a review of medical countermeasures against chemical warfare

[Guest guest]

A review of multi-threat medical countermeasures against chemical

warfare and terrorism

http://www.cwwg.org/ren12.02.04.html

this is what I got out of it.

Inflammatory responce is a key element in chemical toxicity.

the interaction of multiple toxic agents mediates and signals

pathways that cause and sustain inflamation.

Common biochemical pathways may exist for many chemical agents even

if they have diverse chemistrys,

sites of action,and symptoms.

The presence of inflamation implicates it as a cause or a result of

the toxicity of the agent.

Inflammatory responce can augment sensativity to chemical toxicities.

increased inflamation can synergistically augment chemical toxicity.

Anaphylactoid reactions, by definition, occur apon initial exposure

to a chemical independent of antibody production.

uniformity of biochemicals pathways exists.

biochemical pathways associated with chemical toxicity can involve

proteases and other molecules,

these mediators and receptors can influence inflammatory responces

associated with cellular process,

such as degranulation,apoptosis, and necrosis that contribute to

pathologies caused by chemical agents.

Diverce biochemical pathways that influence inflammatory responces

may explain why many pathologies associated with intoxication by

chemical agents have a inflammatory component.

(LPS)inflammagenic endotoxin lipopolysaccharide in a small dose,

enhanced the hepatotoxic effects of aflatoxin BP.

A similar effect of (LPS) endotoxin occurs with other toxic chemicals

and other target organs.

(LPS) or inflammatory cytokines TNF or IL-1 enhance cytotoxic effects.