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Given the limitations in terms of efficacy, especially long term, and safety of the available unspecific symptom-relieving drugs, such as pure analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) [bjordal et al. 2004], there is a growing need for medications that offer acceptable short-term symptom control, but especially have a role in the medium- and long-term symptom management of the disease (symptom-modifying effect), with the possibility of delaying the progression of joint structure changes (structure-modifying effect), thereby modifying the evolution of the disease, and thus preventing clinically significant disease outcomes (disease-modifying effect). 

http://www.medscape.com/viewarticle/765735  A. Simpson, DC | Vice President, Medical DirectorThe CHP Group | Smart Solutions. Healthy Results.

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