Birth Control for Men that also inhibits HIV in semen...could it be so simple?

[Guest guest]

Very interesting. One has to wonder why this isn't being shouted from the

rooftops. I copied a second follow-up article in regards to the HIV benefits.

http://techcitement.com/culture/the-best-birth-control-in-the-world-is-for-men/#\

..T3HeiTE7WAg

The procedure called RISUG in India (reversible inhibition of sperm under

guidance) takes about 15 minutes with a doctor, is effective after about three

days, and lasts for 10 or more years. A doctor applies some local anesthetic,

makes a small pinhole in the base of the scrotum, reaches in with a pair of very

thin forceps, and pulls out the small white vas deferens tube. Then, the doctor

injects the polymer gel (called Vasalgel here in the US), pushes the vas

deferens back inside, repeats the process for the other vas deferens, puts a

Band-Aid over the small hole, and the man is on his way. If this all sounds

incredibly simple and inexpensive, that's because it is. The chemicals

themselves cost less than the syringe used to administer them. But the science

of what happens next is the really fascinating part.

The two common chemicals — styrene maleic anhydride and dimethyl sulfoxide —

form a polymer that thickens over the next 72 hours, much like a pliable epoxy,

but the purpose of these chemicals isn't to harden and block the vas deferens.

Instead, the polymer lines the wall of the vas deferens and allows sperm to flow

freely down the middle (this prevents any pressure buildup), and because of the

polymer's pattern of negative/positive polarization, the sperm are torn apart

through the polyelectrolytic effect. On a molecular level, it's what

supervillains envision will happen when they stick the good guy between two huge

magnets and flip the switch.

With one little injection, this non-toxic jelly will sit there for 10+ years

without you having to do anything else to not have babies. Set it and forget it.

Oh, and when you do decide you want those babies, it only takes one other

injection of water and baking soda to flush out the gel, and within two to three

months, you've got all your healthy sperm again.

The trouble is, most people don't even know this exists. And if men only need

one super-cheap shot every 10 years 0r more, that's not something that gets big

pharmaceutical companies all fired up, because they'll make zero money on it

(even if it might have the side benefit of, you know, destroying HIV).

If this sounds awesome for you or your loved one, get the word out. Share this

article. Or this link. Or this one. Or this one. Sign this petition. Do

something! A revolutionary contraceptive like this needs all the support it can

get.

UPDATE: A lot of people are asking to be kept in the loop. So here's the

clinical trial/mailing list sign-up from the Parsemus Foundation to get further

information about this procedure's development. And again, please fill out the

short non-spam petition to get the procedure funded and keep buzz going.

Keep reading....

ISUG™ (reversible inhibition of sperm under guidance) – An antimicrobial as male

vas deferens implant for HIV free semen

Summary

HIV transmission from the male to the female is a major health problem. A

hypothesis proposing an intra vas deferens implant of an antimicrobial compound

to prevent the infection spread is presented. Mechanisms of action for the

inhibition could include inactivating HIV in sperms passing through the vas

deferens; drug release from the implant to destroy HIV entering into semen from

genital structures distal to the vas deferens; and sperm acrosome released

hyaluronidase mediated reabsorption of HIV. A subcomponent of the implant

flowing along sperm pathway may have a role in reducing the entry of HIV from a

positive female into penile tissue. A new drug RISUG™ (reversible inhibition of

sperm under guidance) presently undergoing clinical trials for its contraceptive

effect in the male (because it disrupts the sperm acrosome by an electrical

charge and pH lowering effects) has also antimicrobial action. The drug being a

combination of styrene maleic anhydride (SMA) and dimethyl sulfoxide (DMSO) on

being injected into the lumen of the vas deferens produces styrene maleic acid

thereby lowering pH; induces electrochemical action leading to a stable

electrical charge generation; releases mandelic acid; and induces acrosome

reaction in sperms with consequent release of hyaluronidase and sperm

inactivation. Moreover, one time administration into the lumen of the vas gives

long term action. All these phenomena very well match with the needs for HIV

clearance of semen and hence RISUG is here proposed as a possible candidate

material for the HIV inhibiting vas deferens implant when delivered in below

contraceptive threshold dosage.

For experimental validation, after obtaining data on the semen HIV load under

control conditions in the HIV positive males inducted into the study, 30mg of

SMA in 120 & #956;l of DMSO (contraceptive dose being 60mg SMA+120 & #956;l DMSO) is

to be injected into vasa deferens bilaterally. Thereafter at intervals of one

month the viral load needs to be determined in semen obtained either by

masturbation or in lubricant free condom at intercourse – the method of

collection remaining the same throughout for a particular subject. A significant

reduction in the semen viral load following RISUG administration will validate

the hypothesis. Speculated reduced female to male HIV transmission is more

difficult to test. Nonspecific indications will come from a population study of

the incidence of RISUG treated men becoming HIV positive as compared to that in

the general population.