now switching to Inspra

> > To: hyperaldosteronism

> > Date: Saturday, 15 January, 2011, 1:27 PM

> >

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> > Hi all. After 5+ years od drug resist. hypertension and progressively

worsening hypokalemia, we brought Dr. Grim's article about the evolution of PA

to my 42 year old husband's internist. At our urging, he started him on spiro

50mg bid and now that's the only BP med he is taking! He was on 6 different BP

meds and running 160/90. Now were 135/85. Could be better if he was dashing

better but he's trying really hard and getting better at it.

> >

> >

> >

> > Due to the onset of gynocomastia (took almost 3 months to start appearing),

we have filled out the drug reimbursement forms and are waiting for approval for

Inspra. Should come any day now. He'll be starting at 50mg bid and may have to

go up from there. We hope for improvement in the gynocomastia as well as an

improved testosterone level.

> >

> >

> >

> > I'll keep you posted.

> >

>

[Guest guest]

But you are not a man as inrecall Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

You could have Androgen Excess.

> >

> > From: regnnicole <regnnicole@>

> > Subject: Now switching to Inspra

> > To: hyperaldosteronism

> > Date: Saturday, 15 January, 2011, 1:27 PM

> >

> >

> >

> >

> >

> >

> >

> > Â

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> >

> > Hi all. After 5+ years od drug resist. hypertension and progressively worsening hypokalemia, we brought Dr. Grim's article about the evolution of PA to my 42 year old husband's internist. At our urging, he started him on spiro 50mg bid and now that's the only BP med he is taking! He was on 6 different BP meds and running 160/90. Now were 135/85. Could be better if he was dashing better but he's trying really hard and getting better at it.

> >

> >

> >

> > Due to the onset of gynocomastia (took almost 3 months to start appearing), we have filled out the drug reimbursement forms and are waiting for approval for Inspra. Should come any day now. He'll be starting at 50mg bid and may have to go up from there. We hope for improvement in the gynocomastia as well as an improved testosterone level.

> >

> >

> >

> > I'll keep you posted.

> >

>

[Guest guest]

But you are not a man as inrecall Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

You could have Androgen Excess.

> >

> > From: regnnicole <regnnicole@>

> > Subject: Now switching to Inspra

> > To: hyperaldosteronism

> > Date: Saturday, 15 January, 2011, 1:27 PM

> >

> >

> >

> >

> >

> >

> >

> > Â

> >

> >

> >

> >

> >

> >

> >

> >

> >

> > Hi all. After 5+ years od drug resist. hypertension and progressively worsening hypokalemia, we brought Dr. Grim's article about the evolution of PA to my 42 year old husband's internist. At our urging, he started him on spiro 50mg bid and now that's the only BP med he is taking! He was on 6 different BP meds and running 160/90. Now were 135/85. Could be better if he was dashing better but he's trying really hard and getting better at it.

> >

> >

> >

> > Due to the onset of gynocomastia (took almost 3 months to start appearing), we have filled out the drug reimbursement forms and are waiting for approval for Inspra. Should come any day now. He'll be starting at 50mg bid and may have to go up from there. We hope for improvement in the gynocomastia as well as an improved testosterone level.

> >

> >

> >

> > I'll keep you posted.

> >

>

[Guest guest]

Remind us of the Spiro dose you are on. Did DASHING permit you to lower dose. My guess is that the dynia will go away faster than the mast. Might make a good u tube as it regresses. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

I was on Spirinolactone for nearly 25 years. The gynecomastia was pretty painful after about a month. This was before Inspra was first marketed. I learned to live with it. For me, it was/is heartrending when I didn't want my grand-kids in my lap because of the pain and tenderness, significantly worse in the past few months.I am transitioning to Inspra now. I have been on the new drug for a couple of weeks. The tenderness is already less, but I am told to expect it to take a year before I can say is is being reversed.BTW, be careful what information you send to the insurance company to justify Inspra. They rejected my coverage repeatedly. My nephrologist (and I) showered them with reprints & studies justifying the change, to no avail. Finally one day I actually got a phone call from the department head of the appeals and grievance department. After a few minutes of converstaion, me explaning hyperaldo and gynecomastia, "what is this drug going to treat?" he asked.

"bi-lateral adrenal hyperplasia leading to hyperaldosteronism," I answered. "so, what does that condition cause?" he asked, (he was leading me), "drug resistant hypertension," I answered (politely and quietly, because inside I was shouting), "bingo", he said., "you are approved. Inspra is medically indicated for the treatment of hypertension." All the esoteric medical terms I was so proud of spouting were only confusing the issue, because they were not listed in his book under Inspra. Hypertension was, so, now they cover it.As Dr. Grim says, "may your pressure be low," and maybe I can add "may you enjoy hugging your grand-kids!"dk> > From:

regnnicole regnnicole@...> Subject: Now switching to Inspra> To: hyperaldosteronism > Date: Saturday, 15 January, 2011, 1:27 PM> > > > > > > > > > > > > > > > > > Hi all. After 5+ years od drug resist. hypertension and progressively worsening hypokalemia, we brought Dr. Grim's article about the evolution of PA to my 42 year old husband's internist. At our urging, he started him on spiro 50mg bid and now that's the only BP med he is taking! He was on 6 different BP meds and running 160/90. Now were 135/85. Could be better if he was dashing better but he's trying really hard and getting better at it.> > > > Due to the onset of gynocomastia (took almost 3 months to start appearing), we have filled out the drug reimbursement forms and are

waiting for approval for Inspra. Should come any day now. He'll be starting at 50mg bid and may have to go up from there. We hope for improvement in the gynocomastia as well as an improved testosterone level.> > > > I'll keep you posted.>

[Guest guest]

Remind us of the Spiro dose you are on. Did DASHING permit you to lower dose. My guess is that the dynia will go away faster than the mast. Might make a good u tube as it regresses. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

I was on Spirinolactone for nearly 25 years. The gynecomastia was pretty painful after about a month. This was before Inspra was first marketed. I learned to live with it. For me, it was/is heartrending when I didn't want my grand-kids in my lap because of the pain and tenderness, significantly worse in the past few months.I am transitioning to Inspra now. I have been on the new drug for a couple of weeks. The tenderness is already less, but I am told to expect it to take a year before I can say is is being reversed.BTW, be careful what information you send to the insurance company to justify Inspra. They rejected my coverage repeatedly. My nephrologist (and I) showered them with reprints & studies justifying the change, to no avail. Finally one day I actually got a phone call from the department head of the appeals and grievance department. After a few minutes of converstaion, me explaning hyperaldo and gynecomastia, "what is this drug going to treat?" he asked.

"bi-lateral adrenal hyperplasia leading to hyperaldosteronism," I answered. "so, what does that condition cause?" he asked, (he was leading me), "drug resistant hypertension," I answered (politely and quietly, because inside I was shouting), "bingo", he said., "you are approved. Inspra is medically indicated for the treatment of hypertension." All the esoteric medical terms I was so proud of spouting were only confusing the issue, because they were not listed in his book under Inspra. Hypertension was, so, now they cover it.As Dr. Grim says, "may your pressure be low," and maybe I can add "may you enjoy hugging your grand-kids!"dk> > From:

regnnicole regnnicole@...> Subject: Now switching to Inspra> To: hyperaldosteronism > Date: Saturday, 15 January, 2011, 1:27 PM> > > > > > > > > > > > > > > > > > Hi all. After 5+ years od drug resist. hypertension and progressively worsening hypokalemia, we brought Dr. Grim's article about the evolution of PA to my 42 year old husband's internist. At our urging, he started him on spiro 50mg bid and now that's the only BP med he is taking! He was on 6 different BP meds and running 160/90. Now were 135/85. Could be better if he was dashing better but he's trying really hard and getting better at it.> > > > Due to the onset of gynocomastia (took almost 3 months to start appearing), we have filled out the drug reimbursement forms and are

waiting for approval for Inspra. Should come any day now. He'll be starting at 50mg bid and may have to go up from there. We hope for improvement in the gynocomastia as well as an improved testosterone level.> > > > I'll keep you posted.>

[Guest guest]

Thanks Don for your valuable insight. My husband doesn't have tenderness yet,

but there definitely is breast development and we hope to stop this in it's

tracks. I haven't heard back from the insurance company yet, I hope they

approve it right off the bat because I don't want the headache you had. The

form filled out by the doc indicated it was for the treatment of hypertension

and hypokalemia due to hyperaldosteronism caused by adrenal hyperplasia and

indicated that treatment with spiro is causing the undesireable side effect of

gynocomastia that is not associated with Inspra. Will have to wait and see

> >

> > From: regnnicole regnnicole@

> > Subject: Now switching to Inspra

> > To: hyperaldosteronism

> > Date: Saturday, 15 January, 2011, 1:27 PM

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> > Hi all. After 5+ years od drug resist. hypertension and

> progressively worsening hypokalemia, we brought Dr. Grim's article about

> the evolution of PA to my 42 year old husband's internist. At our

> urging, he started him on spiro 50mg bid and now that's the only BP med

> he is taking! He was on 6 different BP meds and running 160/90. Now

> were 135/85. Could be better if he was dashing better but he's trying

> really hard and getting better at it.

> >

> >

> >

> > Due to the onset of gynocomastia (took almost 3 months to start

> appearing), we have filled out the drug reimbursement forms and are

> waiting for approval for Inspra. Should come any day now. He'll be

> starting at 50mg bid and may have to go up from there. We hope for

> improvement in the gynocomastia as well as an improved testosterone

> level.

> >

> >

> >

> > I'll keep you posted.

> >

>