Re: Methotrexate, caffeine, tinnitus

[Guest guest]

Yikes! I drink a lot of coffee and this is the first that I've heard that it may interfere with the effectiveness of Methotrexate. Has anyone else heard this? Do I really have to give up my last (well, almost my last) vice?

[Guest guest]

DITTO!!

Jay

> Yikes! I drink a lot of coffee and this is the first that I've

heard that it

> may interfere with the effectiveness of Methotrexate. Has anyone

else heard

> this? Do I really have to give up my last (well, almost my last)

vice?

[Guest guest]

I've heard this before but it is my understanding that the caffeine only reduces the effectiveness of the MTX so a higher dose of MTX will counteract the loss to caffeine. Also the small study size makes it very difficult to draw conclusions. I think you could also conclude that people with strong, active RA are more likely to need a stimulus and therefore drink more caffeine than those with milder RA. I haven't panicked before and I don't plan on panic now. God bless.

----- Original Message -----

From: annette2ca

Rheumatoid Arthritis

Sent: Wednesday, March 24, 2004 7:10 PM

Subject: Methotrexate, caffeine, tinnitus

I was looking to see if tinnitus (ringing in the ears) was a side effect of methtrexate and I found this article suggesting that too much caffeine may interfere with the usefullness of MTX.Does anyone else find that they have a ringing in the ears?AnnetteCaffeine interferes with rheumatoid arthritis drugAn Israeli study of 39 adults with rheumatoid arthritis who were being treated with methotrexate has found that while intake of caffeine of up to 120mg per day seems to be irrelevant, intakes over 180mg per day reduce the effectiveness of this drug on rheumatoid arthritis. Since strong brewed coffee can contain as much as 120mg per cup, that level can easily be exceeded. Soft drinks today also often contain caffeine. The study did not look for mechanisms, but simply reported that high coffee intake was associated with a reduced improvement in parameters such as morning joint stiffness and joint pain, compared to that reported by those with lower coffee intake. This is an interesting interaction that deserves further study. Source: Nesher G, et al. Arthritis & Rheumatism 2003;48:571-2

[Guest guest]

Yes..same for me, though, I AIN'T GONNA GIVE UP MY COFFFFEEE.....

that is my last vice...I just have a few cups in the morning, then no

more after 10 am...but yes, I have ringing in my ears but it may be

due to who knows what else going on in my nutso body!??.

Lindy

-- In Rheumatoid Arthritis , " Harold Van Tuyl "

<hvantuyl@c...> wrote:

> I've heard this before but it is my understanding that the caffeine

only reduces the effectiveness of the MTX so a higher dose of MTX will

counteract the loss to caffeine. Also the small study size makes it

very difficult to draw conclusions. I think you could also conclude

that people with strong, active RA are more likely to need a stimulus

and therefore drink more caffeine than those with milder RA. I

haven't panicked before and I don't plan on panic now. God bless.

> ----- Original Message -----

> From: annette2ca

> Rheumatoid Arthritis

> Sent: Wednesday, March 24, 2004 7:10 PM

> Subject: Methotrexate, caffeine, tinnitus

>

>

> I was looking to see if tinnitus (ringing in the ears) was a side

> effect of methtrexate and I found this article suggesting that too

> much caffeine may interfere with the usefullness of MTX.

>

> Does anyone else find that they have a ringing in the ears?

> Annette

>

> Caffeine interferes with rheumatoid arthritis drug

>

> An Israeli study of 39 adults with rheumatoid arthritis who were

> being treated with methotrexate has found that while intake of

> caffeine of up to 120mg per day seems to be irrelevant, intakes

over

> 180mg per day reduce the effectiveness of this drug on rheumatoid

> arthritis. Since strong brewed coffee can contain as much as 120mg

> per cup, that level can easily be exceeded. Soft drinks today also

> often contain caffeine. The study did not look for mechanisms, but

> simply reported that high coffee intake was associated with a

reduced

> improvement in parameters such as morning joint stiffness and

joint

> pain, compared to that reported by those with lower coffee intake.

> This is an interesting interaction that deserves further study.

>

> Source: Nesher G, et al. Arthritis & Rheumatism 2003;48:571-2

>

>

>

>

>

>

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