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GcMAF needs further exploration for HIV cure

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2nd Generation GcMAF for sale:

http://www.nature.com/nature/outlook/breast_cancer/pdf/saisei_mirai.pdf

http://www.saisei-mirai.or.jp/gan/macrophage_eng.html

A Japanese team, led by Japanese-American Nobuto Yamamoto, Ph.D., claimed

(in the below 2009 FOCIS conference abstract) that 8-13 weeks of this 2nd

generation GcMAF cured an undisclosed percentage of 24 (total) (ex-)HIV+

patients.

T.101. Treatment of HIV-Infected Patients with Gc Protein-Derived

Macrophage Activating Factor (GcMAF) and Its Coned Derivative

(GcMAFc) Eradicates HIV-Infection

Nobuto Yamamoto1, Masumi Ueda1, Kazuya Hashinaka1,

Theodore Sery1, Benson2. 1Socrates Institute for

Therapeutic Immunology, Philadelphia, PA; 2University of

Pennsylvania, Philadelphia, PA

Serum Gc protein (known as vitamin D-binding protein) is

the precursor for the principal macrophage activating factor

(MAF). The MAF precursor activity of serum Gc protein of HIV

infected patients was lost or reduced because Gc protein is

deglycosylated by serum á-N-acetylgalactosaminidase (Nagalase)

secreted from HIV-infected cells. Since Nagalase is the

intrinsic component of gp120, serum Nagalase was already

complexed with anti-HIV immunoglobulin G (IgG) in patient

blood stream. The IgG-bound virions were infectious and

retained Nagalase activity, leading to immunosuppression.

Stepwise treatment of purified serum Gc protein or its cloned

Gc protein with immobilized â-galactosidase and sialidase

generated the most potent MAF (termed GcMAF or GcMAFc,

respectively) ever discovered, which produces no side effect in

humans. Macrophages activated by intramuscular administration

of GcMAF or GcMAFc (100 ng/patient) developed a large

amount of Fc-receptors as well as enormous variation of

receptors that phagocytize IgG bound and unbound HIV virions.

Cells harboring HIV provirus were unstable and spontaneously

released the virions at a high rate. After less than 18 weekly

intramuscular administrations of 100 ng GcMAF or GcMAFc to

twenty-four nonanemic patients, they exhibited healthy

control level of Nagalase activity, indicating eradication of

HIV-infection. Since GcMAFc has a potentmitogenic activity on

myeloid progenitor cells (MPC), intravenous administration of

GcMAFc allowed rapid interaction of GcMAFc with MPC in bone

marrow and the systemic cell counts of the activated

macrophages increased to 220-fold in 2 days. Weekly intravenous

administration of 100 ng GcMAFc to HIV-infected patients

eradicated HIV-infection in 8-13 weeks.

doi:10.1016/j.clim.2009.03.234

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One-stop shopping for everything that ails you?  Sign me up!  What number do I dial--are operators waiting?And here I thought that crabby FDA had banned gold ole' snake oil......

JeffRe: GcMAF  needs further exploration for HIV cure

Posted by: " J Barrowster "  barrowster@...   johnftl59

Tue Jun 26, 2012 8:41 am (PDT)

http://scienceblog.cancerresearchuk.org/2008/12/03/cancer-cured-for-good-gc-maf-and-the-miracle-cure/

The same team claims to have " cured " a variety of cancers.Skepticism is more than warranted.JB

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