Guest guest Posted October 26, 2006 Report Share Posted October 26, 2006 Here is article about tricothecene mycotoxins symptoms in biological warfare which include burning skin and eyes and many other symptoms we all have experienced. Interestingly experiments done in giving cancer patients tricothecenes to stop growth of tumors! Another reason to stay away from the medical establishment. <http://www.drthrasher.org/Introduction%20to%20Trichothecenes.html> It is suspected that from 1974 to 1981that toxic agents (trichothecenes) were used in Afghanistan, Laos and Cambodia via aerial application ( " yellow rain " ).12,23 Early symptoms in " yellow rain " victims were severe nausea, vomiting, burning superficial skin discomfort, lethargy, weakness, dizziness, and loss of coordination. Within minutes to hours, diarrhea (first watery brown and later grossly bloody) occurred. From 3 to 12 hours symptoms included dyspnea, coughing, sore mouth, bleeding gums, epistaxis, hematemesis, abdominal pain, and central chest pain. Exposed skin could become red, tender, swollen, painful or pruritic. Small or large vesicles and bullae were observed as well as petechiae, ecchymosis and necrosis of the skin. Marked anorexia and dehydration were frequent. Dying individuals became hypothermic, hypotensive and developed tachycardia. Severely poisoned individuals had bloody ooze from the nares and mouth with an associated hematochezia. Death occurred from minutes to hours and days, and often preceded by tremors, seizures and coma. The most frequent symptoms included vomiting (71%), diarrhea (53%), skin irritation, burning and itching (44%), rash or blisters (33%), bleeding (53%) and dyspnea (48%). All of the symptoms listed could be attributed to trichothecene mycotoxin toxicity.12 Both ocular and upper respiratory effects were observed with the " yellow rain " exposure. Ocular signs and symptoms were tearing, pain conjunctivitis and burning sensations about the eyes. These lasted from 8 to 14 days following exposure. Of interest, a trichothecene (DAS) isolated from one autopsy case instilled into the eyes of rabbits produced reddening, edema and cornea opacity.12 Upper respiratory symptoms included the following: nose (itching, pain rhinorrhea, epistaxis); throat (sore/pain, aphona, voice changes); tracheobronchial tree (cough, hemoptysis, dyspnea, deep chest pain, chest pressure). Agricultural workers exposed to hay or hay dust contaminated with trichothecenes also developed similar signs and symptoms of upper respiratory injury.12 Chronic Toxicological Effects: Chronic exposure to trichothecenes cause Alimentary Toxic Aleukia (ATA) in humans, mycotoxicosis in domestic animals, and adverse outcomes in individuals given trichothecenes intravenously as a chemotherapy for colon adenocarcinoma (for review, see Wannemacher & Wiener12). ATA occurred in Russia during and prior to WW II when peasants consumed field grains contaminated with trichothecene mycotoxins infested with Fusarium. The clinical course of the disease occured in four stages.24 Stage one was characterized by inflammation of the G.I. tract mucosa, vomiting, diarrhea, abdominal pain, excessive salivation, headache, dizziness, weakness, fatigue, tachycardia, fever and sweating. Progression occurs to the second stage (also called leukopenic or latent stage). Leukopenia, granulopenia and progressive lymphocytosis characterize this stage. If ingestion of the contaminated grain is not stopped or if a large dose is taken in, the third stage ensues. The third stage is characterized by a bright red or dark cherry-red, petechial rash on the chest and other areas of the body. These are at first localized and then spread, becoming more numerous. In the most severe cases, intensive ulceration and gangrenous conditions develop in the larynx. This can lead to aphonia and death by strangulation. Concomitantly, hemorrhagic diathesis occurs of the nasal, oral, gastric and intestinal mucosa. The fourth stage, (recovery stage), begins when the necrotic lesions of the body beging to heal and the body temperature drops. The affected individuals are susceptible to secondary infections, including pneumonia. Convalescence takes several weeks and the bone marrow approaches normality by two months. Chemotherapy: The trichothecenes inhibit cell division causing cell death. This was used as a basis for chemotherapy drug trial.25-27 Cancer patients were given daily doses (0.077 mg/kg) of DAS (anguidine) for 5 days. They developed signs and symptoms of toxicity which included nausea, vomiting, diarrhea, burning erythema, confusion, ataxia, chills, fever, hypotension and hair loss.26,27 The antitumor activity was either absent or minimal and the drug trials were stopped because of patient intolerance. Quote Link to comment Share on other sites More sharing options...
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