Guest guest Posted November 13, 2011 Report Share Posted November 13, 2011 Hi If your viral load is currently undetectable why not just change the Kaletra to darunavir/ritonavir? This would be the easiest way to dee whether the diarrhoea improves.Does your doc think Truvada is causing liver problems? I have not heard of this?SimonOn 13 Nov 2011, at 02:07, ld_ng2003 <ld_ng2003@...> wrote: I've been on Truvada and Kaletra for many years, and even though it works well, I have to take 10 Immodium tablets each day to counteract the diarrhea. My doctor wants to change my regimen because of some minor liver issues to darunavir plus Norvir once-a-day dose, Isentress and 3TC. Has anyone switched from a Kaletra regimen to a darunavir one, and if so, how has the diarrhea improved (assuming that you had diarrhea to start with)? The other option is to switch to Isentress + Intelence + 3TC, but even though I think it would minimize diarrhea, I heard the Intelence tablets are huge and chalky and really hard to swallow, which I think I would have a big problem doing. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 13, 2011 Report Share Posted November 13, 2011 "I've been on Truvada and Kaletra for many years, and even though it works well, I have to take 10 Immodium tablets each day to counteract the diarrhea.My doctor wants to change my regimen because of some minor liver issues to darunavir plus Norvir once-a-day dose, Isentress and 3TC. Has anyone switched from a Kaletra regimen to a darunavir one, and if so, how has the diarrhea improved (assuming that you had diarrhea to start with)?The other option is to switch to Isentress + Intelence + 3TC, but even though I think it would minimize diarrhea, I heard the Intelence tablets are huge and chalky and really hard to swallow, which I think I would have a big problem "You could try the Darunavir/Ritonovir containing combo, and see if you tolerated it better.......... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 14, 2011 Report Share Posted November 14, 2011 Do you have resistance problems? I was switched off Kaletra for Issentress only and yes, my diarrhea stopped and my cholesterol and triglycerides numbers dropped dramatically. I don't understand why he's loading you up on the other meds.LarryOn Nov 13, 2011, at 3:26 AM, simon collins wrote: Hi If your viral load is currently undetectable why not just change the Kaletra to darunavir/ritonavir? This would be the easiest way to dee whether the diarrhoea improves.Does your doc think Truvada is causing liver problems? I have not heard of this?SimonOn 13 Nov 2011, at 02:07, ld_ng2003 <ld_ng2003@...> wrote: I've been on Truvada and Kaletra for many years, and even though it works well, I have to take 10 Immodium tablets each day to counteract the diarrhea. My doctor wants to change my regimen because of some minor liver issues to darunavir plus Norvir once-a-day dose, Isentress and 3TC. Has anyone switched from a Kaletra regimen to a darunavir one, and if so, how has the diarrhea improved (assuming that you had diarrhea to start with)? The other option is to switch to Isentress + Intelence + 3TC, but even though I think it would minimize diarrhea, I heard the Intelence tablets are huge and chalky and really hard to swallow, which I think I would have a big problem doing. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 14, 2011 Report Share Posted November 14, 2011 Something that works quite well for diarrhea for many people is the amino acid L-Glutamine powder. It comes in capsules too, but I prefer the powder which barely has a taste mixed in water. My father was having diarrhea for months and I told him about it and it worked within a couple of days. I learned about it in the "old days" when they used to give it to people with HIV at an acupuncture clinic that I went to in the early 90's. Here is a link on it: http://www.ibstales.com/l-glutamine.htm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 14, 2011 Report Share Posted November 14, 2011 Something that works quite well for diarrhea for many people is the amino acid L-Glutamine powder. It comes in capsules too, but I prefer the powder which barely has a taste mixed in water. My father was having diarrhea for months and I told him about it and it worked within a couple of days. I learned about it in the "old days" when they used to give it to people with HIV at an acupuncture clinic that I went to in the early 90's. Here is a link on it: http://www.ibstales.com/l-glutamine.htm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 14, 2011 Report Share Posted November 14, 2011 She's also taking me off Truvada because one of my liver (or kidney, don't really remember) tests is abnormal. She changed my regimen by splitting up the Truvada into tenofovir and emtricitabine, and then when I only took the tenofovir every other day, my labs went closer to normal. She now wants me off tenofovir completely and that's the reason for the switch. So that's why she's giving me the choice of darunavir + Norvir + Isentress + 3TC or Isentress + Intelence + 3TC. Has anyone had problems swallowing the chalky Intelence pills?From: simon collins <simon.collins@...>lsmyle <lsmyle@...>Cc: simon collins <simon.collins@...>; ld_ng2003 <ld_ng2003@...>Sent: Monday, November 14, 2011 6:00 PMSubject: Re: New regimen Hi I'm sure Larry doesn't just mean Isentress monotherapy.You need to be taking tow other drugs with Isentress - but these could be your current nukes (ie Truvada) without needing an NNRTI (Intelence).SimonOn 14 Nov, 2011,at 03:27 PM, lsmyle <lsmyle@...> wrote:Do you have resistance problems? I was switched off Kaletra for Issentress only and yes, my diarrhea stopped and my cholesterol and triglycerides numbers dropped dramatically. I don't understand why he's loading you up on the other meds.LarryOn Nov 13, 2011, at 3:26 AM, simon collins wrote: Hi If your viral load is currently undetectable why not just change the Kaletra to darunavir/ritonavir? This would be the easiest way to dee whether the diarrhoea improves.Does your doc think Truvada is causing liver problems? I have not heard of this?SimonOn 13 Nov 2011, at 02:07, ld_ng2003 <ld_ng2003@...> wrote: I've been on Truvada and Kaletra for many years, and even though it works well, I have to take 10 Immodium tablets each day to counteract the diarrhea. My doctor wants to change my regimen because of some minor liver issues to darunavir plus Norvir once-a-day dose, Isentress and 3TC. Has anyone switched from a Kaletra regimen to a one, and if so, how has the diarrhea improved (assuming that you had diarrhea to start with)? The other option is to switch to Isentress + Intelence + 3TC, but even though I think it would minimize diarrhea, I heard the Intelence tablets are huge and chalky and really hard to swallow, which I think I would have a big problem doing. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 15, 2011 Report Share Posted November 15, 2011 The Intelence pills are a bit chalky, but they're not THAT bad. The new 200mg pills are big but they're smaller than (x2) 100mg pills. I just switched this very week to the 200mg pills, and I actually prefer them. If you take your pills all at once in a handfull and a big gulp, you'll probably not have any problem. I haven't. Also, they don't have any taste at all. Unlike a lot of pills that taste disgusting if they dissolve in your mouth, these pills have absolutely no taste whatsoever. So even if one doesn't go down the first time, they don't taste bad anyway. Plus, even though I was cross-resistant to all the other NNRTI drugs, Intelence works for me. That's a big plus if you have NNRTI cross-resistance. I would not fear Intelence. For me, it's been a good drug and it has no unpleasant gastrointestinal side effects at all. > >> > >> > >> > >>>I've been on Truvada and Kaletra for many years, and even though it works well, I have to take 10 Immodium tablets each day to counteract the diarrhea. > >>>My doctor wants to change my regimen because of some minor liver issues to darunavir plus Norvir once-a-day dose, Isentress and 3TC. Has anyone switched from a Kaletra regimen to a one, and if so, how has the diarrhea improved (assuming that you had diarrhea to start with)? > >>>The other option is to switch to Isentress + Intelence + 3TC, but even though I think it would minimize diarrhea, I heard the Intelence tablets are huge and chalky and really hard to swallow, which I think I would have a big problem doing. > >>> > >>> > >>> > >>> > >> > >> > >> > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 15, 2011 Report Share Posted November 15, 2011 , I switched from Kaletra/norvir/truvada/fuzeon regimen a couple of years back to Prezista/norvir/isentress/intelence. I did have a significant change in motility from loose to completely locked up! Evidently the muscles in my colon had gotten lazy with the years of using Kaletra. I had abdominal pain and had to start taking fiber and probiotics. Once I did that everything calmed down. Unlike most patients I switched one medication at a time,then waited for about three months then switched another. I had virtually no issues with Isentress and Intelence. My doctor has has very good luck with this combination. And, although Intelence tablets occasionally lodge in my throat, it is SO much better than twice daily Fuzeon shots I couldn't care less. --JJ > > I've been on Truvada and Kaletra for many years, and even though it works well, I have to take 10 Immodium tablets each day to counteract the diarrhea. > My doctor wants to change my regimen because of some minor liver issues to darunavir plus Norvir once-a-day dose, Isentress and 3TC. Has anyone switched from a Kaletra regimen to a darunavir one, and if so, how has the diarrhea improved (assuming that you had diarrhea to start with)? > The other option is to switch to Isentress + Intelence + 3TC, but even though I think it would minimize diarrhea, I heard the Intelence tablets are huge and chalky and really hard to swallow, which I think I would have a big problem doing. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 15, 2011 Report Share Posted November 15, 2011 Hi JJ,I think I will then switch to the Prezista/Norvir/isentress/3TC combo as it's just one more pill per day than isentress/intelence/3TC, but without the hard to swallow chalky pill.Thanks for your helpjamesFrom: JJMc <jj.mcmillen@...> Sent: Tuesday, November 15, 2011 9:23 PMSubject: Re: New regimen , I switched from Kaletra/norvir/truvada/fuzeon regimen a couple of years back to Prezista/norvir/isentress/intelence. I did have a significant change in motility from loose to completely locked up! Evidently the muscles in my colon had gotten lazy with the years of using Kaletra. I had abdominal pain and had to start taking fiber and probiotics. Once I did that everything calmed down. Unlike most patients I switched one medication at a time,then waited for about three months then switched another. I had virtually no issues with Isentress and Intelence. My doctor has has very good luck with this combination. And, although Intelence tablets occasionally lodge in my throat, it is SO much better than twice daily Fuzeon shots I couldn't care less. --JJ > > I've been on Truvada and Kaletra for many years, and even though it works well, I have to take 10 Immodium tablets each day to counteract the diarrhea. > My doctor wants to change my regimen because of some minor liver issues to darunavir plus Norvir once-a-day dose, Isentress and 3TC. Has anyone switched from a Kaletra regimen to a darunavir one, and if so, how has the diarrhea improved (assuming that you had diarrhea to start with)? > The other option is to switch to Isentress + Intelence + 3TC, but even though I think it would minimize diarrhea, I heard the Intelence tablets are huge and chalky and really hard to swallow, which I think I would have a big problem doing. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 16, 2011 Report Share Posted November 16, 2011 Hi JJ,My doctor was also worried about that, so I will go with the prezista/isenstress/norvir/3tc combo. Thanks ,From: J.J. McMillen <jj.mcmillen@...>'' <ld_ng2003@...>Sent: Wednesday, November 16, 2011 1:13 PMSubject: RE: Re: New regimen I would actually be concerned about isentress/intelence/3tc holding the virus down. Both isentress and intelence are easy to become resistant to if you do not have other effective drugs in the mix. And, after years of treatment for most of us that includes a PI. Isentress is one of the best drugs, maybe best ever being in a different class, so it would be terrible to waste it. --JJ From: [mailto:ld_ng2003@...] Sent: Wednesday, November 16, 2011 12:59 AMJJMc; Subject: Re: Re: New regimen Hi JJ, I think I will then switch to the Prezista/Norvir/isentress/3TC combo as it's just one more pill per day than isentress/intelence/3TC, but without the hard to swallow chalky pill. Thanks for your help james Quote Link to comment Share on other sites More sharing options...
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