Answer and Citation to how many donors per dose.

[Guest guest]

Actually, it is likely to be way closer to 60 for one dose (but even taht is

high, unless someone is getting 240 grams) - I think what's happening is people

are talking about two seperate things -

a lot vs a dose

A Lot is the large amount of plasma that is pooled together to make MANY MANY

vials.

A DOSE is individual to the person, and is measured in GRAMS.

A company will likely give you basic info/averages, but would likley not provide

specifics, as each lot will be slightly different. What I was able to find was

an industry average for you all.

Here is the deal -

Tens to Hundreds to Thousands of Donations are pooled together to make a

specific LOT of Ig (and actually, it doesn't just make IgG, it makes MULTIPLE

medicines). That LOT is broken into many different VIAL's which are used to

make a specific DOSE.

SO.... if 20,000 donations are pooled together to make a lot - that lot may make

(and this is an arbitrary number, that I just pulled out of a hat) 5,000 - 20

gram vials. If someone gets 20 grams - it didn't take 20,000 donors to make that

individual DOSE - it took 20,000 donors to make 100,000 grams, of which, our

patient in question used 20 grams.

Now, my point here is this. There isn't really a way to be SPECIFIC with how

many donors it takes - WHY?

Well, every donor can donate a different amount depending on their weight (the

heavier the donor, the more they can donate) and each company gets a different

YIELD from each LOT. Meaning, some companies are better at getting MORE out of

each donation than others.

That being said - THE INDUSTRY AVERAGE is 4 grams of IgG per plasma donation -

and here is your citation:

http://www.pptaglobal.org/UserFiles/file/FS_PPT%20Manufacturing_v3%20final.pdf

SO - take your dose (let's go back to our imaginary 20 gram's per 3 week patient

above) and divide that number by 4. So, 20/4= 5 So this patient would need 5

donors ever 3 weeks.

The PPTA site is a great one - and has VERY good information on plasma

collection: pptaglobal.org

Hope this helps .

Dayna

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> > > I have read so many different statistics.....anywhere from 1,000 to 10,000

per " lot " or " unit " but I cant find anything that specifies exactly what a " lot "

or " unit " is....one bottle? one dose? one bunch mixed and prepared at the same

time?

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> > > I am trying to figure out how many donors must donate in order to make one

bottle/dose of IVIG.

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> > > anybody know? I am preparing a speech for my COMM class and want to

include pics of my kids during infusion, including this particular stat along

with our price per infusion (current $6200...per kid!)

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> > > thanks

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> > > valarie

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> > > mom to 3 w/cvid

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