Understanding BP etc. Guyton. Here are 3 free articles but still recommend the book to get all the basics. Figure 1 in the First one

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Go to http://patf-biokyb.lf1.cuni.cz/wiki/hummod/hummod and you can download the model. Looks like it help if you read Czeck.Physiol Res. 2010;59(6):897-908. Epub 2010 Jun 9.Restoration of Guyton´s diagram for regulation of the circulation as a basis for quantitative physiological model development.Kofránek J, Rusz J.Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic. ruszjan@....AbstractWe present the current state of complex circulatory dynamics model development based on Guyton's famous diagram. The aim is to provide an open-source model that will allow the simulation of a number of pathological conditions on a virtual patient including cardiac, respiratory, and kidney failure. The model will also simulate the therapeutic influence of various drugs, infusions of electrolytes, blood transfusion, etc. As a current result of implementation, we describe a core model of human physiology targeting the systemic circulation, arterial pressure and body fluid regulation, including short- and long-term regulations. The model can be used for educational purposes and general reflection on physiological regulation in pathogenesis of various diseases.PMID: 20533860 [PubMed - in process]Free ArticleRelated citations2.Exp Physiol. 2009 Apr;94(4):382-8.Understanding the contribution of Guyton's large circulatory model to long-term control of arterial pressure.Montani JP, Van Vliet BN.Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musée 5, CH-1700 Fribourg, Switzerland. jean-pierre.montani@...Comment in:Exp Physiol. 2009 Apr;94(4):388-9.AbstractWith the publication in 1972 of a large computer model of circulatory control, Guyton and colleagues challenged the then prevailing views on how blood pressure and cardiac output were controlled. At that time, it was widely accepted that the heart controlled cardiac output and that peripheral resistance controlled arterial blood pressure. By incorporating the empirically demonstrated concepts of blood flow autoregulation and the pressure-natriuresis relationship into their mathematical model, Guyton and colleagues were able to develop a number of revolutionary concepts. Guyton's circulatory model was particularly instrumental in exploring the linkage between blood pressure and sodium balance and in demonstrating an overriding importance of renal salt and water balance in setting the long-term blood pressure level. In both the model and experimental data, any long-lasting imbalance between salt intake and salt excretion leads to a progressive alteration of the degree of filling of the vascular system and thus to parallel changes in blood pressure. In turn, changes in blood pressure alter sodium excretion, opposing the initial salt imbalance. Although Guyton's model does not include the most recent cardiovascular discoveries, the concepts underlying the basic functioning of the cardiovascular system can serve as a well-built basis for the development of new, large and integrative cardiovascular models.PMID: 19286638 [PubMed - indexed for MEDLINE]Free ArticleRelated citationsMeSH Terms3.Hypertension. 2008 Apr;51(4):811-6. Epub 2008 Mar 10.Kidney in hypertension: guyton redux.Coffman TM, Crowley SD.Division of Nephrology, Department of Medicine, Duke University and Durham Veterans'Affairs Medical Centers, Durham, NC, USA. tcoffman@...PMID: 18332286 [PubMed - indexed for MEDLINE]Free ArticleRelated citations() Marie...I have been quietly researching and reading since I "got in trouble" for mentioning something that Dr. Grim had already mentioned and he felt I was "wasting his time". I think there may be a more tangiable answer as to why your heart appeared better now than three yrs ago. I am not a doctor but I am keying in on the "left ventricular hypertrophy". From what I have read this is just the tip of the iceburg and the studying is ongoing. It appears that getting rid of the excess aldosterone via either meds. or surgery can have a positive impact on a lot more than just BP. My understanding is that the systems correct themselves once the source is removed (or at least things get better.) (I personally have progressed into looking into "Metabolic Syndrome" which Conn's may be just a part of. (Adrenalecotmy and loose 30 lbs. for the first year!) I'll update you in 3 years if I am sucessful!Without further ado, at the risk of going beyond the scope of this project I will quote a paragraph out of "SAGE journals" entitled "Regression of left ventricular hypertrophy: hoping for a longer life" by Sharp and Jamil Mayet:"In recent years, we have gathered more insights into therole of aldosterone and its potential adverse effects on thecardiovascular system, independent of its effect on BP.Patients with PA are at higher risk of stroke, myocardialinfarction, atrial fibrillation and left ventricular hypertrophythan matched individuals with essential hypertension.16Additionally, a higher prevalence of metabolic syndromeand greater insulin resistance have been demonstrated inpatients with PA.40,41 These metabolic abnormalities werecorrected following the removal of the APA.19, 20 Takentogether with the findings of the study by Umpierrezet al.,23 our study reinforces the need to screen for PA intype 2 diabetic patients with resistant hypertension." Full text is available at:http://jra.sagepub.com/content/3/3/141.full.pdf--- In hyperaldosteronism , Clarence Grim wrote:>> the heart is better because you no loner have full blown PA.> > Have any of your relatives has low K problems.> > > Here is a recent report from Down under on post op. you can get the > whole article for free as well> > J Clin Endocrinol Metab. 2010 Mar;95(3):1360-4. Epub 2010 Jan 20.> Improved quality of life, blood pressure, and biochemical status > following laparoscopic adrenalectomy for unilateral primary > aldosteronism.> Sukor N, Kogovsek C, Gordon RD, Robson D, Stowasser M.> Hypertension Unit, University of Queensland School of Medicine, > Princess andra Hospital, Ipswich Road, Woolloongabba, Brisbane > 4102, Australia.> Abstract> Context: In 22 patients with unilateral primary aldosteronism (UPA), > unilateral laparoscopic adrenalectomy (ADX) not only corrected > hypokalemia and led to cure or improvement of hypertension, but also > significantly improved quality of life (QOL). Setting and Design: In > this pilot study, QOL was evaluated prospectively using SF-36 > questionnaire before and 3 and 6 months after ADX in 22 patients [14 > males] with UPA who underwent ADX within the Endocrine Hypertension > Research Center, Greenslopes and Princess andra Hospitals, between > June 2007 and June 2008. Results: Eighty-six percent of patients were > cured of hypertension, and the remainder improved. Plasma potassium > normalized and, whereas renin concentration increased, plasma > aldosterone, aldosterone/renin ratio, and number of antihypertensive > agents decreased. Preoperatively, SF-36 scores for each QOL domain > were lower for UPA patients than reported for the Australian general > population, especially for physical functioning, role physical, > vitality, and general health. Significant improvements were seen at 3 > months in physical functioning, role physical, social functioning, > role emotional, general health, mental health, and vitality and at 6 > months in physical functioning, role physical, general health, role > emotional, mental health, and vitality. Conclusion: Unilateral > adrenalectomy had positive impacts not only on blood pressure and > biochemical parameters, but also on QOL, which was impaired > preoperatively but significantly improved by 3 months postoperatively.> > > >> > Dr Gim> > just responding to your questions......yes I do have a copy of the > > pathology report......and I have told my family about what I have, > > they live in Michigan & I live in Florida so I can not be at there > > dr when they go to see them so I did send them the info I had got > > from my nephrologist and this group to give to there doctors......if > > they did, they didnt tell me yet.......I do dash but not like my > > life depends on it.......I use to use onion, garlic salt & almost > > always salted my foods but now I use powders and never salt my foods > > and have been watching the sodium in all the foods that I > > buy.......considering 110-125/74-80 I think I am doing so much > > better than before..........I have my own bp monitor so I do keep > > track of my bp.....I had an echo done a few weeks ago and my pcp > > says my heart is in better shape now than it was 3 years ago, now > > how did that happen..............I do have valve leakage though > > atleast that is what she told me..........> > the metoprolo has helped with my heart flutters/palpitations> > the nefedipine is a calcium chanel blocker right?????> > Thanks> > () Marie> > 50 y F W Laparoscopy left adrenal December 15, 2010 doing much > > better........> >> >> > Re: Re: what is post op adrenal > >> surgery like?> >>> >>> >> Yes unfortunately (or fortunately) most return to normal and are > >> out of here unless surgery did not get the correct side.> >>> >>> >> CE Grim MD> >> On Mar 26, 2011, at 9:24 AM, Francis Bill SUSPECTED PA wrote:> >>> >>> Not many post here much after having surgery. You may find some > >>> information here.> >>> http://hyperaldosteronism.blogsp ot.com/> >>>> >>> > >>> >> >>> > Can someone post what post op surgery is like?> >>> > Did you need transitional rehab care for a few weeks in assisted > >>> living?> >>> > Were you bedridden or was walking a problem?> >>> > Did your urine volume increase?> >>> > Did anyone have any post op complications?> >>> > Thanks for any feedback.> >>> >> >>>> >>>> >>> >>> >> >> >> >> >> >>