[occ-env-med-l] NAS: Asbestos CA epidemiology reviewed (fwd)

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Asbestos: Selected Cancers

http://www.nap.edu/catalog/11665.html#orgs

Released On: June 06, 2006

The use of asbestos in many products surged during the 20th century,

and asbestos exposure continues despite a sharp reduction in

production since the 1980s. Asbestos is an established cause of

mesothelioma, an uncommon cancer that arises in the mesothelial cells

lining the chest and abdominal cavities, and of lung cancer. It also

causes non-malignant respiratory diseases, including asbestosis, a

fibrotic disorder of the lung.

In addition, the findings of some epidemiologic studies of

asbestos-exposed workers have suggested that exposure to asbestos may

increase risk of other cancers.

This Institute of Medicine committee was charged with evaluating the

evidence relevant to the causation of cancers of the pharynx, larynx,

esophagus, stomach, and colon and rectum by asbestos and with judging

whether the evidence is sufficient to infer a causal association.

The committee concluded that the evidence is:

* sufficient to infer a causal relationship between asbestos exposure

and laryngeal cancer;

* suggestive but not sufficient to infer a causal relationship between

asbestos exposure and pharyngeal, stomach, and colorectal cancers; and

* inadequate to infer a causal relationship between asbestos exposure

and esophageal cancer.

Table of Contents

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Front Matter

Executive Summary

1 Introduction

2 Committee s Approach to Its Charge and Methods Used in Evaluation

3 Background Information on Asbestos

4 Exposure and Disposition

5 Biological Aspects of Asbestos Related Diseases

6 Description of Epidemiologic Studies Included in Evidentiary Dataset

7 Pharyngeal Cancer and Asbestos

8 Laryngeal Cancer and Asbestos

9 Esophageal Cancer and Asbestos

10 Stomach Cancer and Asbestos

11 Colorectal Cancer and Asbestos

12 Summary

A Agendas of Public Meetings

B Lineage Cohort Populations and Design Properties of Studies on Them

C Design Tables Case-Control Cancer Studies

D Cohort Results Tables

E Case-Control Results Tables

F Colon and Rectum

G Committee on Asbestos: Selected Health Effects Bios