Guest guest Posted October 26, 2006 Report Share Posted October 26, 2006 Next two paragraphs are interesting too regarding tricothecenes and skin, and statement that main organ that metabolizes tricothecenes is liver, so one could get itching and irritation from two sources, from tricothecenes directly and also from liver toxicity indirectly: http://www.drthrasher.org/Introduction%20to%20Trichothecenes.html ### Metabolism of trichothecenes Trichothecenes, unlike other mycotoxins, do not require metabolic activation to exert their toxic effects.28 Direct dermal application leads to immediate skin irritation. They directly act with cellular organelles and structures causing inhibition of protein, RNA and DNA synthesis, disaggregation of polyribosomes and rough endoplasmic reticulum, inhibition of mitochondrial functions and cause cell death (apoptosis).13-22,24,28-31 Tricothecenes are lipophilic and are easily absorbed through the skin, respiratory and intestinal tracts. A single oral dose peaks in the blood at one hour. Inhaled median lethal dose is equal to or less than a systemic dose. Death in rodents and guinea pigs occurs in 1 to 12 hours following inhalation of lethal aerosol concentrations without pulmonary edema.24 Tissue distribution studies show that liver is the major organ of metabolism of trichothecenes. Radioactivity from labeled mycotoxins following different routes of administration (oral, IM, IV, dermal) appear in the bile, liver, and gastrointestinal tract with metabolites and glucuronide conjugates appearing in the urine and feces.32,33 Trichothecenes are metabolized via deacetylation and de-expoxidation (hyrdrolysis). --- barb1283 <barb1283@...> wrote: > Here is article about tricothecene mycotoxins > symptoms in biological > warfare which include burning skin and eyes and Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 26, 2006 Report Share Posted October 26, 2006 For all the people who are living with situations like this, w.r.t. burning eyes, etc. If winter weather starts and you cannot get it cleaned out.. (say you rent) and find like we did that HEPA filtration does not remove all of the poison.. just the bigger pieces.. and no VOCs - even if it gets freezing cold YOU HAVE TO DILUTE IT DOWN WITH FRESH AIR, and if that means leaving the windows open and being very cold, that is BETTER BY FAR than the alternative which is breathing and absorbing more of that stuff. Quote Link to comment Share on other sites More sharing options...
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