Re: NATAP: QUAD-Panel Votes 13-1 To Recommend Approval

[Guest guest]

Would someone doing well on atripla, switch to the quad if approved?

[Guest guest]

do u feel that cobicistat by itself is too worrisome in terms of kidney damage?

or is it the combo of cobicistat and tenofovir together?

i myself have been anxiously awaiting the Prezista all-in-one with GS7340. i'm

presently on Prezista, Norvir, and Truvada and i don't think i'd want to be on

cobicistat plus viread, but was hoping that cobicistat plus gs7340 would be a

wash compared to norvir and viread.

Jeton

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> > Would someone doing well on atripla, switch to the quad if approved?

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> --

> Regards,

>

> Vergel

> Books <http://amzn.to/HbQ8sH>

>

[Guest guest]

We know that boosted PI + Truvada regimens cause higher decreases in creatinine

clearance than non boosted combos. But Cobicistat is not what we hoped as a

boosted to replace Norvir. Cobicistat may have a stronger negative influence in

the presence of tenofovir than Norvir did. And the interactions it may cause

with other drugs are complicated. I would not switch to QUAD from Atripla.

Having said that, a switch from Atripla to Isentress plus Truvada has shown

great efficacy and safety. But isentress needs to be taken twice a day, which

may not be a big deal for some people having side effects from Atripla who may

want to switch away from that once a day pill.

Boosted Prezista plus Truvada will be the next one pill a day combo after QUAD.

After that, we will have dolutegravir plus Epzicom. So, in 3 years we will have

5 once a day one pill combos. 5 years from now we will have a once a week

combo. 10 to 15: a cure made up of a combination approach.

I just polished my crystal ball. I hope I am alive to see all that become a

reality.

Re: NATAP: QUAD-Panel Votes 13-1 To Recommend Approval

do u feel that cobicistat by itself is too worrisome in terms of kidney damage?

or is it the combo of cobicistat and tenofovir together?

i myself have been anxiously awaiting the Prezista all-in-one with GS7340. i'm

presently on Prezista, Norvir, and Truvada and i don't think i'd want to be on

cobicistat plus viread, but was hoping that cobicistat plus gs7340 would be a

wash compared to norvir and viread.

Jeton

>

> > **

> >

> >

> > Would someone doing well on atripla, switch to the quad if approved?

> >

> >

> >

>

>

>

>

> --

> Regards,

>

> Vergel

> Books <http://amzn.to/HbQ8sH>

>

------------------------------------

[Guest guest]

,i assume u already know that the Prezista-combo pill will not contain Truvada, as the Viread is being replaced by a new pro-drug of Tenofovir currently labeled "GS7340". i also assume u know that Gilead is testing a separate formulation of the elvitegravir-"QUAD" replacing tenofovir with GS7340 (that newer version is in Phase 2 currently).do u feel that the claims of reduced nephrotoxicity for GS7340 vs Tenofovir r overstated?i gather that norvir + tenofovir is less nephrotoxic than cobicistat + tenofovir......but what i really hoped u n the list might know (or have an opinion on) is whether or not norvir + tenofovir is more or less nephrotoxic than cobicistat + GS7340....any idea? Jeton> Subject: Re: Re: NATAP: QUAD-Panel Votes 13-1 To Recommend Approval> jeton@...; > From: nelsonvergel@...> Date: Tue, 15 May 2012 03:26:44 +0000> > > We know that boosted PI + Truvada regimens cause higher decreases in creatinine clearance than non boosted combos. But Cobicistat is not what we hoped as a boosted to replace Norvir. Cobicistat may have a stronger negative influence in the presence of tenofovir than Norvir did. And the interactions it may cause with other drugs are complicated. I would not switch to QUAD from Atripla. > > Having said that, a switch from Atripla to Isentress plus Truvada has shown great efficacy and safety. But isentress needs to be taken twice a day, which may not be a big deal for some people having side effects from Atripla who may want to switch away from that once a day pill.> > Boosted Prezista plus Truvada will be the next one pill a day combo after QUAD. After that, we will have dolutegravir plus Epzicom. So, in 3 years we will have 5 once a day one pill combos. 5 years from now we will have a once a week combo. 10 to 15: a cure made up of a combination approach.> > I just polished my crystal ball. I hope I am alive to see all that become a reality.> > > Re: NATAP: QUAD-Panel Votes 13-1 To Recommend Approval> > do u feel that cobicistat by itself is too worrisome in terms of kidney damage? or is it the combo of cobicistat and tenofovir together?> > i myself have been anxiously awaiting the Prezista all-in-one with GS7340. i'm presently on Prezista, Norvir, and Truvada and i don't think i'd want to be on cobicistat plus viread, but was hoping that cobicistat plus gs7340 would be a wash compared to norvir and viread.> > Jeton> > > > > > > **> > >> > >> > > Would someone doing well on atripla, switch to the quad if approved?> > >> > >> > > > > > > > > > > > > -- > > Regards,> > > > Vergel> > Books <http://amzn.to/HbQ8sH>> >> > > > > ------------------------------------> >