2004 Creatine and Exercise Study: REPOST

[Guest guest]

(Note to all, I am reposting this abstract at Barb's request. Some of

our newer members may not be aware that this was previously posted in

2004 and is in our archives. Drs. Tarnopolsky and Chetlin are the

real experts and have done a vast amount of research in this area)

~ Gretchen

Muscle Nerve. 2004 Jul;30(1):69-76.

Resistance training exercise and creatine in patients with Charcot-

Marie-Tooth disease.

Chetlin RD, Gutmann L, Tarnopolsky MA, Ullrich IH, Yeater RA.

Department of Human Performance and Applied Exercise Science, West

Virginia University, P.O. Box 9139, town, West Virginia 26506-

9139, USA.

Resistance exercise and creatine supplementation independently

improve strength and function in patients with certain neuromuscular

diseases. The purpose of this study was to examine the effects of

resistance training with and without creatine supplementation on

muscle, strength, and function in patients with Charcot-Marie-Tooth

(CMT) disease. Twenty patients with CMT consumed 5 g/day creatine or

placebo while participating in resistance training for 12 weeks.

Energy metabolites, muscle fiber type and size, strength, and timed

activities of daily living were measured before and after training.

There were no differences between creatine or placebo groups for any

outcome. For the groups combined, exercise training increased type I

muscle fiber diameter (48.2 +/- 14.2 microm vs. 55.4 +/- 14.8

microm), strength, and activities of daily living (ADL) times. Thus,

patients respond to resistance training with muscle fiber

adaptations, and improvements in strength and function. Creatine was

not beneficial.