Re: side effect/Ariad

[Guest guest]

Hi Bobby:  I have been on Nexium for GERD, and it was quite awhile before I

found out that Gleevec causes the reflux.  I wonder if anyone that is on

Sprycel or Tasigna has had that problem.  Everytime my side effects get to me,

I just have to stop and have a talk with myself about how far I have come.  I

guess we all do that from time to time.

I have been so achy all over for weeks now, and I never know if its Arthritis

pain or Gleevec pain.

     Its good that we all share things, because it really helps the next

person.

A.

From: ROBERTA DOYLE <rcd1929@...>

Subject: [ ] side effect/Ariad

" " < >

Date: Friday, November 27, 2009, 8:13 PM

 

Hi everyone, I told my trial nurse I was having a lot of acid reflux.  I have

had it for years, and take Prevacid for it.  She said it is one of the side

effects of Ariad.  i did not know that, and even went for an endoscopy to 

have things checked out.   And here I was changing my diet and trying to

figure out why it was so prevalent, and it's the drug.  Just thought I would

mention it, as I am always bragging about this wonderful drug that gives me NO

side effects....

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

o2/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

#840 Zavie's Zero Club

[Guest guest]

, I was at doctors last week, and told the PA that I was hurting all

over. She said it must be the weather because there have been a lot of

Gleevec patients saying that they hurt - more than usual.

I have been working on the house, climbing up ladders and painting... so I

am in pain often just from that.

Oh well, at least I can still do it.

Tammy

_____

From: Armour [mailto:suzzienovember@...]

Sent: Friday, November 27, 2009 9:26 PM

Subject: Re: [ ] side effect/Ariad

Hi Bobby: I have been on Nexium for GERD, and it was quite awhile before I

found out that Gleevec causes the reflux. I wonder if anyone that is on

Sprycel or Tasigna has had that problem. Everytime my side effects get to

me, I just have to stop and have a talk with myself about how far I have

come. I guess we all do that from time to time.

I have been so achy all over for weeks now, and I never know if its

Arthritis pain or Gleevec pain.

Its good that we all share things, because it really helps the next

person.

A.

From: ROBERTA DOYLE <rcd1929sbcglobal (DOT) <mailto:rcd1929%40sbcglobal.net>

net>

Subject: [ ] side effect/Ariad

" " <groups (DOT) <mailto:%40> com>

Date: Friday, November 27, 2009, 8:13 PM

Hi everyone, I told my trial nurse I was having a lot of acid reflux. I

have had it for years, and take Prevacid for it. She said it is one of the

side effects of Ariad. i did not know that, and even went for an endoscopy

to have things checked out. And here I was changing my diet and trying to

figure out why it was so prevalent, and it's the drug. Just thought I would

mention it, as I am always bragging about this wonderful drug that gives me

NO side effects....

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

o2/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

#840 Zavie's Zero Club

[Guest guest]

I was on protonix for acid reflux for years while on gleevec. If i missed a

couple of days i was in bad condition Last summer I started having very big

problems with acid and painful bm's. And lots of gas. I thought I should see a

gastro dr but couldn't decide who to see. In the meantime at my 3 month check I

was found to be failing gleevec. Was switched to sprycel and paniced when

reading the instructions that said no acid reflux meds. Had to have it the first

week a couple of times. I don't take it anymore and eat activia every morning. I

feel better on sprycel and feel heartsick for the UK people who are threatened

with no access to the 2nd generation cml drugs.

Sent from my iPhone

On Nov 27, 2009, at 9:25 PM, Armour <suzzienovember@...> wrote:

Hi Bobby: I have been on Nexium for GERD, and it was quite awhile before I

found out that Gleevec causes the reflux. I wonder if anyone that is on Sprycel

or Tasigna has had that problem. Everytime my side effects get to me, I just

have to stop and have a talk with myself about how far I have come. I guess we

all do that from time to time.

I have been so achy all over for weeks now, and I never know if its Arthritis

pain or Gleevec pain.

Its good that we all share things, because it really helps the next person.

A.

From: ROBERTA DOYLE <rcd1929@...>

Subject: [ ] side effect/Ariad

" " < >

Date: Friday, November 27, 2009, 8:13 PM

Hi everyone, I told my trial nurse I was having a lot of acid reflux. I have

had it for years, and take Prevacid for it. She said it is one of the side

effects of Ariad. i did not know that, and even went for an endoscopy to have

things checked out. And here I was changing my diet and trying to figure out

why it was so prevalent, and it's the drug. Just thought I would mention it, as

I am always bragging about this wonderful drug that gives me NO side effects....

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

o2/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

#840 Zavie's Zero Club

[Guest guest]

Thanks for the heads up. I haven't had that bit of joy. It does kind of make

sense since we have to take it on an empty stomach.

Been slammed with a flu/cold since Wednesday--no family Thanksgiving for me.

Just been hanging on the couch reading, sleeping, watching tv. I got the go

ahead to take Sudafed, but have noticed it takes me a lot longer to metabolize

it--almost 24 hours per pill! (this is normally a 4 hour pill). Can you say

mini-pity party for one? :-)

Beth

[ ] side effect/Ariad

 

Hi everyone, I told my trial nurse I was having a lot of acid reflux.  I have

had it for years, and take Prevacid for it.  She said it is one of the side

effects of Ariad.  i did not know that, and even went for an endoscopy to 

have things checked out.   And here I was changing my diet and trying to

figure out why it was so prevalent, and it's the drug.  Just thought I would

mention it, as I am always bragging about this wonderful drug that gives me NO

side effects....

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

o2/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

#840 Zavie's Zero Club

[Guest guest]

I think we are all entitled to a pity party every now and then, be it mini or

major!

I have suffered from heart burn since 1966, did not know what it was so went to

the dr. to see if it was my heart.  He never said it was heart burn or GERD or

anything, just said keep doing what i was doing.  And that was eating soda

crackers or drinking milk.  I never went anywhere without milk in the car for

years.  finally it got so bad I went to another doctor.  And this was years

later.  He did an ultra sound, and an upper GI, and said I had a hiatal hernia

(sp) , take Tums !  Some where along the line some dr. put me on Prevacid, and

it has only been recent that the acid reflux hit again, which made me mention it

to the nurse. Even with Prevacid, I sleep with my bed cranked up to a sitting

position, thanks to a Craftmatic bed.  But, it is not what I call a side

effect, because I have had it for over 44 years!  And I'm surely not

complaining, I love this Ariad pill, and pray it continues to work, for all of

us that are on it.  Bobby

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

o2/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

#840 Zavie's Zero Club

From: bethgalliart@... <bethgalliart@...>

Subject: Re: [ ] side effect/Ariad

Date: Saturday, November 28, 2009, 10:46 AM

 

Thanks for the heads up. I haven't had that bit of joy. It does kind of make

sense since we have to take it on an empty stomach.

Been slammed with a flu/cold since Wednesday--no family Thanksgiving for me.

Just been hanging on the couch reading, sleeping, watching tv. I got the go

ahead to take Sudafed, but have noticed it takes me a lot longer to metabolize

it--almost 24 hours per pill! (this is normally a 4 hour pill). Can you say

mini-pity party for one? :-)

Beth

[ ] side effect/Ariad

 

Hi everyone, I told my trial nurse I was having a lot of acid reflux.  I have

had it for years, and take Prevacid for it.  She said it is one of the side

effects of Ariad.  i did not know that, and even went for an endoscopy to 

have things checked out.   And here I was changing my diet and trying to

figure out why it was so prevalent, and it's the drug.  Just thought I would

mention it, as I am always bragging about this wonderful drug that gives me NO

side effects....

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

o2/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

#840 Zavie's Zero Club

[Guest guest]

>

> Hi everyone, I told my trial nurse I was having a lot of acid reflux.  I have

had it for years, and take Prevacid for it.  She said it is one of the side

effects of Ariad.  i did not know that, and even went for an endoscopy to  have

things checked out.   And here I was changing my diet and trying to figure out

why it was so prevalent, and it's the drug.  Just thought I would mention it, as

I am always bragging about this wonderful drug that gives me NO side effects....

____________________________

Hi Bobby and others interested in this topic,

When I was on 800mg Gleevec for about 5 years (waiting for a new drug) I had

quite a bit of acid reflux. When I had an endoscopy, the doc said I had

esaphagitis (inflammation of the esaphagus) and gastritis (inflammation of the

stomach lining). I was quite a mess in his opinion and he wanted me to take Rx

Prevacid (I think that was the one). My acid reflux was so bad that many

mornings I would vomit a small amount of stomach juices.

On the other hand, my oncology naturopath said that it was NOT good to take

these meds, because they reduced the 'normal' stomach acid that you needed to

digest food. All these drugs are acid, so we are dumping more acid into our

stomach when we take them. The better route is to offset the acid with more

alkaline foods or drinks.

The product that I took that really turned this around for me was Acid Defense

by Garden of Life. It is a powder that I dissolved in water and drank every PM

before bed and every AM. (I am not sure that they are still making this product,

there was a problem with it caking in it's container when it was not used on a

regular basis). BUT basically it is an alkalizing formula that you can get in

many ways.

This made such a quick and huge difference for me that even Dr. Druker's nurse

Carolyn started telling other patients about this product. When I had a

follow-up endoscopy one year later, I did not have any of the previous problems

(esaghagitis, gastritis) and that doctor assumed (incorrectly) that I was using

the Prevacid.

It is really important to have an alkaline diet to offset the acid we keep

dumping into our systems with these drugs. I rarely have a problem now (but I am

on Sprycel). There are many greens drinks that you can use to help these, they

are all alkaline. The one I use the most is called Greens First (it is

comparable to 10 servings of fruits and veggies). Sometimes if my stomach has

been bothering me a little bit I will even use a green drink with my meal.

The other thing that acid reflux does is cause tooth cavities and dental

problems. I was getting small cavities at the base of some teeth that the

dentist said was from acid reflux. This has stopped also.

I was even using Tums a lot before, and now I never do (this was OK with

Gleevec, at a different time than the med).

So, this is a different approach to consider....than taking another med. If you

can find " Acid Defense " by Garden of Life it is definitely worth a try.

C.

[Guest guest]

G’day ,

I am on Tasigna and was dx with a stomach ulcer in July after experiencing

stomach pain and bloating. I am back on Somac which has healed my ulcer,

although I still have problems with some nausea at times and reflux/gastric pain

(like a gall bladder attack), especially if acidic. I had a nasty attack when I

was at my brothers for a birthday celebration and had a glass of wine and

homemade sausage rolls………..was not a good mix! Now I make sure I have had

something to eat before having any wine. I love Tasigna, however the longer I am

on it (commenced August 2008), I am experiencing problems; now with aching

muscles and fatigue, it is sooooo frustrating, but still 300 times better than

when I was on Glivec. I am now taking Panadol Osteo which is helping – 2 tabs

3 times a day, slow release and I certainly know if I don’t take it. As a last

resort I take Naprosyn SR but that plays havoc with my gut (I have low grade

Crohns). My medical plan is Pandadol Osteo 2 x 8 hourly + Endone (usually at

night if I can’t sleep) + Naprosyn x 4 days as required. I try to avoid taking

Endone and Naprosyn works wonders bummer.

I discussed the fatigue problem the other day with my haem/t and he said he has

no doubts that the TKI’s cause fatigue and the aching muscle pains – still a

small cost to be alive and otherwise well.

Regards,

From: [mailto: ] On Behalf Of

Armour

Sent: Saturday, 28 November 2009 1:26 PM

Subject: Re: [ ] side effect/Ariad

Hi Bobby: I have been on Nexium for GERD, and it was quite awhile before I

found out that Gleevec causes the reflux. I wonder if anyone that is on Sprycel

or Tasigna has had that problem. Everytime my side effects get to me, I just

have to stop and have a talk with myself about how far I have come. I guess we

all do that from time to time.

I have been so achy all over for weeks now, and I never know if its Arthritis

pain or Gleevec pain.

Its good that we all share things, because it really helps the next person.

A.

From: ROBERTA DOYLE <rcd1929@... <mailto:rcd1929%40sbcglobal.net> >

Subject: [ ] side effect/Ariad

" " < <mailto:%40> >

Date: Friday, November 27, 2009, 8:13 PM

Hi everyone, I told my trial nurse I was having a lot of acid reflux. I have

had it for years, and take Prevacid for it. She said it is one of the side

effects of Ariad. i did not know that, and even went for an endoscopy to have

things checked out. And here I was changing my diet and trying to figure out

why it was so prevalent, and it's the drug. Just thought I would mention it, as

I am always bragging about this wonderful drug that gives me NO side effects....

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

o2/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

#840 Zavie's Zero Club