thyroid - iodine

[Guest guest]

I realize that taking iodine is

in vogue right now but I would take it only if I had a goiter but otherwise,

no.

Research:

http://lpi.oregonstate.edu/infocenter/minerals/iodine/index.html

Notice

that one says 1100 mcg is the tolerable upper limit.

http://www.inchem.org/documents/pims/pharm/iodine.htm#SectionTitle:2.1%20Main%20risks%20and%20target%20organs

http://www.ncbi.nlm.nih.gov/pubmed/19808851?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=19

http://www.ncbi.nlm.nih.gov/pubmed/19762181?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum & ordinalpos=22

http://www.endocrinetoday.com/comments.aspx?rid=38977

Here's

something I posted last summer:

Below

is some research. I thought it

important to point out that the 50 - 100 mg of iodine being widely advocated is

many, many times the RDA.

Granted,

the RDA may be wrong, but shouldn't people know that alternative opinion does

exist? While I believe that

adequate iodine intake is mandatory, I also believe that excess iodine intake

can be thyroid-damaging.

I

was given iodine when pregnant with my first child 35+ years ago, apparently

without adverse effect and perhaps with positive effect. I did go hyperthyroid (then hypothyroid)

later but have no idea if there was a connection.

Certainly,

women here should be aware that not everything in " Webland "

is accurate and safe. It is also

important to know that anecdotal evidence is not reliable and cannot be

applicable to everyone, or even to anyone.

From

the Linus ing Institute:

http://lpi.oregonstate.edu/infocenter/minerals/iodine/

The

Recommended Dietary Allowance (RDA)

" The

RDA for iodine was reevaluated by the Food and Nutrition Board (FNB) of the

Institute of Medicine in 2001. The recommended amounts were calculated using

several methods, including the measurement of iodine accumulation in the

thyroid glands of individuals with normal thyroid function (6). These

recommendations are in agreement with those of the International Council for

the Control of Iodine Deficiency Disorders, the World Health Organization, and

UNICEF (2). . The recommended amount for adults, 19 years and older, is 150

mcg/d. . The tolerable upper intake level (UL) for iodine for adults, 19 years

and older, is 1,100 mcg/d. . Individuals with iodine deficiency, nodular

goiter, or autoimmune thyroid disease may be sensitive to intake levels

considered safe for the general population and may not be protected by the UL

for iodine intake. . Observational studies have found increased iodine intake

to be associated with an increased incidence of thyroid papillary cancer. The

reasons for this association are not clear. In populations that were previously

iodine deficient, salt iodization programs have resulted in relative increases

in thyroid papillary cancers and relative decreases in thyroid follicular

cancers. In general, thyroid papillary cancers are less aggressive and have a

better prognosis than thyroid follicular cancers (30). "

The

Linus ing Institute has a pretty good discussion

of iodine, with references.

If

one wants to argue that the RDA is too low, certainly, I'd like to see the

arguments, supported with research.

If, in fact, large doses of iodine are safe and effective for people

with autoimmune thyroid disease, I'd like to see the research. So far, I haven't found any.

One

of the Institute's citations used 1.5, 3 and 6 mg iodine/d for relief of breast

pain and fibrosis and found good results with the 3 mg and 6 mg doses. That article called those amounts " supraphysiologic levels. " [PMID: 15239792]

_________________________

Below

are some other article excerpts.

The full abstracts can be found through Pubmed.

J

Clin Endocrinol Metab. 2008 Feb 12

Anti-thyroperoxidase and anti-thyroglobulin

antibodies in a 5-year follow-up survey of populations with different iodine intakes.

Li

Y, et. al. Department of

Endocrinology and Metabolism and the Institute of Endocrinology, First

Affiliated Hospital, China Medical University, No.155 Nanjing Bei St., Heping District,

Shenyang, 110001, China.

Conclusions:

Subjects who were TPOAb and TgAb

positive at baseline developed thyroid dysfunctions more frequently than seronegative subjects. High iodine intake was a risk factor

for developing hypothyroidism in antibody positive subjects. A constant

exposure to excessive iodine intake increased the incidence of positive TgAb.

PMID:

18270254

_______________

Eur J Endocrinol.

2008 Feb;158(2):209-15.

Serum

TSH and serum thyroid peroxidase antibody fluctuate

in parallel and high urinary iodine excretion predicts subsequent thyroid

failure in a 1-year study of patients with untreated subclinical

hypothyroidism.

Karmisholt J, Laurberg P.

CONCLUSION:

At the time of inclusion, it was not possible to identify the 24% of SH

patients who would show deterioration in thyroid function over the following

year. Impairment in thyroid function varied in parallel with thyroid

autoimmunity, whereas high urinary iodine excretion predicted high s-TSH and

s-TPO-Ab 1 month later. PMID: 18230828 _______________

Clin Nephrol. 2008 Feb;69(2):107-13.

Reversible

primary hypothyroidism in Japanese patients undergoing maintenance hemodialysis.

Sanai T, et. al.

Department

of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine,

Saga, Japan.

CONCLUSION:

A high prevalence of reversible primary hypothyroidism was found in end-stage

renal disease patients on hemodialysis. Retention of

excess iodide may be the mechanism responsible for reversible hypothyroidism

rather than immunological perturbations. It is, therefore, recommended to

attempt iodide restriction before starting l-thyroxine

replacement therapy. PMID:

18218304

_______________

World

J Surg. 2008 Feb 28 [Epub ahead of print]

Hashimoto's

Thyroiditis.

Takami HE, Miyabe R, Kameyama K.

Department

of Surgery, Teikyo University School of Medicine,

Tokyo, Japan, takami@....

However,

some goiters seem not to be related to iodine deficiency.

_______________

Nutr Health.

2007;18(4):333-41.

Population

living in the Red Sea State of Sudan may need urgent intervention to correct

the excess dietary iodine intake.

Izzeldin HS, et. al.

Institute

of Brain Chemistry and Human Nutrition, London Metropolitan University.

BACKGROUND:

Both inadequate and high intakes of iodine are associated with thyroid disease

and associated abnormalities. . CONCLUSIONS: . There is an urgent need for a

regulatory mechanism during the process of iodine fortification and at the

point of entry of imported and donated iodized salt as well as the mode of

delivery in order to avoid hyperthyroidism and associated disorders. In

addition, independent professionals should critically evaluate the health

impact of excessive consumption of the nutrient. PMID: 18087865

_______________

J

Endocrinol Invest. 2008 Jan;31(1):29-34.

Transient

congenital hypothyroidism in an iodine-replete area is not related to parental

consanguinity, mode of delivery, goitrogens, iodine

exposure, or thyrotropin receptor autoantibodies.

Ordookhani A, Endocrine

Research Center, Shaheed Beheshti

University of Medical Sciences, Tehran, Iran.

CONCLUSIONS:

Elevated UIC [urinary iodine concentration]was the most frequent finding in

newborns with TCH [transient congenital hypothyroidism]

Val

From:

hyperaldosteronism [mailto:hyperaldosteronism ] On

Behalf Of charlotte zahnd

You should google

that. I believe the opposite as you never see many large Japanese people

9 (at least not in my area). They do eat their fair share of fish and

rice so maybe the EFA’s help them out, genetics, etc. But it

amazing how they keep their weight in check. You very seldom see

overweight Japanese or Chinese people and there is no telling what their salt

intake is. They use a lot of soy sauce and it is loaded.

From: hyperaldosteronism [mailto:hyperaldosteronism ]

On Behalf Of Valarie

I have never taken Iodoral. My research on it

would lead me to believe that iodine may not be good for thyroid – beyond

some minimum level. There is just no good research to take iodine beyond

a normal amount. I believe the Japanese have a much higher incidence of

hypothyroidism because of their ingesting of kelp.

Val

From: hyperaldosteronism [mailto:hyperaldosteronism ]

On Behalf Of charlotte zahnd

Have you ever tried Iodoral for hypo? I had a thyroid of 2.5 when

I went to my endo in 2008

and due to my fatigue he gave me a script for levothyroxin. I filled it but didn’t

take it because he told me if it we not for the fatigue he would have never

wrote the prescription. I began taking a b complex vitamin. It had

300 mg niacin and I think like 25 mg of some of the other b1-b6 vitamins and

the normal folic acid and b12 as most other vitamins, choline, inositol

and paba. That was

the only thing I added to my regime. I went back to him in 4 months and

the thyroid was 1.5. I do not know if the b complex was a factor or not.