Guest guest Posted July 18, 2006 Report Share Posted July 18, 2006 Has anyone heard of ODG which is said to be used below for oxidative stress? - Stan -------------- Phytother Res. 2006 Mar;20(3):235-6. Related Articles, Links Protective effects of Korean herbal remedy against oxidative stress in cardiomyocytes. Kim MS, Kwon DY, Cho HJ, Lee MS. Korea Food Research Institute, Kyongki-do, 463-746, Republic of Korea. Ondamtanggagambang (ODG) has been used as a prescription for psychological anxiety and depression in Korean medicine. In this study, we found that ODG have protective effects against oxidative stress in cardiomyocytes. Pretreatment with ODG extract prevented H2O2 and ZnCl2-induced cell damage in H9c2 cardiomyocytes, whereas simultaneous treatment of ODG extract did not. The protective effect of ODG extract on oxidative stress-induced damage was suppressed significantly by heme oxygenase (HO) inhibitors, zinc protoporphyrin-IX (ZnPP-IX, p < 0.01) and tin protoporphyrin-IX (SnPP-IX, p < 0.01) in H9c2 cells. ODG stimulation of cells strongly induced the expression of HO-1 protein. Taken together, it is suggested that ODG-induced expression of HO-1 may have a beneficial role in cardiomyocytes under oxidative stress. Copyright 2006 Wiley & Sons, Ltd. PMID: 16521115 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.