Re: Stress as cause of hyperaldosteronism

February 2, 2011

Your brain is stuck in the starvation mode. Must read the Psychology of Starvation in Keys The Physiology of Starvation. One key is what you choose to eat every 3 hours. You cannot eat enough rice/fruit to get fat.CE Grim MDI am hearing from a very proficient psychologist on radio that this is one of the symptoms of depression resulting from anxiety disorder....etc.| Even now, I have to eat every three|hours or I start to feel unpleasantly "strange"(the only way I|know to describe it). |

February 2, 2011

Thanks, Dr. Grim. I will read the Bravo paper. Is <1500 mg sodium a day and

>4500 mg K a day what you recommend?

> > > > >

> > > > > From: callie.nelle <callie.nelle@>

> > > > > Subject: Stress as cause of

> > hyperaldosteronism

> > > > > To: hyperaldosteronism

> > > > > Date: Tuesday, February 1, 2011, 4:53 PM

> > > > >

> > > > > Â

> > > > >

> > > > > Dr. Grim:

> > > > >

> > > > > I noticed in your paper " Evolution of PA " in the site files that

> > > > " psycosocial stress has created adrenal cortical hyperplasia and

> > > > hypertension in mice " . You recommended that this be further

> > studied

> > > > in humans.

> > > > >

> > > > > I believe absolutely that stress caused my PA. My condition

> > > > started during a period of extreme stress in my life. While

> > reading

> > > > the posts, I have noticed that others on the site have mentioned

> > the

> > > > same thing.

> > > > >

> > > > > While my condition is well controlled 90% of the time with

> > > > spironolactone (thank you for your work that has helped make this

> > > > possible), I can still get an occasional " episode " , which I can

> > > > always tie to something stressful going on in my life. Also,

> > > > forgetting to eat for too long of a time can exacerbate the

> > problem.

> > > > Stress and not eating are a bad combination for me.

> > > > >

> > > > > Do you have any suggestions for what I can do to prevent an

> > > > " episode " when I am under unavoidable stress?

> > > > >

> > > > > Also, I would love to see you do a survey of site members to see

> > > > how many of them first exhibited symptoms during a very stressful

> > > > period in their lives.

> > > > >

> > > > > Thanks so much for your time and knowledge,

> > > > >

> > > > > Callie

> > > > >

> > > >

> > >

> >

>

February 2, 2011

Yes that is the DASH low sodium one they used for the study. Have you gotten the book yet?CE Grim MDThanks, Dr. Grim. I will read the Bravo paper. Is <1500 mg sodium a day and >4500 mg K a day what you recommend? > > > > >> > > > > From: callie.nelle <callie.nelle@>> > > > > Subject: Stress as cause of > > hyperaldosteronism> > > > > To: hyperaldosteronism > > > > > Date: Tuesday, February 1, 2011, 4:53 PM> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > > Â> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > > Dr. Grim:> > > > >> > > > >> > > > >> > > > > I noticed in your paper "Evolution of PA" in the site files that> > > > "psycosocial stress has created adrenal cortical hyperplasia and> > > > hypertension in mice". You recommended that this be further > > studied> > > > in humans.> > > > >> > > > >> > > > >> > > > > I believe absolutely that stress caused my PA. My condition> > > > started during a period of extreme stress in my life. While > > reading> > > > the posts, I have noticed that others on the site have mentioned > > the> > > > same thing.> > > > >> > > > >> > > > >> > > > > While my condition is well controlled 90% of the time with> > > > spironolactone (thank you for your work that has helped make this> > > > possible), I can still get an occasional "episode", which I can> > > > always tie to something stressful going on in my life. Also,> > > > forgetting to eat for too long of a time can exacerbate the > > problem.> > > > Stress and not eating are a bad combination for me.> > > > >> > > > >> > > > >> > > > > Do you have any suggestions for what I can do to prevent an> > > > "episode" when I am under unavoidable stress?> > > > >> > > > >> > > > >> > > > > Also, I would love to see you do a survey of site members to see> > > > how many of them first exhibited symptoms during a very stressful> > > > period in their lives.> > > > >> > > > >> > > > >> > > > > Thanks so much for your time and knowledge,> > > > >> > > > >> > > > >> > > > > Callie> > > > >> > > >> > > >> > > >> > >> >> >> >>

February 2, 2011

I have gotten the book and it is sitting on the bookshelf behind me. Now I see

I will have to start using it. Thanks.

> > > > > > >

> > > > > > > From: callie.nelle <callie.nelle@>

> > > > > > > Subject: Stress as cause of

> > > > hyperaldosteronism

> > > > > > > To: hyperaldosteronism

> > > > > > > Date: Tuesday, February 1, 2011, 4:53 PM

> > > > > > >

> > > > > > > Â

> > > > > > >

> > > > > > > Dr. Grim:

> > > > > > >

> > > > > > > I noticed in your paper " Evolution of PA " in the site

> > files that

> > > > > > " psycosocial stress has created adrenal cortical hyperplasia

> > and

> > > > > > hypertension in mice " . You recommended that this be further

> > > > studied

> > > > > > in humans.

> > > > > > >

> > > > > > > I believe absolutely that stress caused my PA. My condition

> > > > > > started during a period of extreme stress in my life. While

> > > > reading

> > > > > > the posts, I have noticed that others on the site have

> > mentioned

> > > > the

> > > > > > same thing.

> > > > > > >

> > > > > > > While my condition is well controlled 90% of the time with

> > > > > > spironolactone (thank you for your work that has helped make

> > this

> > > > > > possible), I can still get an occasional " episode " , which I

> > can

> > > > > > always tie to something stressful going on in my life. Also,

> > > > > > forgetting to eat for too long of a time can exacerbate the

> > > > problem.

> > > > > > Stress and not eating are a bad combination for me.

> > > > > > >

> > > > > > > Do you have any suggestions for what I can do to prevent an

> > > > > > " episode " when I am under unavoidable stress?

> > > > > > >

> > > > > > > Also, I would love to see you do a survey of site members

> > to see

> > > > > > how many of them first exhibited symptoms during a very

> > stressful

> > > > > > period in their lives.

> > > > > > >

> > > > > > > Thanks so much for your time and knowledge,

> > > > > > >

> > > > > > > Callie

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

February 2, 2011

Hi,

I am new to PA having diagnosed as PA about 2 years ago. Doctors here in

Singapore are also quite ignorant of PA as a whole. Only specialist on

Endocrinology will be asked to step in and help. Doctors especially GP will only

" follow " or ape the prescriptions.

There are many undetected cases in Asia, probably diagnosed as Parkinsons

(shaking of limbs bit) or HTN or stroke, and given the respective drugs. Later

these patients died of diseases which were nor even present in the first place.

I was fortunate because my test results were sent to an Endo before I got

discharged, you know, high BP and low K. One doctor exclaimed how low my K was

before I was discharged, and said that he would be stuck in bed if he had that

level of K !!

Back to the topic..... I was first admitted to ER on very high BP, 200/140 after

taking D.O.M. and Actifed for my flu to get to sleep. In the IU room, I got

tubed all over with catheters to find out what's wrong with me. The doctors

thought I was an alcoholic !! but I said I barely drink alcoholic drinks.

I found out I had a heated argument argument with my wife a few days ago, she

challenged me to hit her which I did, then she reported to family court for PPO.

These on top of the flu I had, and the meds to calm me down to sleep at night,

were tremendous stress to my body that resulted in ER situation, I was in a

dream with eyes wide open when taken into an ambulance. Strangely, I was arguing

with the attendants not to take me to the hospital.!!

Second time was during the marking of exam papers and answering a pesky business

enquiry. On the cell phone for about 1.5 hrs, thought I saw bright lights.

Admitted myself to A & E for " stroke " and after a few days discharged. Follow up

showed that I had some tumour on the right Adrenal gland. So I believe stress

triggers high BP and a PA.

Also, I would like to request for more articles on the social and economic

problems arising from PA....like how long a person can hold on to a job with PA

and what are the legal concessions if the accused in an assault case has PA.

Thanks.

Edem Ong

> > > > >

> > > > > From: callie.nelle <callie.nelle@>

> > > > > Subject: Stress as cause of

> > hyperaldosteronism

> > > > > To: hyperaldosteronism

> > > > > Date: Tuesday, February 1, 2011, 4:53 PM

> > > > >

> > > > > Â

> > > > >

> > > > > Dr. Grim:

> > > > >

> > > > > I noticed in your paper " Evolution of PA " in the site files that

> > > > " psycosocial stress has created adrenal cortical hyperplasia and

> > > > hypertension in mice " . You recommended that this be further

> > studied

> > > > in humans.

> > > > >

> > > > > I believe absolutely that stress caused my PA. My condition

> > > > started during a period of extreme stress in my life. While

> > reading

> > > > the posts, I have noticed that others on the site have mentioned

> > the

> > > > same thing.

> > > > >

> > > > > While my condition is well controlled 90% of the time with

> > > > spironolactone (thank you for your work that has helped make this

> > > > possible), I can still get an occasional " episode " , which I can

> > > > always tie to something stressful going on in my life. Also,

> > > > forgetting to eat for too long of a time can exacerbate the

> > problem.

> > > > Stress and not eating are a bad combination for me.

> > > > >

> > > > > Do you have any suggestions for what I can do to prevent an

> > > > " episode " when I am under unavoidable stress?

> > > > >

> > > > > Also, I would love to see you do a survey of site members to see

> > > > how many of them first exhibited symptoms during a very stressful

> > > > period in their lives.

> > > > >

> > > > > Thanks so much for your time and knowledge,

> > > > >

> > > > > Callie

> > > > >

> > > >

> > >

> >

>

February 2, 2011

OMG!Â

Somebody has to be productive.Â We

can't all live off the dole.

From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of StudyCircle

We all suffer from the symptoms of Industrial Slavery in North

America. Chattel slavery was abolished not because politicians were so kind,

but rather because it was no longer economical to keep slaves in chains...so

the wealthy and powerful devised the new system of industrial slavery which is

gradually is known to be the cause of many health issues in the West now...Some

30 years ago when the leaders realized that industrial slavery is also becoming

difficult to manage then they used psychologists to cheer slaves by injecting

them with vain imaginations like sense of uniqueness, superiority, ....etc...

and hence by using the narcissism epidemic we are all put to a kind of

anesthetic posture to forget how like a donkey we must carry loads of work so

that leaders keep their position and add to their wealth....and so we develop

all kinds of physical and mental disorders while industrial slavery prevails.

Max.

February 2, 2011

Followers of some religions are so lucky never get HTN or PA by beating

their wives because beating wife or wives is prescribed in their holy book!!

|

|I found out I had a heated argument argument with my wife a

|few days ago, she challenged me to hit her which I did, then

|she reported to family court for PPO. These on top of the flu

|I had, and the meds to calm me down to sleep at night, were

|tremendous stress to my body that resulted in ER situation, I

|was in a dream with eyes wide open when taken into an

|ambulance. Strangely, I was arguing with the attendants not to

|take me to the hospital.!!

|

February 3, 2011

All my research was based on humans. I'm a social worker so not much interest in animal research.

Juli

To: hyperaldosteronism Cc: Clarence Grim Sent: Wed, February 2, 2011 8:33:55 PMSubject: Re: Re: Stress as cause of hyperaldosteronism

Show us the data in humans.

CE Grim MD

I did a research paper in college on the physiological effects of stress on the body. I always knew stress took a tremendous physical toll on the body but had no idea the extent of it until I did the research. Stress can cause many ailments and exacerbate any weakness, deficiency or latent disease on a very large scale.

I believe stress can be a contribuing factor to just about any physiological or psychological condition.

Juli >> What you describe is exactly the kind of year I was experiencing when I first started exhibiting symptoms. But I had never had high BP or low K (as far as I know) before that time. I was trying to care for my mother who was dying, keep peace with my siblings, care for my daughter who was having a difficult pregnancy with twins, and I was dealing with extremely difficult situations at work. I have never had a more stressful year. Then suddenly the high BP etc. etc., though the PA took about a year to diagnose.> > And now,though the PA is under control, stress still seems to affect me more strongly

than it ever did before.> > Callie> > > > > > From: callie.nelle <callie.nelle@>> > Subject: Stress as cause of hyperaldosteronism> > To: hyperaldosteronism > > Date: Tuesday, February 1, 2011, 4:53 PM>

> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > >

Ã‚ > > > > > > > > > > > > > > > > > > > > Dr. Grim:> > > > > > > > I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in

humans.> > > > > > > > I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. > > > > > > > > While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the

problem. Stress and not eating are a bad combination for me.> > > > > > > > Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?> > > > > > > > Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. > > > > > > > > Thanks so much for

your time and knowledge,> > > > > > > > Callie> >>

February 3, 2011

Note my admonition to not only get the book but to read it.Like you life depended on it.CE Grim MD Welcome to the exciting world of Hyperaldosteronism! You are in the right place! I am Dr. CE Grim a retired Professor of Medicine and Endocrinology. I have a long standing interest is Primary Aldosteronism since medical school days when I saw my first patient with Primary Aldosteronism in 1963. I trained with Dr. Jerome W. Conn in Endocrinology and Metabolism 1969-70 and have published over 240 papers and book chapters in most areas of the broad discipline of High Blood Pressure. My CV is in our files for details. The goal of our group is to teach you and your health care team about the ins and outs of the causes, diagnosis and control of the many forms of hyperaldosteronism. The steps below will introduce you into the fascinating world of high blood pressure, salt (sodium(Na) chloride (Cl) or NaCL) and potassium (K) and the role of the adrenal hormone aldosterone in health and disease. Doing these in sequence will save you time and effort in getting up to speed in taking control of you health and educating your own health care team. While we can’t make you into a doctor we will make you into a pretty good BP doctor-a skill that you will have for life and you can transfer to the rest of your family who will likely have high blood pressure eventually-if they live long enough. 1. A brief history of Primary Aldosteronsim and why it is so common today in drug resistant high blood pressure. Read my article in our files on the evolution of PA (Evolution_of_PA-Grim.pdf ) and take to all members of health care team. Tell us what stage you believe you are in. This is a brief review of most causes of hyperaldosteronism, high blood pressure, low potassium (K). READING THIS HOW WILL SAVE YOU TIME AND MONEY. By taking it to your health care team they will not treat their other patients as badly as they may have treated you. 2. Read about other patients with hyperaldosteronism (Conn’s syndrome). Read our Conn's stories in our files and then give us your own in as much detail as you can. Dr. Conn was the first to describe this disease process and the syndrome is named after him. The first patient is described in my review article.To see others' stories, on the Hyperaldosteronism home page, go to Files/Conn’s Stories. You'll find instructions in "A - How to put your story here.doc " First send us your story in an email and they we may have questions and suggestions before you upload it to our files. 3. DASH to lower your BP. Your and my tax dollars funded the most important series of studies on how to improve blood pressure, blood sugar, blood lipids and make your heart smaller: The DASH Eating Plan to control high blood pressure due to hyperaldosteronism and most others with high blood pressure. This will reduce your need for medications and in many will get your BP and K to goal without meds.. Get the DASH diet book by T. et al, (http://www.amazon.com/DASH-Diet-Hypertension--/dp/0743202953) read it and use it: ~$8 in paperback at your local bookstore or online. If they don’t have it ask them to order it for you. You can also get the hardback larger print version as well at Amazon. Learning to eat the DASH way will play a major role in your road to good BP and K control and, in many of our folks here, will revolutionize your life. See http://en.wikipedia.org/wiki/DASH_diet for an overview and more details. In the book go to chapter 9 and do the 14 day challenge. Tell your Dr you are doing this as your BP may plummet if you are on other meds. Measure your BP every day and post to us. or go to http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/new_dash.pdf download this 64 page booklet free and do the Week on the DASH Diet for 2 weeks. If you are on BP meds be prepared for a large fall in BP (20/10 mm Hg or more) and let your Dr. know you are doing this. And/Or go to (but costs money monthly) DASH Diet for Health Program (http://www.dashforhealth.com/pages/public/tour.php)The DASH Diet for Health Program is designed to help you improve your eating and exercise habits. Twice each week they will provide you with information on our website about food, food preparation, eating out, losing weight, getting fit and much more. In addition to providing new information each week on the website, they create a web page specially for you where you can track progress in areas such as your weight, blood pressure, and exercise. I strongly recommend you get this book by .... and read it. 4. Measure your BP: Measure your BP daily so you can see if it is getting better. If you are taking meds be sure to tell your health care team you are doing this as your BP may plummet to normal quickly. We recommend you use a device you listen to and will help you learn how to do this. If this is not something you want to do we can teach a significant other how to do it. See sharedcareinc.com or email to sharedcare@... to order a video on how to do this. If you already have one we will teach you how to teach your health care team how to validate your device. Your life and health depends on accurate BP measurements. Go to the amricanheart.org and download the Guidelines for Human Blood Pressure Measurement. Insist that your health care team do BP the AHA way. Never trust your life to an automatic BP machine unless you know it is accurate on YOU. 5. Genetics and your BP: Go to familyhistory.hhs.gov and do your detailed family medical history (FHx or FH) so we can review with you to help diagnosis (Dx) and treat (Rx) familial causes of high blood pressure and heart disease. If BP runs in your family you may save lives in your family by checking their BP yourself. 6. How to DX and treat PA: Go to our file/Conn's Articles of Note/Medications/Bravo spir 1973.pdf and read this article and take to your health care team. It is old but still one of the best in the medical management of PA. DX: Also see our file from the Endocrine Society Guidelines on PA. 7. Dr. Grim's Perfect Primary Aldosteronism Blood and Urine Testing to diagnose PA in one day. 1. Eat a regular to high salt diet for 2 weeks.2. No BP meds in last 4-12 weeks depending on meds.3. Collect 24 hr urine for Na, K and creatinine and aldosterone. Do not lose a drop of this liquid gold. It is impossible to interpret the renin and aldo without this.4. The morning you finish the 24 hr urine have fasting blood drawn for renin, aldo and K using our guidelines to get an accurate K. Try to get this done about 4 hours after you have been out of bed.5. Send us the results with the normal values for your lab.6. If you ever have a salt (saline) infusion test for PA be certain to ask them to measure how much you pee during the 4 hours of the infusion. If it is 1-1.5 liter of urine it strongly suggests that you may have PA. If more tha 1.5 L you almost certainly have PA. 8. Become a participant in our PA Registry and contribute to our large database on PA: If you have been Dxed with PA already and are on Rx or have had surgery please go to http://www.kwiksurveys.com/online-survey.php?surveyID=HIJIO_f2685379 and complete our survey with as much information as you know. If there is some information you don't know ask us and we will help. If you need to update this as you journey thru the diagnostic/treatment process you can add another entry but label it as Nameyymmdd. For example today 6/12/09 for me would be Grim090612. This ever increasing number will allow us and you to sort your multiple entries into a dated order. 9. Learn the language: If you are new to medical lingo then download the acroyms from http://health.groups.yahoo.com/group/bloodpressureline/message/2918610. Salt and high blood pressure: To learn the state of the science of salt and blood pressure please spend some time looking at http://www.worldactiononsalt.com/evidence/treatment_trials.htm11. Become a HBP expert consumer: Expect that it will take at least several weeks to get all this digested and to learn the new language of high blood pressure health care. As most doctors and nurses in practice have had very little training in high blood pressure you must become an expert yourself. For example most have never had anyone listen with them with a double stethoscope to verify that they can hear BP sounds. We cannot make you a doctor but we will make you a pretty good BP doctor.12. How High Blood Pressure should be managed: Go to nih.gov and download and read the Joint National Commission (JNC) Report 7 to get an overview on current guidelines. I ask all my secretaries to read this so they can communicate the importance of high blood pressure to my patients. JNC 8 will be out soon.Then: get (and study) the Hypertension Primer from americanheart.org 4th addition. I coauthored the chapter on BP measurement. You can also get this for about $6 from Amazon.com. This is the most up-to-date compendium of what is known about high blood pressure and what every Dr. should know when they graduate from Medical School. Every chapter is only 2-3 pages. Read one chapter every week-night and you will finish it in about a year. I am working on a reading guide for lay people for the Primer. Stay tuned. If you don't like it take it to your health care team so they will know what every medical student today should know.13. Ask us questions: Ask any questions about high blood pressure you want answered. That is what we are here for. We have had this site for 10 years and over 30,000 emails are searchable. This is the largest collection of communications about Conn's Syndrome in the World. 14. One-on-one Consulting: I can provide individual consulting if you do not want to go public. If you want individual one-on-one consulting for you and your Doctor contract me directly at lowerbp2@....15: Abbreviations of common use in aldo speak include: AME apparent mineralocorticoid excess AVS adrenal vein sampling BB beta blockers CCB calcium channel blockers Dx diagnosis FHx family history GRE glucocorticoid remedial aldosteronism MCB mineralocorticoid blocker also called AB aldosterone blocker. MHx medical history Rx treatment SHx social history May your pressure be low!Clarence E. Grim BS, MS, MD, FACP, FACC, FAHA Council for High Blood Pressure Research. Board Certified in Internal Medicine, Geriatrics, and High Blood Pressure by the American Society of Hypertension. Retired Faculty/Professor of Medicine (U of MO, Indiana, UCLA/DREW, Medical College of Wisconsin in Nephrology, Endocrinology, Cardiology, and Epidemiology. Specializing in Primary Aldosteronism and Difficult to Control High Blood Pressure. I have gotten the book and it is sitting on the bookshelf behind me. Now I see I will have to start using it. Thanks.> > > > > > >> > > > > > > From: callie.nelle <callie.nelle@>> > > > > > > Subject: Stress as cause of> > > > hyperaldosteronism> > > > > > > To: hyperaldosteronism > > > > > > > Date: Tuesday, February 1, 2011, 4:53 PM> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > > Â> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > >> > > > > > > Dr. Grim:> > > > > > >> > > > > > >> > > > > > >> > > > > > > I noticed in your paper "Evolution of PA" in the site > > files that> > > > > > "psycosocial stress has created adrenal cortical hyperplasia > > and> > > > > > hypertension in mice". You recommended that this be further> > > > studied> > > > > > in humans.> > > > > > >> > > > > > >> > > > > > >> > > > > > > I believe absolutely that stress caused my PA. My condition> > > > > > started during a period of extreme stress in my life. While> > > > reading> > > > > > the posts, I have noticed that others on the site have > > mentioned> > > > the> > > > > > same thing.> > > > > > >> > > > > > >> > > > > > >> > > > > > > While my condition is well controlled 90% of the time with> > > > > > spironolactone (thank you for your work that has helped make > > this> > > > > > possible), I can still get an occasional "episode", which I > > can> > > > > > always tie to something stressful going on in my life. Also,> > > > > > forgetting to eat for too long of a time can exacerbate the> > > > problem.> > > > > > Stress and not eating are a bad combination for me.> > > > > > >> > > > > > >> > > > > > >> > > > > > > Do you have any suggestions for what I can do to prevent an> > > > > > "episode" when I am under unavoidable stress?> > > > > > >> > > > > > >> > > > > > >> > > > > > > Also, I would love to see you do a survey of site members > > to see> > > > > > how many of them first exhibited symptoms during a very > > stressful> > > > > > period in their lives.> > > > > > >> > > > > > >> > > > > > >> > > > > > > Thanks so much for your time and knowledge,> > > > > > >> > > > > > >> > > > > > >> > > > > > > Callie> > > > > > >> > > > > >> > > > > >> > > > > >> > > > >> > > >> > > >> > > >> > >> >> >> >>

February 3, 2011

Please start all of your notes withage, singapore, WM with HTN Low K and adrenal massCE Grim MEHi,I am new to PA having diagnosed as PA about 2 years ago. Doctors here in Singapore are also quite ignorant of PA as a whole. Only specialist on Endocrinology will be asked to step in and help. Doctors especially GP will only "follow" or ape the prescriptions.There are many undetected cases in Asia, probably diagnosed as Parkinsons (shaking of limbs bit) or HTN or stroke, and given the respective drugs. Later these patients died of diseases which were nor even present in the first place.I was fortunate because my test results were sent to an Endo before I got discharged, you know, high BP and low K. One doctor exclaimed how low my K was before I was discharged, and said that he would be stuck in bed if he had that level of K !!Back to the topic..... I was first admitted to ER on very high BP, 200/140 after taking D.O.M. and Actifed for my flu to get to sleep. In the IU room, I got tubed all over with catheters to find out what's wrong with me. The doctors thought I was an alcoholic !! but I said I barely drink alcoholic drinks.I found out I had a heated argument argument with my wife a few days ago, she challenged me to hit her which I did, then she reported to family court for PPO. These on top of the flu I had, and the meds to calm me down to sleep at night, were tremendous stress to my body that resulted in ER situation, I was in a dream with eyes wide open when taken into an ambulance. Strangely, I was arguing with the attendants not to take me to the hospital.!!Second time was during the marking of exam papers and answering a pesky business enquiry. On the cell phone for about 1.5 hrs, thought I saw bright lights. Admitted myself to A & E for "stroke" and after a few days discharged. Follow up showed that I had some tumour on the right Adrenal gland. So I believe stress triggers high BP and a PA.Also, I would like to request for more articles on the social and economic problems arising from PA....like how long a person can hold on to a job with PA and what are the legal concessions if the accused in an assault case has PA.Thanks.Edem Ong > > > > >> > > > > From: callie.nelle <callie.nelle@>> > > > > Subject: Stress as cause of > > hyperaldosteronism> > > > > To: hyperaldosteronism > > > > > Date: Tuesday, February 1, 2011, 4:53 PM> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > > Â> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > >> > > > > Dr. Grim:> > > > >> > > > >> > > > >> > > > > I noticed in your paper "Evolution of PA" in the site files that> > > > "psycosocial stress has created adrenal cortical hyperplasia and> > > > hypertension in mice". You recommended that this be further > > studied> > > > in humans.> > > > >> > > > >> > > > >> > > > > I believe absolutely that stress caused my PA. My condition> > > > started during a period of extreme stress in my life. While > > reading> > > > the posts, I have noticed that others on the site have mentioned > > the> > > > same thing.> > > > >> > > > >> > > > >> > > > > While my condition is well controlled 90% of the time with> > > > spironolactone (thank you for your work that has helped make this> > > > possible), I can still get an occasional "episode", which I can> > > > always tie to something stressful going on in my life. Also,> > > > forgetting to eat for too long of a time can exacerbate the > > problem.> > > > Stress and not eating are a bad combination for me.> > > > >> > > > >> > > > >> > > > > Do you have any suggestions for what I can do to prevent an> > > > "episode" when I am under unavoidable stress?> > > > >> > > > >> > > > >> > > > > Also, I would love to see you do a survey of site members to see> > > > how many of them first exhibited symptoms during a very stressful> > > > period in their lives.> > > > >> > > > >> > > > >> > > > > Thanks so much for your time and knowledge,> > > > >> > > > >> > > > >> > > > > Callie> > > > >> > > >> > > >> > > >> > >> >> >> >>

February 3, 2011

And the data is?CE Grim MDAll my research was based on humans. I'm a social worker so not much interest in animal research. JuliTo: hyperaldosteronism Cc: Clarence Grim Sent: Wed, February 2, 2011 8:33:55 PMSubject: Re: Re: Stress as cause of hyperaldosteronism Show us the data in humans. CE Grim MDI did a research paper in college on the physiological effects of stress on the body. I always knew stress took a tremendous physical toll on the body but had no idea the extent of it until I did the research. Stress can cause many ailments and exacerbate any weakness, deficiency or latent disease on a very large scale. I believe stress can be a contribuing factor to just about any physiological or psychological condition. Juli Subject: Re: Stress as cause of hyperaldosteronismTo: hyperaldosteronism Date: Wednesday, February 2, 2011, 6:19 PM I have to agree that there may very well be a link between the escalation of PA and stress. We first discovered my husband's very high BP (210/120)in our ER where he was being seen for what seemed like a severe migraine. As a nursing student and then a nurse, I have practised on and evaluated my husband's BP for years. It was always normal. So his severe HTN came as a shock. Looking back to that time frame, my husband was dealing with the worst stress of his life - work related - that nearly broke him. Panicked, anxious and emotional. I had never seen him like that before and thankfully not since we got through that bad time. I do believe that his crazy high BP's at that time were an exaggerated response to stress. That was over 5 years ago and finally he's off of the 6 BP meds and K pills and being successfully managed on spiro alone. He still reacts ineffectively to extreme stress and I firmly believe it's all part of the PA picture.> > > > From: callie.nelle <callie.nelle@>> > Subject: Stress as cause of hyperaldosteronism> > To: hyperaldosteronism > > Date: Tuesday, February 1, 2011, 4:53 PM> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Â > > > > > > > > > > > > > > > > > > > > Dr. Grim:> > > > > > > > I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.> > > > > > > > I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. > > > > > > > > While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.> > > > > > > > Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?> > > > > > > > Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. > > > > > > > > Thanks so much for your time and knowledge,> > > > > > > > Callie> >>

February 3, 2011

Yes, you are right as always!!!!!! I drastically changed my diet there and I noticed before when I ate outside I didn't feel well. I definitely could feel connection between food and my condition, but I didn't know what exactly was it. More salt, more sweets, more meat, more wine etc. Now I think this is much more important influence than stress. And we are capable to change it even if we cannot eliminate stress in our life. From:

Clarence Grim To: hyperaldosteronism Cc: Clarence Grim Sent: Wed, February 2, 2011 8:42:57 PMSubject: Re: Re: Stress as cause of hyperaldosteronism

Most likely an acute salt load in the classical stage of PA. CE Grim MDProbably I ill be the one who is going on opposite site. I was under tremendous stress all my 18 years in the USA. I came here on a busyness trip with Ph.D.and nothing else in my

pocket and with 9 years old daughter when I was almost 50 and without good knowledge of English. I was laid off many, many times just because I could not express myself properly in English and because I did not have a green card for many years. For many times we literally had nothing to eat. I worked as a babysitter, housekeeper and picked up strawberries and other crop, when I didn't have my professional job.Finally I retired three years ago and was happy that my daughter had a good higher education and I could relax a little bit. I was invited by my ex daughter in law to her yacht in Mediterranean in last September. The weather, company, crew, food and wine were excellent and very relaxing, when I all of sudden was partially paralyzed and almost died. My BP was 245/135. Not only I but the whole bunch of friends were

sure that I was dying. So, what would you say? Delayed stress? Maybe. But maybe it is just when my adrenal lump became big enough to attack me? Natalia KamnevaTo: hyperaldosteronism Sent: Wed, February 2, 2011 6:19:28 PMSubject: Re: Stress as cause of hyperaldosteronism I have to agree that there may very well be a link between the escalation of PA and stress. We first discovered my husband's very high BP (210/120)in our ER where he was being seen for what seemed like a severe migraine. As a nursing student and then a nurse, I have practised on and evaluated my husband's BP for years. It was always normal. So his severe HTN came as a shock. Looking back to that time frame, my husband was dealing with the worst

stress of his life - work related - that nearly broke him. Panicked, anxious and emotional. I had never seen him like that before and thankfully not since we got through that bad time. I do believe that his crazy high BP's at that time were an exaggerated response to stress. That was over 5 years ago and finally he's off of the 6 BP meds and K pills and being successfully managed on spiro alone. He still reacts ineffectively to extreme stress and I firmly believe it's all part of the PA picture.> > > > From: callie.nelle <callie.nelle@>> > Subject: Stress as cause of hyperaldosteronism> > To: hyperaldosteronism > > Date: Tuesday, February 1, 2011, 4:53 PM> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Ã‚ > > > > > > > > > > > > > > > > > > > > Dr. Grim:> > > > > > > > I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.> > > > > > > > I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. > > > > > > > > While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.> > > > > > > > Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?> > > > > > > > Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. > > > > > > > > Thanks so much for your time and knowledge,> > > > > > > > Callie> >>

February 3, 2011

Good point. You can change to DASH and you see the effects in 2 weeks. Most cannot change their stress situation.CE Grim MDYes, you are right as always!!!!!! I drastically changed my diet there and I noticed before when I ate outside I didn't feel well. I definitely could feel connection between food and my condition, but I didn't know what exactly was it. More salt, more sweets, more meat, more wine etc. Now I think this is much more important influence than stress. And we are capable to change it even if we cannot eliminate stress in our life. To: hyperaldosteronism Cc: Clarence Grim Sent: Wed, February 2, 2011 8:42:57 PMSubject: Re: Re: Stress as cause of hyperaldosteronism Most likely an acute salt load in the classical stage of PA. CE Grim MDProbably I ill be the one who is going on opposite site. I was under tremendous stress all my 18 years in the USA. I came here on a busyness trip with Ph.D.and nothing else in my pocket and with 9 years old daughter when I was almost 50 and without good knowledge of English. I was laid off many, many times just because I could not express myself properly in English and because I did not have a green card for many years. For many times we literally had nothing to eat. I worked as a babysitter, housekeeper and picked up strawberries and other crop, when I didn't have my professional job.Finally I retired three years ago and was happy that my daughter had a good higher education and I could relax a little bit. I was invited by my ex daughter in law to her yacht in Mediterranean in last September. The weather, company, crew, food and wine were excellent and very relaxing, when I all of sudden was partially paralyzed and almost died. My BP was 245/135. Not only I but the whole bunch of friends were sure that I was dying. So, what would you say? Delayed stress? Maybe. But maybe it is just when my adrenal lump became big enough to attack me? Natalia KamnevaTo: hyperaldosteronism Sent: Wed, February 2, 2011 6:19:28 PMSubject: Re: Stress as cause of hyperaldosteronism I have to agree that there may very well be a link between the escalation of PA and stress. We first discovered my husband's very high BP (210/120)in our ER where he was being seen for what seemed like a severe migraine. As a nursing student and then a nurse, I have practised on and evaluated my husband's BP for years. It was always normal. So his severe HTN came as a shock. Looking back to that time frame, my husband was dealing with the worst stress of his life - work related - that nearly broke him. Panicked, anxious and emotional. I had never seen him like that before and thankfully not since we got through that bad time. I do believe that his crazy high BP's at that time were an exaggerated response to stress. That was over 5 years ago and finally he's off of the 6 BP meds and K pills and being successfully managed on spiro alone. He still reacts ineffectively to extreme stress and I firmly believe it's all part of the PA picture.> > > > From: callie.nelle <callie.nelle@>> > Subject: Stress as cause of hyperaldosteronism> > To: hyperaldosteronism > > Date: Tuesday, February 1, 2011, 4:53 PM> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Â > > > > > > > > > > > > > > > > > > > > Dr. Grim:> > > > > > > > I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.> > > > > > > > I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. > > > > > > > > While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.> > > > > > > > Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?> > > > > > > > Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. > > > > > > > > Thanks so much for your time and knowledge,> > > > > > > > Callie> >>

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