Guest guest Posted April 5, 2011 Report Share Posted April 5, 2011 If he went off antibiotics in mid-Feb and has had diarrhea since mid-Feb or March (you said 1+ mons ago) the diarrhea could still be from the antibiotics disrupting his flora. Has he had stool samples checked? Or flex sig for c.dif toxin? I haven't heard of diarrhea from hizentra but anything is possible. Mom to Dani, cvid Sent from my Sprint® BlackBerry ~~~~~~~~~~~~~~~~~~~~~~ Diarrhea and Hizentra Has anyone else had diarrhea as an ongoing side effect of Hizentra? My son switched from IVIG to Hizentra SubQ in January and has had diarrhea daily for about the last month or month and a half. He has also had more headaches than he used to, but that started back with the IVIG and they aren't nearly as severe. He has been off antibiotics since at least mid-February. Thanks Mom to Caelan 11 (CVID, specific antibody deficiency, asthma) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2011 Report Share Posted April 5, 2011 Have you done stool tests/cultures? Could be cdiff from the antibiotics. Ursula - mom to Macey On Apr 5, 2011, at 12:28 PM, Herzberg <skgcifamily@...> wrote: > Has anyone else had diarrhea as an ongoing side effect of Hizentra? My son > switched from IVIG to Hizentra SubQ in January and has had diarrhea daily > for about the last month or month and a half. He has also had more headaches > than he used to, but that started back with the IVIG and they aren't nearly > as severe. He has been off antibiotics since at least mid-February. > > Thanks > > > > Mom to Caelan 11 (CVID, specific antibody deficiency, asthma) > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2011 Report Share Posted April 5, 2011 We have not yet. I'm going to ask his immuno when we are in next. It isn't constant or anything, but it is a few times per day from what he is telling me. Thanks, _____ From: [mailto: ] On Behalf Of Ursula Holleman Sent: Tuesday, April 05, 2011 11:59 AM Subject: Re: Diarrhea and Hizentra Have you done stool tests/cultures? Could be cdiff from the antibiotics. Ursula - mom to Macey Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2011 Report Share Posted April 5, 2011 My son does that pattern of stools with yeast. He had (we assume) dropped Ig with dose change to Hizentra, because he immediately developed GI yeast infection and topical rash, bacterial skin infections. The doctor increased the Hizentra dose, but we are still battling the infections. He is also having a lot of migraines with the Hizentra (and for several days after), so we are adjusting his premeds each week to attempt to achieve the best results, ie. no headache. So I definitely think a stool culture for bacterial, viral, fungal and C-diff would be helpful. Mindy, mom of , 9, CVID plus > We have not yet. I'm going to ask his immuno when we are in next. It isn't > constant or anything, but it is a few times per day from what he is > telling > me. > > > > Thanks, > > > > > > > > _____ > > From: [mailto: ] On Behalf Of > Ursula Holleman > Sent: Tuesday, April 05, 2011 11:59 AM > > Subject: Re: Diarrhea and Hizentra > > > > > > Have you done stool tests/cultures? Could be cdiff from the antibiotics. > > Ursula - mom to Macey > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2011 Report Share Posted April 5, 2011 If they do stool tests...make sure u give fresh sample (within 2 hrs of stooling) in an airtight container. C.dif has high false negative rate. (Our 1st immuno didn't know this and accepted a 24+ hour old sample from a diaper in plastic!) Mom to Dani, CVID Sent from my Sprint® BlackBerry ~~~~~~~~~~~~~~~~~~~~~~ Re: Diarrhea and Hizentra Have you done stool tests/cultures? Could be cdiff from the antibiotics. Ursula - mom to Macey Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2011 Report Share Posted April 5, 2011 This sounds very familiar. We have had more problems with infections and headaches with Hizentra as well. The last stool culture had no C. Diff., but also NO normal flora and heavy yeast. We've hit our breaking point because he has so many side effects that we can't adjust his dose further and he can't get healthy. We are trying another product hopefully starting next week. We've tried for months and now he can't tolerate the Hizentra without terrible headaches for 3 days which is his next infusion since he infuses twice weekly without steroids. The steroids are not helping the yeast or infections and so the cycle goes. I know Hizentra works very well for some, we just are not among them. Tate 13-years-old, CVID > > My son does that pattern of stools with yeast. He had (we assume) dropped > Ig with dose change to Hizentra, because he immediately developed GI yeast > infection and topical rash, bacterial skin infections. The doctor > increased the Hizentra dose, but we are still battling the infections. He > is also having a lot of migraines with the Hizentra (and for several days > after), so we are adjusting his premeds each week to attempt to achieve > the best results, ie. no headache. > > So I definitely think a stool culture for bacterial, viral, fungal and > C-diff would be helpful. > > Mindy, mom of , 9, CVID plus > > > We have not yet. I'm going to ask his immuno when we are in next. It isn't > > constant or anything, but it is a few times per day from what he is > > telling > > me. > > > > > > > > Thanks, > > > > > > > > > > > > > > > > _____ > > > > From: [mailto: ] On Behalf Of > > Ursula Holleman > > Sent: Tuesday, April 05, 2011 11:59 AM > > > > Subject: Re: Diarrhea and Hizentra > > > > > > > > > > > > Have you done stool tests/cultures? Could be cdiff from the antibiotics. > > > > Ursula - mom to Macey > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2011 Report Share Posted April 5, 2011 Has all this been reported to CSL Behring? Ursula On Apr 5, 2011, at 8:12 PM, " sievertlaura " <sievertlaura@...> wrote: > > This sounds very familiar. We have had more problems with infections and headaches with Hizentra as well. The last stool culture had no C. Diff., but also NO normal flora and heavy yeast. We've hit our breaking point because he has so many side effects that we can't adjust his dose further and he can't get healthy. We are trying another product hopefully starting next week. We've tried for months and now he can't tolerate the Hizentra without terrible headaches for 3 days which is his next infusion since he infuses twice weekly without steroids. The steroids are not helping the yeast or infections and so the cycle goes. I know Hizentra works very well for some, we just are not among them. > > > Tate 13-years-old, CVID > > > > > > My son does that pattern of stools with yeast. He had (we assume) dropped > > Ig with dose change to Hizentra, because he immediately developed GI yeast > > infection and topical rash, bacterial skin infections. The doctor > > increased the Hizentra dose, but we are still battling the infections. He > > is also having a lot of migraines with the Hizentra (and for several days > > after), so we are adjusting his premeds each week to attempt to achieve > > the best results, ie. no headache. > > > > So I definitely think a stool culture for bacterial, viral, fungal and > > C-diff would be helpful. > > > > Mindy, mom of , 9, CVID plus > > > > > We have not yet. I'm going to ask his immuno when we are in next. It isn't > > > constant or anything, but it is a few times per day from what he is > > > telling > > > me. > > > > > > > > > > > > Thanks, > > > > > > > > > > > > > > > > > > > > > > > > _____ > > > > > > From: [mailto: ] On Behalf Of > > > Ursula Holleman > > > Sent: Tuesday, April 05, 2011 11:59 AM > > > > > > Subject: Re: Diarrhea and Hizentra > > > > > > > > > > > > > > > > > > Have you done stool tests/cultures? Could be cdiff from the antibiotics. > > > > > > Ursula - mom to Macey > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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