Guest guest Posted April 26, 2011 Report Share Posted April 26, 2011 Inspra is the brand name for eplerenone , which is the only other HTN med that is effective in PA. If spiro causes side effects, Inspra is usually the drug of choice.> >> > Progesterone is a spironolactone agonist.I felt that spiro blocked my > > body's reception of progesterone.The result was polyps, a lining that > > would not shed, and eventually, a D & C.I am on Inspra now.Not sure my > > theory is correct.> >> > Val> >> > *From:*hyperaldosteronism > > [mailto:hyperaldosteronism ] *On Behalf Of *Clarence Grim> >> > Progesterone cream should also block Aldo I suppose. But other risks > > as I recall> >> >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2011 Report Share Posted April 26, 2011 Thank you. I have heard of eplerenone. I thought my body adjusted not well in the beginning of spiro but she didn't want to make the switch?? Inspra is the brand name for eplerenone , which is the only other HTN med that is effective in PA. If spiro causes side effects, Inspra is usually the drug of choice. > > > > Progesterone is a spironolactone agonist.I felt that spiro blocked my > > body's reception of progesterone.The result was polyps, a lining that > > would not shed, and eventually, a D & C.I am on Inspra now.Not sure my > > theory is correct. > > > > Val > > > > *From:*hyperaldosteronism > > [mailto:hyperaldosteronism ] *On Behalf Of *Clarence Grim > > > > Progesterone cream should also block Aldo I suppose. But other risks > > as I recall > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2011 Report Share Posted April 26, 2011 Insurance companies typically put up a fight about covering eplerenone, so doctors are sometimes reluctant to prescribe it. > > > > > > > > Progesterone is a spironolactone agonist.I felt that spiro blocked my > > > > body's reception of progesterone.The result was polyps, a lining that > > > > would not shed, and eventually, a D & C.I am on Inspra now.Not sure my > > > > theory is correct. > > > > > > > > Val > > > > > > > > *From:*hyperaldosteronism > > > > [mailto:hyperaldosteronism ] *On Behalf Of > > *Clarence Grim > > > > > > > > Progesterone cream should also block Aldo I suppose. But other risks > > > > as I recall > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2011 Report Share Posted April 26, 2011 She prob has no experience with it. We do here. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension Insurance companies typically put up a fight about covering eplerenone, so doctors are sometimes reluctant to prescribe it. > > > > > > > > Progesterone is a spironolactone agonist.I felt that spiro blocked my > > > > body's reception of progesterone.The result was polyps, a lining that > > > > would not shed, and eventually, a D & C.I am on Inspra now.Not sure my > > > > theory is correct. > > > > > > > > Val > > > > > > > > *From:*hyperaldosteronism > > > > [mailto:hyperaldosteronism ] *On Behalf Of > > *Clarence Grim > > > > > > > > Progesterone cream should also block Aldo I suppose. But other risks > > > > as I recall > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2011 Report Share Posted April 26, 2011 So is there any way spiro can disable progesterone's effect on the uterus? Or, could excess aldosterone suck up all the progesterone and leave none for uterine protection? My progesterone surely got disabled. Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim No Spiro and progesterone occupy the Aldo receptors and don't come lose easily thus blocking Aldo activation Of the Aldo receptor and blocks Aldo action. Thus they are MCBs. On Apr 25, 2011, at 8:05 PM, Valarie wrote: I do not know that spiro prevented reception of progesterone. I also have long-term, horribly treated Lyme disease and uterine polyps are know with Lyme. I haven't had any problem with Inspra except nausea at first. I'm going to try spiro again one of these days and see what happens. BTW, breast pain is common in the last 1/3 of the cycle - the period during which progesterone is at its highest. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2011 Report Share Posted April 26, 2011 So is there any way spiro can disable progesterone's effect on the uterus? Or, could excess aldosterone suck up all the progesterone and leave none for uterine protection? My progesterone surely got disabled. Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim No Spiro and progesterone occupy the Aldo receptors and don't come lose easily thus blocking Aldo activation Of the Aldo receptor and blocks Aldo action. Thus they are MCBs. On Apr 25, 2011, at 8:05 PM, Valarie wrote: I do not know that spiro prevented reception of progesterone. I also have long-term, horribly treated Lyme disease and uterine polyps are know with Lyme. I haven't had any problem with Inspra except nausea at first. I'm going to try spiro again one of these days and see what happens. BTW, breast pain is common in the last 1/3 of the cycle - the period during which progesterone is at its highest. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2011 Report Share Posted April 26, 2011 I don't know the association constants for the MC OR progesterone receptions for Aldo Spiro and progesterone these would be the competing forces of interest.Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension So is there any way spiro can disable progesterone's effect on the uterus? Or, could excess aldosterone suck up all the progesterone and leave none for uterine protection? My progesterone surely got disabled. Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim No Spiro and progesterone occupy the Aldo receptors and don't come lose easily thus blocking Aldo activation Of the Aldo receptor and blocks Aldo action. Thus they are MCBs. On Apr 25, 2011, at 8:05 PM, Valarie wrote: I do not know that spiro prevented reception of progesterone. I also have long-term, horribly treated Lyme disease and uterine polyps are know with Lyme. I haven't had any problem with Inspra except nausea at first. I'm going to try spiro again one of these days and see what happens. BTW, breast pain is common in the last 1/3 of the cycle - the period during which progesterone is at its highest. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 27, 2011 Report Share Posted April 27, 2011 No for the uterine bumps. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension I keep seeing references to Inspra. What is that used to treat? I just had two polyps removed with my ablasion. I wonder if the spiro did that in the 6 months I have been on it? Progesterone is a spironolactone agonist. I felt that spiro blocked my body's reception of progesterone. The result was polyps, a lining that would not shed, and eventually, a D & C. I am on Inspra now. Not sure my theory is correct. Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim Progesterone cream should also block Aldo I suppose. But other risks as I recall Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 27, 2011 Report Share Posted April 27, 2011  That is probably true because I asked if she had anyone on it and I believe she said no.  She prob has no experience with it. We do here. Tiped sad Send form mi iPhone ;-) May your pressure be low! CE Grim MD Specializing in Difficult Hypertension On Apr 26, 2011, at 3:06 PM, msmith_1928 wrote:  Insurance companies typically put up a fight about covering eplerenone, so doctors are sometimes reluctant to prescribe it. > > > > > > > > Progesterone is a spironolactone agonist.I felt that spiro blocked my > > > > body's reception of progesterone.The result was polyps, a lining that > > > > would not shed, and eventually, a D & C.I am on Inspra now.Not sure my > > > > theory is correct. > > > > > > > > Val > > > > > > > > *From:*hyperaldosteronism > > > > [mailto:hyperaldosteronism ] *On Behalf Of > > *Clarence Grim > > > > > > > > Progesterone cream should also block Aldo I suppose. But other risks > > > > as I recall > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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