Guest guest Posted December 1, 2006 Report Share Posted December 1, 2006 Natasa, Do you have any hunches how this calcium problem evolves? We have a seizure prone young adult here who has been placed on a calcium channel blocker. Once we got the milk free version of the med, it seems to be helping with seizure control. Prior to taking it, she would have approx 24 hour response to dietary infractions; sometimes with a dozen + seizures. With the med, we've still seen seizure activity but very short ones and in a much shorter time frame. This week she had some muscle testing done. It showed lead cropping up as a problem - as did her RBC test earlier in the fall -finally beginning to eliminate as I interpreted it. However, the practitioner who muscle tested her placed her difficulty with the lead elimination in the parotid gland - a startling 'coincidence' to me considering the calcium disregulation that seems to be going on with her. He knew nothing of the labs or new seizure meds role. Do you think the parotid takes a hit like the thyroid with heavy metal overload? or do you think that this is related to electrical activity of the minerals? Is there some enzyme function being blocked which interfers with the elimination of the bone stored lead? i.e. don't lead and calcium traffic in/out of bone? Are there any supps that might enhance parotid function? or enhance bone calcium storage vs lead? Kindergarten level questions, I know, as I don't have the depth for this. > > > > Hi, > > > > I have a friend whose son is 14 and just started biomed. He has had > his > > testosterone levels taken and they are sky high. Has anyone come > across > > this before? > > > > Thanks > > > > Elaine > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 2, 2006 Report Share Posted December 2, 2006 Hi , what type of ca blockers is she taking? what are the foods she reacts to? sorry, I do not believe I have any useful answers here, just digging for more possible clues. I do not know much about parathyroid, from what can recollect it supposedly 'reads' the calcium dynamics in the body (including, but not exclusive to the bones?) and reacts by shuffling it around... sort of thing from what little I read about it it looked like this gland would be affected downstream of other things going on. Don't know if it can be affected by toxins in a more direct way, or how/if its functioning could affect detox. few more questions: have you tried chelating lead, recently or in the past? how did it go? lastly, how has she been doing lately in terms of behaviours etc? do you think seizure control has any impact on her general autistic symptoms? Best, Natasa > > > > > > Hi, > > > > > > I have a friend whose son is 14 and just started biomed. He has > had > > his > > > testosterone levels taken and they are sky high. Has anyone > come > > across > > > this before? > > > > > > Thanks > > > > > > Elaine > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 2, 2006 Report Share Posted December 2, 2006 Hi , what type of ca blockers is she taking? what are the foods she reacts to? sorry, I do not believe I have any useful answers here, just digging for more possible clues. I do not know much about parathyroid, from what can recollect it supposedly 'reads' the calcium dynamics in the body (including, but not exclusive to the bones?) and reacts by shuffling it around... sort of thing from what little I read about it it looked like this gland would be affected downstream of other things going on. Don't know if it can be affected by toxins in a more direct way, or how/if its functioning could affect detox. few more questions: have you tried chelating lead, recently or in the past? how did it go? lastly, how has she been doing lately in terms of behaviours etc? do you think seizure control has any impact on her general autistic symptoms? Best, Natasa > > > > > > Hi, > > > > > > I have a friend whose son is 14 and just started biomed. He has > had > > his > > > testosterone levels taken and they are sky high. Has anyone > come > > across > > > this before? > > > > > > Thanks > > > > > > Elaine > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 2, 2006 Report Share Posted December 2, 2006 Natasa, She's taking lamotrigine at her father's insistance. He's unwillling to monitor diet. We found back in summer 2000 that gluten and casein were the major triggers for her seizures. Since then I'd gradually withdrawn her tegretol. She's continued to have some seizures due to dietary infractions but nothing like pre 2000. She truly is seizure free if she stays pure on her diet. Dietary control also seems to help her detox. As she's gotten older, the monitoring has become more of a problem. Other foods, such as soy[sometimes willl also trigger the seizures], peanuts, cocoa, orange, grape send her into what I call 'pre-seizure' behavior' - irritable, aggressive, totally defiant and anxious. Recent testing put other foods off limits for awhile -egg, cashew, codfish[probably from all the clo oil I poured down her as a little one!], spinach, olive and grapefruit[which is probably why I couldn't use ole or gfe without seeing VERY negative response that didn't sound like die off], walnut, mushroom, cauliflower, pepper, potato, yeast, sesame, bean[lima, pinto]. A couple of these foods she's never even sniffed at in her life. However, I like grapefruit and limas. Can't believe she was sensitized so long ago in utero. Others are showing + but are being rotated currently. Seizure control with diet gives us a calm reasonable young adult. She's verbal and anxious most of the time. The medication is currently shifting her to a 'manic' mode with lots of repetitive verbage and obsession on her favorite things as well as periods plagued with aggression. Pupillary response has gotten inappropriate again with this med. A swollen, cracked lower lip is back again[b2, biotin? not doing much for it], as is orange peel facial skin. Both lip and skin sx had gone away gradually on the lod this past year. She has been chelating since early 2002 using Cutler's protocol- 1.5 year intense. I'd drawn back on this due to family conflict but got back in gear this fall. We had a few months in 2004 of topical dmps - a disaster using it qod or every 8 hours x 3 days. Chelation has definitely been of benefit. So that's the 'short' of it now. -- In Autism Treatment , " natasa778 " wrote: > > Hi , > > what type of ca blockers is she taking? > > what are the foods she reacts to? > > sorry, I do not believe I have any useful answers here, just digging for > more possible clues. > > I do not know much about parathyroid, from what can recollect it > supposedly 'reads' the calcium dynamics in the body (including, but not > exclusive to the bones?) and reacts by shuffling it around... sort of > thing from what little I read about it it looked like this gland > would be affected downstream of other things going on. Don't know if it > can be affected by toxins in a more direct way, or how/if its > functioning could affect detox. > > few more questions: > > have you tried chelating lead, recently or in the past? how did it go? > > lastly, how has she been doing lately in terms of behaviours etc? do you > think seizure control has any impact on her general autistic symptoms? > > Best, > Natasa > > > > > > > > > > > > Hi, > > > > > > > > I have a friend whose son is 14 and just started biomed. He has > > had > > > his > > > > testosterone levels taken and they are sky high. Has anyone > > come > > > across > > > > this before? > > > > > > > > Thanks > > > > > > > > Elaine > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 2, 2006 Report Share Posted December 2, 2006 > Natasa, > > She has been chelating since early 2002 using Cutler's protocol- 1.5 > year intense. I'd drawn back on this due to family conflict but got > back in gear this fall. We had a few months in 2004 of topical dmps - > a disaster using it qod or every 8 hours x 3 days. Chelation has > definitely been of benefit. > So that's the 'short' of it now. Could you elaborate, what was the disaster... Not the Andy Cutler protocol, but the transdermal / topiacel DMPS (Buttar ?-) protocol ?? Geir Flatabø Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 2, 2006 Report Share Posted December 2, 2006 Sorry about the confusion. Cutler's protocol has been the MOST beneficial. Some improvements - stone cold, mottled extremities [hands/lower arms, feet and lower legs return to normal color/temperature; peripheral neuropathy is gone; pupil response had begun to approximate normal[until she began this new seizure med]; tolerance for visually busy and noisy places is about normal; pain tolerance has gone from super high[nothing hurt] to what seems like much closer to normal; a return of much more normal emotional state- actual tears and empathy... We also saw great response in our litle grandson on the Cutler protocol. When he was 2, he had a significant lead problem with blood levels into almost 50's[?units of meaasure] while mainstream only wanted to monitor! He also counted out toxic for mercury by Cutler's criteria. Several months of chelation, supplements, and speech therapy improved him dramatically. He's in first grade now [bright, funny, very social etc] totally mainstreamed and no one the wiser. However, strep remains a problem for him intermittently. He will get very obsessive/compulsive-no temp, no wbc change, usually negative on rapid test and positive on full culture; but no real signs of illness exc the ocd. His doc treats this agressively. His younger brother, now 4, has had no vaccines and has been such a healthy kid. The 'disaster' for this daughter[21yrs and the grandson's aunt] was td-dmps. We tried every other day for a couple of months; also every 8 hours x 3 days/4 days off. We were never able to work up anywhere near the recommended number of drops per day. She had horrible behavior during this time. I felt as if there was constant redistribution going on so we quit. Hope that clarifies things. > > Natasa, > > > > She has been chelating since early 2002 using Cutler's protocol- 1.5 > > year intense. I'd drawn back on this due to family conflict but got > > back in gear this fall. We had a few months in 2004 of topical dmps - > > a disaster using it qod or every 8 hours x 3 days. Chelation has > > definitely been of benefit. > > So that's the 'short' of it now. > > Could you elaborate, > what was the disaster... > Not the Andy Cutler protocol, > but the transdermal / topiacel DMPS (Buttar ?-) protocol ?? > > Geir Flatabø > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 2, 2006 Report Share Posted December 2, 2006 In a message dated 03/12/2006 08:53:19 GMT Standard Time, geirf@... writes: Others seen this problem withButtar - TD DMPS ?? >>>>>Loads and loads, I used to keep a file about it. Only heard of a few with issues with frequent dosing and my theory on that is the way you switch from 48 hourly to 8 hourly. Some folks have seen great things, some put their childs recovery down to the TD DMPS but as a subscriber to 27 I think I have quite a good overview. FWIW Mandi x Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 2, 2006 Report Share Posted December 2, 2006 In a message dated 03/12/2006 08:53:19 GMT Standard Time, geirf@... writes: Others seen this problem withButtar - TD DMPS ?? >>>>>Loads and loads, I used to keep a file about it. Only heard of a few with issues with frequent dosing and my theory on that is the way you switch from 48 hourly to 8 hourly. Some folks have seen great things, some put their childs recovery down to the TD DMPS but as a subscriber to 27 I think I have quite a good overview. FWIW Mandi x Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 Others seen this problem with Buttar - TD DMPS ?? Geir Flatabø On 12/3/06, mbrookh <mbrookh@...> wrote: > Sorry about the confusion. Cutler's protocol has been the MOST > beneficial. Some improvements - stone cold, mottled extremities > [hands/lower arms, feet and lower legs return to normal > color/temperature; peripheral neuropathy is gone; pupil response had > begun to approximate normal[until she began this new seizure med]; > tolerance for visually busy and noisy places is about normal; pain > tolerance has gone from super high[nothing hurt] to what seems like > much closer to normal; a return of much more normal emotional state- > actual tears and empathy... > We also saw great response in our litle grandson on the Cutler > protocol. When he was 2, he had a significant lead problem with > blood levels into almost 50's[?units of meaasure] while mainstream > only wanted to monitor! He also counted out toxic for mercury by > Cutler's criteria. Several months of chelation, supplements, and > speech therapy improved him dramatically. He's in first grade now > [bright, funny, very social etc] totally mainstreamed and no one the > wiser. However, strep remains a problem for him intermittently. He > will get very obsessive/compulsive-no temp, no wbc change, usually > negative on rapid test and positive on full culture; but no real > signs of illness exc the ocd. His doc treats this agressively. His > younger brother, now 4, has had no vaccines and has been such a > healthy kid. > The 'disaster' for this daughter[21yrs and the grandson's aunt] was > td-dmps. We tried every other day for a couple of months; also every > 8 hours x 3 days/4 days off. We were never able to work up anywhere > near the recommended number of drops per day. She had horrible > behavior during this time. I felt as if there was constant > redistribution going on so we quit. > Hope that clarifies things. > > > > > > > Natasa, > > > > > > She has been chelating since early 2002 using Cutler's protocol- > 1.5 > > > year intense. I'd drawn back on this due to family conflict but > got > > > back in gear this fall. We had a few months in 2004 of topical > dmps - > > > a disaster using it qod or every 8 hours x 3 days. Chelation has > > > definitely been of benefit. > > > So that's the 'short' of it now. > > > > Could you elaborate, > > what was the disaster... > > Not the Andy Cutler protocol, > > but the transdermal / topiacel DMPS (Buttar ?-) protocol ?? > > > > Geir Flatabø > > > > > > > DISCLAIMER > No information contained in this post is to be construed as medical advice. If you need medical advice, please seek it from a suitably qualified practitioner. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 Others seen this problem with Buttar - TD DMPS ?? Geir Flatabø On 12/3/06, mbrookh <mbrookh@...> wrote: > Sorry about the confusion. Cutler's protocol has been the MOST > beneficial. Some improvements - stone cold, mottled extremities > [hands/lower arms, feet and lower legs return to normal > color/temperature; peripheral neuropathy is gone; pupil response had > begun to approximate normal[until she began this new seizure med]; > tolerance for visually busy and noisy places is about normal; pain > tolerance has gone from super high[nothing hurt] to what seems like > much closer to normal; a return of much more normal emotional state- > actual tears and empathy... > We also saw great response in our litle grandson on the Cutler > protocol. When he was 2, he had a significant lead problem with > blood levels into almost 50's[?units of meaasure] while mainstream > only wanted to monitor! He also counted out toxic for mercury by > Cutler's criteria. Several months of chelation, supplements, and > speech therapy improved him dramatically. He's in first grade now > [bright, funny, very social etc] totally mainstreamed and no one the > wiser. However, strep remains a problem for him intermittently. He > will get very obsessive/compulsive-no temp, no wbc change, usually > negative on rapid test and positive on full culture; but no real > signs of illness exc the ocd. His doc treats this agressively. His > younger brother, now 4, has had no vaccines and has been such a > healthy kid. > The 'disaster' for this daughter[21yrs and the grandson's aunt] was > td-dmps. We tried every other day for a couple of months; also every > 8 hours x 3 days/4 days off. We were never able to work up anywhere > near the recommended number of drops per day. She had horrible > behavior during this time. I felt as if there was constant > redistribution going on so we quit. > Hope that clarifies things. > > > > > > > Natasa, > > > > > > She has been chelating since early 2002 using Cutler's protocol- > 1.5 > > > year intense. I'd drawn back on this due to family conflict but > got > > > back in gear this fall. We had a few months in 2004 of topical > dmps - > > > a disaster using it qod or every 8 hours x 3 days. Chelation has > > > definitely been of benefit. > > > So that's the 'short' of it now. > > > > Could you elaborate, > > what was the disaster... > > Not the Andy Cutler protocol, > > but the transdermal / topiacel DMPS (Buttar ?-) protocol ?? > > > > Geir Flatabø > > > > > > > DISCLAIMER > No information contained in this post is to be construed as medical advice. If you need medical advice, please seek it from a suitably qualified practitioner. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 > > Others seen this problem with > Buttar - TD DMPS ?? > > Geir Flatabø I should be interested to know this too. Has everyone largely abandoned the Buttar protocol now? Margaret Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 > > Others seen this problem with > Buttar - TD DMPS ?? > > Geir Flatabø I should be interested to know this too. Has everyone largely abandoned the Buttar protocol now? Margaret Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 On 12/3/06, Mum231ASD@... <Mum231ASD@...> wrote: In a message dated 03/12/2006 08:53:19 GMT Standard Time, geirf@... writes: Others seen this problem withButtar - TD DMPS ?? >>>>>Loads and loads, I used to keep a file about it. Only heard of a few with issues with frequent dosing and my theory on that is the way you switch from 48 hourly to 8 hourly. Some folks have seen great things, some put their childs recovery down to the TD DMPS but as a subscriber to 27 I think I have quite a good overview. FWIW Mandi xYou say it is OK to dose each 48 hours, but not 8 hours dosing ??According to Buttar himselfit is a continous supply of DMPS that makes the best effect. In the Bella (iv ) protocol DMPS is always dosed together with lots of antioxydants ( Vitamin C and GSH) would that do the difference ??Geir Flatabø Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 On 12/3/06, Mum231ASD@... <Mum231ASD@...> wrote: In a message dated 03/12/2006 08:53:19 GMT Standard Time, geirf@... writes: Others seen this problem withButtar - TD DMPS ?? >>>>>Loads and loads, I used to keep a file about it. Only heard of a few with issues with frequent dosing and my theory on that is the way you switch from 48 hourly to 8 hourly. Some folks have seen great things, some put their childs recovery down to the TD DMPS but as a subscriber to 27 I think I have quite a good overview. FWIW Mandi xYou say it is OK to dose each 48 hours, but not 8 hours dosing ??According to Buttar himselfit is a continous supply of DMPS that makes the best effect. In the Bella (iv ) protocol DMPS is always dosed together with lots of antioxydants ( Vitamin C and GSH) would that do the difference ??Geir Flatabø Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 , how long has she been on lamotrigene? is she on full adult dose or have you tried different dosing? was she taking it while chelating? Natasa > > > > > > > > > > Hi, > > > > > > > > > > I have a friend whose son is 14 and just started biomed. He > has > > > had > > > > his > > > > > testosterone levels taken and they are sky high. Has anyone > > > come > > > > across > > > > > this before? > > > > > > > > > > Thanks > > > > > > > > > > Elaine > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 , how long has she been on lamotrigene? is she on full adult dose or have you tried different dosing? was she taking it while chelating? Natasa > > > > > > > > > > Hi, > > > > > > > > > > I have a friend whose son is 14 and just started biomed. He > has > > > had > > > > his > > > > > testosterone levels taken and they are sky high. Has anyone > > > come > > > > across > > > > > this before? > > > > > > > > > > Thanks > > > > > > > > > > Elaine > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 Natasa, The lamotrigene is new ~ 6 weeks~. Initially, she was on tablets that had lactose. We saw a mini return of what she'd experienced on gluten/casein - ataxia, pupil irregularity, high pain level, very irritable/oppositional behavior[esp close to next dosing time-like an adict needing a 'fix'] It was heart breaking for me. The last couple of weeks with the non lactose form, the ataxia has subsided, pupils are more normal but the behavior pattern remains very 'pre-seizure; cracked lip adn mottled skin remain. The doc is a 'good old boys club' one who will not even discuss things with me - only says that the behavior indices the need for increased dose! This is somewhat out of my hands until formal intervention. She has been worked up to a full adult dose[120# young adult]. Yes, she's taking it as I've begun to chelate agian. -- In Autism Treatment , " natasa778 " <neno@...> wrote: > > , how long has she been on lamotrigene? is she on full adult dose or > have you tried different dosing? > was she taking it while chelating? > > Natasa > > > > > > > > > > > > > > Hi, > > > > > > > > > > > > I have a friend whose son is 14 and just started biomed. He > > has > > > > had > > > > > his > > > > > > testosterone levels taken and they are sky high. Has anyone > > > > come > > > > > across > > > > > > this before? > > > > > > > > > > > > Thanks > > > > > > > > > > > > Elaine > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 Not sure if this might be of any help to you: Ann Pharmacother. 2002 May;36(5):860-73. Lamotrigine update and its use in mood disorders. Hurley SC. College of Pharmacy, Idaho State University, Pocatello, ID, USA. hurley@... OBJECTIVE: To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine. DATA SOURCES: Citations obtained from MEDLINE searches (1985-September 2001) using lamotrigine as a text word, articles identified in reference lists of pertinent articles, abstracts presented at conferences, and research data from GlaxoKline. DATA EXTRACTION: English-language articles were considered for possible inclusion. Each title and abstract was examined to determine whether the publication contained up-to-date information relevant to the objective. Twenty clinical trials that provided data on response rates in mood disorders were tabulated. DATA SYNTHESIS: Lamotrigine's primary action is to modulate voltage-gated sodium channels. Evidence suggests that it decreases glutamate transmission, directly reduces calcium influx, mildly blocks transmitter reuptake, and alters intracellular mechanisms of resting transmitter release. The average half-life of lamotrigine is approximately 24 hours, but decreases to approximately 7.4 hours when used concurrently with phenytoin, and increases to approximately 59 hours with valproic acid. Seven of the 20 clinical trials were randomized, double-blind, and controlled. Existing data are inadequate to evaluate lamotrigine use in major depression. The pooled response rates for patients with depressed, manic, mixed, and rapid cycling bipolar disorder were similar, ranging from 52% to 63%. Adverse effects are infrequent when the drug is used alone, but become more frequent when lamotrigine is combined with other anticonvulsants. While most rashes are mild, approximately 1 in 500 patients develops exfoliative dermatitis. A slow upward dose titration is recommended to reduce the incidence of serious rash, but this may delay the attainment of adequate dosage for 6 weeks. Lamotrigine has positive effects on cognitive function, but occasionally produces insomnia. Lamotrigine costs 2-4 times more than lithium, carbamazepine, and generic valproic acid. CONCLUSIONS: When efficacy, adverse effects, and cost are considered, lamotrigine should probably be reserved as a second-line agent for bipolar depression. Publication Types: * Review PMID: 11978166 [PubMed - indexed for MEDLINE] it sounds like this drug is having the opposite effect of what it should be doing - could it be one of those things where 'less is more'? just a thought, but maybe it would be worth trying much lower doses for a while, especially while chelating (as chelating agents might be working on the same/similar mechanisms as this drug, and producing additive effects). Natasa > > > > > > >> > > > > > > Hi,> > > > > > >> > > > > > > I have a friend whose son is 14 and just started biomed. > He> > > has> > > > > had> > > > > > his> > > > > > > testosterone levels taken and they are sky high. Has > anyone> > > > > come> > > > > > across> > > > > > > this before?> > > > > > >> > > > > > > Thanks> > > > > > >> > > > > > > Elaine> > > > > > >> > > > > >> > > > >> > > >> > >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 3, 2006 Report Share Posted December 3, 2006 Not sure if this might be of any help to you: Ann Pharmacother. 2002 May;36(5):860-73. Lamotrigine update and its use in mood disorders. Hurley SC. College of Pharmacy, Idaho State University, Pocatello, ID, USA. hurley@... OBJECTIVE: To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine. DATA SOURCES: Citations obtained from MEDLINE searches (1985-September 2001) using lamotrigine as a text word, articles identified in reference lists of pertinent articles, abstracts presented at conferences, and research data from GlaxoKline. DATA EXTRACTION: English-language articles were considered for possible inclusion. Each title and abstract was examined to determine whether the publication contained up-to-date information relevant to the objective. Twenty clinical trials that provided data on response rates in mood disorders were tabulated. DATA SYNTHESIS: Lamotrigine's primary action is to modulate voltage-gated sodium channels. Evidence suggests that it decreases glutamate transmission, directly reduces calcium influx, mildly blocks transmitter reuptake, and alters intracellular mechanisms of resting transmitter release. The average half-life of lamotrigine is approximately 24 hours, but decreases to approximately 7.4 hours when used concurrently with phenytoin, and increases to approximately 59 hours with valproic acid. Seven of the 20 clinical trials were randomized, double-blind, and controlled. Existing data are inadequate to evaluate lamotrigine use in major depression. The pooled response rates for patients with depressed, manic, mixed, and rapid cycling bipolar disorder were similar, ranging from 52% to 63%. Adverse effects are infrequent when the drug is used alone, but become more frequent when lamotrigine is combined with other anticonvulsants. While most rashes are mild, approximately 1 in 500 patients develops exfoliative dermatitis. A slow upward dose titration is recommended to reduce the incidence of serious rash, but this may delay the attainment of adequate dosage for 6 weeks. Lamotrigine has positive effects on cognitive function, but occasionally produces insomnia. Lamotrigine costs 2-4 times more than lithium, carbamazepine, and generic valproic acid. CONCLUSIONS: When efficacy, adverse effects, and cost are considered, lamotrigine should probably be reserved as a second-line agent for bipolar depression. Publication Types: * Review PMID: 11978166 [PubMed - indexed for MEDLINE] it sounds like this drug is having the opposite effect of what it should be doing - could it be one of those things where 'less is more'? just a thought, but maybe it would be worth trying much lower doses for a while, especially while chelating (as chelating agents might be working on the same/similar mechanisms as this drug, and producing additive effects). Natasa > > > > > > >> > > > > > > Hi,> > > > > > >> > > > > > > I have a friend whose son is 14 and just started biomed. > He> > > has> > > > > had> > > > > > his> > > > > > > testosterone levels taken and they are sky high. Has > anyone> > > > > come> > > > > > across> > > > > > > this before?> > > > > > >> > > > > > > Thanks> > > > > > >> > > > > > > Elaine> > > > > > >> > > > > >> > > > >> > > >> > >> >> Quote Link to comment Share on other sites More sharing options...
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