Guest guest Posted February 20, 2004 Report Share Posted February 20, 2004 Marilyn Thank you so much for the information about RMA, you really helped clear up some confusion here. I had listened to the doctor but had not yet looked at the diagram on paper he had drawn for me. I had heard him say IL-6 and what I thought I heard was " isle 6 " and I had no idea what that was. I came home to look it up and could not find anything but got your message before I wasted to much time. I don't know where my head was that day or should I say ears, my kids have been saying for two years now that I need hearing aids, guess there is some truth in that, lol! Take care all, Louise. Marilyn Hogg wrote: > *Hi Louise, how nice it is to hear from you and what great news you > bring with you. There are some articles on the net in regard to IL6 > Inhibitors (RMA) and here is something that I found.* > > *Marilyn* > > *Anti–Interleukin–6 (IL–6)* > _Abstract 1328_ *A Double–blind, Randomized, Placebo–Controlled trial > of Anti–interleukin–6 (IL–6) Receptor Monoclonal Antibody in > Rheumatoid Arthritis (RA). * > /EH Choy, DA Isenberg, S Farrow, T Garrood, et al. London; Leeds; > Cardiff; Cambridge; Greenwich; Osaka./ > > IL–6 is a proinflammatory cytokine and elevated IL–6 levels are > observed in the sera and synovial fluid of RA patients. MRA is a > recombinant humanized anti-human IL–6 receptor monoclonal antibody > that inhibits the binding of IL–6 to its receptor. > > *Methods:* 45 patients with active RA were allocated to four treatment > groups to receive a single IV dose of either 0.1, 1.0, 5.0 or 10.0 > mg/kg of MRA or placebo. The primary endpoint was the percentage of > patients who achieved an ACR20 response at week 2. > > *Results:* Baseline demographic data were similar among treatment > groups. A significant difference was observed between the 5.0 mg/kg > and placebo groups at week 2 (p=0.011). Five (55.6%) of the 5.0 mg/kg > group and no plaebo patients demonstrated ACR20 responses. There was > no statistical difference in ACR20 response rates between placebo and > the other MRA dosage groups, although there was a trend favoring the > 10 mg/kg group. Baseline disease activity scores (DAS) ranged from 6.5 > to 6.9. At week 2, the DAS for the 5.0 and 10.0 mg/kg groups were 4.8 > and 4.7, respectively. ESR and CRP in the 5 and 10 mg/kg groups > normalized 1 week after treatment and remained normal for 3 weeks. The > most common adverse event reported was diarrhea, occurring in 17.8% of > patients. One patient died due to myocardial infarction but this was > not felt to related to study medication. > > *Conclusion:* This study suggests that anti–IL–6 therapy may improve > signs and symptoms of RA. The apparent therapeutic dose of MRA in this > single dose study was at least 5 mg/kg. > > *Editorial Comment:* IL–6 is more distal on the inflammatory pathway > than TNF and IL–1, and TNF and IL–1 have broader proinflammatory > actions than IL–6 (in fact, they induce IL–6). Insofar as anti-TNF and > anti–IL1 therapies have been shown to be very effective at lowering > IL–6 levels, as well as a myriad of other proinflammatory cytokines, > prostanoids and metalloproteases, the rationale for directed anti–IL–6 > therapy remains elusive. Anti–IL6 therapy may be useful, however, in > elucidating which manifestations of disease are related to IL–6 alone. > > > > ----Original Message Follows---- From: Darlingtons I just got home > from our trip to Boise and I have great news for all Stilligans from > Dr. Knibbe, he said to spread the news! Some docs in Europe have used > a new drug, MRA, which caused remissions in 11 of 12 people with > Stills Disease!!! It is what he called " An IL6 inhibitor " [isle 6 > inhibitor] and shows much promise. The drug is not approved yet in the > US but he said it will likely be a very good drug for me when it does > become available. He knows of no written information available yet, it > was something he heard at the most recent Rheumatology conference. > Louise. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 2004 Report Share Posted February 20, 2004 Marilyn Thank you so much for the information about RMA, you really helped clear up some confusion here. I had listened to the doctor but had not yet looked at the diagram on paper he had drawn for me. I had heard him say IL-6 and what I thought I heard was " isle 6 " and I had no idea what that was. I came home to look it up and could not find anything but got your message before I wasted to much time. I don't know where my head was that day or should I say ears, my kids have been saying for two years now that I need hearing aids, guess there is some truth in that, lol! Take care all, Louise. Marilyn Hogg wrote: > *Hi Louise, how nice it is to hear from you and what great news you > bring with you. There are some articles on the net in regard to IL6 > Inhibitors (RMA) and here is something that I found.* > > *Marilyn* > > *Anti–Interleukin–6 (IL–6)* > _Abstract 1328_ *A Double–blind, Randomized, Placebo–Controlled trial > of Anti–interleukin–6 (IL–6) Receptor Monoclonal Antibody in > Rheumatoid Arthritis (RA). * > /EH Choy, DA Isenberg, S Farrow, T Garrood, et al. London; Leeds; > Cardiff; Cambridge; Greenwich; Osaka./ > > IL–6 is a proinflammatory cytokine and elevated IL–6 levels are > observed in the sera and synovial fluid of RA patients. MRA is a > recombinant humanized anti-human IL–6 receptor monoclonal antibody > that inhibits the binding of IL–6 to its receptor. > > *Methods:* 45 patients with active RA were allocated to four treatment > groups to receive a single IV dose of either 0.1, 1.0, 5.0 or 10.0 > mg/kg of MRA or placebo. The primary endpoint was the percentage of > patients who achieved an ACR20 response at week 2. > > *Results:* Baseline demographic data were similar among treatment > groups. A significant difference was observed between the 5.0 mg/kg > and placebo groups at week 2 (p=0.011). Five (55.6%) of the 5.0 mg/kg > group and no plaebo patients demonstrated ACR20 responses. There was > no statistical difference in ACR20 response rates between placebo and > the other MRA dosage groups, although there was a trend favoring the > 10 mg/kg group. Baseline disease activity scores (DAS) ranged from 6.5 > to 6.9. At week 2, the DAS for the 5.0 and 10.0 mg/kg groups were 4.8 > and 4.7, respectively. ESR and CRP in the 5 and 10 mg/kg groups > normalized 1 week after treatment and remained normal for 3 weeks. The > most common adverse event reported was diarrhea, occurring in 17.8% of > patients. One patient died due to myocardial infarction but this was > not felt to related to study medication. > > *Conclusion:* This study suggests that anti–IL–6 therapy may improve > signs and symptoms of RA. The apparent therapeutic dose of MRA in this > single dose study was at least 5 mg/kg. > > *Editorial Comment:* IL–6 is more distal on the inflammatory pathway > than TNF and IL–1, and TNF and IL–1 have broader proinflammatory > actions than IL–6 (in fact, they induce IL–6). Insofar as anti-TNF and > anti–IL1 therapies have been shown to be very effective at lowering > IL–6 levels, as well as a myriad of other proinflammatory cytokines, > prostanoids and metalloproteases, the rationale for directed anti–IL–6 > therapy remains elusive. Anti–IL6 therapy may be useful, however, in > elucidating which manifestations of disease are related to IL–6 alone. > > > > ----Original Message Follows---- From: Darlingtons I just got home > from our trip to Boise and I have great news for all Stilligans from > Dr. Knibbe, he said to spread the news! Some docs in Europe have used > a new drug, MRA, which caused remissions in 11 of 12 people with > Stills Disease!!! It is what he called " An IL6 inhibitor " [isle 6 > inhibitor] and shows much promise. The drug is not approved yet in the > US but he said it will likely be a very good drug for me when it does > become available. He knows of no written information available yet, it > was something he heard at the most recent Rheumatology conference. > Louise. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 2004 Report Share Posted February 20, 2004 Hi Louise, you are most welcome for the information, I'm just glad that I could help. If you have anything else you would like me to look up....just ask! It's very easy to misinterpret what doctors are saying with all that medical jargin. Take care, Marilyn mhogg69@... ----Original Message Follows---- From: Darlingtons Marilyn Thank you so much for the information about RMA, you really helped clear up some confusion here. I had listened to the doctor but had not yet looked at the diagram on paper he had drawn for me. I had heard him say IL-6 and what I thought I heard was "isle 6" and I had no idea what that was. I came home to look it up and could not find anything but got your message before I wasted to much time. I don't know where my head was that day or should I say ears, my kids have been saying for two years now that I need hearing aids, guess there is some truth in that, lol! Take care all, Louise. Tired of spam? Get advanced junk mail protection with MSN 8. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 2004 Report Share Posted February 20, 2004 I remember that my rheumy was most interested when I mentioned interleukin 6 (Lynn Paarman mentioned it, I wonder where Lynn is?) My doc. Said he found disease with the very expensive interleukin test when all else had failed, so I’m thinking this medication may be important for us. tkufahl@... " The unleashed power of the atom has changed everything, except our mode of thinking. " Albert Einstein Home Page http://webpages.charter.net/tkufahl/tkufahl/publish2/index.html A new site, http://www.cwwcbc.us/tk From: Marilyn Hogg [mailto:mhogg69@...] Sent: Friday, February 20, 2004 11:08 PM Stillsdisease Subject: Louise/IL6 Inhibitor Hi Louise, you are most welcome for the information, I'm just glad that I could help. If you have anything else you would like me to look up....just ask! It's very easy to misinterpret what doctors are saying with all that medical jargin. Take care, Marilyn mhogg69@... ----Original Message Follows---- From: Darlingtons Marilyn Thank you so much for the information about RMA, you really helped clear up some confusion here. I had listened to the doctor but had not yet looked at the diagram on paper he had drawn for me. I had heard him say IL-6 and what I thought I heard was " isle 6 " and I had no idea what that was. I came home to look it up and could not find anything but got your message before I wasted to much time. I don't know where my head was that day or should I say ears, my kids have been saying for two years now that I need hearing aids, guess there is some truth in that, lol! Take care all, Louise. Tired of spam? Get advanced junk mail protection with MSN 8. Visit the Still's Disease Message Board http://disc.server.com/Indices/148599.html The materials and information contained in this message are not intended to replace the services of a trained health professional or to be a substitute for medical advice of physicians and/or other health care professionals. The International Still's Disease Foundation is not engaged in rendering medical or professional medical services. You should consult your physician on specific medical questions, particularly in matters requiring diagnosis or medical attention. The International Still's Disease Foundation makes no representations or warranties with respect to any treatment, action, application, medication or preparation by any person following the information offered or provided within this support form. ion by any person following the information offered or provided within this support form. Quote Link to comment Share on other sites More sharing options...
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