Fwd: Fractures in HIV+

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Fractures in HIV+

Here are studies on fractures in HIV reported at CROI 2010, a conference report by Yin for NATAP, there were several studies reported at CROI on fractures and increased risk of fracture was found in 1 of the 3 studies, in the 2nd there was a risk not as obvious, the third was odd because it was in premenopausa women; and a study published in JCEM in Summer 2008 which found increased fracture risk. Every individual should make their own decision about therapy but fractures in the HIV-negative population has been associated with increased frailty & mortality. Therapy with a bisphosphonate is usually for 5 years or less. Jules

Fracture Prevalence Among HIV-Infected versus Non HIV-Infected Patients in a Large U.S. Healthcare System - (07/02/08) JCEM

Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection [EPIDEMIOLOGY AND SOCIAL] - (09/3/08)

Bone Fractures at CROI 2010 - see slides below - (02/23/10)

Bone/Osteoporosis/Vitamin D CROI 2010 Update - written by Yin, MD MS Assistant Professor of Clinical Medicine Columbia University Medical Center New York, NY- (03/14/10)

Bone Loss in HIV+ Premenopausal Women & Fracture Risk

Mortality Risk Associated With Low-Trauma Osteoporotic Fracture ...Feb 4, 2009 ... "The increased mortality observed here following other major and minor fractures is not well appreciated. Indeed this is the first finding ...

www.natap.org/2009/HIV/020509_06.htm

Effect of Osteoporosis Treatment on Mortality: A Meta-AnalysisEffective osteoporosis treatment can reduce fracture incidence, ... as well as 2000-2008 American Society for Bone and Mineral Research conference abstracts. ..... Society's Journals Online web site at http://jcem.endojournals.org). ...

www.natap.org/2010/HIV/032810_02.htm

Changes in Bone Mineral Density: two-years follow-up of the ANRS CO3 Aquitaine Cohort - Bone Metabolism Evolves- in 11% from osteopenia to osteoporosis and to osteopenia, bone markers worsen in 41% - (03/10/10)

Assessment of Vitamin D Levels Among HIV-infected Persons in the Study To Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study) - (02/26/10)