Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 Does anyone here have any experience of using xylitol (especially with a view to controlling strep)? >>>You need to make sure its not Xylitol from corn which the cheaper brands are, I have used the nasal spray with good effect but have no idea if I have strep. It is in Amy Yasko's list of recommneded things for strep Mandi x Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 HI Tim I know that its recommended by Yasko, Theresa has some info I remember form Yasko Europe. You can buy a Nasal Spray and toothpaste containing Xylitol and a mouthwash. I think they are aclled something like x-clear or soemthing like that. I wonder if its maybe because often streps exist in biofilms like on your teeth gunk stuff like that, if xylitol is used in toothpaste and stuff and somehow mucks them up, you are probably reducing the amount in those reservoirs... not terribly scientific but heh its my bedtime now!! I didnt see Dr U's presntation with this bit but I dont reckon she was suggesting you consume xylitol (could be wrong!) but I do know about these products being recommended.. HTH Luv Caroline xxx PS I bought the toothpaste at our pharmacy, was very expensive probably cheaper from Cenaverde or somewhere... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 2007/2/18, Sandy and Tim S.I.Woolley@...: Does anyone here have any experience of using xylitol (especiallywith a view to controlling strep)? thanks Tim And dosage - protocol ?? Geir Flatabø DISCLAIMERNo information contained in this post is to be construed as medical advice. If you need medical advice, please seek it from a suitably qualified practitioner. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 Hey There, Here is my understanding of the full strep protocol a la Yasko: • ImmuneFactor 5 – ½ capsule daily or every other day, especially if you are NOS+ • Microbial Support RNA – 3-4 drops once a day and then work up to ½ dropper if no reaction • Caprylic acid -- ½-1 per day (can cause a reaction in many) • Lactoferrin – ½-1 per day at night time • Xylitol toothpaste, mouthwash and sugar • Papaya enzyme and Vitamin C until bowel tolerance • Gut herbs: Some people rotate the gut herbs daily, others give a mix of all of them once they know they are tolerated. Dosing for herbs - 1/4-1/2 capsule 1- 3 x a day work up to 1 capsule as tolerated, or cut back to a sprinkle to too much. These include: o Neem (this one tastes unbearably bitter, so my approach to this for kids who don't swallow pills is that if you don't want to do it and something else shows up on the sensitivity testing, don't do it) o Myrrh o Oregon grape o Golden seal o Cranberry o Oregano o Uva ursi – same dosing, but do 2 weeks on and 2 weeks off for this herb • For OCD behaviour: o Benfotiamine – ¼ - ½ per day o Nerve Calm RNA – 2-4 drops 2x daily o Behavior RNA -- 2-4 drops 2x daily It's good to start with sprinkles and work up. There is a xylitol and lactoferrin/lysozyme toothpaste available in the UK -- Biotene. They have a product for babies called First Teeth that has no flouride in it. Spry Toothpaste has xylitol in it and is an excellent choice as well. Cenaverde int he Netherlands carries Spry nasal spray (Xlear), toothpaste, gum and xylitol sugar (they had a booth at the TA conference, I believe). Maybe Mandi carries some Spry stuff as well? Love the xylitol and have used it for some time with Lulu. Xylitol in VERY high doses in IVs (FAR more than these products give you) has been known to raise urinary oxalates. Hugs, > > HI Tim > > I know that its recommended by Yasko, Theresa has some info I remember form > Yasko Europe. You can buy a Nasal Spray and toothpaste containing Xylitol and > a mouthwash. I think they are aclled something like x-clear or soemthing like > that. > > I wonder if its maybe because often streps exist in biofilms like on your > teeth gunk stuff like that, if xylitol is used in toothpaste and stuff and > somehow mucks them up, you are probably reducing the amount in those > reservoirs... not terribly scientific but heh its my bedtime now!! > > I didnt see Dr U's presntation with this bit but I dont reckon she was > suggesting you consume xylitol (could be wrong!) but I do know about these > products being recommended.. > > HTH Luv > Caroline > xxx > > PS I bought the toothpaste at our pharmacy, was very expensive probably > cheaper from Cenaverde or somewhere... > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 I've seen a lot of reference to strep throat which is probably what the toothpaste, gum and nasal spray are aimed at. We're more interested in the other end at the moment so I'd expect to be consuming it. Not at all sure if this is the same type of strep with the same sensitivities, etc. (but we think it is). thanks Tim > > HI Tim > > I know that its recommended by Yasko, Theresa has some info I remember form > Yasko Europe. You can buy a Nasal Spray and toothpaste containing Xylitol and > a mouthwash. I think they are aclled something like x-clear or soemthing like > that. > > I wonder if its maybe because often streps exist in biofilms like on your > teeth gunk stuff like that, if xylitol is used in toothpaste and stuff and > somehow mucks them up, you are probably reducing the amount in those > reservoirs... not terribly scientific but heh its my bedtime now!! > > I didnt see Dr U's presntation with this bit but I dont reckon she was > suggesting you consume xylitol (could be wrong!) but I do know about these > products being recommended.. > > HTH Luv > Caroline > xxx > > PS I bought the toothpaste at our pharmacy, was very expensive probably > cheaper from Cenaverde or somewhere... > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 Thanks for the extensive info. We've been looking at Yasko for a while but haven't really got to stage one yet. We have, however, tried (and are trying) lots of stuff on the list so hopefully we'll get on top of this one before too long! Do you know if there are there any dosage recommendations for the xylitol 'sugar'? Tim > > > > HI Tim > > > > I know that its recommended by Yasko, Theresa has some info I > remember form > > Yasko Europe. You can buy a Nasal Spray and toothpaste containing > Xylitol and > > a mouthwash. I think they are aclled something like x-clear or > soemthing like > > that. > > > > I wonder if its maybe because often streps exist in biofilms like > on your > > teeth gunk stuff like that, if xylitol is used in toothpaste and > stuff and > > somehow mucks them up, you are probably reducing the amount in > those > > reservoirs... not terribly scientific but heh its my bedtime now!! > > > > I didnt see Dr U's presntation with this bit but I dont reckon she > was > > suggesting you consume xylitol (could be wrong!) but I do know > about these > > products being recommended.. > > > > HTH Luv > > Caroline > > xxx > > > > PS I bought the toothpaste at our pharmacy, was very expensive > probably > > cheaper from Cenaverde or somewhere... > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 Hi, i know this to be a fact that using xylitol can increase urinary oxalates, cos this happened with our ds, so is something you need to be aware of if using alot of this product. We were only using small amounts regularly in drinks and xylitol gum and this caused us problems. Having said that xylitol gum (and i expect toothpaste and mouthwash) was brilliant at keeping ds teeth clean. Killing off all the nasty bacteria in his mouth - so is entirely possible IMO that it would also help control Strep. Nikki > Love the xylitol and have used it for some time with Lulu. Xylitol in > VERY high doses in IVs (FAR more than these products give you) has > been known to raise urinary oxalates. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 Yes, apart from creating oxalate problems in those who are prone, there is reason to believe that xylitol may be problematic for kids who do not tolerate calcium supplements, as it greatly increases calcium absorbtion (as do other complex sugars and polyol sweeteners). Natasa > > > Hi, > > i know this to be a fact that using xylitol can increase urinary > oxalates, cos this happened with our ds, so is something you need to be > aware of if using alot of this product. We were only using small > amounts regularly in drinks and xylitol gum and this caused us problems. > > Having said that xylitol gum (and i expect toothpaste and mouthwash) > was brilliant at keeping ds teeth clean. Killing off all the nasty > bacteria in his mouth - so is entirely possible IMO that it would also > help control Strep. > > Nikki > > > > > > > > > Love the xylitol and have used it for some time with Lulu. Xylitol in > > VERY high doses in IVs (FAR more than these products give you) has > > been known to raise urinary oxalates. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 Wow, thanks, Natasa, we can't get enough calcium into her...wondering how we could introduce some xylitol, maybe in gum. Honest I would never do IV's but if we were calcium would be the first out of the block. Re: Xylitol for Strep Yes, apart from creating oxalate problems in those who are prone, thereis reason to believe that xylitol may be problematic for kids who do nottolerate calcium supplements, as it greatly increases calcium absorbtion(as do other complex sugars and polyol sweeteners).Natasa>>> Hi,>> i know this to be a fact that using xylitol can increase urinary> oxalates, cos this happened with our ds, so is something you need tobe> aware of if using alot of this product. We were only using small> amounts regularly in drinks and xylitol gum and this caused usproblems.>> Having said that xylitol gum (and i expect toothpaste and mouthwash)> was brilliant at keeping ds teeth clean. Killing off all the nasty> bacteria in his mouth - so is entirely possible IMO that it would also> help control Strep.>> Nikki>>>>>>>> > Love the xylitol and have used it for some time with Lulu. Xylitolin> > VERY high doses in IVs (FAR more than these products give you) has> > been known to raise urinary oxalates.> >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 , the essential sugar that xylitol is derived from, xylose, also increases calcium absorbtion (also good for candida and bacteria). It's available in supplements but also in Guava, Pears, Blackberries, Loganberries, Raspberries, Aloe Vera gel, Kelp, Echinacea, Boswellia, Psyllium, Broccoli, Spinach, Eggplant, Peas, Green Beans, Okra, Cabbage, Corn. http://www.innvista.com/health/nutrition/essensug/xylose.htm take care Rene > > Wow, thanks, Natasa, we can't get enough calcium into her...wondering how we could introduce some xylitol, maybe in gum. Honest I would never do IV's but if we were calcium would be the first out of the block. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 The xylitol was like a big 'fix' for my daughter! She used the gum- thought from what I read that it would be good for dental health. She just could not get enough of the stuff, became very irritable, nasty etc. As it is high in oxalates, that may have been part of the problem. I always get suspicious when food products cause addictive type behaviors and this one did. > > > > Wow, thanks, Natasa, we can't get enough calcium into > her...wondering how we could introduce some xylitol, maybe in gum. > Honest I would never do IV's but if we were calcium would be the > first out of the block. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2007 Report Share Posted February 18, 2007 My daughter has persistent infection in her gums that I can't get rid of or even get under proper control although she eats a very low-sugar diet and I clean her teeth a lot. Would Xylitol help with this? Is there any wider connection to her guts because it is one of the obvious odd things about her xx Sally CarolineTraa@... wrote: HI Tim I know that its recommended by Yasko, Theresa has some info I remember form Yasko Europe. You can buy a Nasal Spray and toothpaste containing Xylitol and a mouthwash. I think they are aclled something like x-clear or soemthing like that. I wonder if its maybe because often streps exist in biofilms like on your teeth gunk stuff like that, if xylitol is used in toothpaste and stuff and somehow mucks them up, you are probably reducing the amount in those reservoirs.. . not terribly scientific but heh its my bedtime now!! I didnt see Dr U's presntation with this bit but I dont reckon she was suggesting you consume xylitol (could be wrong!) but I do know about these products being recommended. . HTH Luv Caroline xxx PS I bought the toothpaste at our pharmacy, was very expensive probably cheaper from Cenaverde or somewhere... No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.441 / Virus Database: 268.18.1/690 - Release Date: 16/02/2007 14:25 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2007 Report Share Posted February 19, 2007 Hey Sally, Barring what has been said about the calcium and oxalates issue -- this is very interesting, Natasa -- the xylitol will help with breaking up various bacterial biofilms in the mouth, etc. However, the Biotene toothpaste and maybe even the mouthwash (I don't know) also has lactoferrin and lysozyme, both of which are very abundant in human breast milk and are there in the milk to keep iron away from bacteria and make it available to the body for use -- they are human iron binding proteins. I would suggest the Biotene, and I would really suggest trying some lactoferrin mixed in something like rice milk. We give Lulu 1 capsule of lactoferrin every night with some rice milk before going to bed, as well as 1/16th of a teaspoon of the xylitol sugar. This has been really great for the strep in her gut. Lactoferrin is a truly amazing protein -- helps with bone resorption, immune stimulation, it's an anti-inflammatory, anti-microbial, antiviral and of course is the best way to keep the iron away from the bacteria, helps with both anemia and high iron conditions -- I can't say enough good things about lactoferrin. I have read maybe 30 articles on it and there are whole books written and it's really amazing how crucial it is -- why it is comprises 20% of the protein in human breast milk. See some sources on this below. Amazing! Hugs, Theresa Interesting articles and books on lactoferrin at BioInfo - http://lib.bioinfo.pl/meid:18045 and http://www.amazon.com/s/104- 8507128-8259949?ie=UTF8 & tag2=bioinfobank- 20 & keywords=lactoferrin & search-type=ss & index=books Check out the table of contents in some of these books – very interesting. Try this one, for example, published in 1998 - http://www.amazon.com/gp/reader/0306459264/ref=sib_dp_pop_toc/104- 8507128-8259949?ie=UTF8 & p=S00D#reader-link -- It seems that Lactoferrin is involved in a great number of issues – antibacterial activity, antiviral activity, antiyeast activity, iron regulatory protein activity, lipid metabolism enhancement (LDL), immune enhancement, IL6 interaction, antibodies against lactoferrin in neurological disorders, etc. Or this one, published in 2000 – http://www.elsevier.com/wps/find/bookdescription.cws_home/620805/descr iption - antiinflammation, immunomodulating effects, antimicrobial activity, antitumor activity, prevention of preterm delivery, hepatitis C virus viremia inhibition, iron absorption. Wow, do I want this book… Or this one published in 1997 - http://www.amazon.com/gp/reader/089603366X/ref=sib_dp_pt/104-8507128- 8259949#reader-link Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2007 Report Share Posted February 19, 2007 Hi Could you tell me what flavour the Spry toothpaste is? Is it minty? Thanks Kay. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2007 Report Share Posted February 19, 2007 Dear Theresa, thank you. I will do all that. Thank you for writing me such a good explanation xx Sally tltbaku wrote: Hey Sally, Barring what has been said about the calcium and oxalates issue -- this is very interesting, Natasa -- the xylitol will help with breaking up various bacterial biofilms in the mouth, etc. However, the Biotene toothpaste and maybe even the mouthwash (I don't know) also has lactoferrin and lysozyme, both of which are very abundant in human breast milk and are there in the milk to keep iron away from bacteria and make it available to the body for use -- they are human iron binding proteins. I would suggest the Biotene, and I would really suggest trying some lactoferrin mixed in something like rice milk. We give Lulu 1 capsule of lactoferrin every night with some rice milk before going to bed, as well as 1/16th of a teaspoon of the xylitol sugar. This has been really great for the strep in her gut. Lactoferrin is a truly amazing protein -- helps with bone resorption, immune stimulation, it's an anti-inflammatory, anti-microbial, antiviral and of course is the best way to keep the iron away from the bacteria, helps with both anemia and high iron conditions -- I can't say enough good things about lactoferrin. I have read maybe 30 articles on it and there are whole books written and it's really amazing how crucial it is -- why it is comprises 20% of the protein in human breast milk. See some sources on this below. Amazing! Hugs, Theresa Interesting articles and books on lactoferrin at BioInfo - http://lib.bioinfo. pl/meid:18045 and http://www.amazon. com/s/104- 8507128-8259949? ie=UTF8 & tag2= bioinfobank- 20 & keywords= lactoferrin & search-type= ss & index= books Check out the table of contents in some of these books – very interesting. Try this one, for example, published in 1998 - http://www.amazon. com/gp/reader/ 0306459264/ ref=sib_dp_ pop_toc/104- 8507128-8259949? ie=UTF8 & p= S00D#reader- link -- It seems that Lactoferrin is involved in a great number of issues – antibacterial activity, antiviral activity, antiyeast activity, iron regulatory protein activity, lipid metabolism enhancement (LDL), immune enhancement, IL6 interaction, antibodies against lactoferrin in neurological disorders, etc. Or this one, published in 2000 – http://www.elsevier ..com/wps/ find/bookdescrip tion.cws_ home/620805/ descr iption - antiinflammation, immunomodulating effects, antimicrobial activity, antitumor activity, prevention of preterm delivery, hepatitis C virus viremia inhibition, iron absorption. Wow, do I want this book… Or this one published in 1997 - http://www.amazon. com/gp/reader/ 089603366X/ ref=sib_dp_ pt/104-8507128- 8259949#reader- link No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.441 / Virus Database: 268.18.2/692 - Release Date: 18/02/2007 16:35 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2007 Report Share Posted February 19, 2007 I doubt that it is 'high' in oxalate itself, it is a case of highten absorbtion and production in the body.... Seriously, there are cases in literature where highter doses caused severe hyperoxaluria (spell?) and brain inflammation. Natasa > > > > > > Wow, thanks, Natasa, we can't get enough calcium into > > her...wondering how we could introduce some xylitol, maybe in gum. > > Honest I would never do IV's but if we were calcium would be the > > first out of the block. > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2007 Report Share Posted February 19, 2007 Rene, Thanks, she gets plenty of most of these fruits and vegetables with the exception of cabbage and okra. Re: Xylitol for Strep , the essential sugar that xylitol is derived from, xylose, also increases calcium absorbtion (also good for candida and bacteria). It's available in supplements but also in Guava, Pears, Blackberries, Loganberries, Raspberries, Aloe Vera gel, Kelp, Echinacea, Boswellia, Psyllium, Broccoli, Spinach, Eggplant, Peas, Green Beans, Okra, Cabbage, Corn. http://www.innvista.com/health/nutrition/essensug/xylose.htmtake careRene>> Wow, thanks, Natasa, we can't get enough calcium into her...wondering how we could introduce some xylitol, maybe in gum. Honest I would never do IV's but if we were calcium would be the first out of the block. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2007 Report Share Posted February 19, 2007 Yes, Natasa, but I've always wondered if that is dose-dependent, given that these were given in high doses via IV and were I think also given in cases where there already renal issues involved. So I wonder what the mechanism is here, given that this is a sugar and thus will work on those pathways. I think that's interesting to look into further, especially in relation to the calcium stuff. Can we maybe take a look at the literature on this one? I think I have some abstracts womewhere in my mass of emails. I would like to do this, but have to run to pick up Lulu and run some errands, so won't get to it today, probably. Hugs, Theresa > > > > > > > > Wow, thanks, Natasa, we can't get enough calcium into > > > her...wondering how we could introduce some xylitol, maybe in gum. > > > Honest I would never do IV's but if we were calcium would be the > > > first out of the block. > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2007 Report Share Posted February 19, 2007 Of course, it wasn't my intention to imply that any amound (and way of administration) of xylitol would lead to brain inflammation, but to raise awareness of the issue for people with oxalate issues, or suspected dietary calcium/oxalate related problems.. I never saved those specific abstracts, but here are some of the ones I have, lots of food for thought: J Nutr. 2004 Aug;134(8):1935-41. Various nondigestible saccharides open a paracellular calcium transport pathway with the induction of intracellular calcium signaling in human intestinal Caco-2 cells. * Suzuki T, * Hara H. Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan. Ingestion of soluble nondigestible saccharides increases calcium absorption, and it is suggested that paracellular calcium transport contributes to this effect. However, cellular mechanisms and the contribution of active transport have not been clarified. This study examined the effects of 4 nondigestible saccharides, difructose anhydride (DFA) III, DFAIV, fructooligosaccharides, and raffinose, on active and passive calcium transport, permeability of paracellular pathways, and intracellular calcium signaling in a human intestinal Caco-2 cell monolayer. Net, active, and passive calcium transport were evaluated using (45)Ca. Transepithelial electrical resistance (TEER) and transport of lucifer yellow were measured as indicators of paracellular passage in differentiated Caco-2 cell monolayers incubated with 0-100 mmol/L of the various saccharides. The changes in intracellular calcium ion concentrations ([Ca(2+)](i)) were measured by fura-2 loading before and after the addition of each saccharide (50 or 100 mmol/L). The addition of 100 mmol/L of each saccharide to the apical medium of the Caco-2 cells enhanced net calcium transport without any changes in active calcium transport. Relative TEER was dose dependently and reversibly decreased by the addition of saccharides, and the decreases in TEER were highly correlated with net calcium transport (P < 0.001). Basolateral application of the saccharides had a slight or no effect on indicators of the paracellular pathway. Each saccharide caused an immediate and dose-dependent rise in [Ca(2+)](i) in the cells. The 4 nondigestible saccharides increased net calcium transport in the cells via the paracellular route through tight junctions. The rise in [Ca(2+)](i) induced by these saccharides may be involved in the opening of tight junctions. PMID: 15284379 [PubMed - indexed for MEDLINE] Dig Dis Sci. 2004 Jan;49(1):122-32. Indigestible disaccharides open tight junctions and enhance net calcium, magnesium, and zinc absorption in isolated rat small and large intestinal epithelium. * Mineo H, Northern Advancement Center for Science and Technology, Colabo-Hokkaido, Sapporo 001-0021, Japan. The effects of three indigestible disaccharides on net calcium (Ca), magnesium (Mg), and zinc (Zn) transport in isolated rat jejunal, ileal, cecal, and colonic epithelium were determined. Permeability of fluorescein isothiocynate-dextran-4 (FD4) and transepithelial electrical resistance (TEER), which vary according to tight junction (TJ) activity in the intestinal mucosa, were also determined. The addition of 1-100 mM melibiose, difructose anhydride (DFA) III, or DFA IV to the mucosal medium increased the net absorption of the three minerals and FD4 permeability, while decreasing TEER dose dependently in the four intestinal portions. Positive linear relations were found between the net transport of the three minerals and FD4 passage in all portions of the intestine, whereas negative linear relations were observed between net absorption of the three minerals and TEER. We concluded that the three indigestible saccharides directly affect the epithelial tissue and open TJs, thereby promoting Ca, Mg, and Zn absorption in the small and large intestine in vitro. PMID: 14992446 [PubMed - indexed for MEDLINE] J Ocul Pharmacol Ther. 1995 Winter;11(4):527-31. Inhibition of polyol formation in rat lens by verapamil. * Devamanoharan PS, * Varma SD. Department of Opthalmology, University of land at Baltimore, USA. Accumulation of sorbitol and xylitol in rat lenses incubated in medium-199 with and without verapamil has been studied. This antihypertensive drug, known to attenuate hypertension by its calcium channel blocking effect, is also known to inhibit cataract formation in diabetes. The present studies have demonstrated that verapamil's effect against cataract could also be partially related to its aldose reductase inhibitory activity, in addition to the Ca++ channel blocking activity. The accumulation of sorbitol in the lenses incubated with high glucose in the presence of 400 microM verapamil was only 2.3 mmoles/Kg wet weight against 11.3 mmoles/Kg in its absence. The level of xylitol attained in the presence of 10 mM xylose was 25.7 +/- 2.4 mmoles/Kg. It decreased to 4.8 +/- 1.2 mmoles/Kg in presence of 400 microM verapamil. Hence, verapamil is significantly effective in inhibiting lens aldose reductase dependent polyol synthesis, an action simultaneous with its effect on calcium penetration. PMID: 8574816 [PubMed - indexed for MEDLINE] Dig Dis Sci. 2002 Jun;47(6):1326-33. Related Articles, Links Click here to read Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro. Mineo H, Hara H, Tomita F. Hokkaido Foundation for the Promotion of Scientific and Industrial Technology, Colabo-Hokkaido, Sapporo, Japan. We compared the effect of a variety of sugar alcohols on calcium absorption from the rat small and large intestine in vitro. An Ussing chamber technique was used to determine the net transport of Ca across the epithelium isolated from the jejunum, ileum, cecum, and colon of rats. The concentration of Ca in the serosal and mucosal Tris buffer solution was 1.25 mM and 10 mM, respectively. The Ca concentration in the serosal medium was determined after incubation for 30 min and the net Ca absorption was evaluated. The addition of 0.1-200 mM erythritol, xylitol, sorbitol, maltitol, palatinit, or lactitol to the mucosal medium affected net Ca absorption in the intestinal preparations. Differences in Ca transport were observed between portions of the intestine, but not between sugar alcohols tested. We concluded that sugar alcohols directly affect the epithelial tissue and promote Ca absorption from the small and large intestine in vitro. PMID: 12064809 [PubMed - indexed for MEDLINE] Int J Legal Med. 2004 Apr;118(2):98-100. Epub 2003 Nov 22. Related Articles, Links Click here to read Fatal cerebro-renal oxalosis after appendectomy. Pfeiffer H, Weiss FU, Karger B, Aghdassi A, Lerch MM, Brinkmann B. Institute of Legal Medicine, Rontgenstrasse 23, 48149 Muenster, Germany. pfeiffh@... A case of a 24-year-old male with fatal cerebro-renal oxalosis assumed to be due to infusions of the sugar surrogate xylitol after appendectomy is reported. The diagnosis was established only after intensive histological investigations following the autopsy. The clinical picture was characterized by an acute seizure, coma and renal failure 2 days after the first xylitol infusion. Death occurred due to cerebral dysregulation as a very rare complication after parenteral administration of xylitol. Subendothelial double refractive calcium oxalate crystals were found in the walls of cerebral blood vessels, in particular in the stem ganglion regions and in the cortical renal tubules. The most common type of primary oxalosis was excluded by sequencing analysis. The young age, the minor surgical intervention and the otherwise unremarkable history are special features of this case. Since the genetic background of xylitol intolerance is still unclear, it is suggested that it should be banned as a sugar surrogate in clinical practice. Publication Types: * Case Reports PMID: 14634832 [PubMed - indexed for MEDLINE] 3: Int J Food Sci Nutr. 2000 Jan;51(1):45-54. Related Articles, Links Investigation of an in vitro model for predicting the effect of food components on calcium availability from meals. Kennefick S, Cashman KD. Department of Nutrition, University College, Cork, Ireland. The availability of calcium from semi-synthetic meals and model food systems was studied by an in vitro method using equilibrium dialysis after simulating gastric digestion. Twelve different food components (phytate, oxalate, wheat fibre- and barley fibre-extract, D-sorbitol, xylitol, galactitol, casein, three different casein phosphopeptide preparations, and lactose) were added to the semi-synthetic meal and their effect on the relative index of availability of 45Ca was studied. Phytate, oxalate, wheat fibre-extract and barley fibre-extract, and, surprisingly, casein had a negative effect on availability of calcium. The most pronounced effect was observed for the addition of phytate. The other dietary factors had no effect on calcium availability. Therefore, this rapid and inexpensive in vitro model could be a useful screening method for factors affecting calcium absorption, especially inhibitory factors, in future human calcium bioavailability studies. PMID: 10746104 [PubMed - indexed for MEDLINE] 4: Arch Oral Biol. 1995 Dec;40(12):1137-41. Related Articles, Links Click here to read Effects of xylitol and carbohydrate diets on dental caries, dentine formation and mineralization in young rats. Hietala EL, Larmas M. Institute of Dentistry, University of Oulu, Finland. Female Wistar rats were weaned at the age of 3 weeks and fed for 7 weeks either a high-sucrose diet, a non-cariogenic raw potato-starch diet, a high-sucrose diet with 5% xylitol supplement, a raw potato-starch diet with 5% xylitol supplement or a non-cariogenic, commercial, powdered rat food (Ewos R3) for reference. A low xylitol concentration reduced the progression and severity of carious lesions but did not affect dentine apposition or the width of predentine in rats fed high-carbohydrate diets. Widening of the predentine zone in rats fed a high-sucrose diet might reflect disturbed mineralization, which could not be explained by serum ionized calcium or phosphate ion levels and which could not be corrected by low xylitol concentrations. It is concluded that the reduced area of dentinal carious lesions after low xylitol supplementation is not dependent on dentine formation or mineralization, but rather on direct effects in the mouth. PMID: 8850653 [PubMed - indexed for MEDLINE] 5: Calcif Tissue Int. 1995 Mar;56(3):232-5. Related Articles, Links Diminished bone resorption in rats after oral xylitol administration: a dose-response study. Mattila P, Svanberg M, Knuuttila M. Institute of Dentistry, University of Oulu, Finland. The effects of 5, 10, and 20% dietary xylitol supplementations on the resorption of bone were studied. The resorption was measured by the urinary excretion of [3H] radioactivity from [3H]tetracycline-prelabeled rats. The 10 and 20% oral xylitol administrations caused a significant decrease in the excretion of [3H] as compared with the control group with no xylitol supplementation. The effect was detected as early as 2 days after the beginning of xylitol-feeding and was maintained throughout the experimental period of 31 days. The retarding effect on bone resorption was about 25% in the 10% xylitol group, about 40% in the 20% xylitol group, and undetectable in the 5% xylitol group. The amount of preserved [3H] radioactivity in the tibiae of the 10 and 20% xylitol groups after the experiment clearly exceeded the values of the control group. The mechanism of the retarded bone resorption caused by dietary xylitol still remains obscure, but an increased absorption of calcium may be involved. In conclusion, dietary xylitol supplementation in rats seems to retard the bone resorption in a dose-dependent way. The effect is achieved rapidly and is maintained at least over a period of 1 month xylitol feeding. PMID: 7750030 [PubMed - indexed for MEDLINE] 6: J Nutr. 1994 Jun;124(6):874-81. Related Articles, Links Bone repair in calcium-deficient rats: comparison of xylitol+calcium carbonate with calcium carbonate, calcium lactate and calcium citrate on the repletion of calcium. Hamalainen MM. Institute of Dentistry, University of Turku, Finland. The potential value of xylitol in calcium therapy was evaluated by comparing the effect of dietary xylitol (50 g/kg diet) + calcium carbonate with the effects of calcium carbonate, calcium lactate and calcium citrate on bone repair of young male rats after the rats consumed for 3 wk a calcium-deficient diet (0.2 g Ca/kg diet). After this calcium-depletion period, the rats were fed for 2 wk one of four diets, each containing 5 g Ca/kg diet as one of the four dietary calcium sources. The diet of the control animals was supplemented with CaCO3 (5 g Ca/kg diet) throughout the study. The Ca-deficient rats showed low bone mass, low serum calcium and high serum 1,25-dihydroxycholecalciferol, parathyroid hormone (1-34 fraction) and osteocalcin concentrations. They also excreted magnesium, phosphate and hydroxyproline in the urine in high concentrations, and had high bone alkaline phosphatase and tartrate-resistant acid phosphatase activities. Most of these changes were reversed by the administered of the calcium salts. The highest recoveries of femoral dry weight, calcium, magnesium and phosphate were observed in the groups receiving xylitol+CaCO3 and calcium lactate. Calcium lactate and calcium citrate caused low serum phosphate concentration compared with rats receiving CaCO3 and with the age-matched Ca-replete controls. Xylitol-treated rats excreted more calcium and magnesium in urine than did the other rats, probably due to increased absorption of these minerals from the gut. These results suggest that dietary xylitol improves the bioavailability of calcium salts. PMID: 8207545 [PubMed - indexed for MEDLINE] 7: Miner Electrolyte Metab. 1994;20(3):153-7. Related Articles, Links Dietary xylitol retards bone resorption in rats. Svanberg M, Knuuttila M. Institute of Dentistry, University of Oulu, Finland. Dietary xylitol has previously been found to promote the content of calcium and minerals of the bone during rehabilitation following dietary calcium deficiency and during a normocalcemic diet in rats. This in vivo experiment was performed in order to study whether a short-term dietary xylitol supplementation affects bone resorption and calcium incorporation into bone during two different experiments utilizing either calcium-deficient or normocalcemic diets. Xylitol reduced bone resorption measured by the urinary excretion of 3H radioactivity both during calcium-deficient and normocalcemic diets. However xylitol reduced vitamin D levels only during calcium deficiency, indicating that the decreased bone dissolution was not associated with changes in 1,25(OH)2D3 concentration alone. Dietary xylitol did not alter 45Ca incorporation into bone, although this does not exclude the possibility that xylitol may have caused alterations in bone apposition. These results suggest that a short-term xylitol ingestion retards bone resorption in the rat. PMID: 7816005 [PubMed - indexed for MEDLINE] 8: J Nutr. 1993 Dec;123(12):2186-94. Related Articles, Links Intestinal calcium absorption in rats is stimulated by dietary lactulose and other resistant sugars. Brommage R, Binacua C, Antille S, AL. Nestle Research Centre, Vers-chez-les-Blanc, Lausanne, Switzerland. Lactulose is a disaccharide analogue of lactose that is resistant to metabolism in the small intestine but not in the large intestine. The effects of lactulose and other sugars on intestinal Ca absorption were determined from the decrease in the 47Ca:47 Sc ratio between diet and feces after feeding male rats diets containing these sugars during a single night. Dietary lactulose was more potent than lactose in stimulating Ca absorption and was effective between 5 and 38 wk of age. The component sugars of lactulose, galactose and fructose, did not influence Ca absorption when provided together at concentrations equimolar to that of lactulose. The stimulation of Ca absorption by dietary lactulose increased as dietary Ca concentration was raised and was not influenced by prior injections of calcitriol. Lactulose must be present in the same meal as Ca to stimulate Ca absorption, but this stimulation was lost if the rats were fed lactulose continuously for 2 or 7 d prior to the test diet. Other sugars thought to be poorly absorbed in the small intestine (xylitol, lactobionate, arabinose, raffinose, pyroglutamate, sorbitol, gluconate and raftilose) stimulated Ca absorption to an identical extent as lactulose. Cecectomy did not influence the enhancement of Ca absorption by lactulose. These results indicate that sugars resistant to metabolism and absorption in the small intestine but not the large intestine stimulate Ca absorption in the small intestine. PMID: 8263614 [PubMed - indexed for MEDLINE] 9: Miner Electrolyte Metab. 1993;19(2):103-8. Related Articles, Links Citric acid concentration compared to serum parathyroid hormone, 1,25(OH)2D3 and calcitonin during dietary Ca deficiency and rehabilitation enhanced with xylitol in rats. Svanberg M, Knuuttila M, Hamalainen M. Institute of Dentistry, University of Oulu, Finland. Young male Wistar rats were fed on a Ca-deficient diet for 3 weeks, after which dietary Ca was restored with either CaCO3 or CaCO3 + xylitol (5% per weight). Citric acid, Ca, Mg, Zn and P were determined in the tibia and femur at the beginning and after 2 and 4 weeks of rehabilitation, and serum and urinary citric acid and serum 1,25(OH)2D3, parathyroid hormone (PTH) and calcitonin were measured at the same points in time. The diminished bone Ca (p < 0.001) after 3 weeks of deficiency did not reduce the bone citric acid concentration, although serum citrate increased markedly. Simultaneously the serum 1,25(OH)2D3 concentration more than doubled and PTH increased (p < 0.01). Rehabilitation with CaCO3 + xylitol reduced the 1,25(OH)2D3 concentration to below the control level (p < 0.05), while serum citric acid remained elevated. CaCO3 alone normalized the elevated hormone and citric acid levels in the serum. Dietary CaCO3 and CaCO3 + xylitol normalized the PTH concentration equally well. The gain in bone Ca after 4 weeks of rehabilitation was significantly greater when xylitol was added compared with CaCO3 alone (p < 0.05). Only the 4-week CaCO3 + xylitol group attained the bone Ca concentration of the controls. Xylitol supplementation seems to affect the serum citric acid concentration independent of 1,25(OH)2D3 and PTH concentrations. The elevated citric acid concentration could be associated with increasing bone Ca. PMID: 8377724 [PubMed - indexed for MEDLINE] 10: Acta Physiol Scand. 1987 Aug;130(4):687-93. Related Articles, Links Adrenal function of the rat in relation to peroral administration of xylitol: depression of aldosterone. Hamalainen MM, Makinen KK. The effect of peroral administration of xylitol (5% or 20% in food) on adrenal function was investigated in thirty-five Long- male rats. The control rats were fed either a non-substituted stock diet or a 20% glucose diet. Glucose elevated and 20% xylitol reduced the growth of the rats (P less than 0.001), but 5% xylitol had no effect on the body weight. The concentrations of serum glucose and lactic acid decreased in rats fed 20% and 5% xylitol, respectively, but those of insulin, glucagon, corticosterone and aldosterone were not affected. In the adrenal glands, 20% xylitol loading was associated with increased epinephrine (P less than 0.05) and norepinephrine (P less than 0.001), but with decreased aldosterone (P less than 0.001) concentrations. The weights and histological picture of adrenal glands were normal. The urinary pH of xylitol-fed rats decreased significantly (P less than 0.01). Although peroral xylitol affected the levels of aldosterone and catecholamines, a normal glucocorticoid metabolism was permitted. The reduced aldosterone levels were regarded as secondary reactions, possibly resulting from alterations in electrolyte and/or acid-base balance. The increased catecholamine synthesis may be associated with the promoting effect of xylitol on intestinal calcium absorption. PMID: 3630741 [PubMed - indexed for MEDLINE] 11: Miner Electrolyte Metab. 1985;11(3):178-81. Related Articles, Links Peroral xylitol increases intestinal calcium absorption in the rat independently of vitamin D action. Hamalainen MM, Makinen KK, Parviainen MT, Koskinen T. The absorption of 45Ca from the diet in the presence of xylitol was investigated with 28 adult male rats. The supplementation of the diet with 10% xylitol for 3 weeks augmented the urinary excretion of 45Ca 2.5-fold p less than 0.001), but did not affect the urinary excretion of sodium. The concentration of calcium in the serum remained unchanged. The serum levels of vitamin D metabolites [1,25-(OH)2D; 24,25-(OH)2D, and 25-(OH)D] did not correlate with the augmentation of Ca absorption. The diuretic effect of xylitol and the complex formation between polyols and calcium in rat intestine were considered responsible for the changes in calcium metabolism. PMID: 4010648 [PubMed - indexed for MEDLINE] Caries Res. 2006;40(1):43-6. Related Articles, Links Click here to read The effect of adding calcium lactate to xylitol chewing gum on remineralization of enamel lesions. Suda R, Suzuki T, Takiguchi R, Egawa K, Sano T, Hasegawa K. Department of Periodontology, Showa University Dental School, Tokyo, Japan. suda@... The purpose of the study was to determine whether adding calcium lactate to chewing gum containing xylitol enhances remineralization of enamel surfaces using an early caries lesion model. Enamel slabs were cut from human extracted sound teeth and artificial subsurface lesions created within each. Half the enamel slabs were used as controls and stored in a humidifier while half were mounted into oral appliances worn by 10 volunteers (22-27 years old, 2 males and 8 females) in a three-leg trial, during which they wore the appliance without chewing gum, chewed gum containing xylitol + calcium lactate or chewed gum containing only xylitol 4 times a day for 2 weeks. Calcium concentrations in the enamel surfaces of control and test slabs were measured by X-ray spectrometry and degrees of remineralization were calculated. The mean degree of remineralization was greater after chewing xylitol-Ca gum (0.46 +/- 0.10) than after no gum (0.16 +/- 0.14) or after chewing xylitol gum (0.33 +/- 0.10) (p < 0.01). In conclusion, chewing gum containing xylitol + calcium lactate could enhance remineralization of enamel surface compared to chewing gum containing only xylitol or no gum chewing. Publication Types: * Randomized Controlled Trial PMID: 16352880 [PubMed - indexed for MEDLINE] > > > > > > > > > > Wow, thanks, Natasa, we can't get enough calcium into > > > > her...wondering how we could introduce some xylitol, maybe in > gum. > > > > Honest I would never do IV's but if we were calcium would be the > > > > first out of the block. > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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