Basic fibroblast growth factor promotes nerve regeneration in a C(-)-ion-implant

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Brain Res. 2006 May 3

Basic fibroblast growth factor promotes nerve regeneration in a C(-)-

ion-implanted silicon chamber.

Ikeguchi R, Kakinoki R, Matsumoto T, Yamakawa T, Nakayama K, Morimoto

Y, Tsuji H, Ishikawa J, Nakamura T.

Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto

University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

We reported previously that a silicone tube whose inner surface has

been implanted with negatively charged carbon ions (C(-)) enables a

nerve to regenerate across a 15-mm inter-stump gap. In this study, we

investigated whether a C(-)-ion-implanted tube pretreated with basic

fibroblast growth factor promotes peripheral nerve regeneration. The C(-

)-ion-implanted tube significantly accelerated nerve regeneration, and

this effect was enhanced by basic fibroblast growth factor.