RE: Answer and Citation to how many donors per dose.

[Guest guest]

DAYNA YOU ROCK!!!! lol

Thanks. I can't beleive I've been googling this for about 10 days now and havent

come across this site.

I just thought, you know, I had to pick a disease to write the speech on, and

with April being awareness month, it'd be a good time to get this info out

there.

Now, I'm going to sit here and try to figure out how many for one of my kids

bottles of IG...which is about 500mg.

thanks again!

valarie

mom to 3 w/cvid

> > >

> > > >

> > >

> > > > I have read so many different statistics.....anywhere from 1,000 to

10,000 per " lot " or " unit " but I cant find anything that specifies exactly what

a " lot " or " unit " is....one bottle? one dose? one bunch mixed and prepared at

the same time?

> > >

> > > >

> > >

> > > > I am trying to figure out how many donors must donate in order to make

one bottle/dose of IVIG.

> > >

> > > >

> > >

> > > >

> > >

> > > > anybody know? I am preparing a speech for my COMM class and want to

include pics of my kids during infusion, including this particular stat along

with our price per infusion (current $6200...per kid!)

> > >

> > > >

> > >

> > > >

> > >

> > > > thanks

> > >

> > > > valarie

> > >

> > > > mom to 3 w/cvid

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[Guest guest]

wait....500mg can't be right..., I know that cant be right. Thats what is on the

EOB Im looking at but that must be before its mixed.

OMG this is aggravating.

valarie

> > > >

> > > > >

> > > >

> > > > > I have read so many different statistics.....anywhere from 1,000 to

10,000 per " lot " or " unit " but I cant find anything that specifies exactly what

a " lot " or " unit " is....one bottle? one dose? one bunch mixed and prepared at

the same time?

> > > >

> > > > >

> > > >

> > > > > I am trying to figure out how many donors must donate in order to make

one bottle/dose of IVIG.

> > > >

> > > > >

> > > >

> > > > >

> > > >

> > > > > anybody know? I am preparing a speech for my COMM class and want to

include pics of my kids during infusion, including this particular stat along

with our price per infusion (current $6200...per kid!)

> > > >

> > > > >

> > > >

> > > > >

> > > >

> > > > > thanks

> > > >

> > > > > valarie

> > > >

> > > > > mom to 3 w/cvid

> > > >

> > > > >

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[Guest guest]

wait....500mg can't be right..., I know that cant be right. Thats what is on the

EOB Im looking at but that must be before its mixed.

OMG this is aggravating.

valarie

> > > >

> > > > >

> > > >

> > > > > I have read so many different statistics.....anywhere from 1,000 to

10,000 per " lot " or " unit " but I cant find anything that specifies exactly what

a " lot " or " unit " is....one bottle? one dose? one bunch mixed and prepared at

the same time?

> > > >

> > > > >

> > > >

> > > > > I am trying to figure out how many donors must donate in order to make

one bottle/dose of IVIG.

> > > >

> > > > >

> > > >

> > > > >

> > > >

> > > > > anybody know? I am preparing a speech for my COMM class and want to

include pics of my kids during infusion, including this particular stat along

with our price per infusion (current $6200...per kid!)

> > > >

> > > > >

> > > >

> > > > >

> > > >

> > > > > thanks

> > > >

> > > > > valarie

> > > >

> > > > > mom to 3 w/cvid

> > > >

> > > > >

> > > >

> > > >

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[Guest guest]

Great clarification Dayna and YES 60 was what we were told about 10 years ago at

the conference for each dose of Gamma not LOT made.

From: dfladhammer@...

Date: Wed, 4 Apr 2012 18:12:28 +0000

Subject: Answer and Citation to how many donors per dose.

Actually, it is likely to be way closer to 60 for one dose (but even taht

is high, unless someone is getting 240 grams) - I think what's happening is

people are talking about two seperate things -

a lot vs a dose

A Lot is the large amount of plasma that is pooled together to make MANY MANY

vials.

A DOSE is individual to the person, and is measured in GRAMS.

A company will likely give you basic info/averages, but would likley not provide

specifics, as each lot will be slightly different. What I was able to find was

an industry average for you all.

Here is the deal -

Tens to Hundreds to Thousands of Donations are pooled together to make a

specific LOT of Ig (and actually, it doesn't just make IgG, it makes MULTIPLE

medicines). That LOT is broken into many different VIAL's which are used to

make a specific DOSE.

SO.... if 20,000 donations are pooled together to make a lot - that lot may make

(and this is an arbitrary number, that I just pulled out of a hat) 5,000 - 20

gram vials. If someone gets 20 grams - it didn't take 20,000 donors to make that

individual DOSE - it took 20,000 donors to make 100,000 grams, of which, our

patient in question used 20 grams.

Now, my point here is this. There isn't really a way to be SPECIFIC with how

many donors it takes - WHY?

Well, every donor can donate a different amount depending on their weight (the

heavier the donor, the more they can donate) and each company gets a different

YIELD from each LOT. Meaning, some companies are better at getting MORE out of

each donation than others.

That being said - THE INDUSTRY AVERAGE is 4 grams of IgG per plasma donation -

and here is your citation:

http://www.pptaglobal.org/UserFiles/file/FS_PPT%20Manufacturing_v3%20final.pdf

SO - take your dose (let's go back to our imaginary 20 gram's per 3 week patient

above) and divide that number by 4. So, 20/4= 5 So this patient would need 5

donors ever 3 weeks.

The PPTA site is a great one - and has VERY good information on plasma

collection: pptaglobal.org

Hope this helps .

Dayna

> >

> > >

> >

> > > I have read so many different statistics.....anywhere from 1,000 to 10,000

per " lot " or " unit " but I cant find anything that specifies exactly what a " lot "

or " unit " is....one bottle? one dose? one bunch mixed and prepared at the same

time?

> >

> > >

> >

> > > I am trying to figure out how many donors must donate in order to make one

bottle/dose of IVIG.

> >

> > >

> >

> > >

> >

> > > anybody know? I am preparing a speech for my COMM class and want to

include pics of my kids during infusion, including this particular stat along

with our price per infusion (current $6200...per kid!)

> >

> > >

> >

> > >

> >

> > > thanks

> >

> > > valarie

> >

> > > mom to 3 w/cvid

> >

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[Guest guest]

Thanks Dayna

Ursula

On Apr 4, 2012, at 2:12 PM, " crionafam " <dfladhammer@...> wrote:

> Actually, it is likely to be way closer to 60 for one dose (but even taht is

high, unless someone is getting 240 grams) - I think what's happening is people

are talking about two seperate things -

> a lot vs a dose

>

> A Lot is the large amount of plasma that is pooled together to make MANY MANY

vials.

>

> A DOSE is individual to the person, and is measured in GRAMS.

>

> A company will likely give you basic info/averages, but would likley not

provide specifics, as each lot will be slightly different. What I was able to

find was an industry average for you all.

>

> Here is the deal -

>

> Tens to Hundreds to Thousands of Donations are pooled together to make a

specific LOT of Ig (and actually, it doesn't just make IgG, it makes MULTIPLE

medicines). That LOT is broken into many different VIAL's which are used to make

a specific DOSE.

>

> SO.... if 20,000 donations are pooled together to make a lot - that lot may

make (and this is an arbitrary number, that I just pulled out of a hat) 5,000 -

20 gram vials. If someone gets 20 grams - it didn't take 20,000 donors to make

that individual DOSE - it took 20,000 donors to make 100,000 grams, of which,

our patient in question used 20 grams.

>

> Now, my point here is this. There isn't really a way to be SPECIFIC with how

many donors it takes - WHY?

>

> Well, every donor can donate a different amount depending on their weight (the

heavier the donor, the more they can donate) and each company gets a different

YIELD from each LOT. Meaning, some companies are better at getting MORE out of

each donation than others.

>

> That being said - THE INDUSTRY AVERAGE is 4 grams of IgG per plasma donation -

and here is your citation:

>

> http://www.pptaglobal.org/UserFiles/file/FS_PPT%20Manufacturing_v3%20final.pdf

>

> SO - take your dose (let's go back to our imaginary 20 gram's per 3 week

patient above) and divide that number by 4. So, 20/4= 5 So this patient would

need 5 donors ever 3 weeks.

>

> The PPTA site is a great one - and has VERY good information on plasma

collection: pptaglobal.org

>

> Hope this helps .

>

> Dayna

>

>

> > >

> > > >

> > >

> > > > I have read so many different statistics.....anywhere from 1,000 to

10,000 per " lot " or " unit " but I cant find anything that specifies exactly what

a " lot " or " unit " is....one bottle? one dose? one bunch mixed and prepared at

the same time?

> > >

> > > >

> > >

> > > > I am trying to figure out how many donors must donate in order to make

one bottle/dose of IVIG.

> > >

> > > >

> > >

> > > >

> > >

> > > > anybody know? I am preparing a speech for my COMM class and want to

include pics of my kids during infusion, including this particular stat along

with our price per infusion (current $6200...per kid!)

> > >

> > > >

> > >

> > > >

> > >

> > > > thanks

> > >

> > > > valarie

> > >

> > > > mom to 3 w/cvid

> > >

> > > >

> > >

> > >

> > >

> > >

> > >

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[Guest guest]

Thanks Dayna

Ursula

On Apr 4, 2012, at 2:12 PM, " crionafam " <dfladhammer@...> wrote:

> Actually, it is likely to be way closer to 60 for one dose (but even taht is

high, unless someone is getting 240 grams) - I think what's happening is people

are talking about two seperate things -

> a lot vs a dose

>

> A Lot is the large amount of plasma that is pooled together to make MANY MANY

vials.

>

> A DOSE is individual to the person, and is measured in GRAMS.

>

> A company will likely give you basic info/averages, but would likley not

provide specifics, as each lot will be slightly different. What I was able to

find was an industry average for you all.

>

> Here is the deal -

>

> Tens to Hundreds to Thousands of Donations are pooled together to make a

specific LOT of Ig (and actually, it doesn't just make IgG, it makes MULTIPLE

medicines). That LOT is broken into many different VIAL's which are used to make

a specific DOSE.

>

> SO.... if 20,000 donations are pooled together to make a lot - that lot may

make (and this is an arbitrary number, that I just pulled out of a hat) 5,000 -

20 gram vials. If someone gets 20 grams - it didn't take 20,000 donors to make

that individual DOSE - it took 20,000 donors to make 100,000 grams, of which,

our patient in question used 20 grams.

>

> Now, my point here is this. There isn't really a way to be SPECIFIC with how

many donors it takes - WHY?

>

> Well, every donor can donate a different amount depending on their weight (the

heavier the donor, the more they can donate) and each company gets a different

YIELD from each LOT. Meaning, some companies are better at getting MORE out of

each donation than others.

>

> That being said - THE INDUSTRY AVERAGE is 4 grams of IgG per plasma donation -

and here is your citation:

>

> http://www.pptaglobal.org/UserFiles/file/FS_PPT%20Manufacturing_v3%20final.pdf

>

> SO - take your dose (let's go back to our imaginary 20 gram's per 3 week

patient above) and divide that number by 4. So, 20/4= 5 So this patient would

need 5 donors ever 3 weeks.

>

> The PPTA site is a great one - and has VERY good information on plasma

collection: pptaglobal.org

>

> Hope this helps .

>

> Dayna

>

>

> > >

> > > >

> > >

> > > > I have read so many different statistics.....anywhere from 1,000 to

10,000 per " lot " or " unit " but I cant find anything that specifies exactly what

a " lot " or " unit " is....one bottle? one dose? one bunch mixed and prepared at

the same time?

> > >

> > > >

> > >

> > > > I am trying to figure out how many donors must donate in order to make

one bottle/dose of IVIG.

> > >

> > > >

> > >

> > > >

> > >

> > > > anybody know? I am preparing a speech for my COMM class and want to

include pics of my kids during infusion, including this particular stat along

with our price per infusion (current $6200...per kid!)

> > >

> > > >

> > >

> > > >

> > >

> > > > thanks

> > >

> > > > valarie

> > >

> > > > mom to 3 w/cvid

> > >

> > > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

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> > >

[Guest guest]

thanks for the breakdown,that makes more sense ) oh and I spelled donor

wrong...ugh lol....that is bugging me!

lol

> > >

> > > >

> > >

> > > > I have read so many different statistics.....anywhere from 1,000 to

10,000 per " lot " or " unit " but I cant find anything that specifies exactly what

a " lot " or " unit " is....one bottle? one dose? one bunch mixed and prepared at

the same time?

> > >

> > > >

> > >

> > > > I am trying to figure out how many donors must donate in order to make

one bottle/dose of IVIG.

> > >

> > > >

> > >

> > > >

> > >

> > > > anybody know? I am preparing a speech for my COMM class and want to

include pics of my kids during infusion, including this particular stat along

with our price per infusion (current $6200...per kid!)

> > >

> > > >

> > >

> > > >

> > >

> > > > thanks

> > >

> > > > valarie

> > >

> > > > mom to 3 w/cvid

> > >

> > > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

[Guest guest]

thanks for the breakdown,that makes more sense ) oh and I spelled donor

wrong...ugh lol....that is bugging me!

lol

> > >

> > > >

> > >

> > > > I have read so many different statistics.....anywhere from 1,000 to

10,000 per " lot " or " unit " but I cant find anything that specifies exactly what

a " lot " or " unit " is....one bottle? one dose? one bunch mixed and prepared at

the same time?

> > >

> > > >

> > >

> > > > I am trying to figure out how many donors must donate in order to make

one bottle/dose of IVIG.

> > >

> > > >

> > >

> > > >

> > >

> > > > anybody know? I am preparing a speech for my COMM class and want to

include pics of my kids during infusion, including this particular stat along

with our price per infusion (current $6200...per kid!)

> > >

> > > >

> > >

> > > >

> > >

> > > > thanks

> > >

> > > > valarie

> > >

> > > > mom to 3 w/cvid

> > >

> > > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

> > >

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