Re: Methylcobalamin: A Potential Breakthrough in Neurological Disease

[Guest guest]

thanks again angel, yes, was just telling my mom that I though b12

shots would help me. this would be much

better.

--

- In , LymeAngl@... wrote:

>

>

> This is what I use 2 to 3 times a week, IM....good stuff

> Angel huggzz

> or angel

> =================================================

> _http://www.immunesupport.com/message/neurob12.htm_

> (http://www.immunesupport.com/message/neurob12.htm)

> Methylcobalamin: A Potential Breakthrough in Neurological Disease

> Japanese scientists have identified a form of _vitamin B12_

> (http://www.immunesupport.com/coderedirect.cfm?Product__Code=PH19)

that protects against

> neurological disease and aging by a unique mechanism that differs

from current

> therapies. Some of the disorders that may be preventable or

treatable with

> this natural vitamin therapy, called _methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) , include chronic fatigue syndrome,

> Parkinson's disease, peripheral neuropathies, Alzheimer's disease,

muscular

> dystrophy and neurological aging. Americans have immediate access

to this

> unique and new form of vitamin B12, and, unlike prescription

drugs, it costs very

> little and is free of side effects.

> _vitamin B12_

> (http://www.immunesupport.com/coderedirect.cfm?Product__Code=PH19)

is a general label for a group of essential biological compounds

knows

> as cobalamins. The cobalamins are structurally related to

hemoglobin in the

> blood, and a deficiency of vitamin B12 can cause anemia. The

primary concern of

> conventional doctors is to maintain adequate cobalamin status to

protect

> against anemia.

> The most common form of vitamin B12 is called cyanocobalamin.

However, over

> the last ten years, a number of central and peripheral

neurological diseases

> have been linked to a deficiency of a very specific cobalamin, the

> _methylcobalamin_ (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278)

> form, that is required to protect against neurological diseases and

aging. The

> liver converts a small amount of cyanocobalamin into

methylcobalamin within

> the body, but larger amounts of methylcobalamin are necessary to

correct

> neurological defects and protect against aging.

> Published studies show that high doses of _methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) are needed to regenerate

> neurons as well as the myelin sheath that protects nerve axons and

peripheral

> nerves.

> CFIDS and B-12

> In the Summer 1998 issue of Healthwatch, an important research

article

> reported a fascinating new finding. Over 60% of CFIDS and FM

patients cerebral

> spinal fluids contained subnormal levels of vitamin B12. On the

other hand,

> vitamin B12 levels in the blood did not significantly deviate from

normal

> ranges.

> According to Dr. Cheney's treatment pyramid for CFIDS,

vitamin B12 in

> its non-cyanocobalamin form (the type commercially available) is a

potent

> detoxifier of the brain. Recent studies in Europe suggest that it

needs to be

> given in large doses in the range of 10 - 20 mg per day, or even

more. This

> supplementation of methylcobalamin might protect the cognitive

function of

> patients with CFIDS by preventing the death of brain cells.

> One cause of brain cell death is glutamate toxicity. Brain cells

use

> glutamate as a neurotransmitter, but unfortunately glutamate is a

double-edged sword

> in that it can also kill brain cells. The release of glutamate

from the

> synapses is a usual means by which neurons communicate with each

other.

> Effective communication means controlled release of glutamate at

the right

> time to the right cells, but when glutamate is released in

excessive amounts,

> intercellular communication ceases. The flood of glutamate into

the receiving

> neurons drives them into hyperactivity, and the excessive activity

leads to

> cellular degradation.

> The good news is that it may now be possible to protect brain

cells against

> glutamate toxicity by taking methylcobalamin supplementation. In a

study in

> the European Journal of Pharmacology, it was shown that

methylcobalamin

> protected against glutamate-, aspartate- and nitroprusside-

induced neurotoxicity

> in rat cortical neurons.

> Researchers concluded that _methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) protects against neurotoxicity by

> enhancing brain cell methylation. The CFIDS & Fibromyalgia Health

Resource

> recommends methylation-enhancing therapies such as vitamin B6,

vitamin B12, folic acid

> and trimethylglycine (TMG), taken together, to protect against

heart

> disease, stroke and other aging-related diseases.

> The scientists who conducted the _methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) studies emphasize that ongoing

> intake of methylcobalamin is necessary to protect against

neurotoxicity. Thus

> for methylcobalamin to be effective in protecting against

neurological disease,

> daily supplementation may be required.

> An appropriate dose to protect against neurological aging might be

1 to 5 mg

> a day taken under the tongue in lozenge form.

> Sleep

> A recent German study appearing in Neuropharmacology showed

methylcobalamin

> reduced the amount of time subjects slept; sleep quality was better

and

> subjects awoke feeling refreshed, with better alertness and

concentration. Part of

> this effect was apparently due to melatonin suppression during the

daytime

> because morning methylcobalamin supplementation reduces drowsiness

by

> decreasing daytime melatonin levels.

> Multiple Sclerosis

> According to a recent study at Vanderbilt University, chlamydia

pneumoniae

> might link multiple sclerosis (MS) to CFIDS. This makes the

published effect

> of methylcobalamin treatment on MS of great importance to those

who suffer

> from CFIDS.

> A study in the Journal of Internal Medicine investigated the daily

> administration of 60 mg of methylcobalamin to patients with

chronic progressive

> multiple sclerosis (MS), a disease that has a poor prognosis and

feature side

> spread demyelination in the central nervous system.

> Although motor disability did not improve, there were clinical

improvements

> in visual and auditory MS related disabilities. The scientist

stated that

> methylcobalamin might be an effective adjunct to immunosuppressive

treatment for

> chronic, progressive MS. Those with less serious forms of MS may

consider

> adding methylcobalamin to their daily treatment regimen.

> The effects of methylcobalamin were studied on an animal model of

muscular

> dystrophy. This study, published in Neuroscience Letter looked at

> degeneration of axon motor terminals. In mice receiving

_methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) , nerve sprouts were more

> frequently observed and regeneration of motor nerve terminals

occurred in

> sites that had been previously degenerating.

> Regenerating Nerves

> Few substances have been shown to regenerate nerves in humans with

> peripheral neuropathies. However, a study in the Journal of

Neurological Science

> postulated that methylcobalamin could increase protein synthesis

and help

> regenerate nerves. The scientists showed that very high doses of

methylcobalamin

> produce nerve regeneration in laboratory rats.

> The scientists stated that ultra-high doses of _methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) might be of clinical

> use for patients with peripheral neuropathies. The human

equivalent dose the

> scientists used is about 40 mg of sublingually administered

methylcobalamin

> on a daily basis.

> Those suffering from peripheral neuropathies often take alpha

lipoic acid.

> Based on our new understanding of peripheral neuropathy, it may be

prudent

> that anyone using alpha lipoic acid also take at least 5 mg a day

of

> sublingually administered methylcobalamin to ensure that alpha

lipoic acid will be

> bioavailable to the peripheral nerves.

> Cancer/Immune Function

> A study in the journal Oncology examined the effects of

_methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) on several

> different kinds of tumors in mice. The administration of

methylcobalamin for

> seven days suppressed liver, lung and ascites tumor growth. Mice

receiving

> methylcobalamin survived longer than control mice did. In mice

irradiated

> before tumor cell inoculation, methylcobalamin did not improve

survival.

> The effects of _methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) on human immune function was investigated in

the

> Journal of Clinical Immunology. The study showed that

methylcobalamin

> demonstrated remarkable T cell-enhancing effects when the T cells

were exposed to

> certain antigens.

> The scientists also showed that methylcobalamin improved the

activity of T

> helper cells. The scientists concluded that methylcobalamin could

modulate

> lymphocyte function by augmenting regulatory T cell activities.

> Americans need to know about this important natural therapy that

could

> extend the healthy human life span. A search of the scientific

literature reveals

> 334 published studies on methylcobalamin. However, it would not be

an

> exaggeration to say that virtually no doctors know of it or are

recommending it.

> Methylcobalamin should be considered for the treatment of any

neurological

> disease. For example, based on its unique mechanisms of action,

> methylcobalamin could be effective in slowing the progression

of " untreatable " diseases

> such as ALS (Lou Gerhig's disease).

> Since _methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) is not a drug, there is little economic

incentive to conduct

> expensive clinical studies on it, so it may be a long time before

we know just

> how effective this unique form of vitamin B12 is in slowing the

progression

> of common diseases like Parkinson's disease.

> The sublingual intake of _methylcobalamin_

> (http://www.immunesupport.com/coderedirect.cfm?

Product__Code=P278) is an affordable and effective natural

> therapy, and has proven even safe when given in large doses.

> (euro-journ-pharm; 1993 Sep.7;7;241 (1):1-6) (Experientia; 1992

> Aug;48[8]:716-720)

> (Neuropharmacology; 1996;15[5]:456-464)

> (journ-int-med; 1994 Feb. 33(2):82-86)

> (Neuroscience Letter; 1994 Mar 28; 170[1] 195-197)

> (journ-neuro-sci 1994 Apr. 122[2]:140-143)

> (journ-inherited-meta-dis 1993;16[4]:762-770) (Oncology; 1987;44

[3]:169-173)

> (journ-clin-immuno 1982 Apr 2;[2]:101-109)

>

>

>

[Guest guest]

> =================================================

> _http://www.immunesupport.com/message/neurob12.htm_

> (http://www.immunesupport.com/message/neurob12.htm)

> Methylcobalamin: A Potential Breakthrough in Neurological Disease

> Japanese scientists have identified a form of _vitamin B12_

> (http://www.immunesupport.com/coderedirect.cfm?

We were using that back in the '80's during the Incline Village CFS

epidemic - along with CoQ10 and L-Carnitine.

Seemed to noticeably help some people.

-

(I just got " The Air Here is Poison " friend moved out and into a safe

environment. And THAT is already helping more than the most dramatic

benefits I EVER saw with ANY vitamin or chemotherapy)