Re: Stress as cause of hyperaldosteronism

February 1, 2011

That is interesting what you say about stress causing PA. I think I had

some signs of PA, but did not start having problems until I became

pregnant.

polymac

>

> Dr. Grim:

>

> I noticed in your paper " Evolution of PA " in the site files that

" psycosocial stress has created adrenal cortical hyperplasia and

hypertension in mice " . You recommended that this be further studied in

humans.

>

> I believe absolutely that stress caused my PA. My condition started

during a period of extreme stress in my life. While reading the posts, I

have noticed that others on the site have mentioned the same thing.

>

> While my condition is well controlled 90% of the time with

spironolactone (thank you for your work that has helped make this

possible), I can still get an occasional " episode " , which I can always

tie to something stressful going on in my life. Also, forgetting to eat

for too long of a time can exacerbate the problem. Stress and not eating

are a bad combination for me.

>

> Do you have any suggestions for what I can do to prevent an " episode "

when I am under unavoidable stress?

>

> Also, I would love to see you do a survey of site members to see how

many of them first exhibited symptoms during a very stressful period in

their lives.

>

> Thanks so much for your time and knowledge,

>

> Callie

>

February 1, 2011

I will throw this out there, but I call something that is similar to this, when I am taking care of my patients, the "food poisoning syndrome" - where someone wakes up Monday morning throwing up, and the first thing they do is to attribute it to the lasagna they had for dinner the night before and are positive it was the lasagna and even "remember" it tasted funny, when in reality it was likely just a virus that decided to start on Monday morning.

It is pretty common I would guess for all of us to do that with anything, because we want answers, especially when we are trying to figure out when we "got" sick.

One question would be to ask yourself, or any of us thinking that, is "have you had a stressful time in your life when you DIDN'T get it?" Why then did you get it now. I bet most of us never really know how we got it, unless genetic testing confirms a hereditary link to it.

But according to Dr Grimms and others writings on this topic stress could surely add to it/cause it.

I know in my situation it was present for years, but undiagnosed, yet during this time I also got sick ALL THE TIME with something and everyone around me blamed it on getting older or being "out of shape" (things got so critical for me with the conditions that I actually feel that it WAS my being in good shape and taking care of myself until I could not excersise due to illness, that saved me)!) I didn't have the flu for 15 years than got it 3 years straight, very severely, then hyperthyroidism on top of PA during this period.

My point is this: was it the chicken or the egg? Did PA cause a weak immune system and more stress, or maybe I could ask myself if the PA made it a harder time for the adrenals in responding to the stress; or did the stress lead to the adrenals not working right ?(given, I do not know yet if it is hyperplasia or adenoma's in myself as I have more studies next week - I should say "better" studies since they never did them right the first time according to the endocrinologist).

Autism has been a great example of this and the ONE commonality that people cling to is immunizations, yet study after study shows no link between them and yet nearly all kids get them and millions and millions do not get autism. But understandably parents WANT an answer and it is elusive. As an aside, some studies that do not get alot of publicity in the autism arena, but that nearly clearly show a link to something is that has been linked to autism are older aged mother and fathers (but would mothers accept this and blame themselves? - the autism advocacy celebrity mothers like Holly Peete and McCarthy do not seem to take any "self" attitude toward the possible causes and only blame others) {http://www.nytimes.com/2010/02/09/health/09autism.html}

Some strong links to autism include autoimmune disease in the mother, maternal stress, being the first born, and some others. The strongest link studied link is the age of the mother (and I do not have an autistic child, but am just making the point how hard it is to tell when the start of something was, but of course, we still have a natural desire for an answer).

I often wonder if PA is most often found only after the blood pressure is noted to be high and found on a routine checkup or when they are ill, since it (the BP) tends to be silent for a while, and it is also naturally higher in times of stress. But we are also more likely to go to the doctors in times if stress and duress, emotionally or physically, so that connection is first and foremost in our minds. But how long was it there and yet we felt good still, or just attributed the fatigue, headaches, etc to "flu season" or something similar.

Subject: Stress as cause of hyperaldosteronismTo: hyperaldosteronism Date: Tuesday, February 1, 2011, 6:53 PM

Dr. Grim:I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?Also, I would love to

see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. Thanks so much for your time and knowledge,Callie

February 1, 2011

My understanding is that effect of stress on hypertension or Hyperaldosteronism perhaps is part of a wider category of medicine called Psychosomatic Medicine:

Psychosomatic medicine is an interdisciplinary medical field studying the relationships of social, psychological, and behavioral factors on bodily processes and well-being in humans and animals. The influence that the mind has over physical processes â€” including the manifestations of physical disabilities that are based on intellectual infirmities, rather than actual injuries or physical limitations â€” is manifested in treatment by phrases such as the power of suggestion, the use of "positive thinking" and concepts like "mind over matter".

The academic forebear of the modern field of behavioral medicine and a part of the practice of consultation-liaison psychiatry, psychosomatic medicine integrates interdisciplinary evaluation and management involving diverse specialties including psychiatry, psychology, neurology, surgery, allergy, dermatology and psychoneuroimmunology. Clinical situations where mental processes act as a major factor affecting medical outcomes are areas where psychosomatic medicine has competence.[1]

Max.

I will throw this out there, but I call something that is similar to this, when I am taking care of my patients, the "food poisoning syndrome" - where someone wakes up Monday morning throwing up, and the first thing they do is to attribute it to the lasagna they had for dinner the night before and are positive it was the lasagna and even "remember" it tasted funny, when in reality it was likely just a virus that decided to start on Monday morning. ....

Dr. Grim:I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans. .....

February 1, 2011

Interesting point. FWIW, my first episode of hypertension coincided with my

first ever period of unemployment/unemployability. Which was probably the most

stressful thing I've ever experienced in my life.

>

> Dr. Grim:

>

> I noticed in your paper " Evolution of PA " in the site files that " psycosocial

stress has created adrenal cortical hyperplasia and hypertension in mice " . You

recommended that this be further studied in humans.

>

> I believe absolutely that stress caused my PA. My condition started during a

period of extreme stress in my life. While reading the posts, I have noticed

that others on the site have mentioned the same thing.

>

> While my condition is well controlled 90% of the time with spironolactone

(thank you for your work that has helped make this possible), I can still get an

occasional " episode " , which I can always tie to something stressful going on in

my life. Also, forgetting to eat for too long of a time can exacerbate the

problem. Stress and not eating are a bad combination for me.

>

> Do you have any suggestions for what I can do to prevent an " episode " when I

am under unavoidable stress?

>

> Also, I would love to see you do a survey of site members to see how many of

them first exhibited symptoms during a very stressful period in their lives.

>

> Thanks so much for your time and knowledge,

>

> Callie

>

February 1, 2011

Looking back at my medical records, mine started during my first pregnancy as well.

Juli

Subject: Re: Stress as cause of hyperaldosteronismTo: hyperaldosteronism Date: Tuesday, February 1, 2011, 7:13 PM

That is interesting what you say about stress causing PA. I think I hadsome signs of PA, but did not start having problems until I becamepregnant.polymac>> Dr. Grim:>> I noticed in your paper "Evolution of PA" in the site files that"psycosocial stress has created adrenal cortical hyperplasia andhypertension in mice". You recommended that this be further studied inhumans.>> I believe absolutely that stress caused my PA. My condition startedduring a period of extreme stress in my life. While reading the posts, Ihave noticed that others on the site have mentioned the same thing.>> While

my condition is well controlled 90% of the time withspironolactone (thank you for your work that has helped make thispossible), I can still get an occasional "episode", which I can alwaystie to something stressful going on in my life. Also, forgetting to eatfor too long of a time can exacerbate the problem. Stress and not eatingare a bad combination for me.>> Do you have any suggestions for what I can do to prevent an "episode"when I am under unavoidable stress?>> Also, I would love to see you do a survey of site members to see howmany of them first exhibited symptoms during a very stressful period intheir lives.>> Thanks so much for your time and knowledge,>> Callie>

February 1, 2011

What we need is a good data base to assess these sort of issues and so far have not found someone who can help. Sounds like we need to think about contracting with someone to do this.Note humans are not mice-well maybe there are a few that are rats.Stress normally can be expected to activate the short term flight or fight mechanisms as well as the longer term ACTH driven adrenal cortical mechanisms. There is no convincing data that stress in humans contributes to blood pressure.This includes studies in air traffic controllers or bus drivers two very stressful jobs or so it is said. On the other hand my guess is that those who go into ATC like this kind of stress. So interesting to talk about but hard to define stress in a way that can be quantitate. So how do you rank your stress days? 1-3 or 1-5 or 1-10. Would others rank you days the same?I have spent over 40 years struggling with this issue and it is not easy.CE Grim MDDr. Grim:I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. Thanks so much for your time and knowledge,Callie

February 1, 2011

competence maybe results: few.CE Grim MDMy understanding is that effect of stress on hypertension or Hyperaldosteronism perhaps is part of a wider category of medicine calledPsychosomatic Medicine: Psychosomatic medicine is an interdisciplinary medical field studying the relationships of social, psychological, and behavioral factors on bodily processes and well-being in humans and animals. The influence that the mind has over physical processes — including the manifestations of physical disabilities that are based on intellectual infirmities, rather than actual injuries or physical limitations — is manifested in treatment by phrases such as the power of suggestion, the use of "positive thinking" and concepts like "mind over matter".The academic forebear of the modern field of behavioral medicine and a part of the practice of consultation-liaison psychiatry, psychosomatic medicine integrates interdisciplinary evaluation and management involving diverse specialties including psychiatry, psychology, neurology, surgery, allergy, dermatology andpsychoneuroimmunology. Clinical situations where mental processes act as a major factor affecting medical outcomes are areas where psychosomatic medicine has competence.[1]Max. I will throw this out there, but I call something that is similar to this, when I am taking care of my patients, the "food poisoning syndrome" - where someone wakes up Monday morning throwing up, and the first thing they do is to attribute it to the lasagna they had for dinner the night before and are positive it was the lasagna and even "remember" it tasted funny, when in reality it was likely just a virus that decided to start on Monday morning. .... Dr. Grim:I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans. .....

February 1, 2011

How does one separate this from happenstance?CE Grim MDInteresting point. FWIW, my first episode of hypertension coincided with my first ever period of unemployment/unemployability. Which was probably the most stressful thing I've ever experienced in my life.>> Dr. Grim:> > I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.> > I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. > > While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.> > Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?> > Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. > > Thanks so much for your time and knowledge,> > Callie>

February 1, 2011

When did the low K start?Looking back at my medical records, mine started during my first pregnancy as well. JuliSubject: Re: Stress as cause of hyperaldosteronismTo: hyperaldosteronism Date: Tuesday, February 1, 2011, 7:13 PM That is interesting what you say about stress causing PA. I think I hadsome signs of PA, but did not start having problems until I becamepregnant.polymac>> Dr. Grim:>> I noticed in your paper "Evolution of PA" in the site files that"psycosocial stress has created adrenal cortical hyperplasia andhypertension in mice". You recommended that this be further studied inhumans.>> I believe absolutely that stress caused my PA. My condition startedduring a period of extreme stress in my life. While reading the posts, Ihave noticed that others on the site have mentioned the same thing.>> While my condition is well controlled 90% of the time withspironolactone (thank you for your work that has helped make thispossible), I can still get an occasional "episode", which I can alwaystie to something stressful going on in my life. Also, forgetting to eatfor too long of a time can exacerbate the problem. Stress and not eatingare a bad combination for me.>> Do you have any suggestions for what I can do to prevent an "episode"when I am under unavoidable stress?>> Also, I would love to see you do a survey of site members to see howmany of them first exhibited symptoms during a very stressful period intheir lives.>> Thanks so much for your time and knowledge,>> Callie>

February 1, 2011

It was discovered in 2001. My pregnancies were in 1990 and 1995. The HTN started during my first pregnancy and never went away. I was not overweight or out of shape ). I think I had little to no lab done between 1990 and 2001 other than during pregnancy so it's hard to tell when it started (the low K).

Juli

Subject: Re: Stress as cause of hyperaldosteronismTo: hyperaldosteronism Date: Tuesday, February 1, 2011, 7:13 PM

That is interesting what you say about stress causing PA. I think I hadsome signs of PA, but did not start having problems until I becamepregnant.polymac>> Dr. Grim:>> I noticed in your paper "Evolution of PA" in the site files that"psycosocial stress has created adrenal cortical hyperplasia andhypertension in mice". You recommended that this be further studied inhumans.>> I believe absolutely that stress caused my PA. My condition startedduring a period of extreme stress in my life. While reading the posts, Ihave noticed that others on the site have mentioned

the same thing.>> While my condition is well controlled 90% of the time withspironolactone (thank you for your work that has helped make thispossible), I can still get an occasional "episode", which I can alwaystie to something stressful going on in my life. Also, forgetting to eatfor too long of a time can exacerbate the problem. Stress and not eatingare a bad combination for me.>> Do you have any suggestions for what I can do to prevent an "episode"when I am under unavoidable stress?>> Also, I would love to see you do a survey of site members to see howmany of them first exhibited symptoms during a very stressful period intheir lives.>> Thanks so much for your time and knowledge,>> Callie>

February 1, 2011

I think you can separate this from happenstance if you have the same

thing happen to multiple people in your family that is initiated by the

same circumstance. I believe my PA was present before my pregnancies,

but the stress of pregnancy brought it on full force. I also have a

sister that has signs of PA. She also was diagnosed with high blood

pressure during her pregnancy and had low potassium and continues to

have problems with blood pressure and low potassium. If you can document

familial causes where similar types of stressors results in disease

(such as pregnancy), this may be a statistically significant finding.

polymac

> > >

> > > Dr. Grim:

> > >

> > > I noticed in your paper " Evolution of PA " in the site files that

> > " psycosocial stress has created adrenal cortical hyperplasia and

> > hypertension in mice " . You recommended that this be further studied

> > in humans.

> > >

> > > I believe absolutely that stress caused my PA. My condition

> > started during a period of extreme stress in my life. While reading

> > the posts, I have noticed that others on the site have mentioned the

> > same thing.

> > >

> > > While my condition is well controlled 90% of the time with

> > spironolactone (thank you for your work that has helped make this

> > possible), I can still get an occasional " episode " , which I can

> > always tie to something stressful going on in my life. Also,

> > forgetting to eat for too long of a time can exacerbate the problem.

> > Stress and not eating are a bad combination for me.

> > >

> > > Do you have any suggestions for what I can do to prevent an

> > " episode " when I am under unavoidable stress?

> > >

> > > Also, I would love to see you do a survey of site members to see

> > how many of them first exhibited symptoms during a very stressful

> > period in their lives.

> > >

> > > Thanks so much for your time and knowledge,

> > >

> > > Callie

> > >

> >

>

February 2, 2011

WE do know there are several forms of familial PA. Review my article again and read about GRA.These could be called genostance I suppose to coin a new word.CE Grim MDI think you can separate this from happenstance if you have the samething happen to multiple people in your family that is initiated by thesame circumstance. I believe my PA was present before my pregnancies,but the stress of pregnancy brought it on full force. I also have asister that has signs of PA. She also was diagnosed with high bloodpressure during her pregnancy and had low potassium and continues tohave problems with blood pressure and low potassium. If you can documentfamilial causes where similar types of stressors results in disease(such as pregnancy), this may be a statistically significant finding.polymac> > >> > > Dr. Grim:> > >> > > I noticed in your paper "Evolution of PA" in the site files that> > "psycosocial stress has created adrenal cortical hyperplasia and> > hypertension in mice". You recommended that this be further studied> > in humans.> > >> > > I believe absolutely that stress caused my PA. My condition> > started during a period of extreme stress in my life. While reading> > the posts, I have noticed that others on the site have mentioned the> > same thing.> > >> > > While my condition is well controlled 90% of the time with> > spironolactone (thank you for your work that has helped make this> > possible), I can still get an occasional "episode", which I can> > always tie to something stressful going on in my life. Also,> > forgetting to eat for too long of a time can exacerbate the problem.> > Stress and not eating are a bad combination for me.> > >> > > Do you have any suggestions for what I can do to prevent an> > "episode" when I am under unavoidable stress?> > >> > > Also, I would love to see you do a survey of site members to see> > how many of them first exhibited symptoms during a very stressful> > period in their lives.> > >> > > Thanks so much for your time and knowledge,> > >> > > Callie> > >> >> >> >>

February 2, 2011

I totally believe that stress was a major factor in the escalation of my PA. While I had high BP and low K for many years, and it was undiagnosed as PA then, my BP did not start to go out of control until a year of major stress.Within one year 3 of my closest women friends died, one of whom I largely took care of and the others who were part of my basic emotional support system. Added to this was my son's contentious divorce, where our relationships with our grandchildren (which have always been very close) was jeopardized. This amount of stressful change exacerbated what was already in place.Naturally there is no way to prove this, but I know the link between stress and PA exists, at least for me.DianneSubject: Stress as cause of hyperaldosteronismTo: hyperaldosteronism Date: Tuesday, February 1, 2011, 4:53 PM

Dr. Grim:

I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.

I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing.

While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.

Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?

Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives.

Thanks so much for your time and knowledge,

Callie

February 2, 2011

What you describe is exactly the kind of year I was experiencing when I first

started exhibiting symptoms. But I had never had high BP or low K (as far as I

know) before that time. I was trying to care for my mother who was dying, keep

peace with my siblings, care for my daughter who was having a difficult

pregnancy with twins, and I was dealing with extremely difficult situations at

work. I have never had a more stressful year. Then suddenly the high BP etc.

etc., though the PA took about a year to diagnose.

And now,though the PA is under control, stress still seems to affect me more

strongly than it ever did before.

Callie

>

> Subject: Stress as cause of hyperaldosteronism

> To: hyperaldosteronism

> Date: Tuesday, February 1, 2011, 4:53 PM

>

> Â

>

> Dr. Grim:

>

> I noticed in your paper " Evolution of PA " in the site files that " psycosocial

stress has created adrenal cortical hyperplasia and hypertension in mice " . You

recommended that this be further studied in humans.

>

> I believe absolutely that stress caused my PA. My condition started during a

period of extreme stress in my life. While reading the posts, I have noticed

that others on the site have mentioned the same thing.

>

> While my condition is well controlled 90% of the time with spironolactone

(thank you for your work that has helped make this possible), I can still get an

occasional " episode " , which I can always tie to something stressful going on in

my life. Also, forgetting to eat for too long of a time can exacerbate the

problem. Stress and not eating are a bad combination for me.

>

> Do you have any suggestions for what I can do to prevent an " episode " when I

am under unavoidable stress?

>

> Also, I would love to see you do a survey of site members to see how many of

them first exhibited symptoms during a very stressful period in their lives.

>

> Thanks so much for your time and knowledge,

>

> Callie

>

February 2, 2011

I have to agree that there may very well be a link between the escalation of PA

and stress. We first discovered my husband's very high BP (210/120)in our ER

where he was being seen for what seemed like a severe migraine. As a nursing

student and then a nurse, I have practised on and evaluated my husband's BP for

years. It was always normal. So his severe HTN came as a shock. Looking back

to that time frame, my husband was dealing with the worst stress of his life -

work related - that nearly broke him. Panicked, anxious and emotional. I had

never seen him like that before and thankfully not since we got through that bad

time. I do believe that his crazy high BP's at that time were an exaggerated

response to stress. That was over 5 years ago and finally he's off of the 6 BP

meds and K pills and being successfully managed on spiro alone. He still reacts

ineffectively to extreme stress and I firmly believe it's all part of the PA

picture.

> >

> > From: callie.nelle <callie.nelle@>

> > Subject: Stress as cause of hyperaldosteronism

> > To: hyperaldosteronism

> > Date: Tuesday, February 1, 2011, 4:53 PM

> >

> > Â

> >

> > Dr. Grim:

> >

> > I noticed in your paper " Evolution of PA " in the site files that

" psycosocial stress has created adrenal cortical hyperplasia and hypertension in

mice " . You recommended that this be further studied in humans.

> >

> > I believe absolutely that stress caused my PA. My condition started during

a period of extreme stress in my life. While reading the posts, I have noticed

that others on the site have mentioned the same thing.

> >

> > While my condition is well controlled 90% of the time with spironolactone

(thank you for your work that has helped make this possible), I can still get an

occasional " episode " , which I can always tie to something stressful going on in

my life. Also, forgetting to eat for too long of a time can exacerbate the

problem. Stress and not eating are a bad combination for me.

> >

> > Do you have any suggestions for what I can do to prevent an " episode " when I

am under unavoidable stress?

> >

> > Also, I would love to see you do a survey of site members to see how many of

them first exhibited symptoms during a very stressful period in their lives.

> >

> > Thanks so much for your time and knowledge,

> >

> > Callie

> >

>

February 2, 2011

Hang in there. Things should be getting better. At least you are not living in Chicago now.CE Grim MDI totally believe that stress was a major factor in the escalation of my PA. While I had high BP and low K for many years, and it was undiagnosed as PA then, my BP did not start to go out of control until a year of major stress.Within one year 3 of my closest women friends died, one of whom I largely took care of and the others who were part of my basic emotional support system. Added to this was my son's contentious divorce, where our relationships with our grandchildren (which have always been very close) was jeopardized. This amount of stressful change exacerbated what was already in place.Naturally there is no way to prove this, but I know the link between stress and PA exists, at least for me.DianneSubject: Stress as cause of hyperaldosteronismTo: hyperaldosteronism Date: Tuesday, February 1, 2011, 4:53 PM Dr. Grim:I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. Thanks so much for your time and knowledge,Callie

February 2, 2011

We all suffer from the symptoms of Industrial Slavery in North America. Chattel slavery was abolished not because politicians were so kind, but rather because it was no longer economical to keep slaves in chains...so the wealthy and powerful devised the new system of industrial slavery which is gradually is known to be the cause of many health issues in the West now...Some 30 years ago when the leaders realized that industrial slavery is also becoming difficult to manage then they used psychologists to cheer slaves by injecting them with vain imaginations like sense of uniqueness, superiority, ....etc... and hence by using the narcissism epidemic we are all put to a kind of anesthetic posture to forget how like a donkey we must carry loads of work so that leaders keep their position and add to their wealth....and so we develop all kinds of physical and mental disorders while industrial slavery prevails.

Max.

Probably I ill be the one who is going on opposite site. I was under tremendous stress all my 18 years in the USA. I came here on a busyness trip with Ph.D.and nothing else in my pocket and with 9 years old daughter when I was almost 50 and without good knowledge of English. I was laid off many, many times just because I could not express myself properly in English and because I did not have a green card for many years. For many times we literally had nothing to eat. I worked as a babysitter, housekeeper and picked up strawberries and other crop, when I didn't have my professional job.___

February 2, 2011

So he has PA. Has his salt and K intake improved?CE Grim MDI have to agree that there may very well be a link between the escalation of PA and stress. We first discovered my husband's very high BP (210/120)in our ER where he was being seen for what seemed like a severe migraine. As a nursing student and then a nurse, I have practised on and evaluated my husband's BP for years. It was always normal. So his severe HTN came as a shock. Looking back to that time frame, my husband was dealing with the worst stress of his life - work related - that nearly broke him. Panicked, anxious and emotional. I had never seen him like that before and thankfully not since we got through that bad time. I do believe that his crazy high BP's at that time were an exaggerated response to stress. That was over 5 years ago and finally he's off of the 6 BP meds and K pills and being successfully managed on spiro alone. He still reacts ineffectively to extreme stress and I firmly believe it's all part of the PA picture.> > > > From: callie.nelle <callie.nelle@>> > Subject: Stress as cause of hyperaldosteronism> > To: hyperaldosteronism > > Date: Tuesday, February 1, 2011, 4:53 PM> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Â > > > > > > > > > > > > > > > > > > > > Dr. Grim:> > > > > > > > I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.> > > > > > > > I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. > > > > > > > > While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.> > > > > > > > Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?> > > > > > > > Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. > > > > > > > > Thanks so much for your time and knowledge,> > > > > > > > Callie> >>

February 2, 2011

Show us the data in humans. CE Grim MDI did a research paper in college on the physiological effects of stress on the body. I always knew stress took a tremendous physical toll on the body but had no idea the extent of it until I did the research. Stress can cause many ailments and exacerbate any weakness, deficiency or latent disease on a very large scale. I believe stress can be a contribuing factor to just about any physiological or psychological condition. Juli Subject: Re: Stress as cause of hyperaldosteronismTo: hyperaldosteronism Date: Wednesday, February 2, 2011, 6:19 PM I have to agree that there may very well be a link between the escalation of PA and stress. We first discovered my husband's very high BP (210/120)in our ER where he was being seen for what seemed like a severe migraine. As a nursing student and then a nurse, I have practised on and evaluated my husband's BP for years. It was always normal. So his severe HTN came as a shock. Looking back to that time frame, my husband was dealing with the worst stress of his life - work related - that nearly broke him. Panicked, anxious and emotional. I had never seen him like that before and thankfully not since we got through that bad time. I do believe that his crazy high BP's at that time were an exaggerated response to stress. That was over 5 years ago and finally he's off of the 6 BP meds and K pills and being successfully managed on spiro alone. He still reacts ineffectively to extreme stress and I firmly believe it's all part of the PA picture.> > > > From: callie.nelle <callie.nelle@>> > Subject: Stress as cause of hyperaldosteronism> > To: hyperaldosteronism > > Date: Tuesday, February 1, 2011, 4:53 PM> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Â > > > > > > > > > > > > > > > > > > > > Dr. Grim:> > > > > > > > I noticed in your paper "Evolution of PA" in the site files that "psycosocial stress has created adrenal cortical hyperplasia and hypertension in mice". You recommended that this be further studied in humans.> > > > > > > > I believe absolutely that stress caused my PA. My condition started during a period of extreme stress in my life. While reading the posts, I have noticed that others on the site have mentioned the same thing. > > > > > > > > While my condition is well controlled 90% of the time with spironolactone (thank you for your work that has helped make this possible), I can still get an occasional "episode", which I can always tie to something stressful going on in my life. Also, forgetting to eat for too long of a time can exacerbate the problem. Stress and not eating are a bad combination for me.> > > > > > > > Do you have any suggestions for what I can do to prevent an "episode" when I am under unavoidable stress?> > > > > > > > Also, I would love to see you do a survey of site members to see how many of them first exhibited symptoms during a very stressful period in their lives. > > > > > > > > Thanks so much for your time and knowledge,> > > > > > > > Callie> >>

February 2, 2011

Yep, PA for sure. Keeping salt intake down is hard for him. A slice of deluxe

pizza is nearly 1000mg of Na for God's sake! He finds this DASH diet very bland

and limiting but knows the importance of it so he keeps trying. K on the other

hand is easier to manage. He loves the foods that are high in K and Mrs. Dash

salt substitute is used in abundance here. I only wish more K could trigger

more Na excretion. That would be easier.

> > > >

> > > > From: callie.nelle <callie.nelle@>

> > > > Subject: Stress as cause of

> > hyperaldosteronism

> > > > To: hyperaldosteronism

> > > > Date: Tuesday, February 1, 2011, 4:53 PM

> > > >

> > > > Â

> > > >

> > > > Dr. Grim:

> > > >

> > > > I noticed in your paper " Evolution of PA " in the site files that

> > " psycosocial stress has created adrenal cortical hyperplasia and

> > hypertension in mice " . You recommended that this be further studied

> > in humans.

> > > >

> > > > I believe absolutely that stress caused my PA. My condition

> > started during a period of extreme stress in my life. While reading

> > the posts, I have noticed that others on the site have mentioned the

> > same thing.

> > > >

> > > > While my condition is well controlled 90% of the time with

> > spironolactone (thank you for your work that has helped make this

> > possible), I can still get an occasional " episode " , which I can

> > always tie to something stressful going on in my life. Also,

> > forgetting to eat for too long of a time can exacerbate the problem.

> > Stress and not eating are a bad combination for me.

> > > >

> > > > Do you have any suggestions for what I can do to prevent an

> > " episode " when I am under unavoidable stress?

> > > >

> > > > Also, I would love to see you do a survey of site members to see

> > how many of them first exhibited symptoms during a very stressful

> > period in their lives.

> > > >

> > > > Thanks so much for your time and knowledge,

> > > >

> > > > Callie

> > > >

> > >

> >

>

February 2, 2011

That is an interesting question, which I hadn't thought about until you just

asked it.

For two years I had been on the Weight Watchers CORE weight-loss program, which

I had followed very strictly, not eating any bread or desserts for two years.

CORE mainly emphasizes lean meat, vegetables and fruit. Then I gradually

started adding bread and everything else back and have since regained the 30

pounds I lost. I had gotten off the Core food program when all of this stress

started. And then came the HBP, palpitations, chest pressure, foggy brain,

weakness, shaking, twitching hands, muscle cramps, and low K. H-m-m-m-m?!

I know there is a strong relationship to food because my symptoms would worsen

after eating, especially when I had gone too long not eating. Even now, I have

to eat every three hours or I start to feel unpleasantly " strange " (the only way

I know to describe it).

I noticed in your paper on the progression of PA that " ...subtle disturbances of

glucose metabolism seen in many patients with hypertension(the metabolic

syndrome) could be related to increased aldosterone production. " Maybe

something is going on with my glucose metabolism in addition to the PA.

Anyway, I acknowledge that diet is implicated in my PA--okay, strongly

implicated--but I had eaten a " normal " bad diet until I started CORE and hadn't

gotten PA. The only thing that was absolutely different was that it was the

most stressful year of my life.

> > >

> > > From: callie.nelle <callie.nelle@>

> > > Subject: Stress as cause of hyperaldosteronism

> > > To: hyperaldosteronism

> > > Date: Tuesday, February 1, 2011, 4:53 PM

> > >

> > > Â

> > >

> > > Dr. Grim:

> > >

> > > I noticed in your paper " Evolution of PA " in the site files that

> > " psycosocial stress has created adrenal cortical hyperplasia and

> > hypertension in mice " . You recommended that this be further studied

> > in humans.

> > >

> > > I believe absolutely that stress caused my PA. My condition

> > started during a period of extreme stress in my life. While reading

> > the posts, I have noticed that others on the site have mentioned the

> > same thing.

> > >

> > > While my condition is well controlled 90% of the time with

> > spironolactone (thank you for your work that has helped make this

> > possible), I can still get an occasional " episode " , which I can

> > always tie to something stressful going on in my life. Also,

> > forgetting to eat for too long of a time can exacerbate the problem.

> > Stress and not eating are a bad combination for me.

> > >

> > > Do you have any suggestions for what I can do to prevent an

> > " episode " when I am under unavoidable stress?

> > >

> > > Also, I would love to see you do a survey of site members to see

> > how many of them first exhibited symptoms during a very stressful

> > period in their lives.

> > >

> > > Thanks so much for your time and knowledge,

> > >

> > > Callie

> > >

> >

>

February 2, 2011

You may want to look at this site. Prices a bit on the high side. Shipping adds

a lot to cost but the more you buy the less shiping cost is.

http://healthyheartmarket.com/index.aspx

I have not as yet tried any thing on this site. This store is run by someone

that had a heart tranplant.

> > > > >

> > > > > From: callie.nelle <callie.nelle@>

> > > > > Subject: Stress as cause of

> > > hyperaldosteronism

> > > > > To: hyperaldosteronism

> > > > > Date: Tuesday, February 1, 2011, 4:53 PM

> > > > >

> > > > > Â

> > > > >

> > > > > Dr. Grim:

> > > > >

> > > > > I noticed in your paper " Evolution of PA " in the site files that

> > > " psycosocial stress has created adrenal cortical hyperplasia and

> > > hypertension in mice " . You recommended that this be further studied

> > > in humans.

> > > > >

> > > > > I believe absolutely that stress caused my PA. My condition

> > > started during a period of extreme stress in my life. While reading

> > > the posts, I have noticed that others on the site have mentioned the

> > > same thing.

> > > > >

> > > > > While my condition is well controlled 90% of the time with

> > > spironolactone (thank you for your work that has helped make this

> > > possible), I can still get an occasional " episode " , which I can

> > > always tie to something stressful going on in my life. Also,

> > > forgetting to eat for too long of a time can exacerbate the problem.

> > > Stress and not eating are a bad combination for me.

> > > > >

> > > > > Do you have any suggestions for what I can do to prevent an

> > > " episode " when I am under unavoidable stress?

> > > > >

> > > > > Also, I would love to see you do a survey of site members to see

> > > how many of them first exhibited symptoms during a very stressful

> > > period in their lives.

> > > > >

> > > > > Thanks so much for your time and knowledge,

> > > > >

> > > > > Callie

> > > > >

> > > >

> > >

> >

>

February 2, 2011

Actually there is data that K improves sodium excretion and decrease sodium retention durind salt loading. Some of our own old data.Tell him to keep working on it. Most find that their taste buds come alive after awhile. Ask you Dr. to do a spot urine for Na, K and Creatinine to see how he is doing. He should have more K than Na in the urine.CE Grim MDYep, PA for sure. Keeping salt intake down is hard for him. A slice of deluxe pizza is nearly 1000mg of Na for God's sake! He finds this DASH diet very bland and limiting but knows the importance of it so he keeps trying. K on the other hand is easier to manage. He loves the foods that are high in K and Mrs. Dash salt substitute is used in abundance here. I only wish more K could trigger more Na excretion. That would be easier.> > > >> > > > From: callie.nelle <callie.nelle@>> > > > Subject: Stress as cause of > > hyperaldosteronism> > > > To: hyperaldosteronism > > > > Date: Tuesday, February 1, 2011, 4:53 PM> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > > Â> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > >> > > > Dr. Grim:> > > >> > > >> > > >> > > > I noticed in your paper "Evolution of PA" in the site files that > > "psycosocial stress has created adrenal cortical hyperplasia and > > hypertension in mice". You recommended that this be further studied > > in humans.> > > >> > > >> > > >> > > > I believe absolutely that stress caused my PA. My condition > > started during a period of extreme stress in my life. While reading > > the posts, I have noticed that others on the site have mentioned the > > same thing.> > > >> > > >> > > >> > > > While my condition is well controlled 90% of the time with > > spironolactone (thank you for your work that has helped make this > > possible), I can still get an occasional "episode", which I can > > always tie to something stressful going on in my life. Also, > > forgetting to eat for too long of a time can exacerbate the problem. > > Stress and not eating are a bad combination for me.> > > >> > > >> > > >> > > > Do you have any suggestions for what I can do to prevent an > > "episode" when I am under unavoidable stress?> > > >> > > >> > > >> > > > Also, I would love to see you do a survey of site members to see > > how many of them first exhibited symptoms during a very stressful > > period in their lives.> > > >> > > >> > > >> > > > Thanks so much for your time and knowledge,> > > >> > > >> > > >> > > > Callie> > > >> > >> >> >> >>

February 2, 2011

Diet is implicated in all PA.In rats and humans low sodium diet reverses the damage of high aldo. No salt no aldo damage. Look at Bravo's paper in our file and you will note one pt with full blown PA who became NT on a low sodium diet ONLY.Low K impairs insulin release AKA Type 2 DM and aldo causes insulin resistance aka type 2. See what the sodium content was in your WW program. Prob not <1500 mg a day and prob not >4500 mg K a day.That is an interesting question, which I hadn't thought about until you just asked it. For two years I had been on the Weight Watchers CORE weight-loss program, which I had followed very strictly, not eating any bread or desserts for two years. CORE mainly emphasizes lean meat, vegetables and fruit. Then I gradually started adding bread and everything else back and have since regained the 30 pounds I lost. I had gotten off the Core food program when all of this stress started. And then came the HBP, palpitations, chest pressure, foggy brain, weakness, shaking, twitching hands, muscle cramps, and low K. H-m-m-m-m?! I know there is a strong relationship to food because my symptoms would worsen after eating, especially when I had gone too long not eating. Even now, I have to eat every three hours or I start to feel unpleasantly "strange"(the only way I know to describe it). I noticed in your paper on the progression of PA that "...subtle disturbances of glucose metabolism seen in many patients with hypertension(the metabolic syndrome) could be related to increased aldosterone production." Maybe something is going on with my glucose metabolism in addition to the PA.Anyway, I acknowledge that diet is implicated in my PA--okay, strongly implicated--but I had eaten a "normal" bad diet until I started CORE and hadn't gotten PA. The only thing that was absolutely different was that it was the most stressful year of my life.> > >> > > From: callie.nelle <callie.nelle@>> > > Subject: Stress as cause of hyperaldosteronism> > > To: hyperaldosteronism > > > Date: Tuesday, February 1, 2011, 4:53 PM> > >> > >> > >> > >> > >> > >> > >> > >> > >> > >> > >> > >> > >> > >> > >> > >> > > Â> > >> > >> > >> > >> > >> > >> > >> > >> > >> > > Dr. Grim:> > >> > >> > >> > > I noticed in your paper "Evolution of PA" in the site files that > > "psycosocial stress has created adrenal cortical hyperplasia and > > hypertension in mice". You recommended that this be further studied > > in humans.> > >> > >> > >> > > I believe absolutely that stress caused my PA. My condition > > started during a period of extreme stress in my life. While reading > > the posts, I have noticed that others on the site have mentioned the > > same thing.> > >> > >> > >> > > While my condition is well controlled 90% of the time with > > spironolactone (thank you for your work that has helped make this > > possible), I can still get an occasional "episode", which I can > > always tie to something stressful going on in my life. Also, > > forgetting to eat for too long of a time can exacerbate the problem. > > Stress and not eating are a bad combination for me.> > >> > >> > >> > > Do you have any suggestions for what I can do to prevent an > > "episode" when I am under unavoidable stress?> > >> > >> > >> > > Also, I would love to see you do a survey of site members to see > > how many of them first exhibited symptoms during a very stressful > > period in their lives.> > >> > >> > >> > > Thanks so much for your time and knowledge,> > >> > >> > >> > > Callie> > >> >> >> >>

February 2, 2011

I am hearing from a very proficient psychologist on radio that this is one of the symptoms of depression resulting from anxiety disorder....etc.

| Even now, I have to eat every three|hours or I start to feel unpleasantly "strange"(the only way I|know to describe it). |

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