Bloodwork results-help! Ursula and all

[Guest guest]

It's been a while since my last post here regarding my son, , and I hope

although its Easter break, I am able to get some responses asap.

s past diagnosis was transient CVID, when around 4 yo, and by 6yo had

moved on to Absolute IgA deficiency and queried Selective Antibody deficiency

(dependent on which immunologist interpreted results) and he has been on

prophylactic abx for many years.

7 weeks ago , now 14yo, was hospitalised for upper right ab pain,

subsequent u/s only found slightly bulky spleen but liver, pancreas etc looked

fine. Bloodwork came back neutropenic and showed increased bilirubin. CT with

contrast found bilateral medullary sponge kidneys with calcification but no

issues with gallbladder, pancreas etc.

Two weeks past with pain abaiting to perhaps 2/10, and not rising above 4/10.

When it jumped to 8/10, this time with nausea, we made the drive to the

childrens hospital 3 hours away and he was admitted for 10 days. The only

testing done was endoscopy with biopsies, this due to query of gastritis due to

long term NSAID and GERD. Aside from mucin depletion of stomach lining, I

understand nothing untoward was found. Two days after discharge, was

readmitted to our local country hospital for pain relief with pain up at 8/10

and vomitting. He is looking brighter today and has been discharged to spend

Easter at home.

So here is my query, and I am sorry for the very long post. Immunology hopped

on board while was in the childrens hospital and re-ran testing that

hadnt been done in years. I have been unimpressed with the team in the past and

would like some feedback on what the following numbers may be indicating please,

before I next speak with them.

IgG 5.6 (6.1-13.0)

IgA <0.07 (0.69-3.10)

IgM 1.11 ((0.53-3.32)

subclasses:

IgG1 3.86 (3.70-12.80)

IgG2 1.21 (1.06-6.10)

IgG3 0.17 (0.18-1.63)

IgG4 0.70 (<2.31)

Lymphocyte count 1.8 (1.5-5.0 x10*9/L)

CD3 (T Cells) 61 (58-76%)

CD4 (CD4+TCells) 39 (30-52%)

CD8 (CD8+TCells) 20 (18-40%)

CD8 Absolute Count 360 (400-1300 x10*6/L)

Pneumococcal IgG2 Antibody <1 (mg/L)

Any feedback is hugely appreciated.

,

mum to and

[Guest guest]

,Have they looked into the neutropenia further? what is the differential

on his CBC?Seems like that should be done...also did they do an IgE?

From: buttrfluttr <buttrfluttr@...>

Subject: Bloodwork results-help! Ursula and all

Date: Sunday, April 8, 2012, 6:35 AM

 

It's been a while since my last post here regarding my son, , and I hope

although its Easter break, I am able to get some responses asap.

s past diagnosis was transient CVID, when around 4 yo, and by 6yo had

moved on to Absolute IgA deficiency and queried Selective Antibody deficiency

(dependent on which immunologist interpreted results) and he has been on

prophylactic abx for many years.

7 weeks ago , now 14yo, was hospitalised for upper right ab pain,

subsequent u/s only found slightly bulky spleen but liver, pancreas etc looked

fine. Bloodwork came back neutropenic and showed increased bilirubin. CT with

contrast found bilateral medullary sponge kidneys with calcification but no

issues with gallbladder, pancreas etc.

Two weeks past with pain abaiting to perhaps 2/10, and not rising above 4/10.

When it jumped to 8/10, this time with nausea, we made the drive to the

childrens hospital 3 hours away and he was admitted for 10 days. The only

testing done was endoscopy with biopsies, this due to query of gastritis due to

long term NSAID and GERD. Aside from mucin depletion of stomach lining, I

understand nothing untoward was found. Two days after discharge, was

readmitted to our local country hospital for pain relief with pain up at 8/10

and vomitting. He is looking brighter today and has been discharged to spend

Easter at home.

So here is my query, and I am sorry for the very long post. Immunology hopped on

board while was in the childrens hospital and re-ran testing that hadnt

been done in years. I have been unimpressed with the team in the past and would

like some feedback on what the following numbers may be indicating please,

before I next speak with them.

IgG 5.6 (6.1-13.0)

IgA <0.07 (0.69-3.10)

IgM 1.11 ((0.53-3.32)

subclasses:

IgG1 3.86 (3.70-12.80)

IgG2 1.21 (1.06-6.10)

IgG3 0.17 (0.18-1.63)

IgG4 0.70 (<2.31)

Lymphocyte count 1.8 (1.5-5.0 x10*9/L)

CD3 (T Cells) 61 (58-76%)

CD4 (CD4+TCells) 39 (30-52%)

CD8 (CD8+TCells) 20 (18-40%)

CD8 Absolute Count 360 (400-1300 x10*6/L)

Pneumococcal IgG2 Antibody <1 (mg/L)

Any feedback is hugely appreciated.

,

mum to and

[Guest guest]

Hi! I'm new to the group but wanted to add a couple of thoughts. Did they check

his pancreatic enzyme levels? What about an O & P to check for intestinal

parasites? My daughter has been dealing with a rare one and it causes

intermittent, severe abdominal pain and vomiting (and diarrhea). She has a

Dientamoba Fragilis infection. And of course, did they do a stool culture to see

if anything's growing in there???

Another possiblity could be abdominal migraine?

We will keep you and your family in our prayers. Hope you find some answers

soon.

Meredith

>

>

> From: buttrfluttr <buttrfluttr@...>

> Subject: Bloodwork results-help! Ursula and all

>

> Date: Sunday, April 8, 2012, 6:35 AM

>

>

>

>  

>

>

>

> It's been a while since my last post here regarding my son, , and I

hope although its Easter break, I am able to get some responses asap.

>

> s past diagnosis was transient CVID, when around 4 yo, and by 6yo had

moved on to Absolute IgA deficiency and queried Selective Antibody deficiency

(dependent on which immunologist interpreted results) and he has been on

prophylactic abx for many years.

>

> 7 weeks ago , now 14yo, was hospitalised for upper right ab pain,

subsequent u/s only found slightly bulky spleen but liver, pancreas etc looked

fine. Bloodwork came back neutropenic and showed increased bilirubin. CT with

contrast found bilateral medullary sponge kidneys with calcification but no

issues with gallbladder, pancreas etc.

>

> Two weeks past with pain abaiting to perhaps 2/10, and not rising above 4/10.

When it jumped to 8/10, this time with nausea, we made the drive to the

childrens hospital 3 hours away and he was admitted for 10 days. The only

testing done was endoscopy with biopsies, this due to query of gastritis due to

long term NSAID and GERD. Aside from mucin depletion of stomach lining, I

understand nothing untoward was found. Two days after discharge, was

readmitted to our local country hospital for pain relief with pain up at 8/10

and vomitting. He is looking brighter today and has been discharged to spend

Easter at home.

>

> So here is my query, and I am sorry for the very long post. Immunology hopped

on board while was in the childrens hospital and re-ran testing that

hadnt been done in years. I have been unimpressed with the team in the past and

would like some feedback on what the following numbers may be indicating please,

before I next speak with them.

>

> IgG 5.6 (6.1-13.0)

> IgA <0.07 (0.69-3.10)

> IgM 1.11 ((0.53-3.32)

>

> subclasses:

> IgG1 3.86 (3.70-12.80)

> IgG2 1.21 (1.06-6.10)

> IgG3 0.17 (0.18-1.63)

> IgG4 0.70 (<2.31)

>

> Lymphocyte count 1.8 (1.5-5.0 x10*9/L)

> CD3 (T Cells) 61 (58-76%)

> CD4 (CD4+TCells) 39 (30-52%)

> CD8 (CD8+TCells) 20 (18-40%)

> CD8 Absolute Count 360 (400-1300 x10*6/L)

>

> Pneumococcal IgG2 Antibody <1 (mg/L)

>

> Any feedback is hugely appreciated.

>

> ,

> mum to and

>

>

>

>

>

>

>

>

>

[Guest guest]

s lipase has been elevated in the past but this time both lipase ans

amylase were in range. He is on Creon 10000 with oral intake for pancratic

insufficiency and I have always believed these series of awful abdominal pain

are pancreatic/billiary related but bloodwork, CT and u/s all came in normal for

pancreas this time round.

Bulky spleen and slightly enlarged liver with high bilirubin were the only

findings, aside from the other bloodwork results as mentioned previously.

I did forget to mention the u/s also showed enlarged abdominal lymph nodes.

Stool culture was negative.

I've had no medical training but cant help wondering if this is a mechanical

issue- if can vomit seed calculus, surely that indicates some issue with

valves along the billiary tract?

Sue, I know from years of bloodwork results that is often neutropenic,

which has never been investigated. Why he was neutropeninc this time around was

never looked into or discussed with me by the hospital doctors. It seems it was

a fluke I found out the results at all. I feel so frustrated with the system

here!